JOURNAL ONKOLOGIE – STUDIE
A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC
Rekrutierend
NCT-Nummer:
NCT03052608
Studienbeginn:
April 2017
Letztes Update:
20.01.2021
Wirkstoff:
Lorlatinib, Crizotinib
Indikation (Clinical Trials):
Carcinoma, Non-Small-Cell Lung
Geschlecht:
Alle
Altersgruppe:
Erwachsene (18+)
Phase:
Phase 3
Sponsor:
Pfizer
Collaborator:
-
Studienleiter
Study Director
Pfizer
Kontakt
Kontakt:
Phone: 1-800-718-1021
E-Mail: ClinicalTrials.gov_Inquiries@pfizer.com» Kontaktdaten anzeigen
Studienlocations (3 von 167)
Uberortliche Radiologische Gemeinschaftspraxis Dr. med. Marc Amler
01309 Dresden
(Sachsen)
GermanyAktiv, nicht rekrutierend» Google-MapsTechnische Universitat Dresden , Medizinische Fakultat Carl Gustav Carus
D-01307 Dresden
(Sachsen)
GermanyAktiv, nicht rekrutierend» Google-MapsThoraxklinik Heidelberg gGmbH
D-69126 Heidelberg
(Baden-Württemberg)
GermanyRekrutierend» Google-Maps
01309 Dresden
(Sachsen)
GermanyAktiv, nicht rekrutierend» Google-MapsTechnische Universitat Dresden , Medizinische Fakultat Carl Gustav Carus
D-01307 Dresden
(Sachsen)
GermanyAktiv, nicht rekrutierend» Google-MapsThoraxklinik Heidelberg gGmbH
D-69126 Heidelberg
(Baden-Württemberg)
GermanyRekrutierend» Google-Maps
Universitatsklinikum Heidelberg
D-69126 Heidelberg
(Baden-Württemberg)
GermanyRekrutierend» Google-MapsUniversitätsklinikum des Saarlandes, Innere Medizin V
66421 Homburg - Saar
(Saarland)
GermanyNoch nicht rekrutierend» Google-MapsUniversitäts-Brustzentrum am Universitätsklinikum des Saarlandes
Kirrberger Straße 100
66424 Homburg
DeutschlandNoch nicht rekrutierend» Google-MapsUniversitatsklinikum Regensburg, Institut fur Rontgendiagnostik
93053 Regensburg
(Bayern)
GermanyRekrutierend» Google-MapsUniversitatsklinikum Regensburg, Klinik und Poliklinik fur Innere Medizin II
93053 Regensburg
(Bayern)
GermanyRekrutierend» Google-MapsFlorida Cancer Specialists
32701 Altamonte Springs
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33511 Brandon
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33761 Clearwater
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32605 Gainesville
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33770 Largo
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
34461 Lecanto
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
34655 New Port Richey
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32763 Orange City
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32806 Orlando
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33705 Saint Petersburg
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
34608 Spring Hill
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33607 Tampa
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32778 Tavares
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32159 The Villages
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32792 Winter Park
United StatesAktiv, nicht rekrutierend» Google-MapsMassachusetts Eye and Ear Infirmary
02114 Boston
United StatesAktiv, nicht rekrutierend» Google-MapsMassachusetts General Hospital
02114 Boston
United StatesAktiv, nicht rekrutierend» Google-MapsOphthalmic Consultants of Boston Inc
02114 Boston
United StatesAktiv, nicht rekrutierend» Google-MapsThe William P. Beetham Eye Institute, Joslin Diabetes Center
02215 Boston
United StatesAktiv, nicht rekrutierend» Google-MapsUniversity of Rochester Cancer Center Pharmacy
14642 Rochester
United StatesAktiv, nicht rekrutierend» Google-MapsUniversity of Rochester Medical Center
14642 Rochester
United StatesAktiv, nicht rekrutierend» Google-MapsTennessee Oncology, PLLC
37055 Dickson
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37067 Franklin
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37066 Gallatin
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37076 Hermitage
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37090 Lebanon
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37129 Murfreesboro
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37203 Nashville
United StatesAbgebrochen» Google-MapsThe Sarah Cannon Research Institute.
37203 Nashville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37205 Nashville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37207 Nashville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37211 Nashville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37160 Shelbyville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37167 Smyrna
United StatesAbgebrochen» Google-MapsUniversity of Washington Medical Center
98195 Seattle
United StatesAktiv, nicht rekrutierend» Google-MapsCentro de Investigacion Pergamino SA
B2700CPM Pergamino
ArgentinaRekrutierend» Google-MapsCentro Medico Austral
C1019ABS Caba
ArgentinaRekrutierend» Google-MapsBendigo Day Surgery Collection Centre and Laboratory
3550 Bendigo
AustraliaRekrutierend» Google-MapsBendigo Medical Imaging, Bendigo Hospital
3550 Bendigo
AustraliaRekrutierend» Google-MapsMelbourne Pathology
3550 Bendigo
AustraliaRekrutierend» Google-MapsPeter MacCallum Cancer Centre
3000 Melbourne
AustraliaRekrutierend» Google-MapsGrand Hopital de Charleroi - Site Notre Dame
6000 Charleroi
BelgiumAktiv, nicht rekrutierend» Google-MapsPrincess Margaret Cancer Centre
M5G 2M9 Toronto
CanadaRekrutierend» Google-MapsMcGill University Health Centre
H4A 3J1 Montreal
CanadaRekrutierend» Google-MapsThe Affiliated Hospital of Military Medical Sciences
100071 Beijing
ChinaAktiv, nicht rekrutierend» Google-MapsJilin Provincial Cancer Hospital
130012 Changchun
ChinaAktiv, nicht rekrutierend» Google-MapsShanghai Chest Hospital
200030 Shanghai
ChinaRekrutierend» Google-MapsDepartment of Respiratory,the First Affiliated Hospital of College of Medicine, Zhejiang University
310003 Hangzhou
ChinaAktiv, nicht rekrutierend» Google-MapsThe Second Affiliated Hospital of Zhejiang University School of Medicine
310009 Hangzhou
ChinaAktiv, nicht rekrutierend» Google-MapsZhejiang Cancer Hospital
310022 Hangzhou
ChinaAktiv, nicht rekrutierend» Google-MapsBeijing Cancer Hospital
100142 Beijing
ChinaAktiv, nicht rekrutierend» Google-MapsGuangdong General Hospital
510000 Guangzhou
ChinaAktiv, nicht rekrutierend» Google-MapsFakultni nemocnice Olomouc, Klinika plicnich nemoci a tuberkulozy
779 00 Olomouc
CzechiaAktiv, nicht rekrutierend» Google-MapsVseobecna fakultni nemocnice v Praze
128 08 Praha 2
CzechiaRekrutierend» Google-MapsHopital Haut-Léveque-Centre François Magendie
33604 Pessac
FranceAktiv, nicht rekrutierend» Google-MapsHopital de Chevilly Larue
94550 Chevilly Larue
FranceAktiv, nicht rekrutierend» Google-MapsCentre Hospitalier du Mans
72000 Le Mans
FranceRekrutierend» Google-MapsInstitut Paoli-Calmettes
13273 Marseille cedex 09
FranceRekrutierend» Google-MapsDépartement d'Imagerie Médicale
13915 Marseille cedex 20
FranceRekrutierend» Google-MapsHôpital Nord
13915 Marseille cedex 20
FranceRekrutierend» Google-MapsService Ophtalmologie
13915 Marseille cedex 20
FranceRekrutierend» Google-MapsClinique Monticelli-Paradis-Dr Stephan Fauquier
13008 Marseille
FranceRekrutierend» Google-MapsGroupe Hospitalier Bichat Claude Bernard, AP-HP
75018 Paris
FranceAktiv, nicht rekrutierend» Google-MapsCHU de Rennes Hopital Pontchaillou
35033 Rennes cedex 9
FranceAbgebrochen» Google-MapsCHU de Rennes, Hopital Pontchaillou
35033 Rennes cedex 9
FranceAbgebrochen» Google-MapsHopital Foch
92150 Suresnes
FranceAktiv, nicht rekrutierend» Google-MapsHopital Larrey
31059 Toulouse Cedex 9
FranceAktiv, nicht rekrutierend» Google-MapsHopital Pierre Paul Riquet
31059 Toulouse cedex 9
FranceAktiv, nicht rekrutierend» Google-MapsHôpital Larrey
31059 Toulouse Cedex 9
FranceAktiv, nicht rekrutierend» Google-MapsDepartment d'imagerie medicale
94805 Villejuif
FranceAktiv, nicht rekrutierend» Google-MapsInstitut Gustave Roussy
94805 Villejuif
FranceAktiv, nicht rekrutierend» Google-MapsThe University of Hong Kong, Department of Clinical Oncology
Hong Kong
Hong KongAktiv, nicht rekrutierend» Google-MapsThe University of Hong Kong, Department of Medicine
Hong Kong
Hong KongAktiv, nicht rekrutierend» Google-MapsTuen Mun Hospital
Hong Kong
Hong KongAktiv, nicht rekrutierend» Google-MapsArtemis Hospital
122001 Gurugram
IndiaAktiv, nicht rekrutierend» Google-MapsManipal Hospital
560017 Bangalore
IndiaAbgebrochen» Google-MapsSrinivasam Cancer Care Multispeciality Hospitals India Pvt Ltd
560072 Bangalore
IndiaAktiv, nicht rekrutierend» Google-MapsSahyadri Clinical Research and Development Centre
411004 Pune
IndiaAktiv, nicht rekrutierend» Google-MapsSahyadri Specialty Hospital
411004 Pune
IndiaAktiv, nicht rekrutierend» Google-MapsAOU Policlinico Vittorio Emanuele-P.O.G. Rodolico
95123 Catania
ItalyAktiv, nicht rekrutierend» Google-MapsASST Monza - A.O. San Gerardo
20900 Monza
ItalyRekrutierend» Google-MapsIRCCS Ospedale San Raffaele
20132 Milano
ItalyAktiv, nicht rekrutierend» Google-MapsFondazione IRCCS Istituto Nazionale dei Tumori
20133 Milano
ItalyRekrutierend» Google-MapsIstituto Europeo di Oncologia
20141 Milano
ItalyRekrutierend» Google-MapsIstituto Clinico Humanitas
20089 Rozzano
ItalyRekrutierend» Google-MapsAzienda Ospedaliera di Perugia - Ospedale S. M. Misericordia
06132 Perugia
ItalyRekrutierend» Google-MapsCentro di Riferimento Oncologico-IRCCS
33081 Pordenone
ItalyRekrutierend» Google-MapsAzienda Ospedaliero-Universitaria di Parma
43126 Parma
ItalyAbgebrochen» Google-MapsIstituto Nazionale Tumori Regina Elena
00144 Roma
ItalyAktiv, nicht rekrutierend» Google-MapsAz.Osp.San Camillo-Forlanini
00152 Roma
ItalyRekrutierend» Google-MapsAzienda Ospedaliera Dei Colli Ospedale Monaldi
80131 Napoli
ItalyRekrutierend» Google-MapsIstituto Nazionale Tumori di Napoli
80131 Napoli
ItalyRekrutierend» Google-MapsAusl della Romagna- Ravenna
48121 Ravenna
ItalyAktiv, nicht rekrutierend» Google-MapsAichi cancer center central hospital
464-8681 Nagoya
JapanAbgebrochen» Google-MapsNagoya University Hospital
466-8560 Nagoya
JapanAktiv, nicht rekrutierend» Google-MapsNational Hospital Organization Shikoku Cancer Center
791-0280 Matsuyama
JapanAktiv, nicht rekrutierend» Google-MapsKurume University Hospital
830-0011 Kurume
JapanAktiv, nicht rekrutierend» Google-MapsNational Hospital Organization Hokkaido Cancer Center
003-0804 Sapporo
JapanAktiv, nicht rekrutierend» Google-MapsKanazawa University Hospital
920-8641 Kanazawa
JapanAbgebrochen» Google-MapsKanagawa Cancer Center
241-8515 Yokohama
JapanAktiv, nicht rekrutierend» Google-MapsSendai Kousei Hospital
980-0873 Sendai
JapanAktiv, nicht rekrutierend» Google-MapsOsaka International Cancer Institute
541-8567 Osaka-shi
JapanAktiv, nicht rekrutierend» Google-MapsKindai University Hospital
589-8511 Osakasayama
JapanAktiv, nicht rekrutierend» Google-MapsShizuoka Cancer Center
411-8777 Sunto-gun
JapanAktiv, nicht rekrutierend» Google-MapsNational Cancer Center Hospital
104-0045 Chuo-Ku
JapanAktiv, nicht rekrutierend» Google-MapsNational Hospital Organization, Yamaguchi-Ube Medical Center
755-0241 Ube
JapanAktiv, nicht rekrutierend» Google-MapsThe Cancer Institute Hospital of JFCR
135-8550 Koto-ku, Tokyo
JapanAktiv, nicht rekrutierend» Google-MapsNiigata Cancer Center Hospital
951-8566 Niigata
JapanAktiv, nicht rekrutierend» Google-MapsOkayama University Hospital
700-8558 Okayama
JapanAktiv, nicht rekrutierend» Google-MapsOsaka City General Hospital
534-0021 Osaka
JapanAktiv, nicht rekrutierend» Google-MapsTokushima University Hospital
770-8503 Tokushima
JapanAktiv, nicht rekrutierend» Google-MapsWakayama Medical University Department of Pulmonary Medicine and Oncology
641-8509 Wakayama
JapanAktiv, nicht rekrutierend» Google-MapsThe Catholic University of Korea, St. Vincents Hospital
16247 Suwon
Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsSeoul National University Hospital
03080 Seoul
Korea, Republic ofRekrutierend» Google-MapsDivision of Medical Oncology, Severance Hospital, Yonsei University Health System
03722 Seoul
Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsAsan Medical Center
05505 Seoul
Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsUlsan University Hospital
44033 Ulsan
Korea, Republic ofRekrutierend» Google-MapsPromotora Medica Aguascalientes SA de CV
20230 Aguascalientes
MexicoRekrutierend» Google-MapsInstituto Nacional de Cancerologia
14080 Distrito Federal
MexicoRekrutierend» Google-MapsInstituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas
14080 Distrito Federal
MexicoRekrutierend» Google-MapsUniversity Medical Center Groningen
9713 GZ Groningen
NetherlandsRekrutierend» Google-MapsKlinika Onkologii i Radioterapii Uniwersyteckie Centrum Kliniczne
80-214 Gdansk
PolandAktiv, nicht rekrutierend» Google-MapsMed-Polonia Sp. z o.o.
60-693 Poznan
PolandRekrutierend» Google-MapsCentrum Medyczne Dom Lekarski S.A.
70-784 Szczecin
PolandRekrutierend» Google-MapsNarodowy Instytut Onkologii im. Marii Sklodowskiej-Curie-Panstwowy Instytut Badawczy
02-781 Warszawa
PolandRekrutierend» Google-MapsRBHI Kursk Regional Clinical Oncology Dispensary
305 524 Kislino, Ryshkovsky Rural Council
Russian FederationAbgebrochen» Google-MapsBudgetary Healthcare Institution Omsk Region "Clinical Oncological Dispensary"
644013 Omsk
Russian FederationRekrutierend» Google-MapsLEC at SBIH "Saint-Petersburg Clinical Research Practical Center of specialized types of
197758 Pesochniy Poselok
Russian FederationRekrutierend» Google-MapsPrivate Medical Institution "Euromedservice"
196603 Pushkin
Russian FederationRekrutierend» Google-MapsRBHI Kursk Regional Clinical Oncology Dispensary
305 035 Kursk
Russian FederationAbgebrochen» Google-MapsFSBI "N.N.Blokhin Medical Research Center of Oncology"
115478 Moscow
Russian FederationRekrutierend» Google-MapsNational University Hospital
119074 Singapore
SingaporeAktiv, nicht rekrutierend» Google-MapsRaffles Hospital
188770 Singapore
SingaporeAktiv, nicht rekrutierend» Google-MapsInstitut Catala d'Oncologia L'Hospitalet
08908 L'Hospitalet de Llobregat
SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario Insular de Gran Canaria
35016 Las Palmas de Gran Canaria
SpainAbgebrochen» Google-MapsHospital Universitario Puerta de Hierro Majadahonda
28222 Majadahonda
SpainAktiv, nicht rekrutierend» Google-MapsComplejo Hospitalario De Navarra
31008 Pamplona
SpainAktiv, nicht rekrutierend» Google-MapsHospital Teresa Herrera C.H.U.A.C.
15006 A Coruna
SpainRekrutierend» Google-MapsHospital De La Santa Creu I Sant Pau
08025 Barcelona
SpainAbgebrochen» Google-MapsHospital Universitari Vall d'Hebron
08035 Barcelona
SpainRekrutierend» Google-MapsHospital Clinic i Provincial de Barcelona
08036 Barcelona
SpainRekrutierend» Google-MapsHospital De La Santa Creu I Sant Pau
08041 Barcelona
SpainAbgebrochen» Google-MapsInstitut Catala d'Oncologia Girona
17007 Girona
SpainRekrutierend» Google-MapsHospital Universitario Ramon y Cajal
28034 Madrid
SpainAktiv, nicht rekrutierend» Google-MapsHospital Clinico San Carlos
28040 Madrid
SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario Fundacion Jimenez Diaz
28040 Madrid
SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario La Fe
46026 Valencia
SpainAbgebrochen» Google-MapsNational Taiwan University Hospital
10002 Taipei
TaiwanRekrutierend» Google-MapsChang Gung Memorial Hospital - Kaohsiung Branch
83301 Kaohsiung
TaiwanAktiv, nicht rekrutierend» Google-MapsChung Shan Medical University Hospital
402 Taichung
TaiwanAbgebrochen» Google-MapsTaichung Veterans General Hospital
40705 Taichung
TaiwanAktiv, nicht rekrutierend» Google-MapsTaipei Veterans General Hospital
112 Taipei
TaiwanRekrutierend» Google-MapsCukurova University Medical Faculty
01330 Adana
TurkeyAktiv, nicht rekrutierend» Google-MapsIstanbul University Oncology Institute
34093 Istanbul
TurkeyAktiv, nicht rekrutierend» Google-MapsMarmara Univ Pendik Training and Research Hospital
34899 Istanbul
TurkeyAbgebrochen» Google-MapsEge University Medical Faculty
35100 Izmir
TurkeyAbgebrochen» Google-MapsThe Ipswich Hospital NHS Trust
IP4 5PD Ipswich
United KingdomAktiv, nicht rekrutierend» Google-MapsHeart of England NHS Foundation Trust, Birmingham Heartlands Hospital
B9 5SS Birmingham
United KingdomAktiv, nicht rekrutierend» Google-MapsThe Christie NHS Foundation Trust
M20 4BX Manchester
United KingdomAktiv, nicht rekrutierend» Google-Maps
Alle anzeigen D-69126 Heidelberg
(Baden-Württemberg)
GermanyRekrutierend» Google-MapsUniversitätsklinikum des Saarlandes, Innere Medizin V
66421 Homburg - Saar
(Saarland)
GermanyNoch nicht rekrutierend» Google-MapsUniversitäts-Brustzentrum am Universitätsklinikum des Saarlandes
Kirrberger Straße 100
66424 Homburg
DeutschlandNoch nicht rekrutierend» Google-MapsUniversitatsklinikum Regensburg, Institut fur Rontgendiagnostik
93053 Regensburg
(Bayern)
GermanyRekrutierend» Google-MapsUniversitatsklinikum Regensburg, Klinik und Poliklinik fur Innere Medizin II
93053 Regensburg
(Bayern)
GermanyRekrutierend» Google-MapsFlorida Cancer Specialists
32701 Altamonte Springs
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33511 Brandon
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33761 Clearwater
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32605 Gainesville
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33770 Largo
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
34461 Lecanto
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
34655 New Port Richey
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32763 Orange City
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32806 Orlando
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33705 Saint Petersburg
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
34608 Spring Hill
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
33607 Tampa
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32778 Tavares
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32159 The Villages
United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists
32792 Winter Park
United StatesAktiv, nicht rekrutierend» Google-MapsMassachusetts Eye and Ear Infirmary
02114 Boston
United StatesAktiv, nicht rekrutierend» Google-MapsMassachusetts General Hospital
02114 Boston
United StatesAktiv, nicht rekrutierend» Google-MapsOphthalmic Consultants of Boston Inc
02114 Boston
United StatesAktiv, nicht rekrutierend» Google-MapsThe William P. Beetham Eye Institute, Joslin Diabetes Center
02215 Boston
United StatesAktiv, nicht rekrutierend» Google-MapsUniversity of Rochester Cancer Center Pharmacy
14642 Rochester
United StatesAktiv, nicht rekrutierend» Google-MapsUniversity of Rochester Medical Center
14642 Rochester
United StatesAktiv, nicht rekrutierend» Google-MapsTennessee Oncology, PLLC
37055 Dickson
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37067 Franklin
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37066 Gallatin
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37076 Hermitage
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37090 Lebanon
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37129 Murfreesboro
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37203 Nashville
United StatesAbgebrochen» Google-MapsThe Sarah Cannon Research Institute.
37203 Nashville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37205 Nashville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37207 Nashville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37211 Nashville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37160 Shelbyville
United StatesAbgebrochen» Google-MapsTennessee Oncology, PLLC
37167 Smyrna
United StatesAbgebrochen» Google-MapsUniversity of Washington Medical Center
98195 Seattle
United StatesAktiv, nicht rekrutierend» Google-MapsCentro de Investigacion Pergamino SA
B2700CPM Pergamino
ArgentinaRekrutierend» Google-MapsCentro Medico Austral
C1019ABS Caba
ArgentinaRekrutierend» Google-MapsBendigo Day Surgery Collection Centre and Laboratory
3550 Bendigo
AustraliaRekrutierend» Google-MapsBendigo Medical Imaging, Bendigo Hospital
3550 Bendigo
AustraliaRekrutierend» Google-MapsMelbourne Pathology
3550 Bendigo
AustraliaRekrutierend» Google-MapsPeter MacCallum Cancer Centre
3000 Melbourne
AustraliaRekrutierend» Google-MapsGrand Hopital de Charleroi - Site Notre Dame
6000 Charleroi
BelgiumAktiv, nicht rekrutierend» Google-MapsPrincess Margaret Cancer Centre
M5G 2M9 Toronto
CanadaRekrutierend» Google-MapsMcGill University Health Centre
H4A 3J1 Montreal
CanadaRekrutierend» Google-MapsThe Affiliated Hospital of Military Medical Sciences
100071 Beijing
ChinaAktiv, nicht rekrutierend» Google-MapsJilin Provincial Cancer Hospital
130012 Changchun
ChinaAktiv, nicht rekrutierend» Google-MapsShanghai Chest Hospital
200030 Shanghai
ChinaRekrutierend» Google-MapsDepartment of Respiratory,the First Affiliated Hospital of College of Medicine, Zhejiang University
310003 Hangzhou
ChinaAktiv, nicht rekrutierend» Google-MapsThe Second Affiliated Hospital of Zhejiang University School of Medicine
310009 Hangzhou
ChinaAktiv, nicht rekrutierend» Google-MapsZhejiang Cancer Hospital
310022 Hangzhou
ChinaAktiv, nicht rekrutierend» Google-MapsBeijing Cancer Hospital
100142 Beijing
ChinaAktiv, nicht rekrutierend» Google-MapsGuangdong General Hospital
510000 Guangzhou
ChinaAktiv, nicht rekrutierend» Google-MapsFakultni nemocnice Olomouc, Klinika plicnich nemoci a tuberkulozy
779 00 Olomouc
CzechiaAktiv, nicht rekrutierend» Google-MapsVseobecna fakultni nemocnice v Praze
128 08 Praha 2
CzechiaRekrutierend» Google-MapsHopital Haut-Léveque-Centre François Magendie
33604 Pessac
FranceAktiv, nicht rekrutierend» Google-MapsHopital de Chevilly Larue
94550 Chevilly Larue
FranceAktiv, nicht rekrutierend» Google-MapsCentre Hospitalier du Mans
72000 Le Mans
FranceRekrutierend» Google-MapsInstitut Paoli-Calmettes
13273 Marseille cedex 09
FranceRekrutierend» Google-MapsDépartement d'Imagerie Médicale
13915 Marseille cedex 20
FranceRekrutierend» Google-MapsHôpital Nord
13915 Marseille cedex 20
FranceRekrutierend» Google-MapsService Ophtalmologie
13915 Marseille cedex 20
FranceRekrutierend» Google-MapsClinique Monticelli-Paradis-Dr Stephan Fauquier
13008 Marseille
FranceRekrutierend» Google-MapsGroupe Hospitalier Bichat Claude Bernard, AP-HP
75018 Paris
FranceAktiv, nicht rekrutierend» Google-MapsCHU de Rennes Hopital Pontchaillou
35033 Rennes cedex 9
FranceAbgebrochen» Google-MapsCHU de Rennes, Hopital Pontchaillou
35033 Rennes cedex 9
FranceAbgebrochen» Google-MapsHopital Foch
92150 Suresnes
FranceAktiv, nicht rekrutierend» Google-MapsHopital Larrey
31059 Toulouse Cedex 9
FranceAktiv, nicht rekrutierend» Google-MapsHopital Pierre Paul Riquet
31059 Toulouse cedex 9
FranceAktiv, nicht rekrutierend» Google-MapsHôpital Larrey
31059 Toulouse Cedex 9
FranceAktiv, nicht rekrutierend» Google-MapsDepartment d'imagerie medicale
94805 Villejuif
FranceAktiv, nicht rekrutierend» Google-MapsInstitut Gustave Roussy
94805 Villejuif
FranceAktiv, nicht rekrutierend» Google-MapsThe University of Hong Kong, Department of Clinical Oncology
Hong Kong
Hong KongAktiv, nicht rekrutierend» Google-MapsThe University of Hong Kong, Department of Medicine
Hong Kong
Hong KongAktiv, nicht rekrutierend» Google-MapsTuen Mun Hospital
Hong Kong
Hong KongAktiv, nicht rekrutierend» Google-MapsArtemis Hospital
122001 Gurugram
IndiaAktiv, nicht rekrutierend» Google-MapsManipal Hospital
560017 Bangalore
IndiaAbgebrochen» Google-MapsSrinivasam Cancer Care Multispeciality Hospitals India Pvt Ltd
560072 Bangalore
IndiaAktiv, nicht rekrutierend» Google-MapsSahyadri Clinical Research and Development Centre
411004 Pune
IndiaAktiv, nicht rekrutierend» Google-MapsSahyadri Specialty Hospital
411004 Pune
IndiaAktiv, nicht rekrutierend» Google-MapsAOU Policlinico Vittorio Emanuele-P.O.G. Rodolico
95123 Catania
ItalyAktiv, nicht rekrutierend» Google-MapsASST Monza - A.O. San Gerardo
20900 Monza
ItalyRekrutierend» Google-MapsIRCCS Ospedale San Raffaele
20132 Milano
ItalyAktiv, nicht rekrutierend» Google-MapsFondazione IRCCS Istituto Nazionale dei Tumori
20133 Milano
ItalyRekrutierend» Google-MapsIstituto Europeo di Oncologia
20141 Milano
ItalyRekrutierend» Google-MapsIstituto Clinico Humanitas
20089 Rozzano
ItalyRekrutierend» Google-MapsAzienda Ospedaliera di Perugia - Ospedale S. M. Misericordia
06132 Perugia
ItalyRekrutierend» Google-MapsCentro di Riferimento Oncologico-IRCCS
33081 Pordenone
ItalyRekrutierend» Google-MapsAzienda Ospedaliero-Universitaria di Parma
43126 Parma
ItalyAbgebrochen» Google-MapsIstituto Nazionale Tumori Regina Elena
00144 Roma
ItalyAktiv, nicht rekrutierend» Google-MapsAz.Osp.San Camillo-Forlanini
00152 Roma
ItalyRekrutierend» Google-MapsAzienda Ospedaliera Dei Colli Ospedale Monaldi
80131 Napoli
ItalyRekrutierend» Google-MapsIstituto Nazionale Tumori di Napoli
80131 Napoli
ItalyRekrutierend» Google-MapsAusl della Romagna- Ravenna
48121 Ravenna
ItalyAktiv, nicht rekrutierend» Google-MapsAichi cancer center central hospital
464-8681 Nagoya
JapanAbgebrochen» Google-MapsNagoya University Hospital
466-8560 Nagoya
JapanAktiv, nicht rekrutierend» Google-MapsNational Hospital Organization Shikoku Cancer Center
791-0280 Matsuyama
JapanAktiv, nicht rekrutierend» Google-MapsKurume University Hospital
830-0011 Kurume
JapanAktiv, nicht rekrutierend» Google-MapsNational Hospital Organization Hokkaido Cancer Center
003-0804 Sapporo
JapanAktiv, nicht rekrutierend» Google-MapsKanazawa University Hospital
920-8641 Kanazawa
JapanAbgebrochen» Google-MapsKanagawa Cancer Center
241-8515 Yokohama
JapanAktiv, nicht rekrutierend» Google-MapsSendai Kousei Hospital
980-0873 Sendai
JapanAktiv, nicht rekrutierend» Google-MapsOsaka International Cancer Institute
541-8567 Osaka-shi
JapanAktiv, nicht rekrutierend» Google-MapsKindai University Hospital
589-8511 Osakasayama
JapanAktiv, nicht rekrutierend» Google-MapsShizuoka Cancer Center
411-8777 Sunto-gun
JapanAktiv, nicht rekrutierend» Google-MapsNational Cancer Center Hospital
104-0045 Chuo-Ku
JapanAktiv, nicht rekrutierend» Google-MapsNational Hospital Organization, Yamaguchi-Ube Medical Center
755-0241 Ube
JapanAktiv, nicht rekrutierend» Google-MapsThe Cancer Institute Hospital of JFCR
135-8550 Koto-ku, Tokyo
JapanAktiv, nicht rekrutierend» Google-MapsNiigata Cancer Center Hospital
951-8566 Niigata
JapanAktiv, nicht rekrutierend» Google-MapsOkayama University Hospital
700-8558 Okayama
JapanAktiv, nicht rekrutierend» Google-MapsOsaka City General Hospital
534-0021 Osaka
JapanAktiv, nicht rekrutierend» Google-MapsTokushima University Hospital
770-8503 Tokushima
JapanAktiv, nicht rekrutierend» Google-MapsWakayama Medical University Department of Pulmonary Medicine and Oncology
641-8509 Wakayama
JapanAktiv, nicht rekrutierend» Google-MapsThe Catholic University of Korea, St. Vincents Hospital
16247 Suwon
Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsSeoul National University Hospital
03080 Seoul
Korea, Republic ofRekrutierend» Google-MapsDivision of Medical Oncology, Severance Hospital, Yonsei University Health System
03722 Seoul
Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsAsan Medical Center
05505 Seoul
Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsUlsan University Hospital
44033 Ulsan
Korea, Republic ofRekrutierend» Google-MapsPromotora Medica Aguascalientes SA de CV
20230 Aguascalientes
MexicoRekrutierend» Google-MapsInstituto Nacional de Cancerologia
14080 Distrito Federal
MexicoRekrutierend» Google-MapsInstituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas
14080 Distrito Federal
MexicoRekrutierend» Google-MapsUniversity Medical Center Groningen
9713 GZ Groningen
NetherlandsRekrutierend» Google-MapsKlinika Onkologii i Radioterapii Uniwersyteckie Centrum Kliniczne
80-214 Gdansk
PolandAktiv, nicht rekrutierend» Google-MapsMed-Polonia Sp. z o.o.
60-693 Poznan
PolandRekrutierend» Google-MapsCentrum Medyczne Dom Lekarski S.A.
70-784 Szczecin
PolandRekrutierend» Google-MapsNarodowy Instytut Onkologii im. Marii Sklodowskiej-Curie-Panstwowy Instytut Badawczy
02-781 Warszawa
PolandRekrutierend» Google-MapsRBHI Kursk Regional Clinical Oncology Dispensary
305 524 Kislino, Ryshkovsky Rural Council
Russian FederationAbgebrochen» Google-MapsBudgetary Healthcare Institution Omsk Region "Clinical Oncological Dispensary"
644013 Omsk
Russian FederationRekrutierend» Google-MapsLEC at SBIH "Saint-Petersburg Clinical Research Practical Center of specialized types of
197758 Pesochniy Poselok
Russian FederationRekrutierend» Google-MapsPrivate Medical Institution "Euromedservice"
196603 Pushkin
Russian FederationRekrutierend» Google-MapsRBHI Kursk Regional Clinical Oncology Dispensary
305 035 Kursk
Russian FederationAbgebrochen» Google-MapsFSBI "N.N.Blokhin Medical Research Center of Oncology"
115478 Moscow
Russian FederationRekrutierend» Google-MapsNational University Hospital
119074 Singapore
SingaporeAktiv, nicht rekrutierend» Google-MapsRaffles Hospital
188770 Singapore
SingaporeAktiv, nicht rekrutierend» Google-MapsInstitut Catala d'Oncologia L'Hospitalet
08908 L'Hospitalet de Llobregat
SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario Insular de Gran Canaria
35016 Las Palmas de Gran Canaria
SpainAbgebrochen» Google-MapsHospital Universitario Puerta de Hierro Majadahonda
28222 Majadahonda
SpainAktiv, nicht rekrutierend» Google-MapsComplejo Hospitalario De Navarra
31008 Pamplona
SpainAktiv, nicht rekrutierend» Google-MapsHospital Teresa Herrera C.H.U.A.C.
15006 A Coruna
SpainRekrutierend» Google-MapsHospital De La Santa Creu I Sant Pau
08025 Barcelona
SpainAbgebrochen» Google-MapsHospital Universitari Vall d'Hebron
08035 Barcelona
SpainRekrutierend» Google-MapsHospital Clinic i Provincial de Barcelona
08036 Barcelona
SpainRekrutierend» Google-MapsHospital De La Santa Creu I Sant Pau
08041 Barcelona
SpainAbgebrochen» Google-MapsInstitut Catala d'Oncologia Girona
17007 Girona
SpainRekrutierend» Google-MapsHospital Universitario Ramon y Cajal
28034 Madrid
SpainAktiv, nicht rekrutierend» Google-MapsHospital Clinico San Carlos
28040 Madrid
SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario Fundacion Jimenez Diaz
28040 Madrid
SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario La Fe
46026 Valencia
SpainAbgebrochen» Google-MapsNational Taiwan University Hospital
10002 Taipei
TaiwanRekrutierend» Google-MapsChang Gung Memorial Hospital - Kaohsiung Branch
83301 Kaohsiung
TaiwanAktiv, nicht rekrutierend» Google-MapsChung Shan Medical University Hospital
402 Taichung
TaiwanAbgebrochen» Google-MapsTaichung Veterans General Hospital
40705 Taichung
TaiwanAktiv, nicht rekrutierend» Google-MapsTaipei Veterans General Hospital
112 Taipei
TaiwanRekrutierend» Google-MapsCukurova University Medical Faculty
01330 Adana
TurkeyAktiv, nicht rekrutierend» Google-MapsIstanbul University Oncology Institute
34093 Istanbul
TurkeyAktiv, nicht rekrutierend» Google-MapsMarmara Univ Pendik Training and Research Hospital
34899 Istanbul
TurkeyAbgebrochen» Google-MapsEge University Medical Faculty
35100 Izmir
TurkeyAbgebrochen» Google-MapsThe Ipswich Hospital NHS Trust
IP4 5PD Ipswich
United KingdomAktiv, nicht rekrutierend» Google-MapsHeart of England NHS Foundation Trust, Birmingham Heartlands Hospital
B9 5SS Birmingham
United KingdomAktiv, nicht rekrutierend» Google-MapsThe Christie NHS Foundation Trust
M20 4BX Manchester
United KingdomAktiv, nicht rekrutierend» Google-Maps
Studien-Informationen
Brief Summary:A phase 3 study to demonstrate whether lorlatinib given as monotherapy is superior to
crizotinib alone in prolonging the progression-free survival in advanced ALK-positive NSCLC
patients who are treatment naïve and to compare lorlatinib to crizotinib with respect to
overall survival in the same population
Ein-/Ausschlusskriterien
Inclusion Criteria:- Histologically or cytologically confirmed diagnosis of locally advanced or metastatic
ALK-positive NSCLC; at least 1 extracranial measurable target lesion not previously
irradiated. CNS metastases allowed if asymptomatic and not currently requiring
corticosteroid treatment.
- Availability of an archival FFPE tissue specimen.
- No prior systemic NSCLC treatment.
- ECOG PS 0, 1, or 2.
- Age ≥18 years .
- Adequate Bone Marrow, Liver, Renal, Pancreatic Function
- Negative pregnancy test for females of childbearing potential
Exclusion Criteria:
- Spinal cord compression unless good pain control attained
- Major surgery within 4 weeks prior to randomization.
- Radiation therapy within 2 weeks prior to randomization, including stereotactic or
partial brain irradiation. Whole brain irradiation within 4 weeks prior to
randomization
- Active bacterial, fungal, or viral infection
- Clinically significant cardiovascular disease, active or within 3 months prior to
enrollment. Ongoing cardiac dysrhythmias, uncontrolled atrial fibrillation,
bradycardia or congenital long QT syndrome
- Predisposing characteristics for acute pancreatitis in the last month prior to
randomization.
- History of extensive, disseminated, bilateral or presence of Grade 3 or 4 interstitial
fibrosis or interstitial lung disease
- Active malignancy (other than NSCLC, non melanoma skin cancer, in situ cervical
cancer, papillary thyroid cancer, LCIS/DCIS of the breast, or localized prostate
cancer) within the last 3 years prior to randomization.
- Concurrent use of any of the following food or drugs within 12 days prior to the first
dose of lorlatinib or crizotinib.
1. known strong CYP3A inhibitors .
2. known strong CYP3A inducers
3. known P gp substrates with a narrow therapeutic index
- Concurrent use of CYP3A substrates with narrow therapeutic indices within 12 days
prior to the first dose of lorlatinib or crizotinib.
- Other severe acute or chronic medical or psychiatric condition, including recent or
active suicidal ideation or behavior, or laboratory abnormality that may increase the
risk associated with study participation or interfere with the interpretation of study
results
- Investigational site staff members directly involved in the conduct of the study and
their family members, or Pfizer employees, including their family members, directly
involved in the conduct of the study.
- Participation in other studies involving investigational drug(s) within 2 weeks prior
to study entry and/or during study participation.
Studien-Rationale
Primary outcome:1. Progression-free survival (PFS) based on blinded independent central review (BICR) assessment (Time Frame - From time of Study Start up to 33 months):
PFS is defined as the time from randomization to the date of the first documentation of objective progression of disease or death due to any cause, whichever occurs first.
Secondary outcome:
1. Overall Survival (OS) (Time Frame - From time of Study Start up to 125 months):
OS is defined as time from date of randomization to date of death due to any cause
2. PFS based on Investigator's assessment (Time Frame - From time of Study Start up to 33 months):
PFS is defined as the time from randomization to the date of the first documentation of objective progression of disease or death due to any cause, whichever occurs first.
3. Objective Response (OR) based on BICR and on Investigator's assessments (Time Frame - From time of Study Start up to 33 months):
OR defined as complete response (CR) or partial response (PR) per RECIST version 1.1 recorded from randomization until disease progression or start of new anti-cancer therapy
4. Intracranial Objective Response (IC-OR) based on BICR assessment (Time Frame - From time of Study Start up to 33 months):
IC-OR defined as complete response (CR) or partial response (PR) based on intracranial disease in the subset of patients with at least 1 intracranial lesion per RECIST version 1.1 (modified) recorded from randomization until disease progression or start of new anti-cancer therapy
5. Intracranial Time to Progression (IC-TTP) based on BIRC assessment (Time Frame - From time of Study Start up to 33 months):
IC-TTP defined as the time from randomization to the date of the first documentation of objective progression of intracranial disease, based on either new brain metastases or progression of existing brain metastases
6. Duration of Response (DR) based on BIRC assessment (Time Frame - From time of Study Start up to 33 months):
DR defined, for patients with an OR per RECIST version 1.1, as the time from the first documentation of objective tumor response (CR or PR) to the first documentation of objective tumor progression or death due to any cause, whichever occurs first
7. intracranial Duration of Response (IC-DR) based on BICR assessment (Time Frame - From time of Study Start up to 33 months):
IC-DR defined, for patients with an IC-BOR of CR or PR, as the time from the first documentation of intracranial objective response (CR or PR) per RECIST 1.1 to the date of first documentation of intracranial objective progression of disease (PD) or death due to any cause.
8. Time to Tumor Response (TTR) based on BIRC assessment (Time Frame - From time of Study Start up to 33 months):
TTR defined, for patients with a confirmed OR, as the time from the date of randomization to the first documentation of objective response (CR or PR) which is subsequently confirmed
9. Intracranial Time to Tumor Response (IC-TTR) based on BICR assessment (Time Frame - from time of Study Start up to 33 months):
IC-TTR is defined, for patients with a confirmed IC-OR, as the time from the date of randomization to the first documentation of intracranial objective response (CR or PR) which is subsequently confirmed.
10. PFS2 based on investigator's assessment (Time Frame - From time of Study Start up to 45 months):
PFS2 is defined as the time from randomization to the date of progression of disease on first subsequent systemic anti-cancer therapy, or death from any cause, whichever occurs first
11. Adverse Event (AE) as graded by NCI CTCAE v 4.03) (Time Frame - From time of Study Start up to 33 months):
Frequency of patients experiencing treatment-emergent AEs (TEAEs)
12. Laboratory abnormalities as graded by NCI CTCAE v 4.03) (Time Frame - From time of Study Start up to 33 months):
Frequency of patients with laboratory test abnormalities
13. Vital signs (blood pressure, pulse rate) and body weight (Time Frame - From time of Study Start up to 33 months):
Summary of actual values and changes from baseline
14. Electrocardiograms (ECG) (Time Frame - From time of Study Start up to 33 months):
Summary of actual values and changes from baseline
15. Echocardiograms or multigated acquisition scan (MUGA) (Time Frame - From time of Study Start up to 33 months):
Summary of actual values and changes from baseline
16. Ophthalmology (Time Frame - From time of Study Start up to 33 months):
Summary of changes from screning results
17. PRO as assessed by EORTC QLQ-C30, EORTC QLQ LC13, and EQ-5D-5L (Time Frame - From time of Study Start up to 33 months):
Summary of absolute scores and mean change of absolute scores from baseline
18. Tumor tissue biomarkers (Time Frame - From time of Study Start up to 33 months):
Summary of baseline levels and changes from baseline
19. Peripheral blood cfDNA (circulating free Deoxyribonucleic acid) biomarkers (Time Frame - From time of Study Start up to 33 months):
Summary of baseline levels and changes from baseline
Studien-Arme
- Experimental: Lorlatinib
Lorlatinib single agent, 100 mg (4 x 25 mg) oral tables, QD, continuously - Active Comparator: Crizotinib
Crizotinib single agent, 250 mg (1 x 250) oral capsules, BID, continuously
Geprüfte Regime
- Lorlatinib (PF-06463922):
ALK-positive NSCL treatment - Crizotinib (Xalkori):
ALK-positive NSCL treatment
Quelle: ClinicalTrials.gov