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1. Part 1: Number Of Participants Experiencing Dose-limiting Toxicities (DLTs) (Time Frame - Up to 1 Year)
2. Part 1: Number of Participants Reporting One or More Treatment-emergent Adverse Events (TEAEs), Serious Adverse Events (SAEs), and adverse events leading to discontinuation. (Time Frame - Up to 5 Years)
3. Part 1: Number of participants experiencing tumor lysis syndrome (TLS) relevant events (Time Frame - Up to 5 Years)
4. Part 2: Overall Response Rate (ORR) as assessed by the Independent Review Committee (IRC) (Time Frame - Up to 4 Years): Defined as the proportion of participants who achieved a complete response (CR), or partial response (PR) per the Lugano Classification
Secondary outcome:
1. Part 1: Single Dose Area Under the Plasma Concentration Time Curve (AUC) (Time Frame - Up to 2 Years)
2. Part 1: Single Dose Maximum Observed Plasma Concentration (Cmax) (Time Frame - Up to 2 Years)
3. Part 1: Single Dose Time to reach Cmax (Tmax) (Time Frame - Up to 2 Years)
4. Part 1: Steady State Area Under the Plasma Concentration Time Curve (AUC) (Time Frame - Up to 2 Years)
5. Part 1: Steady State Maximum Observed Plasma Concentration (Cmax) (Time Frame - Up to 2 Years)
6. Part 1: Steady State Trough Plasma Concentration (CTrough) (Time Frame - Up to 2 Years)
7. Part 1: Steady State Time to reach Cmax (Tmax) (Time Frame - Up to 2 Years)
8. Overall Response Rate (ORR) as assessed by investigator (Time Frame - Up to 4 Years): Defined as the proportion of participants who achieved a complete response (CR), or partial response (PR) per Lugano classification
9. Duration of Response (DOR) as assessed by investigator and IRC (Time Frame - Up to 4 Years): DOR is defined as the time from the date of the first documented response (PR or better) after treatment initiation until the date of first documented disease progression or death due to any cause; whichever occurs first
10. Progression Free Survival (PFS) as assessed by investigator and IRC (Time Frame - Up to 4 Years): PFS is defined as the time from the date of the first study dose until the date of first documented disease progression or death due to any cause, whichever occurs first.
11. Time to Response (TTR) as assessed by investigator and IRC (Time Frame - Up to 4 Years): TTR is defined as the time from start of treatment to first documentation of response of Partial Response (PR) or better
12. Overall Survival (OS) (Time Frame - Up to 4 Years): Defined as time from the start of treatment to the date of death due to any cause
13. Part 2: Number of Participants Reporting One or More Treatment-emergent Adverse Events (TEAEs), Serious Adverse Events (SAEs), and adverse events leading to discontinuation. (Time Frame - Up to 4 Years)
14. Part 2: Number of participants with clinically significant changes from baseline in vital signs (Time Frame - Up to 4 Years): Vital signs include blood pressure and pulse rate
15. Part 2: Number of participants with clinically significant changes from baseline in clinical laboratory values (Time Frame - Up to 4 Years): Laboratory values include hematology, and clinical chemistry
16. Part 2: Number of Participants With Clinically Significant Physical Examination Findings (Time Frame - Up to 4 Years): A Physical examination includes head, ears, eyes, nose, mouth, skin, heart and lung examinations, lymph nodes, gastrointestinal and musculoskeletal systems
17. Part 2: Participant Reported Outcomes as measured by NFLymSI-18 (Time Frame - Up to 4 Years): The National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy Lymphoma Cancer Symptom Index-18 (FLymSI-18) questionnaire contains 18 items, each of which utilizes a Likert scale with 5 possible responses ranging from 0 'Not at all' to 4 'Very much' and is divided into a total score.
18. Part 2: Participant Reported Outcomes as measured by EQ-5D-5L questionnaires (Time Frame - Up to 4 Years): The EQ-5D-5L descriptive system assesses health in five dimensions (MOBILITY, SELF-CARE, USUAL ACTIVITIES, PAIN / DISCOMFORT, ANXIETY / DEPRESSION), each of which has five levels of response (no problems, slight problems, moderate problems, severe problems, extreme problems/unable to). This part of the EQ-5D questionnaire provides a descriptive profile that can be used to generate a health state profile. Health state index scores generally range from less than 0 (where 0 is the value of a health state equivalent to dead; negative values representing values as worse than dead) to 1 (the value of full health), with higher scores indicating higher health utility. The second part of the questionnaire consists of a visual analogue scale (VAS) on which the participant rates his/her perceived health from 0 (the worst imaginable health) to 100 (the best imaginable health).
