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1. Overall Survival (OS) (Time Frame - Up to approximately 58 months): OS will be defined as the time from the date of randomization to the date of death due to any cause.
Secondary outcome:
1. Progression-free Survival (PFS) As Assessed By Investigators (Time Frame - Up to approximately 58 months): PFS will be defined as the time from the date of randomization to the date of the first objectively documented tumor progression per RECIST v1.1, or death, whichever occurs first.
2. Overall Response Rate (ORR) As Assessed By Investigators (Time Frame - Up to approximately 58 months): ORR will be defined as the proportion of participants with a documented, confirmed complete response or partial response per RECIST v1.1.
3. Duration Of Response (DOR) As Assessed By Investigators (Time Frame - Up to approximately 58 months): DOR will be defined as the time from the first determination of an objective response per RECIST v1.1 until the first documentation of progression or death, whichever occurs first.
4. Health-related Quality Of Life (HRQoL): European Organization For Research And Treatment Of Cancer Quality Of Life Questionnaire Core 30 (EORTC QLQ-C30) (Time Frame - Within 7 days after permanent treatment discontinuation): HRQoL will be assessed via patient-reported outcomes (PRO) using the EORTC QLQ-C30.
The EORTC QLQ-C30 (Version 3) consists of Global health status/QoL (score range from 0=very poor to 7=excellent), 5 functioning scales (physical, role, emotional, cognitive, social), 8 symptom scales (fatigue, nausea/vomiting, pain, dyspnea, insomnia, constipation, diarrhea) and financial difficulties with scores ranging from 1 = "Not at all" to 4 = "Very much". For the global health status/QoL and functioning scales, higher scores indicate better outcomes and for symptom scales, lower scores indicate better outcomes.
5. HRQoL: EORTC Lung Cancer Module Quality of Life Questionnaire Lung Cancer 13 (QLQ-LC13) HRQoL will be assessed via PRO using the EORTC QLQ-LC13. (Time Frame - Within 7 days after permanent treatment discontinuation): QLQ-LC13 consists of 10 scales, scores ranging from 1 = "not at all" to 4 = "very much", and 2 questions regarding use of pain medication (yes/no) and if yes, did it help (1 = "not at all" to 4 = "very much"). In symptom scales, lower scores indicate better outcomes.
6. HRQoL: European Quality of Life-5 Level- 5 Dimension (EQ-5D-5L) Questionnaire (Time Frame - Within 7 days after permanent treatment discontinuation): HRQoL will be assessed via PRO using the EQ-5D-5L. The EQ-5D-5L comprises five dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression, and a visual analog scale (VAS). Each dimension has 5 levels: no problems, slight problems, moderate problems, severe problems, and extreme problems. The VAS records the respondent's self-rated health on a 0 to 100 scale, with 100 = "the best health you can imagine" and 0 = "'the worst health you can imagine". Lower scores in descriptive dimension indicate better HRQoL and higher VAS scores indicates better health state.
7. Time To Deterioration (TTD) (Time Frame - Within 7 days after permanent treatment discontinuation): TTD will be analyzed using PRO scores, and will be defined as worsening scores of ≥10 points from baseline for 2 consecutive assessments or 1 assessment followed by death from any cause.
8. Number Of Participants Experiencing Adverse Events (AEs) (Time Frame - 90 days (±14) after last dose): The incidence and severity of AEs will be determined according to National Cancer Institute Common Terminology Criteria for Adverse Events Version 5.0 (NCI CTCAE v5.0).
Experimental: Arm A: Tislelizumab plus Ociperlimab Participants will receive tislelizumab 200 milligrams (mg) intravenously followed by ociperlimab 900 mg intravenously once every 3 weeks.
Active Comparator: Arm B: Pembrolizumab plus Placebo Participants will receive pembrolizumab 200 mg intravenously followed by placebo intravenously once every 3 weeks.
Placebo Comparator: Arm C: Tislelizumab plus Placebo Participants will receive tislelizumab 200 mg intravenously followed by placebo intravenously once every 3 weeks.