CASCADE
Cascade Genetic Testing for Hereditary Breast/Ovarian Cancer and Lynch Syndrome in Switzerland
Rekrutierend
NCT-Nummer:
NCT03124212
Studienbeginn:
April 2017
Letztes Update:
05.12.2023
Wirkstoff:
-
Indikation (Clinical Trials):
Ovarian Neoplasms, Carcinoma, Ovarian Epithelial, Colorectal Neoplasms, Hereditary Nonpolyposis, Hereditary Breast and Ovarian Cancer Syndrome, Syndrome
Geschlecht:
Alle
Altersgruppe:
Erwachsene (18+)
Phase:
-
Sponsor:
University of Basel
Collaborator:
-
Studienleiter
Maria C Katapodi, PhD
Principal Investigator
University of Basel
Kontakt
Maria C Katapodi, PhD
Kontakt:
Phone: ++41791095163
E-Mail: maria.katapodi@unibas.ch» Kontaktdaten anzeigen
Studienlocations
(3 von 9)
Hôpital du Jura Service d'Oncologie
2800 Delémont
SwitzerlandRekrutierend» Google-Maps
Ansprechpartner:
Christian Monnerat, MD
Phone: +41324212887
E-Mail: christian.monnerat@h-ju.ch» Ansprechpartner anzeigenKatonsspital Winterthur Tumorzentrum Brustzentrum
8401 Winterthur
SwitzerlandNoch nicht rekrutierend» Google-Maps
Ansprechpartner:
Ursina Zuerrer-Haerdi, MD
Phone: +41522662583
E-Mail: ursina.zuerrer@ksw.ch» Ansprechpartner anzeigenUniversity Hospital Basel
4056 Basel
SwitzerlandRekrutierend» Google-Maps
Ansprechpartner:
Karl Heinimann, PhD
Phone: ++41612653654
E-Mail: Karl.Heinimann@usb.ch
Nicole Burki, MD
Phone: ++41615565883
E-Mail: nicole.buerki@aeschenpraxis.ch» Ansprechpartner anzeigenIstituto Oncologico della Zvizzera Italiana
6962 Bellinzona
SwitzerlandRekrutierend» Google-Maps
Ansprechpartner:
Olivia Pagani, MD
Phone: ++918118435
E-Mail: olivia.pagani@eoc.ch
Rossella Graffeo, MD
Phone: ++918118435
E-Mail: Rossella.GraffeoGalbiati@eoc.ch» Ansprechpartner anzeigenGastroenterology clinic
2010 Bern
SwitzerlandAbgebrochen» Google-MapsUniversitatklinik fur Medizinische Onkologie, Inselspital
3010 Bern
SwitzerlandRekrutierend» Google-Maps
Ansprechpartner:
Manuela Rabaglio, MD
Phone: ++41316324370
E-Mail: Manuela.Rabaglio@insel.ch
Amina Scherz, MD
Phone: ++41316324114
E-Mail: Amina.Scherz@insel.ch» Ansprechpartner anzeigenHFR Fribourg - Hôpital Cantonal
1752 Fribourg
SwitzerlandNoch nicht rekrutierend» Google-Maps
Ansprechpartner:
Souria Aissaoui, PhD
Phone: +4126306455070
E-Mail: souria.aissaoui@genesupport.ch» Ansprechpartner anzeigenUnite d'Oncogenetique et de Prevention des Cancers
1205 Geneva
SwitzerlandRekrutierend» Google-Maps
Ansprechpartner:
Pierre Chappuis, MD, PhD
Phone: ++41223729853
E-Mail: Pierre.Chappuis@hcuge.ch» Ansprechpartner anzeigenHirslanden Clinic Des Grangettes
1224 Geneva
SwitzerlandNoch nicht rekrutierend» Google-Maps
Ansprechpartner:
Souria Aissaoui, PhD
Phone: +41228071770
E-Mail: Souria.aissaoui@genesupport.ch» Ansprechpartner anzeigen Alle anzeigen
Detailed Description:
Please see study protocol provided in the references
Inclusion Criteria:
1. Carrier of a mutation associated with HBOC or LS
2. Have at least one living blood relative
3. Men and women
4. 18 years old and older
5. Mentally and physically able to provide informed consent
6. Can read and speak German or French or Italian or English
7. Currently living in Switzerland.
Exclusion Criteria:
1. Carriers of unclassified variants (VUS) in BRCA1, BRCA2 or MLH1, MSH2, MSH6, PMS2,
EPCAM genes
2. Not living in Switzerland
3. Patients who are critically ill and cannot complete the CASCADE survey
4. Participants who are institutionalized (e.g., nursing homes) or incarcerated
Primary outcome:
1. Establishing the CASCADE Cohort (Time Frame - 12 months):
Response rate for Index Patients with HBOC and LS and blood relatives
Secondary outcome:
1. Cancer Surveillance (Time Frame - 12 months):
Number of mammograms, CBEs and MRIs of Index Patients and Blood Relatives
- CASCADE genetic screening:
Family-based cohort of mutation carriers, blood relatives who test negative, and untested blood relatives
Quelle: ClinicalTrials.gov
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