Radiation During Osimertinib Treatment: a Safety and Efficacy Cohort Study

Studien-Informationen Einschlusskriterien Studien-Rationale Geprüfte Regime

Rekrutierend

NCT-Nummer:
NCT05089916

Studienbeginn:
Januar 2022

Letztes Update:
26.12.2023

Wirkstoff:
Osimertinib

Indikation (Clinical Trials):
Carcinoma, Non-Small-Cell Lung

Geschlecht:
Alle

Altersgruppe:
Erwachsene (18+)

Phase:
Phase 2

Sponsor:
AIO-Studien-gGmbH

Collaborator:
AstraZeneca

Studienleiter

Amanda Tufman, Prof. Dr.
Principal Investigator
LMU Klinikum der Universität München

Kontakt

Sophie Worthmann
Kontakt:
Phone: +49 30 8145 344 61
E-Mail: sophie.worthmann@aio-studien-ggmbh.de» Kontaktdaten anzeigen

Amanda Tufman, Prof. Dr.
Kontakt:
Phone: +49 89 4400 57545
E-Mail: Amanda.Tufman@med.uni-muenchen.de» Kontaktdaten anzeigen

Studienlocations
(1 von 1)

LMU Klinikum der Universität München
80336 München
(Bayern)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Amanda Tufman, Prof. Dr.
Phone: +49 89 44005 2590
E-Mail: Amanda.Tufman@med.uni-muenchen.de» Ansprechpartner anzeigen

Studien-Informationen

Detailed Description:

Many patients with advanced lung cancer require palliative irradiation of metastases to

relieve symptoms and prevent local complications. In addition, guidelines recommend local

treatment (including radiation) for oligoprogression during TKI treatment. Clinicians are

faced with the decision whether to continue TKI therapy during irradiation, a practice for

which there is little data, or to interrupt the oral treatment for the duration of radiation,

which may lead to progression of non-irradiated lesions. For erlotinib and gefitinib there is

some data indicating that cranial irradiation as well as stereotactic body irradiation may be

carried out safely without discontinuing or interrupting the TKI treatment. Although some

small case series report on a PFS benefit with irradiation during osimertinib treatment,

there is very limited data on the safety of osimertinib during irradiation, and no

evidence-based recommendations around stopping osimertinib for irradiation.

The hypothesis is that osimertinib can be continued without interruption during irradiation

of individual tumor lesions in the setting of oligoprogressive NSCLC, or for local symptom

control of primary tumor or metastasis.

Ein-/Ausschlusskriterien

Inclusion Criteria:

1. Provision of written informed consent prior to any study specific procedures,

including screening evaluations that are not SOC.

2. Age ≥ 18 years at time of study entry.

3. Histologically confirmed NSCLC

4. Ongoing or planned osimertinib treatment according to marketing authorization (first

line treatment of tumor positive for a common or uncommon EGFR mutation, or later line

treatment of tumor positive for EGFR T790M mutation, assessed according to local

standard. First line therapy is defined as therapy used to treat advanced disease.

Each subsequent line of therapy is preceded by disease progression. A switch of an

agent within a regimen in order to manage toxicity does not define the start of a new

line of therapy. Experimental therapies when given as separate regimen are considered

as separate line of therapy. Maintenance therapy following platinum doublet-based

chemotherapy is not considered as a separate regimen of therapy.)

5. Clinical indication for radiotherapy of one or more lesions, for instance for local

symptom control of primary tumor or metastasis, for oligoprogressive metastasis, or

for disease control with conventional or stereotactic strategy. Radiotherapy of

metastatic sites can be for bone, solid organ or soft-tissue lesions; initial size of

brain metastases should be < 3 cm. Lung lesions should be no more than 5 cm.

6. ECOG performance status 0-2.

7. Life expectancy ≥12 weeks

8. Female subjects should be using highly effective contraceptive measures, and must have

a negative pregnancy test and not be breast-feeding prior to start of dosing if of

child-bearing potential or must have evidence of non-child-bearing potential by

fulfilling one of the following criteria at screening:

- Post-menopausal defined as aged 50 years or more and amenorrheic for at least 12

months following cessation of all exogenous hormonal treatments

- Women under 50 years would be considered postmenopausal if they have been

amenorrheic for 12 months or more following cessation of exogenous hormonal

treatments and with LH and FSH levels in the post-menopausal range for the

institution.

- Documentation of irreversible surgical sterilisation by hysterectomy, bilateral

oophorectomy or bilateral salpingectomy but not tubal ligation

9. Male subjects who are sexually active with WOCBP should be willing to use highly

effective contraception. Men who are azoospermic do not require contraception.

10. The patient is willing and able to comply with the protocol for the duration of the

study, including hospital visits for treatment and scheduled follow-up visits and

examinations.

11. Negative COVID-19 test within 1 week prior to starting irradiation if clinically

required by current regional COVID-19 outbreak situation.

Exclusion Criteria:

1. Concurrent enrolment in another clinical study, unless it is an observational

(non-interventional) clinical study, or during the follow-up period of an

interventional study.

2. Treatment with an investigational drug within five half-lives of the compound or 3

months, whichever is greater

3. Previous enrolment in the present study.

4. Any chemotherapy, biologic or hormonal cancer therapy other than EGFR-TKIs used

concurrently or within 4 weeks prior to study enrolment, or checkpoint inhibitors

within 130 days prior to study enrolment. Hormonal therapy for non-cancer-related

conditions (e.g., hormone replacement therapy) is acceptable.

5. Any unresolved toxicities from prior therapy greater than grade I (exception:

alopecia, grade 2 neuropathy) which in the investigator's opinion would jeopardise

compliance with the protocol or worsen during irradiation

6. Cardiac side-effects of osimertinib not sufficiently improved by dose reduction as

suggested by the label/ German "Fachinformation".

7. In patients with indication for radiotherapy of lung lesions: past medical history of

ILD/pneumonitis, radiation pneumonitis grade 2 or higher (CTCAE V5.0) or requiring

steroid treatment, or any evidence of clinically active ILD, in particular

interstitial pulmonary fibrosis (IPF).

8. Major surgery (as defined by the Investigator) within 4 weeks prior to starting the

study; patients must have recovered from effects of preceding major surgery. Note:

Local non-major surgery for palliative intent (e.g., surgery of isolated lesions) is

acceptable.

9. Congenital long QT syndrome

10. Any of the following cardiac criteria:

- Mean resting corrected QT interval (QTc) > 470 msec obtained from 3

electrocardiograms (ECGs), using the screening clinic ECG machine derived QTc

value

- Any clinically important abnormalities in rhythm, conduction or morphology of

resting ECG e.g. complete left bundle branch block, third degree heart block and

second degree heart block.

- Patient with any factors that increase the risk of QTc prolongation or risk of

arrhythmic events such as heart failure, electrolyte abnormalities (including:

Serum/plasma potassium < LLN; Serum/plasma magnesium < LLN; Serum/plasma calcium

< LLN) , congenital long QT syndrome, family history of long QT syndrome or

unexplained sudden death under 40 years of age in first degree relatives or any

concomitant medication known to prolong the QT interval and cause Torsades de

Pointes

11. Inadequate bone marrow reserve or organ function (as demonstrated by any of the

following laboratory values:

- Absolute neutrophil count <1.5 x 109/L;

- Platelet count <100 x 109/L;

- Hemoglobin <90 g/L (9 g/dL);

- Alanine aminotransferase >2.5 times ULN if no demonstrable liver metastases or >5

times ULN in the presence of liver metastases;

- Aspartate aminotransferase >2.5 times ULN if no demonstrable liver metastases or

>5 times ULN in the presence of liver metastases;

- Total bilirubin >1.5 times ULN if no liver metastases or >3 times ULN in the

presence of documented Gilbert's Syndrome [unconjugated hyperbilirubinemia] or

liver metastases;

- Serum creatinine >1.5 times ULN concurrent with creatinine clearance <50 mL/min

[measured or calculated by Cockcroft and Gault equation]-confirmation of

creatinine clearance is only required when creatinine is >1.5 times ULN.

12. Any evidence of severe or uncontrolled systemic diseases, including uncontrolled

hypertension and active bleeding diatheses, which in the investigator's opinion makes

it undesirable for the patient to participate in the trial or which would jeopardise

compliance with the protocol, or active infection.

13. Past medical history of interstitial lung disease, drug-induced interstitial lung

disease, radiation pneumonitis which required steroid treatment, or any evidence of

clinically active interstitial lung disease.

14. History of hypersensitivity to active or inactive excipients of osimertinib or drugs

with a similar chemical structure or class to osimertinib.

15. Judgment by the investigator that the patient should not participate in the study if

the patient is unlikely to comply with study procedures, restrictions and

requirements.

16. Active infection will include any patients receiving treatment for infection.

17. Clinical suspicion of COVID-19 with or without negative COVID-19 test

18. Participants with HBV infection are eligible only if they meet the following criteria:

- Demonstrated absence of HCV co-infection or history of HCV co-infection

- Demonstrated absence of HIV infection

- Participants with active HBV infection are eligible if:

- they are receiving anti-viral treatment for at least 6 weeks prior to study

treatment,

- HBV DNA is suppressed to <100 IU/mL,

- transaminase levels are below ULN.

Participants with a resolved or chronic HBV infection are eligible if they are:

• Negative for HBsAg and positive for hepatitis B core antibody [anti-HBc IgG] In

addition, patients must be receiving anti-viral prophylaxis for 2-4 weeks prior to

study treatment.

or

• Positive for HBsAg, but for > 6 months have had transaminases levels below ULN and

HBV DNA levels <100 IU/mL (i.e., are in an inactive carrier state). In addition,

patients must be receiving anti-viral prophylaxis for 2-4 weeks prior to study

treatment. Refer to section "5.5.2. Special warnings and precautions"

Participants with HIV infection are only eligible if they meet all the following

criteria:

- Undetectable viral RNA load for 6 months

- CD4+ count of >350 cells/μL

- No history of AIDS-defining opportunistic infection within the past 12 months

- Stable for at least 4 weeks on the same anti-HIV medications

19. Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to

swallow the formulated product or previous significant bowel resection that would

preclude adequate absorption of osimertinib.

20. Currently receiving (or unable to stop use prior to receiving the first dose of study

treatment) medications or herbal supplements known to be strong inducers of CYP3A4 (at

least 3 week prior). All patients must try to avoid concomitant use of any

medications, herbal supplements and/or ingestion of foods with known inducer effects

on CYP3A4.

21. Women who are pregnant or breast-feeding

22. Male or female patients of reproductive potential who are not willing to employ highly

effective birth control from screening to 4 months after the last dose of osimertinib

23. Patients who are unable to consent because they do not understand the nature,

significance and implications of the clinical trial and therefore cannot form a

rational intention in the light of the facts [§ 40 Abs. 1 S. 3 Nr. 3a AMG]

Studien-Rationale

Primary outcome:

1. Frequency, time of onset and severity of Adverse Events as assessed by investigator during osimertinib treatment and irradiation therapy (Time Frame - 24 months):
Safety and tolerability (Frequency, time of onset and severity of Adverse Events, grading according to CTCAE V5.0), including pneumonitis, interstitial lung disease, radiation pneumonitis, radionecrosis and cardiac failure (congestive heart failure - CHF) as adverse events of special interest

Secondary outcome:

1. PFS (Time Frame - 24 months):
Progression-free survival: calculated as PFS1, PFS2, PFS3, PFS0 to assess osimertinib treatment continued beyond several progression events entailing radiotherapy, and prior to first radiotherapy

2. TTF (Time Frame - 12 months):
Time to treatment failure

3. Local tumor control (Time Frame - 24 months):
Local tumor control

4. OS (Time Frame - 24 months):
Overall survival

5. QoL (Time Frame - 12 months):
Quality of Life assessed by EORTC QLQ-C30

Geprüfte Regime

Osimertinib (Tagrisso):
Osimertinib: according to its marketing authorization, i.e. at daily doses of 80 mg, for a maximum of 12 months within the study.
Radiotherapy:
Radiotherapy: according to standard of care The target population will comprise 3 parallel cohorts, for each of which a minimum of 10 subjects is planned to be enrolled: Irradiation of bone, solid organ (non-lung, non-brain) or soft-tissue metastases Irradiation of brain metastases (initial lesion size < 3 cm) Irradiation of lung lesions (primary tumor or metastases, lesion size < 5 cm)

Quelle: ClinicalTrials.gov

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