1. Increase in Physical Performance according to Physical Work Capacity (PWC) Test (Time Frame - Between week 0 and 16.): Evidence of a significant increase (at least 15%) in physical work [watt/kilogram bodyweight] at PWC75% of maximum heart rate.
Secondary outcome:
1. Physical Work Capacity (PWC) (Time Frame - Between week 0 and 16 (and 24).): PWC stratified according to:
age (<40, 40-60, >60 years)
Karnofsky performance status (KPS) (70-80 vs. 90-100 %)
Gender
PWC test 130, 150, (170)
2. PWC (Time Frame - after 8, 16 and 24 weeks): changes over time, follow-up
3. Spiroergometry - maximal oxygen consumption (VO2max) (Time Frame - Between week 0 and 16 (and 24).): Changes in the maximal oxygen consumption (measured during spiroergometry)
4. Spiroergometry - lactate (Time Frame - Between week 0 and 16 (and 24).): Changes in the individual anaerobic lactate threshold (measured during spiroergometry)
5. EORTC-QLQ-C30 Brain module (Time Frame - Between week 0 and 16 (and 24).): Changes in Health Related Quality of Life (HRQoL) using a standardized questionnaire; The EORTC QLQ-C30 questionnaire contains 30 questions and assesses the quality of life of oncology patients multidimensionally across 10 subscales. Times of measurement in week 0, 4, 8, 16, 20 and 24.
6. Distress Thermometer (DT) (Time Frame - Between week 0 and 16 (and 24).): Changes in Health Related Quality of Life (HRQoL) using a standardized questionnaire; scale from 1 (not stressed at all) to 10 (extremly stressed); Times of measurement in week 0, 4, 8, 16, 20 and 24.
7. Hospital Anxiety and Depression Scale (HADS) (Time Frame - Between week 0 and 16 (and 24).): Changes in Health Related Quality of Life (HRQoL) using a standardized questionnaire; The Hospital Anxiety and Depression Scale (HADS) is a self-rating scale developed to assess psychological distress in non-psychiatric patients. It consists of two subscales, anxiety and depression (14 items); Times of measurement in week 0, 4, 8, 16, 20 and 24.
Personal Training Program: One training sessions includes an interval training on a bicycle ergometer. The second one is a strength training with exercise machines. Both trainings are supplemented by coordinative aspects.
Quelle: ClinicalTrials.gov
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