JOURNAL ONKOLOGIE – STUDIE
CONTACT-03 A Study of Atezolizumab in Combination With Cabozantinib Compared to Cabozantinib Alone in Participants With Advanced Renal Cell Carcinoma After Immune Checkpoint Inhibitor Treatment
Rekrutierend
NCT-Nummer:
NCT04338269
Studienbeginn:
Juli 2020
Letztes Update:
15.02.2021
Wirkstoff:
Atezolizumab, Cabozantinib
Indikation (Clinical Trials):
Carcinoma, Carcinoma, Renal Cell
Geschlecht:
Alle
Altersgruppe:
Erwachsene (18+)
Phase:
Phase 3
Sponsor:
Hoffmann-La Roche
Collaborator:
Exelixis, Chugai,
Studienleiter
Study Director
Hoffmann-La Roche
Kontakt
Kontakt:
Phone: 888-662-6728 (U.S. and Canada)
E-Mail: global-roche-genentech-trials@gene.com» Kontaktdaten anzeigen
Studienlocations (3 von 169)
Darmzentrum Zeisigwaldkliniken Bethanien
Zeisigwaldstraße 101
9130 Chemnitz
DeutschlandRekrutierend» Google-MapsKlinikum der Johann Wolfgang Goethe-Universitaet; Urologie und Kinderurologie
60590 Frankfurt
(Hessen)
GermanyRekrutierend» Google-MapsUniversitaetsklinikum Freiburg; Urology
79106 Freiburg
(Baden-Württemberg)
GermanyNoch nicht rekrutierend» Google-Maps
Zeisigwaldstraße 101
9130 Chemnitz
DeutschlandRekrutierend» Google-MapsKlinikum der Johann Wolfgang Goethe-Universitaet; Urologie und Kinderurologie
60590 Frankfurt
(Hessen)
GermanyRekrutierend» Google-MapsUniversitaetsklinikum Freiburg; Urology
79106 Freiburg
(Baden-Württemberg)
GermanyNoch nicht rekrutierend» Google-Maps
Krankenhaus Martha-Maria Halle-Dölau, Klinik für Urologie
06120 Halle (Saale)
(Sachsen-Anhalt)
GermanyRekrutierend» Google-MapsUniklinik-Eppendorf; Klinik U Poliklinik F Urologie
20246 Hamburg
(Hamburg)
GermanyRekrutierend» Google-MapsMed. Hochschule Hannover, Hämatologie, Hämostaseologie, Onkologie u. Stammzelltransplantation
30625 Hannover
(Niedersachsen)
GermanyRekrutierend» Google-MapsUniversitaetsklinikum Muenster; Urology
48149 Muenster
(Nordrhein-Westfalen)
GermanyRekrutierend» Google-MapsKlinikum rechts der Isar der TU München; Urologische Klinik und Poliklinik
81675 München
(Bayern)
GermanyRekrutierend» Google-MapsUniversitätsklinikum Tübingen; Klinik für Urologie
72076 Tübingen
(Baden-Württemberg)
GermanyRekrutierend» Google-MapsUniversitätsklinikum Ulm; Klinik für Urologie
89081 Ulm
(Baden-Württemberg)
GermanyRekrutierend» Google-MapsArizona Oncology Associates
86001 Flagstaff
United StatesRekrutierend» Google-MapsUniversity of Arizona
85724-5030 Tucson
United StatesRekrutierend» Google-MapsCity of Hope Comprehensive Cancer Center
91010 Duarte
United StatesRekrutierend» Google-MapsUC San Diego Health System
92093 La Jolla
United StatesRekrutierend» Google-MapsUniversity of Southern California
90033 Los Angeles
United StatesZurückgezogen» Google-MapsUCLA
90095 Los Angeles
United StatesRekrutierend» Google-MapsStanford University
94304 Palo Alto
United StatesRekrutierend» Google-MapsUniversity of California Davis
95817 Sacramento
United StatesZurückgezogen» Google-MapsUniversity of California San Francisco
94117 San Francisco
United StatesNoch nicht rekrutierend» Google-MapsUniversity of Colorado
80045 Aurora
United StatesRekrutierend» Google-MapsHighlands Ranch Hospital
80129 Highlands Ranch
United StatesRekrutierend» Google-MapsRocky Mountain Cancer Center - Denver
80120 Littleton
United StatesRekrutierend» Google-MapsHartford Healthcare
06102 Hartford
United StatesRekrutierend» Google-MapsYale University
06510 New Haven
United StatesZurückgezogen» Google-MapsSibley Memorial Hospital
20016 Washington
United StatesNoch nicht rekrutierend» Google-MapsWoodlands Medical Specialists, P.A.
32503 Pensacola
United StatesRekrutierend» Google-MapsMoffitt Cancer Center
33612 Tampa
United StatesRekrutierend» Google-MapsSidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Skip Viragh Outpatient Cancer Building
21287 Baltimore
United StatesNoch nicht rekrutierend» Google-MapsMGH
02114 Boston
United StatesNoch nicht rekrutierend» Google-MapsBeth Israel Deaconess Med Ctr
02215 Boston
United StatesNoch nicht rekrutierend» Google-MapsDana-Farber Cancer Institute
02215 Boston
United StatesNoch nicht rekrutierend» Google-MapsMinnesota Oncology Hematology
55404 Minneapolis
United StatesRekrutierend» Google-MapsComprehensive Cancer Centers of Nevada (CCCN) - Central Valley
89169 Las Vegas
United StatesRekrutierend» Google-MapsMemorial Sloan Kettering - Monmouth
07748 Middletown
United StatesNoch nicht rekrutierend» Google-MapsMemorial Sloan Kettering Bergen
07645 Montvale
United StatesNoch nicht rekrutierend» Google-MapsNew York Oncology Hematology,P.C.-Albany
12208 Albany
United StatesRekrutierend» Google-MapsMontefiore Medical Center
10461 Bronx
United StatesRekrutierend» Google-MapsMemorial Sloan Kettering Cancer Center - Commack
11725 Commack
United StatesNoch nicht rekrutierend» Google-MapsMSKCC @ West Harrison
10604 Harrison
United StatesNoch nicht rekrutierend» Google-MapsNew York University
10017 New York
United StatesZurückgezogen» Google-MapsMount Sinai Medical Center
10029 New York
United StatesNoch nicht rekrutierend» Google-MapsMemorial Sloan Kettering Cancer Center
10065 New York
United StatesNoch nicht rekrutierend» Google-MapsSUNY Upstate Medical University
13210 Syracuse
United StatesRekrutierend» Google-MapsDuke University Medical Center
27710 Durham
United StatesNoch nicht rekrutierend» Google-MapsCleveland Clinic
44106 Cleveland
United StatesRekrutierend» Google-MapsWillamette Valley Cancer Institute and Research Center
97401 Eugene
United StatesRekrutierend» Google-MapsFox Chase Cancer Center
19111 Philadelphia
United StatesRekrutierend» Google-MapsTexas Onc-Central Austin CA Ct
78731 Austin
United StatesAktiv, nicht rekrutierend» Google-MapsTexas Oncology - Houston (Gessner)
77024 Houston
United StatesRekrutierend» Google-MapsTexas Oncology - Willowbrook
77070 Houston
United StatesRekrutierend» Google-MapsUniversity Of Utah
84108 Salt Lake City
United StatesRekrutierend» Google-MapsVirginia Cancer Specialists - Gainsville
20155 Gainesville
United StatesRekrutierend» Google-MapsVirginia Oncology Associates
23502 Norfolk
United StatesRekrutierend» Google-MapsUniversity of Wisconsin
53792 Madison
United StatesNoch nicht rekrutierend» Google-MapsFundación CENIT para la Investigación en Neurociencias
C1125ABD Buenos Aires
ArgentinaAktiv, nicht rekrutierend» Google-MapsInst. Alexander Fleming; Oncologia
C1426ANZ Buenos Aires
ArgentinaAktiv, nicht rekrutierend» Google-MapsHospital Britanico
C1280AEB Ciudad Autonoma Bs As
ArgentinaRekrutierend» Google-MapsCentro Medico Austral OMI
C1019ABS Ciudad Autonoma Buenos Aires
ArgentinaAktiv, nicht rekrutierend» Google-MapsMacquarie University Hospital
2109 Macquarie Park
AustraliaRekrutierend» Google-MapsOrange Hospital
2800 Orange
AustraliaRekrutierend» Google-MapsIcon Cancer Foundation
4101 South Brisbane
AustraliaRekrutierend» Google-MapsBendigo Cancer Centre
3550 Bendigo
AustraliaRekrutierend» Google-MapsBox Hill Hospital; Oncology
3128 Box Hill
AustraliaNoch nicht rekrutierend» Google-MapsCancer Care Manitoba
R3E 0V9 Winnipeg
CanadaNoch nicht rekrutierend» Google-MapsPrincess Margaret Cancer Center
M5G 1Z5 Toronto
CanadaNoch nicht rekrutierend» Google-MapsHerlev Hospital; Afdeling for Kræftbehandling
2730 Herlev
DenmarkNoch nicht rekrutierend» Google-MapsOdense Universitetshospital, Onkologisk Afdeling R
5000 Odense C
DenmarkNoch nicht rekrutierend» Google-MapsCHU Besançon - Hôpital Jean Minjoz
25030 Besançon Cedex
FranceNoch nicht rekrutierend» Google-MapsCHU de Bordeaux - Groupe Hospitalier Saint-André - Hopital Saint-Andre
33075 Bordeaux
FranceNoch nicht rekrutierend» Google-MapsCentre Francois Baclesse; Oncologie
14076 Caen
FranceNoch nicht rekrutierend» Google-MapsCentre Jean Perrin; Oncologie
63011 Clermont Ferrand
FranceNoch nicht rekrutierend» Google-MapsCentre Oscar Lambret; Chir Cancerologie General
59000 Lille
FranceNoch nicht rekrutierend» Google-MapsCentre Leon Berard; Departement Oncologie Medicale
69373 Lyon
FranceNoch nicht rekrutierend» Google-MapsCentre Antoine Lacassagne
06189 Nice
FranceNoch nicht rekrutierend» Google-MapsInstitut de cancerologie du Gard
30029 Nimes
FranceNoch nicht rekrutierend» Google-MapsHopital Europeen Georges Pompidou; Service D'Oncologie Medicale
75908 Paris
FranceNoch nicht rekrutierend» Google-MapsHopital Hautepierre; Hematologie Oncologie
67098 Strasbourg
FranceNoch nicht rekrutierend» Google-MapsInstitut Claudius Regaud; Departement Oncologie Medicale
31059 Toulouse
FranceZurückgezogen» Google-MapsInstitut Gustave Roussy; Oncologie Medicale
94800 Villejuif
FranceNoch nicht rekrutierend» Google-MapsAlexandras General Hospital of Athens; Oncology Department
115 28 Athens
GreeceRekrutierend» Google-MapsAttikon University General Hospital
124 64 Athens
GreeceRekrutierend» Google-MapsAthens Medical Center; Dept. of Oncology
151 25 Athens
GreeceRekrutierend» Google-MapsUniversity Hospital of Larissa;Department of Medical Oncology
411 10 Larissa
GreeceNoch nicht rekrutierend» Google-MapsPapageorgiou General Hospital; Medical Oncology
564 29 Thessaloniki
GreeceNoch nicht rekrutierend» Google-MapsDiavalkaniko Hospital
570 01 Thessaloniki
GreeceRekrutierend» Google-MapsIstituto Tumori Napoli;Unità Operativa Oncologia Medica Uro-Ginecologica
80131 Napoli
ItalyRekrutierend» Google-MapsAzienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica
40138 Bologna
ItalyRekrutierend» Google-MapsIRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
47014 Meldola
ItalyRekrutierend» Google-MapsIrccs Centro Di Riferimento Oncologico (CRO); SOC Oncologia Medica A
33081 Aviano (PN)
ItalyNoch nicht rekrutierend» Google-MapsPoliclinico Universitario "Agostino Gemelli"; U.O.C. Oncologia Medica
00168 Roma
ItalyRekrutierend» Google-MapsASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia Medica
25123 Brescia
ItalyRekrutierend» Google-MapsIrccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2
20133 Milano
ItalyRekrutierend» Google-MapsFondazione Salvatore Maugeri; Divisione Di Oncologia Medica
27100 Pavia
ItalyRekrutierend» Google-MapsIstituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia
20089 Rozzano
ItalyRekrutierend» Google-MapsOspedale Di Macerata; Oncologia
62100 Macerata
ItalyRekrutierend» Google-MapsFondazione del Piemonte per l'Oncologia (IRCCS); Day Hospital Oncologico Multidisciplinare
10060 Candiolo (TO)
ItalyRekrutierend» Google-MapsAzienda Ospedaliera S. Maria - Terni; Oncologia
05100 Terni
ItalyRekrutierend» Google-MapsKyushu University Hospital
812-8582 Fukuoka
JapanRekrutierend» Google-MapsHokkaido University Hospital
060-8648 Hokkaido
JapanRekrutierend» Google-MapsUniversity of Tsukuba Hospital
305-8576 Ibaraki
JapanRekrutierend» Google-MapsYokohama City University Hospital
236-0004 Kanagawa
JapanRekrutierend» Google-MapsOkayama University Hospital
700-8558 Okayama
JapanRekrutierend» Google-MapsOsaka City University Hospital
545-8586 Osaka
JapanRekrutierend» Google-MapsKindai University Hospital
589-8511 Osaka
JapanNoch nicht rekrutierend» Google-MapsTokushima University Hospital
770-8503 Tokushima
JapanRekrutierend» Google-MapsKeio University Hospital
160-8582 Tokyo
JapanRekrutierend» Google-MapsTokyo Women's Medical University Hospital
162-8666 Tokyo
JapanRekrutierend» Google-MapsChungnam National University Hospital
35015 Daejeon
Korea, Republic ofRekrutierend» Google-MapsNational Cancer Center
10408 Goyang-si
Korea, Republic ofRekrutierend» Google-MapsCHA Bundang Medical Center
13496 Gyeonggi-do
Korea, Republic ofRekrutierend» Google-MapsPusan National University Yangsan Hospital
50612 Gyeongsangnam-do
Korea, Republic ofRekrutierend» Google-MapsChonnam National University Hwasun Hospital
58128 Jeollanam-do
Korea, Republic ofRekrutierend» Google-MapsSeoul National University Bundang Hospital
13605 Seongnam-si
Korea, Republic ofRekrutierend» Google-MapsSamsung Medical Center
(0)6351 Seoul
Korea, Republic ofRekrutierend» Google-MapsSeoul National University Hospital
03080 Seoul
Korea, Republic ofRekrutierend» Google-MapsKangbuk Samsung Medical Center
03181 Seoul
Korea, Republic ofRekrutierend» Google-MapsSeverance Hospital
03722 Seoul
Korea, Republic ofRekrutierend» Google-MapsAsan Medical Center
05505 Seoul
Korea, Republic ofRekrutierend» Google-MapsSzpital Specjalistyczny Podkarpacki Ośrodek Onkologiczny
36-200 Brzozów
PolandRekrutierend» Google-MapsCentrum Onkologii im. Prof. Franciszka Łukaszczyka; Ambulatorium Chemioterapii
85-796 Bydgoszcz
PolandRekrutierend» Google-MapsSP ZOZ Wojewódzki Szpital Specjalistyczny nr 4; Oddzial Onkologii Klinicznej
41-902 Bytom
PolandRekrutierend» Google-MapsEuropejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii
05-400 Otwock
PolandRekrutierend» Google-MapsSzpital Kliniczny Przemienienia Pańskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego
60-570 Poznan
PolandRekrutierend» Google-MapsLecznice Citomed Sp. z o.o.
87-100 Torun
PolandNoch nicht rekrutierend» Google-MapsSzpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o.
04-073 Warszawa
PolandRekrutierend» Google-MapsWojskowy Instytut Medyczny; Klinika Onkologii
04-141 Warszawa
PolandNoch nicht rekrutierend» Google-MapsDolnoslaskie Centrum Onkologii
53-413 Wrocław
PolandRekrutierend» Google-MapsRegional Clinical Oncology Hospital
150054 Yaroslavl
Russian FederationNoch nicht rekrutierend» Google-MapsMEDSI Clinical Hospital on Pyatnitsky Highway; Department of antitumor drug therapy
143422 Moscow
Russian FederationAktiv, nicht rekrutierend» Google-MapsSBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM"
111123 Moskva
Russian FederationRekrutierend» Google-MapsPrivate Healthcare Institution Clinical Hospital RZhD Medicine
195271 St. Petersburg
Russian FederationNoch nicht rekrutierend» Google-MapsTSBHI Altai Territorial oncological dispensary
656045 Barnaul
Russian FederationRekrutierend» Google-MapsSt-Petersburg Regional Oncology Dispensary; Oncology
188663 Kuzmolovo
Russian FederationNoch nicht rekrutierend» Google-MapsFSBSI "Russian Oncological Scientific Center n.a. N.N. Blokhin"
115478 Moscow
Russian FederationRekrutierend» Google-MapsRussian Scientific Center of Roentgenoradiology
117997 Moscow
Russian FederationRekrutierend» Google-MapsMedical Center Avicenna; Urology
630099 Novosibirsk
Russian FederationRekrutierend» Google-MapsFSI Russian Centre of Radiology and Surgical Technologies
197758 Saint-Petersburg
Russian FederationNoch nicht rekrutierend» Google-MapsHospital Univ. Central de Asturias; Servicio de Oncologia
33011 Oviedo
SpainRekrutierend» Google-MapsCorporacio Sanitaria Parc Tauli; Servicio de Oncologia
8208 Sabadell
SpainRekrutierend» Google-MapsHospital Universitario Marques de Valdecilla; Servicio de Oncologia
39008 Santander
SpainRekrutierend» Google-MapsHospital Universitario Reina Sofia; Servicio de Oncologia
14004 Córdoba
SpainRekrutierend» Google-MapsHospital Universitario Son Espases; Servicio de Oncologia
07014 Palma De Mallorca
SpainNoch nicht rekrutierend» Google-MapsHospital Universitario Puerta de Hierro; Servicio de Oncologia
28222 Majadahonda
SpainRekrutierend» Google-MapsHospital Alvaro Cunqueiro; Servicio de Oncologia
36213 Vigo
SpainRekrutierend» Google-MapsHospital Univ Vall d'Hebron; Servicio de Oncologia
08035 Barcelona
SpainNoch nicht rekrutierend» Google-MapsHospital de la Santa Creu i Sant Pau; Servicio de Oncologia
08041 Barcelona
SpainRekrutierend» Google-MapsHospital Universitario de Burgos; Oncología
09006 Burgos
SpainRekrutierend» Google-MapsHospital San Pedro De Alcantara; Servicio de Oncologia
10003 Caceres
SpainNoch nicht rekrutierend» Google-MapsHospital Lucus Augusti; Servicio de Oncologia
27003 Lugo
SpainRekrutierend» Google-MapsHospital General Universitario Gregorio Marañon; Servicio de Oncologia
28007 Madrid
SpainNoch nicht rekrutierend» Google-MapsHospital Ramon y Cajal; Servicio de Oncologia
28034 Madrid
SpainRekrutierend» Google-MapsHospital Clinico San Carlos; Servicio de Oncologia
28040 Madrid
SpainRekrutierend» Google-MapsHospital Universitario 12 de Octubre; Servicio de Oncologia
28041 Madrid
SpainRekrutierend» Google-MapsHospital Universitario La Paz; Servicio de Oncologia
28046 Madrid
SpainRekrutierend» Google-MapsHospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia
29010 Malaga
SpainRekrutierend» Google-MapsHospital Universitario Virgen de Arrixaca; Servicio de Oncologia
30120 Murcia
SpainNoch nicht rekrutierend» Google-MapsHospital de Navarra; Servicio de Oncologia
31008 Navarra
SpainRekrutierend» Google-MapsHospital Universitario Virgen del Rocio; Servicio de Oncologia
41013 Sevilla
SpainRekrutierend» Google-MapsHospital Univ. Nuestra Señora de Valme; Servicio de Oncologia
41014 Sevilla
SpainRekrutierend» Google-MapsInstituto Valenciano Oncologia; Oncologia Medica
46009 Valencia
SpainRekrutierend» Google-MapsHospital Arnau de Vilanova (Valencia) Servicio de Oncologia
46015 Valencia
SpainRekrutierend» Google-MapsHospital Universitario la Fe; Servicio de Oncologia
46026 Valencia
SpainRekrutierend» Google-MapsRoyal Blackburn Hospital
BB2 3HH Blackburn
United KingdomNoch nicht rekrutierend» Google-MapsLeicester Royal Infirmary; Dept. of Medical Oncology
LE1 5WW Leicester
United KingdomRekrutierend» Google-MapsBarts & London School of Med; Medical Oncology
EC1A 7BE London
United KingdomNoch nicht rekrutierend» Google-MapsSt George's Hospital; Oncology
SW17 0QT London
United KingdomNoch nicht rekrutierend» Google-MapsRoyal Marsden Hospital; Dept of Med-Onc
SW3 6JJ London
United KingdomNoch nicht rekrutierend» Google-MapsChristie Hospital Nhs Trust; Medical Oncology
M2O 4BX Manchester
United KingdomNoch nicht rekrutierend» Google-MapsROYAL MARSDEN HOSPITAL; DEPT OF MEDICAL ONCOLOGY; The Bob Champion Unit
SM2 5PT Sutton
United KingdomNoch nicht rekrutierend» Google-Maps
Alle anzeigen 06120 Halle (Saale)
(Sachsen-Anhalt)
GermanyRekrutierend» Google-MapsUniklinik-Eppendorf; Klinik U Poliklinik F Urologie
20246 Hamburg
(Hamburg)
GermanyRekrutierend» Google-MapsMed. Hochschule Hannover, Hämatologie, Hämostaseologie, Onkologie u. Stammzelltransplantation
30625 Hannover
(Niedersachsen)
GermanyRekrutierend» Google-MapsUniversitaetsklinikum Muenster; Urology
48149 Muenster
(Nordrhein-Westfalen)
GermanyRekrutierend» Google-MapsKlinikum rechts der Isar der TU München; Urologische Klinik und Poliklinik
81675 München
(Bayern)
GermanyRekrutierend» Google-MapsUniversitätsklinikum Tübingen; Klinik für Urologie
72076 Tübingen
(Baden-Württemberg)
GermanyRekrutierend» Google-MapsUniversitätsklinikum Ulm; Klinik für Urologie
89081 Ulm
(Baden-Württemberg)
GermanyRekrutierend» Google-MapsArizona Oncology Associates
86001 Flagstaff
United StatesRekrutierend» Google-MapsUniversity of Arizona
85724-5030 Tucson
United StatesRekrutierend» Google-MapsCity of Hope Comprehensive Cancer Center
91010 Duarte
United StatesRekrutierend» Google-MapsUC San Diego Health System
92093 La Jolla
United StatesRekrutierend» Google-MapsUniversity of Southern California
90033 Los Angeles
United StatesZurückgezogen» Google-MapsUCLA
90095 Los Angeles
United StatesRekrutierend» Google-MapsStanford University
94304 Palo Alto
United StatesRekrutierend» Google-MapsUniversity of California Davis
95817 Sacramento
United StatesZurückgezogen» Google-MapsUniversity of California San Francisco
94117 San Francisco
United StatesNoch nicht rekrutierend» Google-MapsUniversity of Colorado
80045 Aurora
United StatesRekrutierend» Google-MapsHighlands Ranch Hospital
80129 Highlands Ranch
United StatesRekrutierend» Google-MapsRocky Mountain Cancer Center - Denver
80120 Littleton
United StatesRekrutierend» Google-MapsHartford Healthcare
06102 Hartford
United StatesRekrutierend» Google-MapsYale University
06510 New Haven
United StatesZurückgezogen» Google-MapsSibley Memorial Hospital
20016 Washington
United StatesNoch nicht rekrutierend» Google-MapsWoodlands Medical Specialists, P.A.
32503 Pensacola
United StatesRekrutierend» Google-MapsMoffitt Cancer Center
33612 Tampa
United StatesRekrutierend» Google-MapsSidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Skip Viragh Outpatient Cancer Building
21287 Baltimore
United StatesNoch nicht rekrutierend» Google-MapsMGH
02114 Boston
United StatesNoch nicht rekrutierend» Google-MapsBeth Israel Deaconess Med Ctr
02215 Boston
United StatesNoch nicht rekrutierend» Google-MapsDana-Farber Cancer Institute
02215 Boston
United StatesNoch nicht rekrutierend» Google-MapsMinnesota Oncology Hematology
55404 Minneapolis
United StatesRekrutierend» Google-MapsComprehensive Cancer Centers of Nevada (CCCN) - Central Valley
89169 Las Vegas
United StatesRekrutierend» Google-MapsMemorial Sloan Kettering - Monmouth
07748 Middletown
United StatesNoch nicht rekrutierend» Google-MapsMemorial Sloan Kettering Bergen
07645 Montvale
United StatesNoch nicht rekrutierend» Google-MapsNew York Oncology Hematology,P.C.-Albany
12208 Albany
United StatesRekrutierend» Google-MapsMontefiore Medical Center
10461 Bronx
United StatesRekrutierend» Google-MapsMemorial Sloan Kettering Cancer Center - Commack
11725 Commack
United StatesNoch nicht rekrutierend» Google-MapsMSKCC @ West Harrison
10604 Harrison
United StatesNoch nicht rekrutierend» Google-MapsNew York University
10017 New York
United StatesZurückgezogen» Google-MapsMount Sinai Medical Center
10029 New York
United StatesNoch nicht rekrutierend» Google-MapsMemorial Sloan Kettering Cancer Center
10065 New York
United StatesNoch nicht rekrutierend» Google-MapsSUNY Upstate Medical University
13210 Syracuse
United StatesRekrutierend» Google-MapsDuke University Medical Center
27710 Durham
United StatesNoch nicht rekrutierend» Google-MapsCleveland Clinic
44106 Cleveland
United StatesRekrutierend» Google-MapsWillamette Valley Cancer Institute and Research Center
97401 Eugene
United StatesRekrutierend» Google-MapsFox Chase Cancer Center
19111 Philadelphia
United StatesRekrutierend» Google-MapsTexas Onc-Central Austin CA Ct
78731 Austin
United StatesAktiv, nicht rekrutierend» Google-MapsTexas Oncology - Houston (Gessner)
77024 Houston
United StatesRekrutierend» Google-MapsTexas Oncology - Willowbrook
77070 Houston
United StatesRekrutierend» Google-MapsUniversity Of Utah
84108 Salt Lake City
United StatesRekrutierend» Google-MapsVirginia Cancer Specialists - Gainsville
20155 Gainesville
United StatesRekrutierend» Google-MapsVirginia Oncology Associates
23502 Norfolk
United StatesRekrutierend» Google-MapsUniversity of Wisconsin
53792 Madison
United StatesNoch nicht rekrutierend» Google-MapsFundación CENIT para la Investigación en Neurociencias
C1125ABD Buenos Aires
ArgentinaAktiv, nicht rekrutierend» Google-MapsInst. Alexander Fleming; Oncologia
C1426ANZ Buenos Aires
ArgentinaAktiv, nicht rekrutierend» Google-MapsHospital Britanico
C1280AEB Ciudad Autonoma Bs As
ArgentinaRekrutierend» Google-MapsCentro Medico Austral OMI
C1019ABS Ciudad Autonoma Buenos Aires
ArgentinaAktiv, nicht rekrutierend» Google-MapsMacquarie University Hospital
2109 Macquarie Park
AustraliaRekrutierend» Google-MapsOrange Hospital
2800 Orange
AustraliaRekrutierend» Google-MapsIcon Cancer Foundation
4101 South Brisbane
AustraliaRekrutierend» Google-MapsBendigo Cancer Centre
3550 Bendigo
AustraliaRekrutierend» Google-MapsBox Hill Hospital; Oncology
3128 Box Hill
AustraliaNoch nicht rekrutierend» Google-MapsCancer Care Manitoba
R3E 0V9 Winnipeg
CanadaNoch nicht rekrutierend» Google-MapsPrincess Margaret Cancer Center
M5G 1Z5 Toronto
CanadaNoch nicht rekrutierend» Google-MapsHerlev Hospital; Afdeling for Kræftbehandling
2730 Herlev
DenmarkNoch nicht rekrutierend» Google-MapsOdense Universitetshospital, Onkologisk Afdeling R
5000 Odense C
DenmarkNoch nicht rekrutierend» Google-MapsCHU Besançon - Hôpital Jean Minjoz
25030 Besançon Cedex
FranceNoch nicht rekrutierend» Google-MapsCHU de Bordeaux - Groupe Hospitalier Saint-André - Hopital Saint-Andre
33075 Bordeaux
FranceNoch nicht rekrutierend» Google-MapsCentre Francois Baclesse; Oncologie
14076 Caen
FranceNoch nicht rekrutierend» Google-MapsCentre Jean Perrin; Oncologie
63011 Clermont Ferrand
FranceNoch nicht rekrutierend» Google-MapsCentre Oscar Lambret; Chir Cancerologie General
59000 Lille
FranceNoch nicht rekrutierend» Google-MapsCentre Leon Berard; Departement Oncologie Medicale
69373 Lyon
FranceNoch nicht rekrutierend» Google-MapsCentre Antoine Lacassagne
06189 Nice
FranceNoch nicht rekrutierend» Google-MapsInstitut de cancerologie du Gard
30029 Nimes
FranceNoch nicht rekrutierend» Google-MapsHopital Europeen Georges Pompidou; Service D'Oncologie Medicale
75908 Paris
FranceNoch nicht rekrutierend» Google-MapsHopital Hautepierre; Hematologie Oncologie
67098 Strasbourg
FranceNoch nicht rekrutierend» Google-MapsInstitut Claudius Regaud; Departement Oncologie Medicale
31059 Toulouse
FranceZurückgezogen» Google-MapsInstitut Gustave Roussy; Oncologie Medicale
94800 Villejuif
FranceNoch nicht rekrutierend» Google-MapsAlexandras General Hospital of Athens; Oncology Department
115 28 Athens
GreeceRekrutierend» Google-MapsAttikon University General Hospital
124 64 Athens
GreeceRekrutierend» Google-MapsAthens Medical Center; Dept. of Oncology
151 25 Athens
GreeceRekrutierend» Google-MapsUniversity Hospital of Larissa;Department of Medical Oncology
411 10 Larissa
GreeceNoch nicht rekrutierend» Google-MapsPapageorgiou General Hospital; Medical Oncology
564 29 Thessaloniki
GreeceNoch nicht rekrutierend» Google-MapsDiavalkaniko Hospital
570 01 Thessaloniki
GreeceRekrutierend» Google-MapsIstituto Tumori Napoli;Unità Operativa Oncologia Medica Uro-Ginecologica
80131 Napoli
ItalyRekrutierend» Google-MapsAzienda Ospedaliero-Universitaria S.Orsola-Malpighi; Unità Operativa Oncologia Medica
40138 Bologna
ItalyRekrutierend» Google-MapsIRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
47014 Meldola
ItalyRekrutierend» Google-MapsIrccs Centro Di Riferimento Oncologico (CRO); SOC Oncologia Medica A
33081 Aviano (PN)
ItalyNoch nicht rekrutierend» Google-MapsPoliclinico Universitario "Agostino Gemelli"; U.O.C. Oncologia Medica
00168 Roma
ItalyRekrutierend» Google-MapsASST DEGLI SPEDALI CIVILI DI BRESCIA; Oncologia Medica
25123 Brescia
ItalyRekrutierend» Google-MapsIrccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 2
20133 Milano
ItalyRekrutierend» Google-MapsFondazione Salvatore Maugeri; Divisione Di Oncologia Medica
27100 Pavia
ItalyRekrutierend» Google-MapsIstituto Clinico Humanitas;U.O. Oncologia Medica Ed Ematologia
20089 Rozzano
ItalyRekrutierend» Google-MapsOspedale Di Macerata; Oncologia
62100 Macerata
ItalyRekrutierend» Google-MapsFondazione del Piemonte per l'Oncologia (IRCCS); Day Hospital Oncologico Multidisciplinare
10060 Candiolo (TO)
ItalyRekrutierend» Google-MapsAzienda Ospedaliera S. Maria - Terni; Oncologia
05100 Terni
ItalyRekrutierend» Google-MapsKyushu University Hospital
812-8582 Fukuoka
JapanRekrutierend» Google-MapsHokkaido University Hospital
060-8648 Hokkaido
JapanRekrutierend» Google-MapsUniversity of Tsukuba Hospital
305-8576 Ibaraki
JapanRekrutierend» Google-MapsYokohama City University Hospital
236-0004 Kanagawa
JapanRekrutierend» Google-MapsOkayama University Hospital
700-8558 Okayama
JapanRekrutierend» Google-MapsOsaka City University Hospital
545-8586 Osaka
JapanRekrutierend» Google-MapsKindai University Hospital
589-8511 Osaka
JapanNoch nicht rekrutierend» Google-MapsTokushima University Hospital
770-8503 Tokushima
JapanRekrutierend» Google-MapsKeio University Hospital
160-8582 Tokyo
JapanRekrutierend» Google-MapsTokyo Women's Medical University Hospital
162-8666 Tokyo
JapanRekrutierend» Google-MapsChungnam National University Hospital
35015 Daejeon
Korea, Republic ofRekrutierend» Google-MapsNational Cancer Center
10408 Goyang-si
Korea, Republic ofRekrutierend» Google-MapsCHA Bundang Medical Center
13496 Gyeonggi-do
Korea, Republic ofRekrutierend» Google-MapsPusan National University Yangsan Hospital
50612 Gyeongsangnam-do
Korea, Republic ofRekrutierend» Google-MapsChonnam National University Hwasun Hospital
58128 Jeollanam-do
Korea, Republic ofRekrutierend» Google-MapsSeoul National University Bundang Hospital
13605 Seongnam-si
Korea, Republic ofRekrutierend» Google-MapsSamsung Medical Center
(0)6351 Seoul
Korea, Republic ofRekrutierend» Google-MapsSeoul National University Hospital
03080 Seoul
Korea, Republic ofRekrutierend» Google-MapsKangbuk Samsung Medical Center
03181 Seoul
Korea, Republic ofRekrutierend» Google-MapsSeverance Hospital
03722 Seoul
Korea, Republic ofRekrutierend» Google-MapsAsan Medical Center
05505 Seoul
Korea, Republic ofRekrutierend» Google-MapsSzpital Specjalistyczny Podkarpacki Ośrodek Onkologiczny
36-200 Brzozów
PolandRekrutierend» Google-MapsCentrum Onkologii im. Prof. Franciszka Łukaszczyka; Ambulatorium Chemioterapii
85-796 Bydgoszcz
PolandRekrutierend» Google-MapsSP ZOZ Wojewódzki Szpital Specjalistyczny nr 4; Oddzial Onkologii Klinicznej
41-902 Bytom
PolandRekrutierend» Google-MapsEuropejskie Centrum Zdrowia Otwock Szpital im. Fryderyka Chopina, Klinika Onkologii
05-400 Otwock
PolandRekrutierend» Google-MapsSzpital Kliniczny Przemienienia Pańskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego
60-570 Poznan
PolandRekrutierend» Google-MapsLecznice Citomed Sp. z o.o.
87-100 Torun
PolandNoch nicht rekrutierend» Google-MapsSzpital Grochowski im. dr med. Rafała Masztaka Sp. z o.o.
04-073 Warszawa
PolandRekrutierend» Google-MapsWojskowy Instytut Medyczny; Klinika Onkologii
04-141 Warszawa
PolandNoch nicht rekrutierend» Google-MapsDolnoslaskie Centrum Onkologii
53-413 Wrocław
PolandRekrutierend» Google-MapsRegional Clinical Oncology Hospital
150054 Yaroslavl
Russian FederationNoch nicht rekrutierend» Google-MapsMEDSI Clinical Hospital on Pyatnitsky Highway; Department of antitumor drug therapy
143422 Moscow
Russian FederationAktiv, nicht rekrutierend» Google-MapsSBIH "Moscow Clinical Scientific and Practical Center named after A.S. Loginov of DHM"
111123 Moskva
Russian FederationRekrutierend» Google-MapsPrivate Healthcare Institution Clinical Hospital RZhD Medicine
195271 St. Petersburg
Russian FederationNoch nicht rekrutierend» Google-MapsTSBHI Altai Territorial oncological dispensary
656045 Barnaul
Russian FederationRekrutierend» Google-MapsSt-Petersburg Regional Oncology Dispensary; Oncology
188663 Kuzmolovo
Russian FederationNoch nicht rekrutierend» Google-MapsFSBSI "Russian Oncological Scientific Center n.a. N.N. Blokhin"
115478 Moscow
Russian FederationRekrutierend» Google-MapsRussian Scientific Center of Roentgenoradiology
117997 Moscow
Russian FederationRekrutierend» Google-MapsMedical Center Avicenna; Urology
630099 Novosibirsk
Russian FederationRekrutierend» Google-MapsFSI Russian Centre of Radiology and Surgical Technologies
197758 Saint-Petersburg
Russian FederationNoch nicht rekrutierend» Google-MapsHospital Univ. Central de Asturias; Servicio de Oncologia
33011 Oviedo
SpainRekrutierend» Google-MapsCorporacio Sanitaria Parc Tauli; Servicio de Oncologia
8208 Sabadell
SpainRekrutierend» Google-MapsHospital Universitario Marques de Valdecilla; Servicio de Oncologia
39008 Santander
SpainRekrutierend» Google-MapsHospital Universitario Reina Sofia; Servicio de Oncologia
14004 Córdoba
SpainRekrutierend» Google-MapsHospital Universitario Son Espases; Servicio de Oncologia
07014 Palma De Mallorca
SpainNoch nicht rekrutierend» Google-MapsHospital Universitario Puerta de Hierro; Servicio de Oncologia
28222 Majadahonda
SpainRekrutierend» Google-MapsHospital Alvaro Cunqueiro; Servicio de Oncologia
36213 Vigo
SpainRekrutierend» Google-MapsHospital Univ Vall d'Hebron; Servicio de Oncologia
08035 Barcelona
SpainNoch nicht rekrutierend» Google-MapsHospital de la Santa Creu i Sant Pau; Servicio de Oncologia
08041 Barcelona
SpainRekrutierend» Google-MapsHospital Universitario de Burgos; Oncología
09006 Burgos
SpainRekrutierend» Google-MapsHospital San Pedro De Alcantara; Servicio de Oncologia
10003 Caceres
SpainNoch nicht rekrutierend» Google-MapsHospital Lucus Augusti; Servicio de Oncologia
27003 Lugo
SpainRekrutierend» Google-MapsHospital General Universitario Gregorio Marañon; Servicio de Oncologia
28007 Madrid
SpainNoch nicht rekrutierend» Google-MapsHospital Ramon y Cajal; Servicio de Oncologia
28034 Madrid
SpainRekrutierend» Google-MapsHospital Clinico San Carlos; Servicio de Oncologia
28040 Madrid
SpainRekrutierend» Google-MapsHospital Universitario 12 de Octubre; Servicio de Oncologia
28041 Madrid
SpainRekrutierend» Google-MapsHospital Universitario La Paz; Servicio de Oncologia
28046 Madrid
SpainRekrutierend» Google-MapsHospital Clinico Universitario Virgen de la Victoria; Servicio de Oncologia
29010 Malaga
SpainRekrutierend» Google-MapsHospital Universitario Virgen de Arrixaca; Servicio de Oncologia
30120 Murcia
SpainNoch nicht rekrutierend» Google-MapsHospital de Navarra; Servicio de Oncologia
31008 Navarra
SpainRekrutierend» Google-MapsHospital Universitario Virgen del Rocio; Servicio de Oncologia
41013 Sevilla
SpainRekrutierend» Google-MapsHospital Univ. Nuestra Señora de Valme; Servicio de Oncologia
41014 Sevilla
SpainRekrutierend» Google-MapsInstituto Valenciano Oncologia; Oncologia Medica
46009 Valencia
SpainRekrutierend» Google-MapsHospital Arnau de Vilanova (Valencia) Servicio de Oncologia
46015 Valencia
SpainRekrutierend» Google-MapsHospital Universitario la Fe; Servicio de Oncologia
46026 Valencia
SpainRekrutierend» Google-MapsRoyal Blackburn Hospital
BB2 3HH Blackburn
United KingdomNoch nicht rekrutierend» Google-MapsLeicester Royal Infirmary; Dept. of Medical Oncology
LE1 5WW Leicester
United KingdomRekrutierend» Google-MapsBarts & London School of Med; Medical Oncology
EC1A 7BE London
United KingdomNoch nicht rekrutierend» Google-MapsSt George's Hospital; Oncology
SW17 0QT London
United KingdomNoch nicht rekrutierend» Google-MapsRoyal Marsden Hospital; Dept of Med-Onc
SW3 6JJ London
United KingdomNoch nicht rekrutierend» Google-MapsChristie Hospital Nhs Trust; Medical Oncology
M2O 4BX Manchester
United KingdomNoch nicht rekrutierend» Google-MapsROYAL MARSDEN HOSPITAL; DEPT OF MEDICAL ONCOLOGY; The Bob Champion Unit
SM2 5PT Sutton
United KingdomNoch nicht rekrutierend» Google-Maps
Studien-Informationen
Brief Summary:This is a Phase III, multicenter, randomized, open-label study designed to evaluate the
efficacy and safety of atezolizumab given in combination with cabozantinib versus
cabozantinib alone in participants with inoperable, locally advanced, or metastatic renal
cell carcinoma (RCC) who experienced radiographic tumor progression during or after Immune
Checkpoint Inhibitor (ICI) treatment in the metastatic setting.
Ein-/Ausschlusskriterien
Inclusion Criteria:- Histologically confirmed locally advanced or metastatic clear cell or non-clear cell
(papillary and unclassified only) RCC. RCC with sarcomatoid features is allowed.
- Radiographic disease progression during or following treatment with ICI for locally
advanced or metastatic RCC either in first- or second-line treatment. ICI is defined
by anti-PD-L1 or anti-PD1 antibody including atezolizumab, avelumab, pembrolizumab, or
nivolumab. Only patients for whom the immediate preceding line of therapy was an ICI
are allowed.
- Measurable disease per RECIST v1.1
- Evaluable IMDC risk score
- Archival tumor specimen, and pretreatment tumor tissue from fresh biopsy at screening,
if clinically feasible
- KPS score of >=70
- Adequate hematologic and end-organ function
- Negative HIV test at screening
- Negative hepatitis B testing at screening
- Negative hepatitis C virus (HCV) antibody test at screening, or positive HCV antibody
test followed by a negative HCV RNA test at screening
- For women of childbearing potential: agreement to remain abstinent (refrain from
heterosexual intercourse) or use contraception and agreement to refrain from donating
eggs
- For men: agreement to remain abstinent (refrain from heterosexual intercourse) or use
a condom, and agreement to refrain from donating sperm
Exclusion Criteria:
- Treatment with anti-cancer therapy within 28 days prior to initiation of study
treatment
- Patients received cabozantinib at any time prior to screening
- Patients who received more than 1 regimen of ICIs
- Patients who received more than 2 prior lines of therapy in the advanced or metastatic
setting
- Patients who received ICI in the adjuvant setting (adjuvant VEGFR-TKI except
cabozantinib is allowed)
- Patients who have received a mammalian target of rapamycin (mTOR) inhibitor in the
advanced or metastatic setting
- Symptomatic, untreated, or actively progressing CNS metastases
- History of leptomeningeal disease
- Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent
drainage procedures
- Uncontrolled or symptomatic hypercalcemia or symptomatic hypercalcemia requiring
continued use of bisphosphonate therapy or denosumab
- History of malignancy other than renal carcinoma within 5 years prior to screening,
with the exception of malignancies with a negligible risk of metastasis or death
- Radiotherapy for RCC within 14 days prior to Day 1 of Cycle 1
- Active tuberculosis
- Major surgical procedure, other than for diagnosis, within 4 weeks prior to initiation
of study treatment, or anticipation of need for a major surgical procedure during the
study
- Pregnancy or breastfeeding, or intention of becoming pregnant during study treatment
or within 5 months after final dose of atezolizumab and 4 months after final dose of
cabozantinib
- Severe infection within 4 weeks prior to initiation of study treatment, including, but
not limited to, hospitalization for complications of infection, bacteremia, or severe
pneumonia
- Uncontrolled hypertension defined as sustained blood pressure >150 mm Hg systolic or >
90 mm Hg diastolic despite optimal antihypertensive treatment
- Significant cardiovascular disease (such as New York Heart Association Class II or
greater cardiac disease, MI, or cerebrovascular accident) within 3 months prior to
initiation of study treatment, unstable arrhythmia, or unstable angina
- Significant vascular disease (e.g., aortic aneurysm requiring surgical repair or
recent peripheral arterial thrombosis) within 6 months prior to Day 1 of Cycle 1
- History of congenital QT syndrome
- History or presence of an abnormal ECG that is clinically significant in the
investigator's opinion
- Concomitant anticoagulation with coumarin agents (e.g., warfarin), direct thrombin
inhibitor dabigatran, direct factor Xa inhibitor betrixaban, or platelet inhibitors
(e.g. clopidogrel)
Studien-Rationale
Primary outcome:1. Progression-Free Survival (PFS), as assessed by Independent Review Facility (IRF) (Time Frame - Randomization up to approximately 27 months):
Progression-free survival (PFS), defined as the time from randomization to the first occurrence of disease progression according to RECIST v1.1, as assessed by Independent Review Facility (IRF-PFS) or death from any cause, whichever occurs first.
2. Overall survival (OS) (Time Frame - Randomization up to approximately 52 months):
Overall survival (OS), defined as the time from randomization to death from any cause.
Secondary outcome:
1. PFS Assessed by the Investigators (INV-PFS) (Time Frame - Randomization up to approximately 27 months):
PFS assessed by the investigators (INV-PFS), defined as the time from randomization to the first occurrence of disease progression according to RECIST v1.1 or death from any cause (whichever occurs first).
2. Investigator Assessed Objective Response Rate (INV-ORR) (Time Frame - Randomization up to approximately 27 months):
INV-ORR, defined as the proportion of patients with a complete response (CR) or partial response (PR) on two consecutive occasions at least 4 weeks apart according to RECIST v1.1.
3. IRF Assessed Objective Response Rate (IRF-ORR) (Time Frame - Randomization up to approximately 27 months):
IRF-ORR, defined as the proportion of patients with a complete response (CR) or partial response (PR) on two consecutive occasions at least 4 weeks apart according to RECIST v1.1.
4. Investigator Assessed Duration of Objective Response (INV-DOR) (Time Frame - Randomization up to approximately 27 months):
INV-DOR, defined as the time from the first occurrence of a documented objective response to disease progression or death from any cause (whichever occurs first) according to RECIST v1.1.
5. IRF Assessed DOR (IRF-DOR) (Time Frame - Randomization up to approximately 27 months):
IRF-DOR, defined as the time from the first occurrence of a documented objective response to disease progression or death from any cause (whichever occurs first) according to RECIST v1.1.
6. Percentage of Participants With Adverse Events (Time Frame - Randomization up to approximately 27 months)
7. Atezolizumab Concentrations (Time Frame - At pre-defined intervals from first administration of study drug up to approximately 27 months)
8. Cabozantinib Concentrations (Time Frame - At pre-defined intervals from first administration of study drug up to approximately 27 months)
9. Prevalence of Anti-Drug Antibodies (ADAs) to Atezolizumab (Time Frame - Baseline)
10. Incidence of ADAs to Atezolizumab During the Study (Time Frame - At pre-defined intervals from first administration of study drug up to approximately 27 months)
Studien-Arme
- Experimental: Atezo+Cabo
Participants will receive atezolizumab every 3 weeks on Day 1 of each 21-day cycle (1 cycle=21 days) plus oral tablets of cabozantinib every day. - Active Comparator: Cabozantinib
Participants will receive cabozantinib every day.
Geprüfte Regime
- Atezolizumab (Tecentriq):
Atezolizumab 1200 mg will be administered at a fixed dose on Day 1 of each 21-day cycle by IV infusion every 3 weeks. - Cabozantinib (Cabometyx):
Cabozantinib 60 mg (three 20-mg tablets) administered orally once daily.
Quelle: ClinicalTrials.gov