JOURNAL ONKOLOGIE – STUDIE
TRANSFORM-2 Study of Oral Navitoclax Tablet in Combination With Oral Ruxolitinib Tablet to Assess Change in Spleen Volume in Adult Participants With Relapsed/Refractory Myelofibrosis
Rekrutierend
NCT-Nummer:
NCT04468984
Studienbeginn:
August 2020
Letztes Update:
04.02.2021
Wirkstoff:
Navitoclax, Ruxolitinib, Best Available Therapy (BAT)
Indikation (Clinical Trials):
Primary Myelofibrosis
Geschlecht:
Alle
Altersgruppe:
Erwachsene (18+)
Phase:
Phase 3
Sponsor:
AbbVie
Collaborator:
-
Studienleiter
Study Director
AbbVie
Kontakt
Kontakt:
Phone: 844-663-3742
E-Mail: abbvieclinicaltrials@abbvie.com» Kontaktdaten anzeigen
Studienlocations (3 von 178)
Universitatsklinikum Mannheim /ID# 221529
68167 Mannheim
(Baden-Württemberg)
GermanyNoch nicht rekrutierend» Google-MapsBAG Freiberg-Richter /ID# 221346
01307 Dresden
(Sachsen)
GermanyRekrutierend» Google-MapsGemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 225025
86150 Augsburg
(Bayern)
GermanyNoch nicht rekrutierend» Google-Maps
68167 Mannheim
(Baden-Württemberg)
GermanyNoch nicht rekrutierend» Google-MapsBAG Freiberg-Richter /ID# 221346
01307 Dresden
(Sachsen)
GermanyRekrutierend» Google-MapsGemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 225025
86150 Augsburg
(Bayern)
GermanyNoch nicht rekrutierend» Google-Maps
Bochum-Mitte Bochum, Germany /ID# 224695
44791 Bochum
(Nordrhein-Westfalen)
GermanyNoch nicht rekrutierend» Google-MapsKlinikum Chemnitz gGmbH /ID# 224575
09116 Chemnitz
(Sachsen)
GermanyNoch nicht rekrutierend» Google-MapsOncoResearch Lerchenfeld GmbH /ID# 225034
22081 Hamburg
(Hamburg)
GermanyNoch nicht rekrutierend» Google-MapsKlinikum Rechts der Isar /ID# 221526
81675 Munich
(Bayern)
GermanyRekrutierend» Google-MapsStauferklinikum Schwaebisch Gmuend /ID# 223948
73557 Mutlangen
(Baden-Württemberg)
GermanyNoch nicht rekrutierend» Google-MapsUniversitaetsklinikum Rostock /ID# 224157
18055 Rostock
(Mecklenburg-Vorpommern)
GermanyNoch nicht rekrutierend» Google-MapsIronwood Cancer & Res Ctr /ID# 222162
85224-5665 Chandler
United StatesRekrutierend» Google-MapsHighlands Oncology Group /ID# 221826
72762 Springdale
United StatesRekrutierend» Google-MapsMoore UC San Diego Cancer Center /ID# 219009
92093 La Jolla
United StatesNoch nicht rekrutierend» Google-MapsLong Beach Memorial Medical Ct /ID# 224542
90806 Long Beach
United StatesNoch nicht rekrutierend» Google-MapsIcri /Id# 221967
90603 Whittier
United StatesNoch nicht rekrutierend» Google-MapsSt. Mary's Hospital Regional Cancer Center /ID# 224229
81501-6132 Grand Junction
United StatesRekrutierend» Google-MapsAugusta University Georgia Cancer Center /ID# 219051
30912-0003 Augusta
United StatesNoch nicht rekrutierend» Google-MapsColumbus Regional Research Institute /ID# 224410
31904-8915 Columbus
United StatesRekrutierend» Google-MapsLoyola University Medical Ctr /ID# 219048
60153 Maywood
United StatesNoch nicht rekrutierend» Google-MapsIndiana Blood & Marrow Transpl /ID# 221587
46237 Indianapolis
United StatesNoch nicht rekrutierend» Google-MapsTulane Medical Center - New Orleans /ID# 222940
70112-2600 New Orleans
United StatesRekrutierend» Google-MapsOchsner Clinic Foundation-New Orleans /ID# 222777
70121 New Orleans
United StatesNoch nicht rekrutierend» Google-MapsDana-Farber Cancer Institute /ID# 218998
02215 Boston
United StatesNoch nicht rekrutierend» Google-MapsUniversity of Michigan /ID# 218463
48109-5000 Ann Arbor
United StatesRekrutierend» Google-MapsWilliam Beaumont Hospital /ID# 222705
48073-6710 Royal Oak
United StatesNoch nicht rekrutierend» Google-MapsSaint Louis University Cancer Center /ID# 222287
63110-2539 Saint Louis
United StatesNoch nicht rekrutierend» Google-MapsSummit Medical Group - Florham Park /ID# 222620
07932-1049 Florham Park
United StatesRekrutierend» Google-MapsHackensack Univ Med Ctr /ID# 219047
07601 Hackensack
United StatesNoch nicht rekrutierend» Google-MapsManhattan Hematology Oncology MHO Associates /ID# 223193
10016-6028 New York
United StatesRekrutierend» Google-MapsWeill Cornell Medical College /ID# 220866
10021 New York
United StatesNoch nicht rekrutierend» Google-MapsMemorial Sloan Kettering Cancer Center-Koch Center /ID# 221081
10065-6007 New York
United StatesNoch nicht rekrutierend» Google-MapsUniv Rochester Med Ctr /ID# 219050
14642 Rochester
United StatesNoch nicht rekrutierend» Google-MapsWake Forest Baptist Medical Center /ID# 222899
27157-0001 Winston-Salem
United StatesNoch nicht rekrutierend» Google-MapsMetroHealth Medical Center /ID# 222650
44109 Cleveland
United StatesNoch nicht rekrutierend» Google-MapsFox Chase Cancer Center /ID# 223955
19111 Philadelphia
United StatesNoch nicht rekrutierend» Google-MapsBaylor Sammons Cancer Center /ID# 222632
75246 Dallas
United StatesNoch nicht rekrutierend» Google-MapsHouston Methodist Hospital /ID# 223103
77030 Houston
United StatesNoch nicht rekrutierend» Google-MapsThe Univ Texas HSC at Tyler /ID# 222810
75708 Tyler
United StatesNoch nicht rekrutierend» Google-MapsUtah Cancer Specialists /ID# 221962
84106 Salt Lake City
United StatesNoch nicht rekrutierend» Google-MapsVirginia Cancer Specialists /ID# 223016
22031 Fairfax
United StatesNoch nicht rekrutierend» Google-MapsProvidence Everett /ID# 223130
98201 Everett
United StatesNoch nicht rekrutierend» Google-MapsYakima Valley Memorial Hosp /ID# 224368
98902 Yakima
United StatesRekrutierend» Google-MapsHSHS St. Vincent Hospital /ID# 224468
54301 Green Bay
United StatesNoch nicht rekrutierend» Google-MapsBorder Medical Oncology Research Unit Albury Wodonga Regional Cancer Centre /ID# 223848
2640 Albury
AustraliaRekrutierend» Google-MapsThe Kinghorn Cancer Centre /ID# 221097
2010 Darlinghurst
AustraliaNoch nicht rekrutierend» Google-MapsThe Tweed Hospital /ID# 224212
2485 Tweed Heads
AustraliaNoch nicht rekrutierend» Google-MapsCalvary Mater Newcastle /ID# 224324
2298 Waratah
AustraliaRekrutierend» Google-MapsThe Alfred Hospital /ID# 221096
3181 Prahran
AustraliaNoch nicht rekrutierend» Google-MapsRoyal Perth Hospital /ID# 221099
6008 Shenton Park
AustraliaRekrutierend» Google-MapsLKH-Univ. Klinikum Graz /ID# 220919
8036 Graz
AustriaRekrutierend» Google-MapsUniversitaetsklinikum St. Poelten /ID# 221709
3100 St. Polten
AustriaNoch nicht rekrutierend» Google-MapsMedizinische Universitaet Wien /ID# 220911
1090 Vienna
AustriaNoch nicht rekrutierend» Google-MapsKlinikum Wels-Grieskirchen GmbH /ID# 220915
4600 Wels
AustriaRekrutierend» Google-MapsHanusch Krankenhaus /ID# 220912
1140 Wien
AustriaRekrutierend» Google-MapsCliniques Universitaires Saint Luc /ID# 224221
1200 Woluwe-Saint-Lambert
BelgiumNoch nicht rekrutierend» Google-MapsZNA Stuivenberg /ID# 221468
2060 Antwerp
BelgiumNoch nicht rekrutierend» Google-MapsGrand Hopital de Charleroi /ID# 224827
6000 Charleroi
BelgiumNoch nicht rekrutierend» Google-MapsGhent University hospital /ID# 220841
9000 Ghent
BelgiumNoch nicht rekrutierend» Google-MapsAZ-Delta /ID# 221469
8800 Roeselare
BelgiumNoch nicht rekrutierend» Google-MapsJuravinski Hosp & Cancer Cntr /ID# 220887
L8V 1C3 Hamilton
CanadaNoch nicht rekrutierend» Google-MapsCISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 222433
G6V 3Z1 Levis
CanadaRekrutierend» Google-MapsMcGill University Health Center Research Institute /ID# 222614
H4A 3J1 Montreal
CanadaNoch nicht rekrutierend» Google-MapsFakultni Nemocnice Brno /ID# 220959
625 00 Brno
CzechiaNoch nicht rekrutierend» Google-MapsVseobecna fakultni nemocnice v Praze /ID# 220969
128 00 Prague 28
CzechiaNoch nicht rekrutierend» Google-MapsAalborg University Hospital /ID# 224391
9000 Aalborg
DenmarkRekrutierend» Google-MapsSjællands Universitetshospital, Roskilde /ID# 224456
4000 Roskilde
DenmarkNoch nicht rekrutierend» Google-MapsHopital Haut-Lévêque /ID# 222696
33604 Pessac CEDEX
FranceRekrutierend» Google-MapsCentre Hospitalier Lyon Sud /ID# 222695
69495 Pierre Benite CEDEX
FranceRekrutierend» Google-MapsCHU d'Angers /ID# 219129
49933 Angers
FranceRekrutierend» Google-MapsHopital Avicenne /ID# 221287
93009 Bobigny
FranceRekrutierend» Google-MapsCentre Hospitalier Metropole Savoie /ID# 223771
73000 Chambery
FranceRekrutierend» Google-MapsCHU de Nantes, Hotel Dieu -HME /ID# 219127
44093 Nantes
FranceRekrutierend» Google-MapsCHU de Nimes /ID# 219128
30029 Nimes
FranceRekrutierend» Google-MapsHopital Saint Louis /ID# 221390
75475 Paris
FranceRekrutierend» Google-MapsGeneral Hospital of Athens Laiko /ID# 221175
115 27 Athens
GreeceNoch nicht rekrutierend» Google-MapsGeneral Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 221179
10676 Athens
GreeceRekrutierend» Google-MapsPatras University General Hosp /ID# 221178
26504 Rion, Patras, Achaia
GreeceNoch nicht rekrutierend» Google-MapsGeneral Hospital of Thessaloniki George Papanikolaou /ID# 221463
57010 Thessaloniki
GreeceRekrutierend» Google-MapsDebreceni Egyetem Klinikai Kozpont /ID# 220947
4032 Debrecen
HungaryRekrutierend» Google-MapsSomogy Megyei Kaposi Mor Oktat /ID# 220948
7400 Kaposvar
HungaryRekrutierend» Google-MapsJosa Andras Oktato Korhaz /ID# 220946
4400 Nyíregyháza
HungaryRekrutierend» Google-MapsUniversity of Szeged /ID# 220955
6720 Szeged
HungaryRekrutierend» Google-MapsFejer Megyei Szent Gyorgy Korhaz /ID# 220949
8000 Szekesfehervar
HungaryRekrutierend» Google-MapsRabin Medical Center /ID# 219139
4941492 Petakh Tikva
IsraelRekrutierend» Google-MapsHadassah Medical Center-Hebrew University /ID# 219111
91120 Jerusalem
IsraelRekrutierend» Google-MapsHaEmek Medical Center /ID# 220839
1834111 Afula
IsraelRekrutierend» Google-MapsAssuta Ashdod Medical Center /ID# 225281
7747629 Ashdod
IsraelNoch nicht rekrutierend» Google-MapsAssaf Harofeh Medical Center /ID# 222972
70300 Be'er Ya'akov
IsraelRekrutierend» Google-MapsRambam Health Care Campus /ID# 219121
3109601 Haifa
IsraelRekrutierend» Google-MapsCarmel Medical Center /ID# 222973
34362 Haifa
IsraelRekrutierend» Google-MapsGalilee Medical Center /ID# 225280
22100 Nahariya
IsraelNoch nicht rekrutierend» Google-MapsSheba Medical Center /ID# 219136
5239424 Ramat Gan
IsraelRekrutierend» Google-MapsTel Aviv Sourasky Medical Center /ID# 219135
6423906 Tel Aviv-Yafo
IsraelRekrutierend» Google-MapsAOU Federico II /ID# 224673
80131 Naples
ItalyNoch nicht rekrutierend» Google-MapsA.O.U. Policlinico S.Orsola-Malpighi /ID# 221077
40138 Bologna
ItalyNoch nicht rekrutierend» Google-MapsA.O.U. Careggi /ID# 219090
50134 Florence
ItalyNoch nicht rekrutierend» Google-MapsAzienda Policlinico Umberto I /ID# 225731
00161 Rome
ItalyNoch nicht rekrutierend» Google-MapsFondazione Policlinico Universitario Agostino Gemelli IRCCS /ID# 219087
00168 Rome
ItalyNoch nicht rekrutierend» Google-MapsAOU Citta della Salute Scienza /ID# 221223
10126 Turin
ItalyNoch nicht rekrutierend» Google-MapsASST Papa Giovanni XXIII /ID# 221222
24127 Bergamo
ItalyNoch nicht rekrutierend» Google-MapsAzienda Ospedaliera Universitaria Policlinico G. Rodolico - San Marco /Id# 219089
95123 Catania
ItalyNoch nicht rekrutierend» Google-MapsAzienda Ospedaliera San Gerardo di Monza _ Oncologia Medica /ID# 225113
20052 Monza
ItalyNoch nicht rekrutierend» Google-MapsA.O.U. Policlinico Palermo /ID# 221078
90127 Palermo
ItalyNoch nicht rekrutierend» Google-MapsAzieda Ospedaliera Bianchi Melacrino Morelli /ID# 221220
89125 Reggio Calabria
ItalyNoch nicht rekrutierend» Google-MapsAzienda Sanitaria Universitaria Friuli Centrale /ID# 221241
33100 Udine
ItalyNoch nicht rekrutierend» Google-MapsULSS na6 Vicenza /ID# 221079
36100 Vicenza
ItalyNoch nicht rekrutierend» Google-MapsJapanese Red Cross Nagoya Daiichi Hospital /ID# 221150
453-8511 Nagoya-shi
JapanNoch nicht rekrutierend» Google-MapsFujita Health University Hospital /ID# 221598
470-1192 Toyoake-shi
JapanNoch nicht rekrutierend» Google-MapsChiba University Hospital /ID# 224546
260-8677 Chiba-shi
JapanNoch nicht rekrutierend» Google-MapsNational Cancer Center Hospital East /ID# 226653
277-8577 Kashiwa-shi
JapanNoch nicht rekrutierend» Google-MapsEhime University Hospital /ID# 221158
791-0295 Toon-shi
JapanNoch nicht rekrutierend» Google-MapsKyushu University Hospital /ID# 221606
812-8582 Fukuoka-shi
JapanNoch nicht rekrutierend» Google-MapsFukushima Medical University Hospital /ID# 221877
960-1295 Fukushima-shi
JapanNoch nicht rekrutierend» Google-MapsGifu University Hospital /ID# 224371
501-1194 Gifu-shi
JapanNoch nicht rekrutierend» Google-MapsSapporo Hokuyu Hospital /ID# 221149
003-0006 Sapporo-shi
JapanNoch nicht rekrutierend» Google-MapsKobe City Medical Center General Hospital /ID# 221156
650-0047 Kobe-shi
JapanNoch nicht rekrutierend» Google-MapsKanazawa University Hospital /ID# 223028
920-8641 Kanazawa-shi
JapanNoch nicht rekrutierend» Google-MapsIwate Medical University Hospital /ID# 222044
028-3695 Shiwa-gun
JapanNoch nicht rekrutierend» Google-MapsShonan Kamakura General Hospital /ID# 223030
247-8533 Kamakura-shi
JapanNoch nicht rekrutierend» Google-MapsKyoto University Hospital /ID# 223008
606-8507 Kyoto-shi
JapanNoch nicht rekrutierend» Google-MapsMie University Hospital /ID# 221665
514-8507 Tsu-shi
JapanNoch nicht rekrutierend» Google-MapsUniversity of Miyazaki Hospital /ID# 221821
889-1692 Miyazaki-shi
JapanNoch nicht rekrutierend» Google-MapsNiigata University Medical & Dental Hospital /ID# 223034
951-8520 Niigata-shi
JapanNoch nicht rekrutierend» Google-MapsKurashiki Central Hospital /ID# 221690
710-8602 Kurashiki-shi
JapanNoch nicht rekrutierend» Google-MapsOsaka University Hospital /ID# 221159
565-0871 Suita-shi
JapanNoch nicht rekrutierend» Google-MapsDokkyo Medical University Saitama Medical Center /ID# 222334
343-8555 Koshigaya-shi
JapanNoch nicht rekrutierend» Google-MapsJuntendo University Shizuoka Hospital /ID# 221780
410-2295 Izunokuni-shi
JapanNoch nicht rekrutierend» Google-MapsJuntendo University Hospital /ID# 221154
113-8431 Bunkyo-ku
JapanNoch nicht rekrutierend» Google-MapsNippon Medical School Hospital /ID# 221676
113-8603 Bunkyo-ku
JapanNoch nicht rekrutierend» Google-MapsTokyo Medical University Hospital /ID# 221540
160-0023 Shinjuku-ku
JapanNoch nicht rekrutierend» Google-MapsUniversity of Yamanashi Hospital /ID# 221706
409-3821 Chuo-shi
JapanNoch nicht rekrutierend» Google-MapsPusan National University Hosp /ID# 220980
49241 Busan
Korea, Republic ofRekrutierend» Google-MapsGachon University Gil Medical Center /ID# 220972
21565 Incheon
Korea, Republic ofRekrutierend» Google-MapsSamsung Medical Center /ID# 221091
06351 Seoul
Korea, Republic ofRekrutierend» Google-MapsThe Catholic Univ. of Korea /ID# 219061
06591 Seocho-gu, Seoul
Korea, Republic ofRekrutierend» Google-MapsSeoul National University Hospital /ID# 219060
03080 Seoul
Korea, Republic ofRekrutierend» Google-MapsWojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im. M. Kopern /Id# 221161
93-513 Lodz
PolandRekrutierend» Google-MapsSamodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie /ID# 221124
20-081 Lublin
PolandRekrutierend» Google-MapsSP ZOZ Szpital Uniwersytecki w Krakowie /ID# 221160
31-501 Krakow
PolandRekrutierend» Google-MapsMTZ Clinical Research SP. zoo /ID# 221759
02-106 Warsaw
PolandRekrutierend» Google-MapsUniwersyteckie Centrum Kliniczne /ID# 221298
80-214 Gdansk
PolandNoch nicht rekrutierend» Google-MapsPratia Onkologia Katowice /ID# 224526
40-519 Katowice
PolandNoch nicht rekrutierend» Google-MapsLux Med Onkologia - Szpital Szamocka /Id# 221265
01-748 Warsaw
PolandRekrutierend» Google-MapsHospital del Centro Comprensivo de Cancer de la UPR /ID# 223281
00927 San Juan
Puerto RicoNoch nicht rekrutierend» Google-MapsCity Clinical Hospital named after S.P. Botkin /ID# 221116
125284 Moscow
Russian FederationRekrutierend» Google-MapsCity Clinical Hospital n.a. V.V. Veresaev of the Moscow Department of Healthcare /ID# 225221
127644 Moscow
Russian FederationNoch nicht rekrutierend» Google-MapsRussian Scientific and Research Institute of Hematology and Transfusiology /ID# 221115
191024 Sankt-Peterburg
Russian FederationRekrutierend» Google-MapsFederal North-West Medical Res /ID# 221114
197341 St. Petersburg
Russian FederationRekrutierend» Google-MapsTula Regional Clinical Hospital /ID# 221302
300053 Tula
Russian FederationRekrutierend» Google-MapsHospital Universitario A Coruña - CHUAC /ID# 224617
15006 A Coruña
SpainRekrutierend» Google-MapsHospital Clínico Universitario de Santiago-CHUS /ID# 221616
15706 Santiago de Compostela
SpainRekrutierend» Google-MapsHospital Universitario Central de Asturias /ID# 224815
33011 Oviedo
SpainNoch nicht rekrutierend» Google-MapsHospital Regional de Malaga /ID# 221906
29010 Málaga
SpainRekrutierend» Google-MapsHospital Parc de Salut del Mar /ID# 220922
08003 Barcelona
SpainRekrutierend» Google-MapsHospital Universitario Dr. Negrin /ID# 220923
35010 Las Palmas de Gran Canaria
SpainRekrutierend» Google-MapsHospital Universitario La Paz /ID# 224813
28046 Madrid
SpainNoch nicht rekrutierend» Google-MapsHospital Clinico Universitario de Salamanca /ID# 221904
37007 Salamanca
SpainRekrutierend» Google-MapsHospital Universitario Virgen del Rocio /ID# 221932
41013 Sevilla
SpainRekrutierend» Google-MapsHospital Clinico Universitario de Valencia /ID# 220920
46010 Valencia
SpainRekrutierend» Google-MapsSkane University Hospital Lund /ID# 220834
SE 221 41 Lund
SwedenNoch nicht rekrutierend» Google-MapsUniversitaetsspital Basel /ID# 221261
4031 Basel
SwitzerlandRekrutierend» Google-MapsInselspital Universitaetsklinik Bern /ID# 223439
3010 Bern
SwitzerlandRekrutierend» Google-MapsChina Medical University Hosp /ID# 218979
40447 Taichung City
TaiwanRekrutierend» Google-MapsKaohsiung Medical University Chung-Ho Memorial Hospital /ID# 218980
80708 Kaohsiung
TaiwanRekrutierend» Google-MapsKaohsiung Chang Gung Memorial Hospital /ID# 218985
833 Kaohsiung
TaiwanRekrutierend» Google-MapsChi Mei Hospital - Liouying /ID# 221144
73657 Tainan City
TaiwanRekrutierend» Google-MapsTaipei Veterans General Hosp /ID# 221147
11217 Taipei City
TaiwanRekrutierend» Google-MapsLinkou Chang Gung Memorial Hos /ID# 218982
33350 Taoyuan County
TaiwanRekrutierend» Google-MapsGulhane Askeri Tip Academy /ID# 224568
06010 Ankara
TurkeyNoch nicht rekrutierend» Google-MapsTrakya University Medical Facu /ID# 224572
22030 Edirne, Istanbul
TurkeyNoch nicht rekrutierend» Google-MapsEge University Medical Faculty /ID# 224570
35040 Izmir
TurkeyNoch nicht rekrutierend» Google-MapsMersin Univ Tip Fakult Hastane /ID# 224571
33000 Mersin
TurkeyNoch nicht rekrutierend» Google-MapsOndokuz mayis University Facul /ID# 224567
55139 Samsun
TurkeyNoch nicht rekrutierend» Google-MapsGuy's and St Thomas' NHS Found /ID# 221041
SE1 9RT London
United KingdomNoch nicht rekrutierend» Google-MapsHeart of England NHS Foundation Trust /ID# 221334
B9 5SS Birmingham
United KingdomNoch nicht rekrutierend» Google-MapsWestern General Hospital /ID# 224378
EH4 2XU Edinburgh
United KingdomNoch nicht rekrutierend» Google-MapsJames Paget University Hosp /ID# 221219
NR31 6LA Great Yarmouth
United KingdomRekrutierend» Google-MapsThe Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 221335
NE7 7DN Newcastle Upon Tyne
United KingdomRekrutierend» Google-MapsOxford Univ Hosp NHS Trust /ID# 221044
OX3 7LE Oxford
United KingdomNoch nicht rekrutierend» Google-Maps
Alle anzeigen 44791 Bochum
(Nordrhein-Westfalen)
GermanyNoch nicht rekrutierend» Google-MapsKlinikum Chemnitz gGmbH /ID# 224575
09116 Chemnitz
(Sachsen)
GermanyNoch nicht rekrutierend» Google-MapsOncoResearch Lerchenfeld GmbH /ID# 225034
22081 Hamburg
(Hamburg)
GermanyNoch nicht rekrutierend» Google-MapsKlinikum Rechts der Isar /ID# 221526
81675 Munich
(Bayern)
GermanyRekrutierend» Google-MapsStauferklinikum Schwaebisch Gmuend /ID# 223948
73557 Mutlangen
(Baden-Württemberg)
GermanyNoch nicht rekrutierend» Google-MapsUniversitaetsklinikum Rostock /ID# 224157
18055 Rostock
(Mecklenburg-Vorpommern)
GermanyNoch nicht rekrutierend» Google-MapsIronwood Cancer & Res Ctr /ID# 222162
85224-5665 Chandler
United StatesRekrutierend» Google-MapsHighlands Oncology Group /ID# 221826
72762 Springdale
United StatesRekrutierend» Google-MapsMoore UC San Diego Cancer Center /ID# 219009
92093 La Jolla
United StatesNoch nicht rekrutierend» Google-MapsLong Beach Memorial Medical Ct /ID# 224542
90806 Long Beach
United StatesNoch nicht rekrutierend» Google-MapsIcri /Id# 221967
90603 Whittier
United StatesNoch nicht rekrutierend» Google-MapsSt. Mary's Hospital Regional Cancer Center /ID# 224229
81501-6132 Grand Junction
United StatesRekrutierend» Google-MapsAugusta University Georgia Cancer Center /ID# 219051
30912-0003 Augusta
United StatesNoch nicht rekrutierend» Google-MapsColumbus Regional Research Institute /ID# 224410
31904-8915 Columbus
United StatesRekrutierend» Google-MapsLoyola University Medical Ctr /ID# 219048
60153 Maywood
United StatesNoch nicht rekrutierend» Google-MapsIndiana Blood & Marrow Transpl /ID# 221587
46237 Indianapolis
United StatesNoch nicht rekrutierend» Google-MapsTulane Medical Center - New Orleans /ID# 222940
70112-2600 New Orleans
United StatesRekrutierend» Google-MapsOchsner Clinic Foundation-New Orleans /ID# 222777
70121 New Orleans
United StatesNoch nicht rekrutierend» Google-MapsDana-Farber Cancer Institute /ID# 218998
02215 Boston
United StatesNoch nicht rekrutierend» Google-MapsUniversity of Michigan /ID# 218463
48109-5000 Ann Arbor
United StatesRekrutierend» Google-MapsWilliam Beaumont Hospital /ID# 222705
48073-6710 Royal Oak
United StatesNoch nicht rekrutierend» Google-MapsSaint Louis University Cancer Center /ID# 222287
63110-2539 Saint Louis
United StatesNoch nicht rekrutierend» Google-MapsSummit Medical Group - Florham Park /ID# 222620
07932-1049 Florham Park
United StatesRekrutierend» Google-MapsHackensack Univ Med Ctr /ID# 219047
07601 Hackensack
United StatesNoch nicht rekrutierend» Google-MapsManhattan Hematology Oncology MHO Associates /ID# 223193
10016-6028 New York
United StatesRekrutierend» Google-MapsWeill Cornell Medical College /ID# 220866
10021 New York
United StatesNoch nicht rekrutierend» Google-MapsMemorial Sloan Kettering Cancer Center-Koch Center /ID# 221081
10065-6007 New York
United StatesNoch nicht rekrutierend» Google-MapsUniv Rochester Med Ctr /ID# 219050
14642 Rochester
United StatesNoch nicht rekrutierend» Google-MapsWake Forest Baptist Medical Center /ID# 222899
27157-0001 Winston-Salem
United StatesNoch nicht rekrutierend» Google-MapsMetroHealth Medical Center /ID# 222650
44109 Cleveland
United StatesNoch nicht rekrutierend» Google-MapsFox Chase Cancer Center /ID# 223955
19111 Philadelphia
United StatesNoch nicht rekrutierend» Google-MapsBaylor Sammons Cancer Center /ID# 222632
75246 Dallas
United StatesNoch nicht rekrutierend» Google-MapsHouston Methodist Hospital /ID# 223103
77030 Houston
United StatesNoch nicht rekrutierend» Google-MapsThe Univ Texas HSC at Tyler /ID# 222810
75708 Tyler
United StatesNoch nicht rekrutierend» Google-MapsUtah Cancer Specialists /ID# 221962
84106 Salt Lake City
United StatesNoch nicht rekrutierend» Google-MapsVirginia Cancer Specialists /ID# 223016
22031 Fairfax
United StatesNoch nicht rekrutierend» Google-MapsProvidence Everett /ID# 223130
98201 Everett
United StatesNoch nicht rekrutierend» Google-MapsYakima Valley Memorial Hosp /ID# 224368
98902 Yakima
United StatesRekrutierend» Google-MapsHSHS St. Vincent Hospital /ID# 224468
54301 Green Bay
United StatesNoch nicht rekrutierend» Google-MapsBorder Medical Oncology Research Unit Albury Wodonga Regional Cancer Centre /ID# 223848
2640 Albury
AustraliaRekrutierend» Google-MapsThe Kinghorn Cancer Centre /ID# 221097
2010 Darlinghurst
AustraliaNoch nicht rekrutierend» Google-MapsThe Tweed Hospital /ID# 224212
2485 Tweed Heads
AustraliaNoch nicht rekrutierend» Google-MapsCalvary Mater Newcastle /ID# 224324
2298 Waratah
AustraliaRekrutierend» Google-MapsThe Alfred Hospital /ID# 221096
3181 Prahran
AustraliaNoch nicht rekrutierend» Google-MapsRoyal Perth Hospital /ID# 221099
6008 Shenton Park
AustraliaRekrutierend» Google-MapsLKH-Univ. Klinikum Graz /ID# 220919
8036 Graz
AustriaRekrutierend» Google-MapsUniversitaetsklinikum St. Poelten /ID# 221709
3100 St. Polten
AustriaNoch nicht rekrutierend» Google-MapsMedizinische Universitaet Wien /ID# 220911
1090 Vienna
AustriaNoch nicht rekrutierend» Google-MapsKlinikum Wels-Grieskirchen GmbH /ID# 220915
4600 Wels
AustriaRekrutierend» Google-MapsHanusch Krankenhaus /ID# 220912
1140 Wien
AustriaRekrutierend» Google-MapsCliniques Universitaires Saint Luc /ID# 224221
1200 Woluwe-Saint-Lambert
BelgiumNoch nicht rekrutierend» Google-MapsZNA Stuivenberg /ID# 221468
2060 Antwerp
BelgiumNoch nicht rekrutierend» Google-MapsGrand Hopital de Charleroi /ID# 224827
6000 Charleroi
BelgiumNoch nicht rekrutierend» Google-MapsGhent University hospital /ID# 220841
9000 Ghent
BelgiumNoch nicht rekrutierend» Google-MapsAZ-Delta /ID# 221469
8800 Roeselare
BelgiumNoch nicht rekrutierend» Google-MapsJuravinski Hosp & Cancer Cntr /ID# 220887
L8V 1C3 Hamilton
CanadaNoch nicht rekrutierend» Google-MapsCISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 222433
G6V 3Z1 Levis
CanadaRekrutierend» Google-MapsMcGill University Health Center Research Institute /ID# 222614
H4A 3J1 Montreal
CanadaNoch nicht rekrutierend» Google-MapsFakultni Nemocnice Brno /ID# 220959
625 00 Brno
CzechiaNoch nicht rekrutierend» Google-MapsVseobecna fakultni nemocnice v Praze /ID# 220969
128 00 Prague 28
CzechiaNoch nicht rekrutierend» Google-MapsAalborg University Hospital /ID# 224391
9000 Aalborg
DenmarkRekrutierend» Google-MapsSjællands Universitetshospital, Roskilde /ID# 224456
4000 Roskilde
DenmarkNoch nicht rekrutierend» Google-MapsHopital Haut-Lévêque /ID# 222696
33604 Pessac CEDEX
FranceRekrutierend» Google-MapsCentre Hospitalier Lyon Sud /ID# 222695
69495 Pierre Benite CEDEX
FranceRekrutierend» Google-MapsCHU d'Angers /ID# 219129
49933 Angers
FranceRekrutierend» Google-MapsHopital Avicenne /ID# 221287
93009 Bobigny
FranceRekrutierend» Google-MapsCentre Hospitalier Metropole Savoie /ID# 223771
73000 Chambery
FranceRekrutierend» Google-MapsCHU de Nantes, Hotel Dieu -HME /ID# 219127
44093 Nantes
FranceRekrutierend» Google-MapsCHU de Nimes /ID# 219128
30029 Nimes
FranceRekrutierend» Google-MapsHopital Saint Louis /ID# 221390
75475 Paris
FranceRekrutierend» Google-MapsGeneral Hospital of Athens Laiko /ID# 221175
115 27 Athens
GreeceNoch nicht rekrutierend» Google-MapsGeneral Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 221179
10676 Athens
GreeceRekrutierend» Google-MapsPatras University General Hosp /ID# 221178
26504 Rion, Patras, Achaia
GreeceNoch nicht rekrutierend» Google-MapsGeneral Hospital of Thessaloniki George Papanikolaou /ID# 221463
57010 Thessaloniki
GreeceRekrutierend» Google-MapsDebreceni Egyetem Klinikai Kozpont /ID# 220947
4032 Debrecen
HungaryRekrutierend» Google-MapsSomogy Megyei Kaposi Mor Oktat /ID# 220948
7400 Kaposvar
HungaryRekrutierend» Google-MapsJosa Andras Oktato Korhaz /ID# 220946
4400 Nyíregyháza
HungaryRekrutierend» Google-MapsUniversity of Szeged /ID# 220955
6720 Szeged
HungaryRekrutierend» Google-MapsFejer Megyei Szent Gyorgy Korhaz /ID# 220949
8000 Szekesfehervar
HungaryRekrutierend» Google-MapsRabin Medical Center /ID# 219139
4941492 Petakh Tikva
IsraelRekrutierend» Google-MapsHadassah Medical Center-Hebrew University /ID# 219111
91120 Jerusalem
IsraelRekrutierend» Google-MapsHaEmek Medical Center /ID# 220839
1834111 Afula
IsraelRekrutierend» Google-MapsAssuta Ashdod Medical Center /ID# 225281
7747629 Ashdod
IsraelNoch nicht rekrutierend» Google-MapsAssaf Harofeh Medical Center /ID# 222972
70300 Be'er Ya'akov
IsraelRekrutierend» Google-MapsRambam Health Care Campus /ID# 219121
3109601 Haifa
IsraelRekrutierend» Google-MapsCarmel Medical Center /ID# 222973
34362 Haifa
IsraelRekrutierend» Google-MapsGalilee Medical Center /ID# 225280
22100 Nahariya
IsraelNoch nicht rekrutierend» Google-MapsSheba Medical Center /ID# 219136
5239424 Ramat Gan
IsraelRekrutierend» Google-MapsTel Aviv Sourasky Medical Center /ID# 219135
6423906 Tel Aviv-Yafo
IsraelRekrutierend» Google-MapsAOU Federico II /ID# 224673
80131 Naples
ItalyNoch nicht rekrutierend» Google-MapsA.O.U. Policlinico S.Orsola-Malpighi /ID# 221077
40138 Bologna
ItalyNoch nicht rekrutierend» Google-MapsA.O.U. Careggi /ID# 219090
50134 Florence
ItalyNoch nicht rekrutierend» Google-MapsAzienda Policlinico Umberto I /ID# 225731
00161 Rome
ItalyNoch nicht rekrutierend» Google-MapsFondazione Policlinico Universitario Agostino Gemelli IRCCS /ID# 219087
00168 Rome
ItalyNoch nicht rekrutierend» Google-MapsAOU Citta della Salute Scienza /ID# 221223
10126 Turin
ItalyNoch nicht rekrutierend» Google-MapsASST Papa Giovanni XXIII /ID# 221222
24127 Bergamo
ItalyNoch nicht rekrutierend» Google-MapsAzienda Ospedaliera Universitaria Policlinico G. Rodolico - San Marco /Id# 219089
95123 Catania
ItalyNoch nicht rekrutierend» Google-MapsAzienda Ospedaliera San Gerardo di Monza _ Oncologia Medica /ID# 225113
20052 Monza
ItalyNoch nicht rekrutierend» Google-MapsA.O.U. Policlinico Palermo /ID# 221078
90127 Palermo
ItalyNoch nicht rekrutierend» Google-MapsAzieda Ospedaliera Bianchi Melacrino Morelli /ID# 221220
89125 Reggio Calabria
ItalyNoch nicht rekrutierend» Google-MapsAzienda Sanitaria Universitaria Friuli Centrale /ID# 221241
33100 Udine
ItalyNoch nicht rekrutierend» Google-MapsULSS na6 Vicenza /ID# 221079
36100 Vicenza
ItalyNoch nicht rekrutierend» Google-MapsJapanese Red Cross Nagoya Daiichi Hospital /ID# 221150
453-8511 Nagoya-shi
JapanNoch nicht rekrutierend» Google-MapsFujita Health University Hospital /ID# 221598
470-1192 Toyoake-shi
JapanNoch nicht rekrutierend» Google-MapsChiba University Hospital /ID# 224546
260-8677 Chiba-shi
JapanNoch nicht rekrutierend» Google-MapsNational Cancer Center Hospital East /ID# 226653
277-8577 Kashiwa-shi
JapanNoch nicht rekrutierend» Google-MapsEhime University Hospital /ID# 221158
791-0295 Toon-shi
JapanNoch nicht rekrutierend» Google-MapsKyushu University Hospital /ID# 221606
812-8582 Fukuoka-shi
JapanNoch nicht rekrutierend» Google-MapsFukushima Medical University Hospital /ID# 221877
960-1295 Fukushima-shi
JapanNoch nicht rekrutierend» Google-MapsGifu University Hospital /ID# 224371
501-1194 Gifu-shi
JapanNoch nicht rekrutierend» Google-MapsSapporo Hokuyu Hospital /ID# 221149
003-0006 Sapporo-shi
JapanNoch nicht rekrutierend» Google-MapsKobe City Medical Center General Hospital /ID# 221156
650-0047 Kobe-shi
JapanNoch nicht rekrutierend» Google-MapsKanazawa University Hospital /ID# 223028
920-8641 Kanazawa-shi
JapanNoch nicht rekrutierend» Google-MapsIwate Medical University Hospital /ID# 222044
028-3695 Shiwa-gun
JapanNoch nicht rekrutierend» Google-MapsShonan Kamakura General Hospital /ID# 223030
247-8533 Kamakura-shi
JapanNoch nicht rekrutierend» Google-MapsKyoto University Hospital /ID# 223008
606-8507 Kyoto-shi
JapanNoch nicht rekrutierend» Google-MapsMie University Hospital /ID# 221665
514-8507 Tsu-shi
JapanNoch nicht rekrutierend» Google-MapsUniversity of Miyazaki Hospital /ID# 221821
889-1692 Miyazaki-shi
JapanNoch nicht rekrutierend» Google-MapsNiigata University Medical & Dental Hospital /ID# 223034
951-8520 Niigata-shi
JapanNoch nicht rekrutierend» Google-MapsKurashiki Central Hospital /ID# 221690
710-8602 Kurashiki-shi
JapanNoch nicht rekrutierend» Google-MapsOsaka University Hospital /ID# 221159
565-0871 Suita-shi
JapanNoch nicht rekrutierend» Google-MapsDokkyo Medical University Saitama Medical Center /ID# 222334
343-8555 Koshigaya-shi
JapanNoch nicht rekrutierend» Google-MapsJuntendo University Shizuoka Hospital /ID# 221780
410-2295 Izunokuni-shi
JapanNoch nicht rekrutierend» Google-MapsJuntendo University Hospital /ID# 221154
113-8431 Bunkyo-ku
JapanNoch nicht rekrutierend» Google-MapsNippon Medical School Hospital /ID# 221676
113-8603 Bunkyo-ku
JapanNoch nicht rekrutierend» Google-MapsTokyo Medical University Hospital /ID# 221540
160-0023 Shinjuku-ku
JapanNoch nicht rekrutierend» Google-MapsUniversity of Yamanashi Hospital /ID# 221706
409-3821 Chuo-shi
JapanNoch nicht rekrutierend» Google-MapsPusan National University Hosp /ID# 220980
49241 Busan
Korea, Republic ofRekrutierend» Google-MapsGachon University Gil Medical Center /ID# 220972
21565 Incheon
Korea, Republic ofRekrutierend» Google-MapsSamsung Medical Center /ID# 221091
06351 Seoul
Korea, Republic ofRekrutierend» Google-MapsThe Catholic Univ. of Korea /ID# 219061
06591 Seocho-gu, Seoul
Korea, Republic ofRekrutierend» Google-MapsSeoul National University Hospital /ID# 219060
03080 Seoul
Korea, Republic ofRekrutierend» Google-MapsWojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im. M. Kopern /Id# 221161
93-513 Lodz
PolandRekrutierend» Google-MapsSamodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie /ID# 221124
20-081 Lublin
PolandRekrutierend» Google-MapsSP ZOZ Szpital Uniwersytecki w Krakowie /ID# 221160
31-501 Krakow
PolandRekrutierend» Google-MapsMTZ Clinical Research SP. zoo /ID# 221759
02-106 Warsaw
PolandRekrutierend» Google-MapsUniwersyteckie Centrum Kliniczne /ID# 221298
80-214 Gdansk
PolandNoch nicht rekrutierend» Google-MapsPratia Onkologia Katowice /ID# 224526
40-519 Katowice
PolandNoch nicht rekrutierend» Google-MapsLux Med Onkologia - Szpital Szamocka /Id# 221265
01-748 Warsaw
PolandRekrutierend» Google-MapsHospital del Centro Comprensivo de Cancer de la UPR /ID# 223281
00927 San Juan
Puerto RicoNoch nicht rekrutierend» Google-MapsCity Clinical Hospital named after S.P. Botkin /ID# 221116
125284 Moscow
Russian FederationRekrutierend» Google-MapsCity Clinical Hospital n.a. V.V. Veresaev of the Moscow Department of Healthcare /ID# 225221
127644 Moscow
Russian FederationNoch nicht rekrutierend» Google-MapsRussian Scientific and Research Institute of Hematology and Transfusiology /ID# 221115
191024 Sankt-Peterburg
Russian FederationRekrutierend» Google-MapsFederal North-West Medical Res /ID# 221114
197341 St. Petersburg
Russian FederationRekrutierend» Google-MapsTula Regional Clinical Hospital /ID# 221302
300053 Tula
Russian FederationRekrutierend» Google-MapsHospital Universitario A Coruña - CHUAC /ID# 224617
15006 A Coruña
SpainRekrutierend» Google-MapsHospital Clínico Universitario de Santiago-CHUS /ID# 221616
15706 Santiago de Compostela
SpainRekrutierend» Google-MapsHospital Universitario Central de Asturias /ID# 224815
33011 Oviedo
SpainNoch nicht rekrutierend» Google-MapsHospital Regional de Malaga /ID# 221906
29010 Málaga
SpainRekrutierend» Google-MapsHospital Parc de Salut del Mar /ID# 220922
08003 Barcelona
SpainRekrutierend» Google-MapsHospital Universitario Dr. Negrin /ID# 220923
35010 Las Palmas de Gran Canaria
SpainRekrutierend» Google-MapsHospital Universitario La Paz /ID# 224813
28046 Madrid
SpainNoch nicht rekrutierend» Google-MapsHospital Clinico Universitario de Salamanca /ID# 221904
37007 Salamanca
SpainRekrutierend» Google-MapsHospital Universitario Virgen del Rocio /ID# 221932
41013 Sevilla
SpainRekrutierend» Google-MapsHospital Clinico Universitario de Valencia /ID# 220920
46010 Valencia
SpainRekrutierend» Google-MapsSkane University Hospital Lund /ID# 220834
SE 221 41 Lund
SwedenNoch nicht rekrutierend» Google-MapsUniversitaetsspital Basel /ID# 221261
4031 Basel
SwitzerlandRekrutierend» Google-MapsInselspital Universitaetsklinik Bern /ID# 223439
3010 Bern
SwitzerlandRekrutierend» Google-MapsChina Medical University Hosp /ID# 218979
40447 Taichung City
TaiwanRekrutierend» Google-MapsKaohsiung Medical University Chung-Ho Memorial Hospital /ID# 218980
80708 Kaohsiung
TaiwanRekrutierend» Google-MapsKaohsiung Chang Gung Memorial Hospital /ID# 218985
833 Kaohsiung
TaiwanRekrutierend» Google-MapsChi Mei Hospital - Liouying /ID# 221144
73657 Tainan City
TaiwanRekrutierend» Google-MapsTaipei Veterans General Hosp /ID# 221147
11217 Taipei City
TaiwanRekrutierend» Google-MapsLinkou Chang Gung Memorial Hos /ID# 218982
33350 Taoyuan County
TaiwanRekrutierend» Google-MapsGulhane Askeri Tip Academy /ID# 224568
06010 Ankara
TurkeyNoch nicht rekrutierend» Google-MapsTrakya University Medical Facu /ID# 224572
22030 Edirne, Istanbul
TurkeyNoch nicht rekrutierend» Google-MapsEge University Medical Faculty /ID# 224570
35040 Izmir
TurkeyNoch nicht rekrutierend» Google-MapsMersin Univ Tip Fakult Hastane /ID# 224571
33000 Mersin
TurkeyNoch nicht rekrutierend» Google-MapsOndokuz mayis University Facul /ID# 224567
55139 Samsun
TurkeyNoch nicht rekrutierend» Google-MapsGuy's and St Thomas' NHS Found /ID# 221041
SE1 9RT London
United KingdomNoch nicht rekrutierend» Google-MapsHeart of England NHS Foundation Trust /ID# 221334
B9 5SS Birmingham
United KingdomNoch nicht rekrutierend» Google-MapsWestern General Hospital /ID# 224378
EH4 2XU Edinburgh
United KingdomNoch nicht rekrutierend» Google-MapsJames Paget University Hosp /ID# 221219
NR31 6LA Great Yarmouth
United KingdomRekrutierend» Google-MapsThe Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 221335
NE7 7DN Newcastle Upon Tyne
United KingdomRekrutierend» Google-MapsOxford Univ Hosp NHS Trust /ID# 221044
OX3 7LE Oxford
United KingdomNoch nicht rekrutierend» Google-Maps
Studien-Informationen
Brief Summary:Myelofibrosis (MF) is a bone marrow illness that affects blood-forming tissues in the body.
MF disturbs the body's normal production of blood cells, causing extensive scarring in the
bone marrow. This leads to severe anemia, weakness, fatigue, and an enlarged spleen. The
purpose of this study is to assess safety and change in spleen volume when navitoclax is
given in combination with ruxolitinib, as compared to best available therapy, for adult
participants with MF.
Navitoclax is an investigational drug (not yet approved) being developed for the treatment of
MF. The study has 2 arms - A and B. In Arm A, participants will receive navitoclax in
combination with ruxolitinib. In Arm B, participants will receive the best available therapy
(BAT) for MF. Adult participants with a diagnosis of relapsed/refractory (R/R) MF will be
enrolled. Approximately 330 participants will be enrolled in approximately 190 sites across
the world.
In Arm A, participants will receive oral navitoclax tablet once daily with oral ruxolitinib
tablet twice daily. In Arm B, participants will receive the BAT as identified by the
investigator. Treatment will continue until clinical benefit is not seen, participants cannot
tolerate the study drugs, or participants withdraw consent. The approximate treatment
duration is about 3 years.
There may be higher treatment burden for participants in this trial compared to their
standard of care. Participants will attend regular visits during the study at a hospital or
clinic. The effect of treatment will be checked by medical assessments, blood and bone marrow
tests, checking for side effects, and completing questionnaires.
Ein-/Ausschlusskriterien
Inclusion Criteria:- Must be able to complete the Myelofibrosis Symptom Assessment Form (MFSAF) v4.0 on at
least 4 out of 7 days prior to randomization.
-- Has at least 2 symptoms with a score >= 3 or a total score of >= 12, as measured by
the MFSAF v4.0.
- Documented diagnosis of primary myelofibrosis (MF), post polycythemia vera (PPV)-MF,
or post essential thrombocytopenia (PET)-MF as defined by the World Health
Organization (WHO) classification.
- Classified as intermediate-2 or high-risk MF, as defined by the Dynamic International
Prognostic Scoring System Plus (DIPSS+).
- Must currently be on treatment or have received prior treatment with a single Janus
Kinase 2 (JAK2) inhibitor, ruxolitinib, and meet one of the following criteria (in
addition to the minimum splenomegaly and symptom burden also required for
eligibility):
- Treatment with ruxolitinib for >= 24 weeks that was stopped due to loss of spleen
response (refractory), or loss of spleen response or symptom control after a
previous response (relapsed), or was continued despite relapsed/refractory
status.
- Treatment with ruxolitinib for < 24 weeks with documented disease progression
while on therapy as defined by any of the following:
- Appearance of new splenomegaly that is palpable to at least 5 cm below the
left costal margin (LCM) in participants with no evidence of splenomegaly
prior to the initiation of ruxolitinib.
- A >= 100% increase in the palpable distance below the LCM in participants
with measurable spleen distance 5 to 10 centimeters (cm) prior to the
initiation of ruxolitinib.
- A >= 50% increase in the palpable distance below the LCM in participants
with measurable spleen distance > 10 cm prior to the initiation of
ruxolitinib.
- A spleen volume increase of >= 25% (as assessed by Magnetic Resonance
Imaging [MRI] or Computed Tomography [CT] scan) in participants with a
spleen volume assessment prior to the initiation of ruxolitinib.
- Prior or current treatment with ruxolitinib for >= 28 days with intolerance defined as
new RBC transfusion requirement (at least 2 units/month for 2 months) while receiving
a total daily ruxolitinib dose of >= 30 mg but unable to reduce dose further due to
lack of efficacy.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2.
- Splenomegaly defined as palpable spleen measurement >= 5 cm below costal margin or
spleen volume >= 450 cm3 as assessed centrally by MRI or CT scan.
- Baseline platelet count >= 100 × 10^9/L.
Exclusion Criteria:
- Received prior treatment with a BH3-mimetic compound, bromodomain and extra-terminal
(BET) inhibitor, or prior use of > 1 JAK2 inhibitor.
- Eligible for allogeneic stem cell transplantation at the time of study entry.
- Receiving medication that interferes with coagulation or platelet function except for
low dose aspirin (up to 100 milligrams daily) and low molecular weight heparin (LMWH)
within 3 days prior to the first dose of study drug or during the study treatment
period.
- Receiving anticancer therapy including chemotherapy, radiation therapy, hormonal
therapy (with the exception of hormones for thyroid conditions or estrogen replacement
therapy) within 30 days prior to first dose of study drug, and during the study
treatment period (other than any overlapping therapy as part of the selected BAT).
Studien-Rationale
Primary outcome:1. Percentage of Participants who achieve Spleen Volume Reduction of at least 35% at Week 24 (SVR35W24) (Time Frame - At Week 24):
Reduction in spleen volume is measured by Magnetic Resonance Imaging (MRI) or Computed Tomography (CT), per International Working Group (IWG) criteria.
Secondary outcome:
1. Percentage of Participants who achieve at least 50% Reduction in Total Symptom Score (TSS) (Time Frame - Baseline (Week 0) Up to Week 24):
Reduction in TSS is measured by Myelofibrosis Symptom Assessment Form (MFSAF) v4.0.
2. Percentage of Participants who achieve Spleen Volume Reduction of at least 35% (SVR35) (Time Frame - Baseline (Week 0) Up to Week 96):
Reduction in spleen volume is measured by Magnetic Resonance Imaging (MRI) or Computed Tomography (CT), per International Working Group (IWG) criteria.
3. Duration of SVR35 (Time Frame - Baseline (Week 0) Up to Week 96):
Duration of SVR35 is defined as the time between the date of first response of spleen volume reduction of 35% achievement to the date of disease progression, or to the date of death, whichever occurs first.
4. Change in Fatigue (Time Frame - Baseline (Week 0) Up to Week 24):
Change in fatigue will be assessed using the Patient Reported Outcomes Measurement Information System (PROMIS) Fatigue Short Form (SF) 7a.
5. Time to Deterioration of Physical Functioning (Time Frame - Baseline (Week 0) Up to Week 96):
Time to deterioration of physical functioning is measured by the physical functioning domain of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ)-C30, or death.
6. Proportion of Participants who achieved Anemia Response (Time Frame - Baseline (Week 0) Up to Week 96):
The rate of anemia response will be assessed according to current International Working Group-Myeloproliferative Neoplasms Research and European LeukemiaNet (IWG-MRT/ELN) criteria.
7. Overall Survival (Time Frame - Up to approximately 3 years):
Overall survival is defined as the time from start of study to the date of death from any cause.
8. Leukemia-Free Survival (Time Frame - Up to approximately 3 years):
Leukemia free survival is the time from start of study to the date of development of leukemia.
9. Overall Response of Clinical Improvement (Time Frame - Baseline (Week 0) Up to Week 96):
Clinical improvement is defined as the achievement of anemia, spleen or symptoms response without progressive disease, per International Working Group (IWG) criteria.
10. Percentage of Participants who achieve Reduction in Grade of Bone Marrow Fibrosis (Time Frame - Baseline (Week 0) Up to Week 96):
Change in grade of bone marrow fibrosis will be measured per the European consensus grading system through bone marrow biopsy.
Studien-Arme
- Experimental: Arm A: Navitoclax + Ruxolitinib
Participants will receive navitoclax tablets once daily and ruxolitinib tablets twice daily. - Active Comparator: Arm B: Best Available Therapy (BAT)
Participants will receive one of the BAT options, per the investigator's discretion.
Geprüfte Regime
- Navitoclax (ABT-263):
Tablet; Oral - Ruxolitinib:
Tablet; Oral - Best Available Therapy (BAT):
Tablet/Capsule; Oral or Solution for Subcutaneous Injection
Quelle: ClinicalTrials.gov