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1. Change in spleen volume (Time Frame - from baseline to week 24): Proportion of subjects who achieve ≥35% change in spleen volume from baseline to Week 24 as measured by MRI (or by CT for applicable subjects)
2. Change in Total Symptom Score (TSS) (Time Frame - from baseline to week 24): Proportion of subjects who achieve ≥50% change in total symptom score from baseline to Week 24 as measured by the MFSAF v4.0
Secondary outcome:
1. Change in spleen volume (Time Frame - from baseline at anytime up to week 24): Proportion of subjects in NS-018 vs BAT arm who achieve ≥35% change in spleen volume from baseline at any time up to Week 24 as measured by MRI (or by CT for applicable subjects)
2. Comparison of treatment-emergent AEs (Time Frame - from baseline to week 24): Laboratory events graded by the NCI CTCAE v5.0 will be assessed in both arms, NS-018 vs BAT.