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Studienlocations (3 von 191)
Klinikum Rechts der Isar der Technischen Universität München Apotheke 81675 München (Bayern) GermanyRekrutierend» Google-MapsUniversitätsklinikum Aachen 52074 Aachen GermanyAktiv, nicht rekrutierend» Google-MapsUniversitaetsklinikum Essen 45147 Essen (Nordrhein-Westfalen) GermanyRekrutierend» Google-Maps
Hauttumorzentrum am Universitätsklinikum Halle Ernst-Grube-Straße 40 06120 Halle (Saale) (Sachsen-Anhalt) DeutschlandRekrutierend» Google-MapsGemeinschaftspraxis Haematologie - Onkologie - Hauptstelle 01307 Dresden (Sachsen) GermanyRekrutierend» Google-MapsTechnische Universität Dresden 01307 Dresden (Sachsen) GermanyRekrutierend» Google-MapsUniversitätsklinikum Jena 07747 Jena (Thüringen) GermanyRekrutierend» Google-MapsCharité Universitätsmedizin Berlin 13353 Berlin (Berlin) GermanyRekrutierend» Google-MapsUKE - Universitätsklinikum Hamburg-Eppendorf 20251 Hamburg (Hamburg) GermanyRekrutierend» Google-MapsUniversitätsmedizin der Johannes Gutenberg Universität Mainz Mainz (Rheinland-Pfalz) GermanyAktiv, nicht rekrutierend» Google-MapsDarmzentrum Stauferklinikum Schwäbisch Gmünd Wetzgauer Straße 85 73557 Mutlangen DeutschlandRekrutierend» Google-MapsPraxis für Hämatologie und Onkologie 66113 Saarbrücken (Saarland) GermanyRekrutierend» Google-MapsThe Kirklin Clinic of UAB Hospital 35294 Birmingham United StatesAktiv, nicht rekrutierend» Google-MapsUniversity of Southern California Norris Comprehensive Cancer Center 90033 Los Angeles United StatesAktiv, nicht rekrutierend» Google-MapsStanford Cancer Center - Palo Alto 94305 Stanford United StatesAktiv, nicht rekrutierend» Google-MapsInnovative Clinical Research Institute 90603 Whittier United StatesAbgeschlossen» Google-MapsUniversity Cancer Institute 33426 Boynton Beach United StatesZurückgezogen» Google-MapsNorthwestern University Feinberg School of Medicine 60611 Chicago United StatesAbgeschlossen» Google-MapsUniversity of Illinois at Chicago 60612 Chicago United StatesRekrutierend» Google-MapsDana-Farber Cancer Institute 02215 Boston United StatesZurückgezogen» Google-MapsWashington University School of Medicine 63110 Saint Louis United StatesRekrutierend» Google-MapsBrookdale University Hospital and Medical Center 11212 Brooklyn United StatesRekrutierend» Google-MapsNew York Presbyterian/Weill Cornell Medical Center 10021 New York United StatesZurückgezogen» Google-MapsMt. Sinai 10029 New York United StatesRekrutierend» Google-MapsGabrail Cancer Center 44718 Canton United StatesRekrutierend» Google-MapsThe Ohio State University Comprehensive Cancer Center 43210 Columbus United StatesAbgeschlossen» Google-MapsOregon Health and Science University 97239 Portland United StatesAbgeschlossen» Google-MapsAvera Cancer Institute 57105 Sioux Falls United StatesRekrutierend» Google-MapsVanderbilt University Medical Center 37203 Nashville United StatesRekrutierend» Google-MapsThe University of Texas MD Anderson Cancer Center 77030 Houston United StatesRekrutierend» Google-MapsMedical College of Wisconsin - Froedtert Hospital 53226 Milwaukee United StatesRekrutierend» Google-MapsSanatorio de la Mujer S2000ORE Rosario ArgentinaRekrutierend» Google-MapsInstituto Medico Alexander Fleming Buenos Aires ArgentinaRekrutierend» Google-MapsCentro Medico San Luis 1425 Caba ArgentinaRekrutierend» Google-MapsHospital Privado - Centro Medico de Cordoba - Oncology X5016KEH Córdoba ArgentinaRekrutierend» Google-MapsMonash Medical Centre 3168 Clayton AustraliaRekrutierend» Google-MapsFiona Stanley Hosital 6150 Murdoch AustraliaRekrutierend» Google-MapsRoyal Adelaide Hospital Adelaide AustraliaRekrutierend» Google-MapsThe Alfred Hospital Melbourne AustraliaRekrutierend» Google-MapsSouth Eastern Private Hospital 3174 Noble Park AustraliaRekrutierend» Google-MapsIcon Cancer Center South Brisbane AustraliaRekrutierend» Google-MapsCentro de oncologia Leonardo da Vinci 60140-025 Fortaleza BrazilRekrutierend» Google-MapsHospital Erasto Gaertner 81520 Curitiba BrazilRekrutierend» Google-MapsUNICAMP - Universidade Estadual de Campinas Hemocentro 13083 Campinas BrazilRekrutierend» Google-MapsHospital das Clínicas UFG 74605 Goiânia BrazilRekrutierend» Google-MapsFundacao Doutor Amaral Carvalho 17210-120 Jau BrazilRekrutierend» Google-MapsHospital de Clinicas de Porto Alegre - Centro de Pesquisa Clinica 90035-903 Porto Alegre BrazilRekrutierend» Google-MapsAssociação Educadora São Carlos AESC - Hospital Mãe de Deus - Centro de Pesquisa 90880-480 Porto Alegre BrazilRekrutierend» Google-MapsInstituto de Ensino e Pesquisa São Lucas 01236-030 Sao Paulo BrazilRekrutierend» Google-MapsHospital A C Camargo - Fundacao Antonio Prudente 01509-900 Sao Paulo BrazilRekrutierend» Google-MapsHospital das Clínicas da Universidade de São Paulo 05403-000 Sao Paulo BrazilRekrutierend» Google-MapsInstituto D'or de Pesquisa e Ensino 04502-001 São Paulo BrazilRekrutierend» Google-MapsInstituto COI São Paulo 1321001 São Paulo BrazilRekrutierend» Google-MapsUniversity Multiprofile Hospital for Active Treatment Dr. Georgi Stranski, Pleven Pleven BulgariaRekrutierend» Google-MapsUniversity Multiprofile Hospital for Active Treatment Sveti Georgi, Plovdiv Plovdiv BulgariaRekrutierend» Google-MapsMilitary Medical Academy, Multiprofile for active treatment, Sofia 1606 Sofia BulgariaRekrutierend» Google-MapsAcibadem City Clinic Tokuda Hospital, Sofia Sofia BulgariaRekrutierend» Google-MapsSpecialized Hospital for Active Therapy of Hematological Disorders Sofia BulgariaRekrutierend» Google-MapsUniversity Multiprofile Hospital for Active Treatment Alexandrovska, Sofia Sofia BulgariaZurückgezogen» Google-MapsUniversity Multiprofile Hospital for Active Treatment Saint Ivan Rilski, Sofia Sofia BulgariaRekrutierend» Google-MapsPrincess Margaret Cancer Center M5G 2M9 Toronto CanadaAktiv, nicht rekrutierend» Google-MapsGeneral Hospital Sibenik 22000 Sibenik CroatiaRekrutierend» Google-MapsClinical Hospital Centre Osijek 10000 Zagreb CroatiaRekrutierend» Google-MapsKB Sestre Milosrdnice 10000 Zagreb CroatiaRekrutierend» Google-MapsFN Hradec Kralove 500 05 Králová CzechiaRekrutierend» Google-MapsVseonecma fakultni nemocrince V Praze Nové Město CzechiaRekrutierend» Google-MapsFakultní Nemocnice Olomouc 779 00 Olomouc CzechiaZurückgezogen» Google-MapsCentre Hospitalier Universitaire D'Amiens (Hopital Sud) - Hématologie Clinique 80054 Amiens FranceRekrutierend» Google-MapsCenter Hospitalier Universitaire d'Angers 49933 Cedex 09 Angers FranceRekrutierend» Google-MapsC.H de la Côte Basque - Serviv 64100 Bayonne FranceRekrutierend» Google-MapsCentre Hospitalier Regional Universitaire Brest Hopital Morvan 29609 Brest Cedex FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire of Caen Normandie - Côte de Nacre 14000 Caen FranceAktiv, nicht rekrutierend» Google-MapsCentre Hospitalier Le Mans Le Mans FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire de Nîmes 30029 Cedex 9 Nîmes FranceAktiv, nicht rekrutierend» Google-MapsHôpital Saint-Louis 75010 Paris FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire de Poitiers Poitiers FranceRekrutierend» Google-MapsInstitut Universitaire du Cancer de Toulouse Oncopole 31059 Toulouse FranceRekrutierend» Google-MapsHopital Paul Brousse - Aphp Hôpitaux Universitaires Paris Su 94800 Villejuif FranceRekrutierend» Google-MapsUniversity General Hospital of Ioannina 45500 Ioánnina GreeceRekrutierend» Google-MapsUniversity Campus of Patras - Hematology 26504 Patras GreeceRekrutierend» Google-MapsAHEPA General Hospital of Thessaloniki 54636 Thessaloníki GreeceRekrutierend» Google-MapsQueen Mary Hospital 150001 Hong Kong Hong KongRekrutierend» Google-MapsPrince of Wales Hospital - Medicine Shatin Hong KongRekrutierend» Google-MapsSomogy Megyei Kaposi Mór Oktató Kórház 7400 Kaposvár HungaryZurückgezogen» Google-MapsSzabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókórház 4400 Nyíregyháza HungaryRekrutierend» Google-MapsMarkusovszky Egyetemi Oktatókórház H-9700 Szombathely HungaryRekrutierend» Google-MapsSemmelweis Egyetem 1083 Budapest HungaryZurückgezogen» Google-MapsDél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet Budapest HungaryRekrutierend» Google-MapsDebreceni Egyetem Orvos es Egeszsegtudomanyi Centrum 4032 Debrecen HungaryAbgeschlossen» Google-MapsSzegedi Tudományegyetem 6725 Szeged HungaryRekrutierend» Google-MapsHa'Emek Medical Center 1834111 Afula IsraelRekrutierend» Google-MapsAssuta Ashdod University Hospital Ashdod IsraelRekrutierend» Google-MapsRambam Medical Centre 31096 Haifa IsraelRekrutierend» Google-MapsCarmel MC Haifa IsraelRekrutierend» Google-MapsHadassah Medical Organisation 91120 Jerusalem IsraelRekrutierend» Google-MapsHematology Institute 44281 Kfar Saba IsraelRekrutierend» Google-MapsWestern Galilee Hospital - Nahariya 22100 Nahariya IsraelRekrutierend» Google-MapsRabin Medical Center - Beilinson Hospital 49100 Petah Tikva IsraelRekrutierend» Google-MapsTel Aviv Sourasky Medical Center - Oncology 6423906 Tel Aviv IsraelRekrutierend» Google-MapsAssuta MC 64239 Tel Aviv IsraelRekrutierend» Google-MapsAssaf Harofeh Medical Center - Hematology 7030000 Zerifin IsraelRekrutierend» Google-MapsA.O. San Gerardo di Monza - L'Ospedale San Gerardo di Monza e l'Università di Milano 20900 Monza ItalyRekrutierend» Google-MapsPO Civile SS.Antonio e Biagio 15121 Alessandria ItalyRekrutierend» Google-MapsAOU Ospedali Riuniti Umberto I G.M. Lancisi G. Salesi 60123 Ancona ItalyRekrutierend» Google-MapsA.O.di Bologna Policl.S.Orsola 41038 Bologna ItalyRekrutierend» Google-MapsAO Spedali Civili di Brescia 25123 Brescia ItalyRekrutierend» Google-MapsAzienda Ospedaliero Universitaria Policlinico - Vittorio Emanuele 95123 Catania ItalyRekrutierend» Google-MapsAOU Careggi 50141 Firenze ItalyRekrutierend» Google-MapsIstituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST IRCCS Meldola ItalyRekrutierend» Google-MapsOspedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda 20122 Milano ItalyRekrutierend» Google-MapsASST Grande Ospedale Metropolitano Niguarda 20162 Milano ItalyRekrutierend» Google-MapsAOU Maggiore della Carità 28100 Novara ItalyRekrutierend» Google-MapsAzienda Ospedaliera Ospedali Riuniti Marche Nord - Pesaro 61121 Pesaro ItalyRekrutierend» Google-MapsArcispedale S. Maria Nuova, AO di Reggio Emilia 42123 Reggio Emilia ItalyRekrutierend» Google-MapsPoliclinico Universitario Agostino Gemelli 00168 Roma ItalyRekrutierend» Google-MapsA.O. Citta della Salute e della Scienza di Torino 10126 Torino ItalyRekrutierend» Google-MapsInje University Busan Paik Hospital 47392 Busan Korea, Republic ofRekrutierend» Google-MapsKyungpook National University Hospital 41944 Daegu Korea, Republic ofRekrutierend» Google-MapsYeungnam University Medical Center 42415 Daegu Korea, Republic ofRekrutierend» Google-MapsKeimyung University Dongsan Medical Center 42601 Daegu Korea, Republic ofRekrutierend» Google-MapsCHA Bundang Medical Center, CHA University Seongnam-si Seongnam-si Korea, Republic ofRekrutierend» Google-MapsSeoul National University Hospital 03080 Seoul Korea, Republic ofRekrutierend» Google-MapsSamsung Medical Center 06351 Seoul Korea, Republic ofRekrutierend» Google-MapsThe Catholic University of Korea, Seoul St. Mary's Hospital 6591 Seoul Korea, Republic ofRekrutierend» Google-MapsHospital of Lithuanian University of Health Sciences Kaunas LT-50161 Kaunas LithuaniaRekrutierend» Google-MapsUniversidad Autonoma de Nuevo Leon (UANL) - Hospital Universitario "Dr. Jose Eleuterio Gonzalez 64460 Monterrey MexicoRekrutierend» Google-MapsInstituto Mexicano del Seguro Social 64180 Monterrey MexicoRekrutierend» Google-MapsOaxaca Site Management Organization OSMO 6800 Oaxaca MexicoRekrutierend» Google-MapsSociedad de Metabolismo y Corazón S.C. - Oncology 91910 Veracruz MexicoRekrutierend» Google-MapsPerpetual Succour Hospital - Hemat/Transfusion Med 6000 Cebu City PhilippinesRekrutierend» Google-MapsUniversity of the Philippines - Philippine General Hospital 1000 Manila PhilippinesRekrutierend» Google-MapsDolnośląskie Centrum Transplantacji Komórkowych z Krajowym Bankiem Dawców Szpiku 53-439 Wrocław PolandRekrutierend» Google-MapsSzpital Specjalistyczny w Brzozowie Podkarpacki Ośrodek Onkologiczny im. Ks. B. Markiewicza 36-200 Brzozow PolandAktiv, nicht rekrutierend» Google-MapsSamodzielny Publiczny Zakład Opieki Zdrowotnej Zespół Szpitali Miejskich 41-500 Chorzów PolandRekrutierend» Google-MapsSzpital Uniwersytecki nr 2 im dr. Jana Biziela 86-168 Bydgoszcz PolandRekrutierend» Google-MapsSamodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie 20-081 Lublin PolandZurückgezogen» Google-MapsSPZOZ MSWiA z Warminsko - Mazurskim Centrum Onkologii Olsztyn PolandRekrutierend» Google-MapsSzpital Wojewódzki w Opolu 45-061 Opole PolandRekrutierend» Google-MapsClinical Research Center Spółka z Ograniczoną Odpowiedzialnością Medic-R sp. k. 60-848 Poznań PolandZurückgezogen» Google-MapsWojewodzki Szpital Specjalistyczny im. Janusza Korczaka w Slupsku Sp. z o.o. 76-200 Słupsk PolandRekrutierend» Google-MapsH. Infante Dom Pedro. Centro Hospitalar do Baixo Vouga 3814-501 Aveiro PortugalRekrutierend» Google-MapsHospital de Braga 4710-243 Braga PortugalRekrutierend» Google-MapsInstituto Português de Oncologia de Coimbra 3000-075 Coimbra PortugalRekrutierend» Google-MapsH. São Francisco Xavier-Centro Hospitalar Lisboa Ocidental 1495-005 Lisboa PortugalRekrutierend» Google-MapsChampalimaud Cancer Center 1400-038 Lisbon PortugalRekrutierend» Google-MapsCen Med de Diagn si Trat Amb NEOMED 500283 Brasov RomaniaRekrutierend» Google-MapsSpitalul Clinic Colentina 020125 Bucharest RomaniaRekrutierend» Google-MapsSpitalul Clinic Coltea 030171 Bucuresti RomaniaRekrutierend» Google-MapsMedicover 060201 Bucuresti RomaniaRekrutierend» Google-MapsInstitutul Oncologic "Prof. Dr. Ion Chiricuta" 400015 Cluj-Napoca RomaniaRekrutierend» Google-MapsSpitalul Clinic Municipal Filantropia Craiova 200143 Craiova RomaniaRekrutierend» Google-MapsInstitutul Regional de Oncologie Iasi 700483 Iaşi RomaniaRekrutierend» Google-MapsSpitalul Clinic Municipal de Urgenta Timisoara 300079 Timişoara RomaniaRekrutierend» Google-MapsOncomed 300329 Timişoara RomaniaRekrutierend» Google-MapsSpitalul Clinic Judetean de Urgenta Tg Mures 540136 Târgu-Mureş RomaniaRekrutierend» Google-MapsClinical oncological dispensary 644013 Omsk Russian FederationZurückgezogen» Google-MapsSaint-Petersburg SMU I.P.Pavlov 197089 St Petersburg Russian FederationZurückgezogen» Google-MapsOncologic dispensary of Komi Republic 167904 Syktyvkar Russian FederationZurückgezogen» Google-MapsHospital Universitari Germans Trias i Pujol 08916 Badalona SpainRekrutierend» Google-MapsHospital Universitario de Gran Canaria Doctor Negrin 35010 Las Palmas De Gran Canaria SpainRekrutierend» Google-MapsHospital Universitario Puerta de Hierro - Majadahonda 28222 Majadahonda SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario Vall d'Hebrón 08035 Barcelona SpainRekrutierend» Google-MapsHospital de La Santa Creu i Sant Pau 8041 Barcelona SpainRekrutierend» Google-MapsHospital San Pedro de Alcantara 1003 Cáceres SpainRekrutierend» Google-MapsHospital Universitario Virgen de la Victoria 29010 Málaga SpainRekrutierend» Google-MapsHospital Universitario Son Espases 07120 Palma de Mallorca SpainRekrutierend» Google-MapsComplejo Hospitalario de Navarra - H. de Navarra, Hematología C/ de Irunlarrea, 3, Pamplona 31008 Pamplona SpainRekrutierend» Google-MapsHospital Universitario de Salamanca 37007 Salamanca SpainRekrutierend» Google-MapsHospital Universitario Doctor Peset 46017 Valencia SpainRekrutierend» Google-MapsH. Quirón Zaragoza 50012 Zaragoza SpainRekrutierend» Google-MapsNational Taiwan University Hospital 100 Taipei City TaiwanRekrutierend» Google-MapsChang Gung Medical Foundation - ChiaYi Chang Gung Memorial Hospital - Chiayi Branch Chiayi City TaiwanRekrutierend» Google-MapsKaohsiung Medical University - Chung-Ho Memorial Hospital 807 Kaohsiung TaiwanRekrutierend» Google-MapsChina Medical University Hospital 40447 Taichung TaiwanRekrutierend» Google-MapsRamathibodi Hospital - Mahidol University - Hematology 10400 Bangkok ThailandRekrutierend» Google-MapsSiriraj Hospital 10700 Bangkok ThailandRekrutierend» Google-MapsThammasat University Hospital 12120 Khlong Luang ThailandRekrutierend» Google-MapsSrinagarind Hospital (KhonKaen University) 40002 Khon Kaen ThailandRekrutierend» Google-MapsSongklanagarind Hospital 90110 Songkhla ThailandRekrutierend» Google-MapsSakarya Research and Training Hospital 54100 Adapazarı TurkeyRekrutierend» Google-MapsAnkara University Faculty of Medicine 06500 Ankara TurkeyRekrutierend» Google-MapsGazi University Medical Faculty 06500 Ankara TurkeyRekrutierend» Google-MapsPamukkale University 20160 Denizli TurkeyRekrutierend» Google-MapsGaziantep University Faculty of Medicine 27100 Gaziantep TurkeyRekrutierend» Google-MapsInonu University Turgut Ozal Medical Center 44280 Malatya TurkeyRekrutierend» Google-MapsMersin University Medical Faculty 33110 Mersin TurkeyRekrutierend» Google-MapsOndokuz Mayis University Medical Faculty - Hematology 55280 Samsun TurkeyRekrutierend» Google-MapsUniversity Hospitals Birmingham NHS Foundation Trust Birmingham United KingdomAktiv, nicht rekrutierend» Google-MapsNHS Greater Glasgow and Clyde Glasgow United KingdomAktiv, nicht rekrutierend» Google-MapsGuy's and Saint Thomas' NHS Foundation Trust SE1 9RT London United KingdomAktiv, nicht rekrutierend» Google-MapsOxford University Hospitals NHS Foundation Trust Oxford United KingdomAktiv, nicht rekrutierend» Google-Maps
1. (Part A Only) Spleen Volume Reduction (SVR) (Time Frame - 24 weeks): The proportion of subjects achieving a ≥ 35% spleen volume reduction (SVR) from Baseline to Week 24, as assessed by magnetic resonance imaging (MRI) or computed tomography (CT) scan
2. (Part B Only) Spleen Volume Reduction (SVR) (Time Frame - 24 Weeks): The proportion of subjects achieving SVR of ≥ 35% at Week 24 by MRI/CT scan (central review)
Secondary outcome:
1. (Part A only) Improvement in Total Symptom Score (TSS) (Time Frame - 48 weeks): The proportion of subjects who have at least a 50% reduction from Baseline to Week 24 and Week 48 in the total symptom score as measured by the modified MPN-SAF v2.0
2. (Part B only) Improvement of Total Symptom Score (TSS) (Time Frame - 24 Weeks): The proportion of subjects who have at least a 50% reduction from Baseline to Week 24 in the total symptom score as measured by the MF-SAF v4.0
3. (Part B only) Overall Survival (OS) (Time Frame - 48 months): Time from randomization to death from any cause
4. (Part B only) Progression free survival (PFS) (Time Frame - 48 months): Time from randomization to either first occurrence of disease progression or death due to any cause
5. (Part B Only) Overall Spleen Volume Reduction (SVR) (Time Frame - 48 months): The proportion of subjects in each arm achieving SVR of ≥ 35% at any time by MRI/CT scan (central review)
6. (Part B Only) Spleen Response Duration (Time Frame - 48 months): Time from initial SVR of ≥ 35% by MRI/CT (central review) until the first occurrence of disease progression
7. (Part B Only) Rate of conversion from RBC transfusion dependent to independent (Time Frame - 24 weeks): The proportion of subjects who have RBC transfusion independence at week 24
Best Available Therapy (BAT): Best available therapy options include:
hydroxyurea
chemotherapy or
supportive care (including but not limited to corticosteroids and androgens; JAK inhibitors not allowed).
Quelle: ClinicalTrials.gov
Sie können folgenden Inhalt einem Kollegen empfehlen:
"KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment"
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