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JOURNAL ONKOLOGIE – STUDIE

Establishment of a Tumor Bank for Tissue Samples

Rekrutierend

NCT-Nummer:
NCT01789229

Studienbeginn:
September 2003

Letztes Update:
23.03.2023

Wirkstoff:
-

Indikation (Clinical Trials):
Neoplasms, Breast Neoplasms, Colorectal Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Endocrine Gland Neoplasms

Geschlecht:
Alle

Altersgruppe:
Erwachsene (18+)

Phase:
-

Sponsor:
Medical University of Vienna

Collaborator:
-

Studienleiter

Robert Zeillinger, Prof.Dr.
Principal Investigator
Medical University of Vienna, Dptm. of Obstetrics & Gynaecology

Kontakt

Robert Zeillinger, Prof.Dr.
Kontakt:
Phone: +43140400
Phone (ext.): 78310
E-Mail: robert.zeillinger@meduniwien.ac.at
» Kontaktdaten anzeigen

Studienlocations
(3 von 3)

Charité University - Campus Virchow Chlinic
13353 Berlin
(Berlin)
GermanyAktiv, nicht rekrutierend» Google-Maps
Medical University Vienna, Dptm. of Obstetrics & Gynaecology
1090 Vienna
AustriaRekrutierend» Google-Maps
Ansprechpartner:
Christoph Grimm, assoc. Prof., MD
E-Mail: christoph.grimm@muv.ac.at

Stephan Polterauer, assoc. Prof., MD
E-Mail: stephan.polterauer@muv.ac.at
» Ansprechpartner anzeigen
University Hospitals Leuven - Department of Obstetrics and Gynaecology
3000 Leuven
BelgiumAbgeschlossen» Google-Maps

Studien-Informationen

Detailed Description:

Recent progress in diagnosis and therapy of cancer diseases can be ascribed mainly to

translational research. The relevance of "translational oncology" will only increase in the

future -"From bench to bedside" - the swift implementation of new science research results in

clinical studies in order to expedite progress in clinical cancer therapy for the benefit of

the patient.

Its almost a matter of course in the medical science today to collect biological samples

together with clinical information thereby creating the foundation for future excellent

fundamental research.

The aim of this tumor bank is to consist of biological samples (together with a blood bank -

see NCT01763125) and isolates of tumor patients and healthy people as controls. The

biological samples, the clinical date together with prospective experimental date constitute

the entity of the tumor bank. The content of the tumor bank can provide essential material

for current and future research (e.g. analyses of prognostic or predictive tumor markers;

genetically analysis (polymorphism, mutation, hypermethylation; verification and

characterisation of disseminated tumor cells).

Ein-/Ausschlusskriterien

Inclusion Criteria:

- Male/Female

- Age 18 to 90 years max.

- Just one current known malignant disease or just one current inflammatory disease

Exclusion Criteria:

- Inflammatory disease and malignant disease

- multiple malignancies

- multiple diseases

- underage

Studien-Rationale

Primary outcome:

1. Establishment of blood/tissue bank consisting of oncological samples from cancer patients and benign and healthy controls. (Time Frame - 14 years)

Studien-Arme

  • Malignant tumors
    Patients who have one of the Neoplasms stated above under "conditions".
  • Benign controls
    Patients with a benign tumor or an inflammatory disease - to be matched by age.
  • Healthy controls
    People/patients who have no known disease at time of sampling or are admitted to the hospital for minor interventions and have no inflammatory disease.

Geprüfte Regime

  • Tumor tissue collection:
    Tissue sample is collected during therapeutic intervention by a medical doctor/surgeon. Frozen tissue sections are first transferred to Dept.of Pathology. Pathologist samples required tissue to obtain enough evidence for analysis/diagnosis. Rest tumor material with or without malignant cells is tranferred to the lab for Molecular Oncology of Prof.Zeillinger.
  • Sampling of ascites and pleural effusion:
    Samples of malignant ascites and/or malignant pleural effusion is only collected during therapeutic intervention from patients at inpatient care.
  • Collecting urine samples:
    Patient is asked to give a urine sample. Urine is collected in urine beaker.
  • Collecting saliva sample:
    Saliva sample is collected by spatula from the mouth cavity of the patient.
  • Collecting sputum:
    Patient is asked to produce sputum into a 50ml lab tube.
  • Collecting stool samples:
    Stool samples are collected prior to bowel preparation for colonoscopy. Device for sampling is provided to the patient.
  • Lavage/Irrigation:
    Irrigation liquid is collected during routine therapeutic or diagnostic procedure, e.g. lavage of the uterine cavity and fallopian tubes of women scheduled for surgery.

Quelle: ClinicalTrials.gov


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