1. Genetic variants in participants as a possible marker of risk of complications after childhood cancer (Time Frame - Genetic sequencing performed at enrollment into study): Genotyping of germline genetic variants (candidate gene, whole exome, or whole genome sequencing data)
Secondary outcome:
1. Number of participants with complications of childhood cancers: specific organ dysfunctions assessed by objective measurements and second primary neoplasms, extracted from medical records and cancer registry information (Time Frame - Data collection at enrollment into study, and longitudinal data collection until last follow-up or death from any cause, approx. 10 years): Specific organ dysfunctions assessed by objective measurements, e.g. audiograms for hearing loss, and self-assessment with questionnaires and
Second primary neoplasms as defined by the International Agency for Research on Cancer (IARC) criteria
2. Demographic and clinical covariates corresponding to possible risk factors for specific complications after childhood cancer, extracted from medical records and cancer registry information (Time Frame - Data collection at enrollment into study, and longitudinal data collection until last follow-up or death from any cause, approx. 10 years): Covariates include but are not restricted to the collection of the following data:
demographic information, e.g. sex, age and year at diagnosis, etc.
cancer-related information, e.g. cancer type, stage, metastases, etc.
treatment-related risk factors, e.g. platinum chemotherapy exposure (with cumulative dose, mg/m2) for hearing impairment, radiation dose (gray) and fields for radiation toxicity, etc.
Procedure: Biospecimen Collection (Medical Chart Review): Collection of saliva, buccal swabs, blood, or other sample adequate for germline DNA extraction
Procedure: Medical Chart Review (Registry data collection): Collection of clinical data
Quelle: ClinicalTrials.gov
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"Genetic Risks for Childhood Cancer Complications in Switzerland"
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