A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer
Indikation (Clinical Trials):
Neoplasms, Neoplasm Metastasis, Breast Neoplasms
Geschlecht:
Alle
Altersgruppe:
Erwachsene (18+)
Phase:
Phase 3
Sponsor:
Eli Lilly and Company
Collaborator:
-
Studienleiter
Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST) Study Director Eli Lilly and Company
Kontakt
There may be multiple sites in this clinical trial. 1-877-CTLILLY (1-877-285-4559) or Kontakt: Phone: 1-317-615-4559 E-Mail: ClinicalTrials.gov@lilly.com» Kontaktdaten anzeigen
Klinikum der Ludwig-Maximilians-Universitaet Muenchen 80336 München (Bayern) GermanyAktiv, nicht rekrutierend» Google-MapsGynäkologisches Krebszentrum Agaplesion Markus Krankenhaus Frankfurt Wilhelm-Epstein-Straße 4 60431 Frankfurt am Main DeutschlandRekrutierend» Google-MapsGynäkologisch-Onkologische Praxis am Pelikanplatz 30177 Hannover (Niedersachsen) GermanyAbgeschlossen» Google-MapsKliniken Essen-Mitte, Evangelische Huyssens-Stiftung 45136 Essen (Nordrhein-Westfalen) GermanyAktiv, nicht rekrutierend» Google-MapsEvangelisches Krankenhaus Bethesda Mönchengladbach 41061 Mönchengladbach (Nordrhein-Westfalen) GermanyRekrutierend» Google-MapsUniversitaetsklinikum Schleswig-Holstein Campus Kiel 24105 Kiel (Schleswig-Holstein) GermanyAbgeschlossen» Google-MapsIronwood Cancer & Research Centers 85224 Chandler United StatesAbgeschlossen» Google-MapsBanner MD Anderson Cancer Center 85234 Gilbert United StatesAktiv, nicht rekrutierend» Google-MapsMarin Cancer Care 94904 Greenbrae United StatesAbgeschlossen» Google-MapsUniversity of California Davis (UC Davis) Comprehensive Cancer Center 95817 Sacramento United StatesAktiv, nicht rekrutierend» Google-MapsBanner MD Anderson Cancer Center at McKee Medical Center 80538 Loveland United StatesAbgeschlossen» Google-MapsClermont Oncology Center 34711 Clermont United StatesRekrutierend» Google-Maps Ansprechpartner:
Phone: 352-242-1366» Ansprechpartner anzeigenUniversity of Florida College of Medicine 32610 Gainesville United StatesAktiv, nicht rekrutierend» Google-MapsMid Florida Hematology and Oncology Center 32763 Orange City United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists 33705 Saint Petersburg United StatesAktiv, nicht rekrutierend» Google-MapsFlorida Cancer Specialists 34232 Sarasota United StatesAktiv, nicht rekrutierend» Google-MapsKaiser Permanente Moanalua Medical Center 96819 Honolulu United StatesAbgeschlossen» Google-MapsUniversity of Chicago Medical Center 60637 Chicago United StatesAktiv, nicht rekrutierend» Google-MapsNorthShore University HealthSystem - Evanston Hospital 60201 Evanston United StatesRekrutierend» Google-MapsIU Health Ball Memorial Hospital, Inc. 47303 Muncie United StatesAbgeschlossen» Google-MapsThe University of Louisville, James Graham Brown Cancer Center 40202 Louisville United StatesRekrutierend» Google-MapsMinnesota Oncology/Hematology PA 55433 Coon Rapids United StatesAbgeschlossen» Google-MapsJackson Oncology Associates, PLLC 39202 Jackson United StatesRekrutierend» Google-MapsCare Access - Clifton 07013 Clifton United StatesRekrutierend» Google-MapsMemorial Sloan Kettering - Bergen 07645 Montvale United StatesAktiv, nicht rekrutierend» Google-MapsColumbia University Medical Center 10032 New York United StatesAktiv, nicht rekrutierend» Google-MapsUniversity of North Carolina Medical Center 27599 Chapel Hill United StatesRekrutierend» Google-MapsAultman Hospital 44710 Canton United StatesRekrutierend» Google-MapsMercy Health - St. Vincent Medical Center 43608 Toledo United StatesRekrutierend» Google-Maps Ansprechpartner:
Phone: 419-251-4919» Ansprechpartner anzeigenAvera Cancer Institute Sioux Falls 57105 Sioux Falls United StatesAktiv, nicht rekrutierend» Google-MapsSarah Cannon Research Institute SCRI 37203 Nashville United StatesRekrutierend» Google-MapsTexas Oncology - Dallas Presbyterian Hospital 75231 Dallas United StatesAbgeschlossen» Google-MapsTexas Oncology Denton 76201 Denton United StatesAktiv, nicht rekrutierend» Google-MapsWillamette Valley Cancer Institute & Research Ctr. 77070 Houston United StatesAbgeschlossen» Google-MapsTexas Oncology - Willowbrook 77380 Houston United StatesRekrutierend» Google-Maps Ansprechpartner:
Phone: 281-863-1000» Ansprechpartner anzeigenBroome Oncology 77380 The Woodlands United StatesAbgeschlossen» Google-MapsTexas Oncology - Denison 77380 The Woodlands United StatesAbgeschlossen» Google-MapsTexas Oncology - McKinney 77380 The Woodlands United StatesRekrutierend» Google-Maps Ansprechpartner:
Phone: 281-863-1000» Ansprechpartner anzeigenTexas Oncology - San Antonio Medical Center 77380 The Woodlands United StatesAktiv, nicht rekrutierend» Google-MapsTexas Oncology - The Woodlands 77380 The Woodlands United StatesAbgeschlossen» Google-MapsTexas Oncology Denton 77380 The Woodlands United StatesAktiv, nicht rekrutierend» Google-MapsTexas Oncology Fort Worth 77380 The Woodlands United StatesAbgeschlossen» Google-MapsTexas Oncology-Baylor Charles A. Sammons Cancer Center 77380 The Woodlands United StatesAktiv, nicht rekrutierend» Google-MapsUS Oncology 77380 The Woodlands United StatesRekrutierend» Google-MapsUtah Cancer Specialists 84106 Salt Lake City United StatesAbgeschlossen» Google-MapsThe University of Vermont Medical Center Inc. 05401 Burlington United StatesAktiv, nicht rekrutierend» Google-MapsInstituto de Investigaciones Clínicas Mar del Plata B7600FZO Mar del Plata ArgentinaAktiv, nicht rekrutierend» Google-MapsCIPREC C1061AAS Buenos Aires ArgentinaAktiv, nicht rekrutierend» Google-MapsFundación Cenit Para La Investigación En Neurociencias 1125 Caba ArgentinaAbgeschlossen» Google-MapsCentro Medico Privado CEMAIC X5008HHW Capital ArgentinaAktiv, nicht rekrutierend» Google-MapsClinica Viedma 8500 Viedma ArgentinaAktiv, nicht rekrutierend» Google-MapsInstituto Argentino de Diagnóstico y Tratamiento (IADT) 1122 Buenos Aires ArgentinaAbgeschlossen» Google-MapsInstituto San Marcos 5400 San Juan ArgentinaAktiv, nicht rekrutierend» Google-MapsSanatorio Norte 4200 Santiago del Estero ArgentinaAktiv, nicht rekrutierend» Google-MapsSt Vincent's Hospital 2010 Darlinghurst AustraliaAktiv, nicht rekrutierend» Google-MapsPrincess Alexandra Hospital 4102 Woolloongabba AustraliaAbgeschlossen» Google-MapsCancer Research SA 5000 Adelaide AustraliaAktiv, nicht rekrutierend» Google-MapsBox Hill Hospital 3128 Box Hill AustraliaAbgeschlossen» Google-MapsMaroondah Hospital 3135 Melbourne AustraliaAktiv, nicht rekrutierend» Google-MapsMedizinische Universität Graz 8036 Graz AustriaAktiv, nicht rekrutierend» Google-MapsMedizinische Universität Wien 1090 Vienna AustriaAbgeschlossen» Google-MapsUniklinikum Salzburg 5020 Salzburg AustriaAbgeschlossen» Google-MapsImelda General Hospital 2820 Bonheiden BelgiumRekrutierend» Google-MapsUZ Brussel 1090 Brussels BelgiumAbgeschlossen» Google-MapsInstitut Jules Bordet 1000 Bruxelles BelgiumAktiv, nicht rekrutierend» Google-MapsUZ Gent 9000 Gent BelgiumAbgeschlossen» Google-MapsAZ Nikolaas B-9100 Sint-Niklaas BelgiumAktiv, nicht rekrutierend» Google-MapsUZ Leuven 3000 Leuven BelgiumAktiv, nicht rekrutierend» Google-MapsAZ Groeninge Campus Kennedylaan 8500 Kortrijk BelgiumAktiv, nicht rekrutierend» Google-MapsCHU UCL Namur/Site Sainte Elisabeth 5000 Namur BelgiumRekrutierend» Google-Maps Ansprechpartner:
Phone: 003281720531» Ansprechpartner anzeigenHospital de Cancer de Londrina 86015-520 Londrina BrazilAktiv, nicht rekrutierend» Google-MapsFaculdade de Medicina do ABC 09060-650 Santo André BrazilAktiv, nicht rekrutierend» Google-MapsIcesp - Instituto Do Câncer Do Estado de São Paulo 01246-000 São Paulo BrazilAktiv, nicht rekrutierend» Google-MapsClínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA 01317-001 São Paulo BrazilAktiv, nicht rekrutierend» Google-MapsNúcleo de Pesquisa Clínica da Rede São Camilo 04014-002 São Paulo BrazilAktiv, nicht rekrutierend» Google-MapsAfflilated Hospital of Bengbu Medical College 233004 Bengbu ChinaRekrutierend» Google-MapsBeijing Hospital 100005 Beijing ChinaRekrutierend» Google-MapsFifth Medical Center of PLA General Hospital 100039 Beijing ChinaNoch nicht rekrutierend» Google-MapsFujian Provincial Cancer Hospital 350014 Fuzhou ChinaRekrutierend» Google-MapsSun Yat-Sen University Cancer Centre 511400 Guangzhou ChinaRekrutierend» Google-MapsJiangmen Center Hospital Jiangmen ChinaRekrutierend» Google-MapsHarbin Medical University Cancer Hospital 150081 Harbin ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Henan University of Science &Technology 471003 Luoyang ChinaRekrutierend» Google-MapsNanyang Second General Hospital 473000 Nanyang ChinaNoch nicht rekrutierend» Google-MapsTongji Hospital Tongji Medical,Science & Technology 430030 Wuhan ChinaRekrutierend» Google-MapsRenmin Hospital of Wuhan University 430060 Wuhan ChinaRekrutierend» Google-MapsHubei Cancer Hospital 430079 Wuhan ChinaRekrutierend» Google-MapsThe First People's Hospital of Changde City 415003 Changde ChinaRekrutierend» Google-MapsHunan Provincial People's Hospital 410005 ChangSha ChinaRekrutierend» Google-MapsXiangya Hospital Central South University 410008 Changsha ChinaRekrutierend» Google-MapsHunan Cancer Hospital 421000 Changsha ChinaRekrutierend» Google-MapsJiangsu Province Hospital 210029 Nanjing ChinaRekrutierend» Google-MapsThe Third Hospital of Nanchang 330009 Nanchang ChinaRekrutierend» Google-MapsThe First Hospital of Jilin University 130021 Changchun ChinaRekrutierend» Google-MapsThe Second Hospital of Jilin University Changchun ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Xi'an Jiaotong University 710061 Xi'an ChinaRekrutierend» Google-MapsJinan Central Hospital 250013 Jinan ChinaRekrutierend» Google-MapsJining Medical University - Affiliated Hospital 272100 Jining ChinaRekrutierend» Google-MapsYantai Yuhuangding Hospital 264000 Yantai ChinaRekrutierend» Google-MapsSichuan Cancer hospital 610042 Chengdu ChinaRekrutierend» Google-MapsThe Second People's Hospital of Neijiang 641000 Neijiang ChinaNoch nicht rekrutierend» Google-MapsTianjin Medical University Cancer Institute and Hospital 300060 Tianjing ChinaRekrutierend» Google-MapsThe First Affiliated Hospital, Zhejiang University 310003 Hangzhou ChinaNoch nicht rekrutierend» Google-MapsSir Run Run Shaw Hospital 310016 Hangzhou ChinaRekrutierend» Google-Maps Ansprechpartner:
Phone: 86 15857121122» Ansprechpartner anzeigenZhejiang Cancer Hospital 310022 Hangzhou ChinaRekrutierend» Google-MapsHwa Mei Hospital University of Chinese Academy of Sciences 315010 Ningbo ChinaRekrutierend» Google-MapsNingbo Medical Center 315048 Ningbo ChinaRekrutierend» Google-Maps Ansprechpartner:
Phone: 8605745583614» Ansprechpartner anzeigenNemocnice Horovice 268 31 Horovice CzechiaRekrutierend» Google-MapsFakultni nemocnice Kralovske Vinohrady 10034 PRague CzechiaRekrutierend» Google-MapsFakultni Thomayerova nemocnice 14059 Prague CzechiaRekrutierend» Google-MapsFakultni nemocnice Bulovka 180 81 Prague CzechiaRekrutierend» Google-MapsOblastni nemocnice Pribram 261 01 Pribram CzechiaAbgeschlossen» Google-MapsInstitut de cancérologie Strasbourg Europe (ICANS) 67033 Strasbourg FranceAktiv, nicht rekrutierend» Google-MapsPolyclinique De Blois 41260 La Chaussée-Saint-Victor FranceAbgeschlossen» Google-MapsCHU Besançon 25000 Besançon FranceAktiv, nicht rekrutierend» Google-MapsInstitut Curie - site Saint-Cloud 92210 Saint-Cloud FranceAktiv, nicht rekrutierend» Google-MapsCentre de Cancérologie du Grand Montpellier 34070 Montpellier FranceAktiv, nicht rekrutierend» Google-MapsClinique Victor Hugo Le Mans 72000 Le Mans FranceAktiv, nicht rekrutierend» Google-MapsCentre Hospitalier de la Côte Basque 64109 Bayonne FranceAktiv, nicht rekrutierend» Google-MapsInstitut Curie 75248 Paris FranceAktiv, nicht rekrutierend» Google-MapsInstitut de Cancérologie de Lorraine Alexis Vautrin 54519 Vandoeuvre-lès-Nancy FranceAbgeschlossen» Google-MapsAgios Savvas Regional Cancer Hospital 115 22 Athens GreeceAktiv, nicht rekrutierend» Google-MapsAlexandra Hospital 115 28 Athens GreeceAktiv, nicht rekrutierend» Google-MapsGeneral Oncology Hospital of Kifissia "Agioi Anargiroi" 14564 Nea Kifissia GreeceRekrutierend» Google-MapsUniversity General Hospital of Heraklion 711 10 Heraklion GreeceAktiv, nicht rekrutierend» Google-MapsEuromedica General Clinic of Thessaloniki 546 45 Thessaloniki GreeceAktiv, nicht rekrutierend» Google-MapsPapageorgiou General Hospital of Thessaloniki 564 29 Thessaloniki GreeceAbgeschlossen» Google-MapsEuropean Interbalkan Medical Center 570 01 Thessaloniki GreeceAktiv, nicht rekrutierend» Google-MapsUniversity General Hospital of Larissa 41110 Larissa GreeceAbgeschlossen» Google-MapsMedstar Speciality Hospital 560092 Bangalore IndiaAktiv, nicht rekrutierend» Google-MapsRegional Cancer Centre - Thiruvananthapuram 695011 Thiruvananthapuram IndiaAbgeschlossen» Google-MapsHCG Cancer Centre 400092 Mumbai IndiaAbgeschlossen» Google-MapsGovernment Medical College And Hospital - Nagpur 440003 Nagpur IndiaAktiv, nicht rekrutierend» Google-MapsRashtrasant Tukdoji Regional Cancer Hospital 440027 Nagpur IndiaAktiv, nicht rekrutierend» Google-MapsHCG Manavata Cancer Centre 422002 Nashik IndiaAktiv, nicht rekrutierend» Google-MapsDeenanath Mangeshkar Hospital & Research Centre 411004 Pune IndiaAktiv, nicht rekrutierend» Google-MapsLifepoint Multispeciality Hospital 411057 Pune IndiaAktiv, nicht rekrutierend» Google-MapsYashoda Hospitals 500082 Hyderabad IndiaAbgeschlossen» Google-MapsUniversity of Naples Federico II 80100 Naples ItalyAktiv, nicht rekrutierend» Google-MapsIstituto Nazionale Tumori IRCCS Fondazione Pascale 80131 Napoli ItalyAktiv, nicht rekrutierend» Google-MapsCro-Irccs 33081 Aviano ItalyAbgeschlossen» Google-MapsFondazione Policlinico Universitario Agostino Gemelli 00168 Roma ItalyAktiv, nicht rekrutierend» Google-MapsOspedale San Martino 16132 Genova ItalyAktiv, nicht rekrutierend» Google-MapsAzienda Ospedaliera Universitaria Careggi 50134 Firenze ItalyAktiv, nicht rekrutierend» Google-MapsIstituto Oncologico Veneto IRCCS 35128 Padova ItalyAktiv, nicht rekrutierend» Google-MapsNagoya University Hospital 466-8560 Nagoya JapanRekrutierend» Google-MapsChiba cancer center 260-8717 Chiba-shi JapanRekrutierend» Google-Maps Ansprechpartner:
Phone: 81120023812» Ansprechpartner anzeigenNational Hospital Organization Shikoku Cancer Center 791-0280 Matsuyama JapanRekrutierend» Google-MapsKurume General Hospital 830-0013 Kurume JapanRekrutierend» Google-MapsGunma Prefectural Cancer Center 373-8550 Otashi JapanRekrutierend» Google-Maps Ansprechpartner:
Phone: 81120023812» Ansprechpartner anzeigenNational Hospital Organization Hokkaido Cancer Center 003-0804 Sapporo JapanRekrutierend» Google-MapsHyogo Cancer Center 673-8558 Akashi JapanRekrutierend» Google-MapsShinko Hospital 651-0072 Kobe JapanRekrutierend» Google-MapsTsuchiura Kyodo General Hospital 300-0028 Tsuchiura JapanRekrutierend» Google-MapsTsukuba University Hospital 305-8576 Tsukuba JapanRekrutierend» Google-MapsSt. Marianna University School of Medicine Hospital 216-8511 Kawasaki JapanRekrutierend» Google-MapsKanagawa cancer center 2418515 Yokohama JapanRekrutierend» Google-MapsNagano Municipal Hospital 381-8551 Tomitake JapanRekrutierend» Google-MapsNiigata Cancer Center Hospital 951-8566 Niigata-shi JapanRekrutierend» Google-MapsShowa University Hospital 142-8555 Shinagawa JapanRekrutierend» Google-MapsNational Hospital Organization Kyushu Cancer Center 811-1395 Fukuoka JapanRekrutierend» Google-MapsHiroshima City Hospital 730-8518 Hiroshima JapanRekrutierend» Google-MapsSagara Hospital 892-0833 Kagoshima JapanRekrutierend» Google-MapsKumamoto Shinto General Hospital 862-8655 Kumamoto JapanRekrutierend» Google-MapsOsaka International Cancer Institute 541-8567 Osaka JapanRekrutierend» Google-MapsShizuoka General Hospital 420-8527 Shizuoka JapanRekrutierend» Google-MapsJuntendo University Hospital 113-8431 Tokyo JapanRekrutierend» Google-MapsSoon Chun Hyang University Cheonan Hospital 31151 Cheonan-si Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsGachon University Gil Medical Center 21565 Namdong-gu Korea, Republic ofAbgeschlossen» Google-MapsAjou University Hospital 16499 Suwon-si Korea, Republic ofAbgeschlossen» Google-MapsYeungnam Univeristy Medical Center 42415 Daegu Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsDong-A University Hospital 49201 Busan Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsSeoul National University Hospital 03080 Seoul Korea, Republic ofAbgeschlossen» Google-MapsKangbuk Samsung Hospital 03181 Seoul Korea, Republic ofAbgeschlossen» Google-MapsSeverance Hospital, Yonsei University Health System 03722 Seoul Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsAsan Medical Center 05505 Seoul Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsGangnam Severance Hospital 06273 Seoul Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsSamsung Medical Center 06351 Seoul Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsKyungpook National University Chilgok Hospital 41404 Daegu Korea, Republic ofAktiv, nicht rekrutierend» Google-MapsCentro de Investigación Clínica de Alta Especialidad 27010 Torreón MexicoAbgeschlossen» Google-MapsGrupo Medico Camino Sc 03310 Mexico City MexicoAktiv, nicht rekrutierend» Google-MapsCOI Centro Oncologico Internacional S.A.P.I. de C.V. 01330 Álvaro Obregón MexicoAktiv, nicht rekrutierend» Google-MapsPrivate Practice - Dr. Joaquin Reinoso 64320 Monterrey MexicoAktiv, nicht rekrutierend» Google-MapsFilios Alta Medicina 64460 Monterrey MexicoAktiv, nicht rekrutierend» Google-MapsCentro Medico Zambrano Hellion 66278 San Pedro Garza Garcia MexicoAktiv, nicht rekrutierend» Google-MapsUnidad de Investigación en Salud 31203 Chihuahua MexicoAbgeschlossen» Google-MapsOaxaca Site Management Organization 68000 Oaxaca MexicoAbgeschlossen» Google-MapsUnidad Médica Onco-hematológica 72424 Puebla MexicoAktiv, nicht rekrutierend» Google-MapsMedische Centrum Leeuwarden 8934 AD Leeuwarden NetherlandsAbgeschlossen» Google-MapsMaastricht UMC+ 6229 HX Maastricht NetherlandsAktiv, nicht rekrutierend» Google-MapsHaga Ziekenhuis locatie Leyweg 2545 AA Den Haag NetherlandsRekrutierend» Google-MapsKaluga Regional Clinical Oncology Center 248007 Kaluga Russian FederationAbgeschlossen» Google-MapsVolgograd Regional Clinical Cancer Clinic No.1 400138 Volgograd Russian FederationRekrutierend» Google-MapsN.N.Petrov Research Institute of Oncology 197758 Saint Petersburg Russian FederationRekrutierend» Google-MapsHospital Universitari Vall d'Hebron 08035 Barcelona SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitari Dexeusa 08028 Barcelona SpainAktiv, nicht rekrutierend» Google-MapsHospital de la Santa Creu i Sant Pau 08041 Barcelona SpainAktiv, nicht rekrutierend» Google-MapsHospital San Pedro de Alcántara 10003 Cáceres SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario Arnau de Vilanova de Lleida 25198 Lleida SpainAbgeschlossen» Google-MapsHospital Universitario Ramón y Cajal 28034 Madrid SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario de Canarias 38320 La Laguna SpainAbgeschlossen» Google-MapsHospital Clinico de Valencia 46010 Valencia SpainAktiv, nicht rekrutierend» Google-MapsHospital Quirónsalud Valencia 46010 Valencia SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario San Cecilio 18016 Granada SpainAktiv, nicht rekrutierend» Google-MapsHospital Clinico San Carlos 28040 Madrid SpainAktiv, nicht rekrutierend» Google-MapsHospital Universitario Virgen Macarena 41009 Sevilla SpainAbgeschlossen» Google-MapsHospital Universitario Virgen Del Rocio 41013 Sevilla SpainAktiv, nicht rekrutierend» Google-MapsChi Mei Hospital - Liouying Branch 73657 Tainan City TaiwanAbgeschlossen» Google-MapsTaichung Veterans General Hospital 407 Taichung TaiwanAktiv, nicht rekrutierend» Google-MapsNational Cheng Kung University Hospital 704 Tainan TaiwanAktiv, nicht rekrutierend» Google-MapsNational Taiwan University Hospital 10002 Taipei TaiwanAktiv, nicht rekrutierend» Google-MapsKoo Foundation Sun Yat-Sen Cancer Center 112 Taipei TaiwanAktiv, nicht rekrutierend» Google-MapsMedipol Mega Universite Hastanesi 34214 Stanbul TurkeyAktiv, nicht rekrutierend» Google-MapsAcibadem Altunizade Hospital Üsküdar / Stanbul TurkeyAktiv, nicht rekrutierend» Google-MapsBaskent University Dr. Turgut Noyan Research and Training Center 01250 Adana TurkeyAktiv, nicht rekrutierend» Google-MapsSbü Gülhane Eğitim Ve Araştirma Hastanesi 06010 Ankara TurkeyAktiv, nicht rekrutierend» Google-MapsDr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi 06200 Ankara TurkeyAktiv, nicht rekrutierend» Google-MapsHacettepe Universitesi 06230 Ankara TurkeyAbgeschlossen» Google-MapsMemorial Ankara Hastanesi 06520 Ankara TurkeyAbgeschlossen» Google-MapsAnkara City Hospital 06800 Ankara TurkeyAktiv, nicht rekrutierend» Google-MapsAkdeniz Universitesi Hastanesi 07059 Antalya TurkeyAktiv, nicht rekrutierend» Google-MapsDicle Üniversitesi 21200 Diyarbakir TurkeyAbgeschlossen» Google-MapsTrakya University 22030 Edirne TurkeyAbgeschlossen» Google-MapsAcıbadem Maslak Hastanesi 34457 İstanbul TurkeyAbgeschlossen» Google-MapsTC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi 34722 Istanbul TurkeyAbgeschlossen» Google-MapsEge Universitesi Hastanesi 35100 Izmir TurkeyAbgeschlossen» Google-Mapsİnönü Üniversitesi Turgut Özal Tıp Merkezi 44280 Malatya TurkeyAbgeschlossen» Google-MapsMersin University 33343 Mersin TurkeyAktiv, nicht rekrutierend» Google-MapsCommunal Enterprise 'Kryvyi Rih Oncology Dispensary' of the Dnipropetrovsk Regional Council 50048 Kryvyi Rih UkraineRekrutierend» Google-MapsCNPE "Regional Center of Oncology" 61070 Kharkiv UkraineRekrutierend» Google-MapsMunicipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council 65025 Odesa UkraineRekrutierend» Google-MapsMunicipal Enterprise "Volyn Regional Medical Oncology Centre" of the Volyn Regional Council 43018 Lutsk UkraineRekrutierend» Google-MapsUzhgorod Central City Clinical Hospital 88000 Uzhhorod UkraineRekrutierend» Google-Maps
1. Progression Free Survival (PFS) in the Intent-to-Treat (IIT) Population (Time Frame - Randomization to the date of first documented progression of disease or death from any cause (estimated as up to 3 years)): PFS by investigator assessment in the IIT population
2. PFS in the Estrogen Receptor 1 (ESR1)-mutation Detected Population (Time Frame - Randomization to the date of first documented progression of disease or death from any cause (estimated as up to 3 years)): PFS by investigator assessment in ESR1-mutation detected population
Secondary outcome:
1. Overall Survival (OS) in the IIT Population (Time Frame - Randomization until death from any cause (estimated as up to 5 years)): OS in the IIT population
2. OS in the ESR1-mutation Detected Population (Time Frame - Randomization until death from any cause (estimated as up to 5 years)): OS in the ESR1-mutation detected population
3. Objective Response Rate (ORR): Percentage of Participants Who Achieve a Confirmed Best Overall Response of Complete Response (CR) or Partial Response (PR) (Time Frame - Randomization until measured progressive disease (estimated as up to 1 year)): ORR
4. Duration of Response (DoR) (Time Frame - Date of CR or PR to date of disease progression or death due to any cause (estimated up to 3 years)): DoR
5. Clinical Benefit Rate (CBR): Percentage of Participants Who Achieve a Best Overall Response of CR, PR or Stable Disease for Greater than or Equal to (≥) 24 Weeks (Time Frame - Randomization until measured progressive disease (estimated as up to 1 year)): CBR
6. Progression Free Survival (PFS) (Time Frame - Randomization to the date of first documented progression of disease or death from any cause(estimated as up to 3 years)): PFS by blinded independent review
7. Patient Reported Outcomes (PRO): Time to Worsening of "Worst Pain" (Time Frame - Screening through follow-up (estimated as up to 3 years)): Measured by the Worst Pain Numeric Rating Scale (NRS). NRS is a single item, participant-administered, 11-point horizontal scale anchored at 0 and 10, with 0 representing "no pain" and 10 representing "pain as bad as you can imagine."
8. Pharmacokinetics (PK): Steady State Plasma Concentrations of Imlunestrant (Time Frame - Cycle 2 to Cycle 4 (cycle = 28 days)): PK: steady state plasma concentrations of imlunestrant
9. PK: Steady State Plasma Concentrations of Imlunestrant and Abemaciclib (Time Frame - Cycle 2 to Cycle 4 (cycle = 28 days)): PK: steady state plasma concentrations of imlunestrant and abemaciclib
Active Comparator: Investigator's Choice of Endocrine Therapy Investigator's choice of exemestane administered orally or fulvestrant administered intramuscularly (IM). See local approved label for additional instructions.
Experimental: Imlunestrant plus Abemaciclib Imlunestrant plus abemaciclib administered orally.
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"A Study of Imlunestrant, Investigator's Choice of Endocrine Therapy, and Imlunestrant Plus Abemaciclib in Participants With ER+, HER2- Advanced Breast Cancer"
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