Universitaetsklinikum Hamburg-Eppendorf (UKE) - Universitaeres Cancer Center Hamburg (UCCH) Hamburg (Hamburg) GermanyRekrutierend» Google-MapsUniversitaetsklinikum Heidelberg (UKHD) - Nationales Centrum fuer Tumorerkrankungen Heidelberg (NCT) Heidelberg (Baden-Württemberg) GermanyRekrutierend» Google-MapsSLK-Kliniken Heilbronn GmbH - Klinikum am Gesundbrunnen - Klinik fuer Innere Medizin III Heilbronn (Baden-Württemberg) GermanyRekrutierend» Google-Maps
Gemeinschaftspraxis fuer Haematologie und Onkologie - Magdeburg Magdeburg (Sachsen-Anhalt) GermanyRekrutierend» Google-MapsUniversitaetsmedizin der Johannes Gutenberg-Universitaet Mainz Mainz (Rheinland-Pfalz) GermanyRekrutierend» Google-MapsThe University of Arizona Cancer Center 85719 Tucson United StatesRekrutierend» Google-MapsUCLA 90404 Los Angeles United StatesRekrutierend» Google-MapsFlorida Cancer Specialists & Research Institute (FCS) 33909 Cape Coral United StatesRekrutierend» Google-MapsFlorida Cancer Specialists & Research Institute 32003 Fleming Island United StatesRekrutierend» Google-MapsFlorida Cancer Specialists & Research Institute 32605 Gainesville United StatesRekrutierend» Google-MapsMiami Cancer Institute 33176 Miami United StatesRekrutierend» Google-MapsFlorida Cancer Specialists & Research Institute 33414 Wellington United StatesRekrutierend» Google-MapsHematology Oncology of Indiana, PC - Indianapolis 46260 Indianapolis United StatesRekrutierend» Google-MapsHematology Oncology Clinic 70809 Baton Rouge United StatesRekrutierend» Google-MapsCenter for Cancer and Blood Disorders 20817 Bethesda United StatesRekrutierend» Google-MapsOncology Hematology Associates - Springfield 65807 Springfield United StatesRekrutierend» Google-MapsNorthwell Health 11020 Lake Success United StatesRekrutierend» Google-MapsNew York University 10016 New York United StatesRekrutierend» Google-MapsCornell University 10021 New York United StatesRekrutierend» Google-MapsMount Sinai Medical Center - New York 10029 New York United StatesRekrutierend» Google-MapsWhite Plains Hospital 10601 White Plains United StatesRekrutierend» Google-MapsMessino Cancer Centers 28806 Asheville United StatesRekrutierend» Google-MapsDuke University Medical Center 27710 Durham United StatesRekrutierend» Google-MapsWake Forest University 27157 Winston-Salem United StatesRekrutierend» Google-MapsPrisma Health Cancer Institute - Faris 29605 Greenville United StatesRekrutierend» Google-MapsSanford Cancer Center 57104 Sioux Falls United StatesRekrutierend» Google-MapsTennessee Oncology 37404 Chattanooga United StatesRekrutierend» Google-MapsSCRI Oncology Partners 37203 Nashville United StatesNoch nicht rekrutierend» Google-MapsTennessee Oncology 37203 Nashville United StatesRekrutierend» Google-MapsMultiCare Tacoma General Hospital 98405 Tacoma United StatesRekrutierend» Google-MapsUniversity of Wisconsin Hospital and Clinics 53792 Madison United StatesRekrutierend» Google-MapsDong-A University Medical Center Busan Korea, Republic ofRekrutierend» Google-MapsKyungpook National University Chilgok Hospital Daegu Korea, Republic ofRekrutierend» Google-MapsGachon University Gil Medical Center Incheon Korea, Republic ofRekrutierend» Google-MapsInha University Hospital Incheon Korea, Republic ofRekrutierend» Google-MapsCHA University - Bundang CHA General Hospital Seongnam-si Korea, Republic ofRekrutierend» Google-MapsSeoul National University Bundang Hospital Seongnam-si Korea, Republic ofRekrutierend» Google-MapsAsan Medical Center Seoul Korea, Republic ofRekrutierend» Google-MapsSamsung Medical Center Seoul Korea, Republic ofRekrutierend» Google-MapsSeoul National University Hospital Seoul Korea, Republic ofRekrutierend» Google-MapsThe Catholic University of Korea - St. Vincent's Hospital Suwon Korea, Republic ofRekrutierend» Google-Maps
1. Progression Free Survival (PFS) (Time Frame - approximately 6 months): PFS, as determined by the Investigator per RECIST v1.1 of DKN-01 plus SOC versus SOC.
Secondary outcome:
1. Objective Response Rate (ORR) (Time Frame - approximately 6 months): ORR, as determined by the Investigator per RECIST v1.1 of DKN-01 plus SOC versus SOC
2. Duration of Response (DoR) (Time Frame - approximately 6 months): DoR, as determined by the Investigator per RECIST v1.1 of DKN-01 plus SOC versus SOC
3. Overall Survival (OS) (Time Frame - approximately 6 months): OS with DKN-01 plus SOC versus SOC
4. Incidence of ≥Grade 3 related treatment-related adverse events (TRAEs). (Time Frame - approximately 6 months)