CBCC Global Research, Inc. 93309 Bakersfield United StatesRekrutierend» Google-MapsComprehensive Blood and Cancer Center 93309 Bakersfield United StatesRekrutierend» Google-MapsCalifornia Cancer Associates for Research and Excellence, Inc. (cCARE) 92024 Encinitas United StatesRekrutierend» Google-MapsCalifornia Cancer Associates for Research and Excellence 93720 Fresno United StatesRekrutierend» Google-MapsProvidence Queen of the Valley Medical Center 94558 Napa United StatesRekrutierend» Google-MapsCalifornia Cancer Associates for Research and Excellence 92069 San Marcos United StatesRekrutierend» Google-MapsProvidence Medical Foundation 95403 Santa Rosa United StatesRekrutierend» Google-MapsOlive View-UCLA Medical Center 91342 Sylmar United StatesRekrutierend» Google-MapsTMPN Cancer Care research office 90505 Torrance United StatesRekrutierend» Google-MapsTorrance Memorial Physician Network / Cancer Care 90505 Torrance United StatesRekrutierend» Google-MapsSmilow Cancer Hospital Care Center at Fairfield 06824 Fairfield United StatesNoch nicht rekrutierend» Google-MapsSmilow Cancer Hospital at Yale-New Haven 06510 New Haven United StatesNoch nicht rekrutierend» Google-MapsYale-New Haven Hospital 06510 New Haven United StatesNoch nicht rekrutierend» Google-MapsSmilow Cancer Hospital Care Center at North Haven 06473 North Haven United StatesNoch nicht rekrutierend» Google-MapsSmilow Cancer Hospital Care Center at Trumbull 06611 Trumbull United StatesNoch nicht rekrutierend» Google-MapsFlorida cancer specialists 32701 Altamonte Springs United StatesRekrutierend» Google-MapsFlorida Cancer Specialists BON 34135 Bonita Springs United StatesRekrutierend» Google-MapsFlorida Cancer Specialists BCC 34205 Bradenton United StatesRekrutierend» Google-MapsFlorida Cancer Specialists LRS 34211 Bradenton United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 33511 Brandon United StatesRekrutierend» Google-MapsFlorida Cancer Specialists NFM 33909 Cape Coral United StatesRekrutierend» Google-MapsMorton Plant Hospital - BayCare Health System 33756 Clearwater United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 33761 Clearwater United StatesRekrutierend» Google-Maps3T Radiology LLC 33073 Coconut Creek United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 32117 Daytona Beach United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 32003 Fleming Island United StatesRekrutierend» Google-MapsFlorida Cancer Specialists - South 33901 Fort Myers United StatesRekrutierend» Google-MapsFlorida Cancer Specialists COL 33905 Fort Myers United StatesRekrutierend» Google-MapsFlorida Cancer Specialists GLO 33908 Fort Myers United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 32605 Gainesville United StatesRekrutierend» Google-MapsLakeland Regional Cancer Center 33805 Lakeland United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 33770 Largo United StatesRekrutierend» Google-MapsBroward P.E.T. Imaging Center 33313 Lauderdale Lakes United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 34461 Lecanto United StatesRekrutierend» Google-MapsFlorida Cancer Specialists NGD 34102 Naples United StatesRekrutierend» Google-MapsFlorida Cancer Specialists NPW 34102 Naples United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 34474 Ocala United StatesRekrutierend» Google-MapsFlorida Cancer specialists 32763 Orange City United StatesRekrutierend» Google-MapsMid Florida Hematology and Oncology Center 32763 Orange City United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 32806 Orlando United StatesRekrutierend» Google-MapsPOM MRI & Radiology Centers 33313 Plantation United StatesRekrutierend» Google-MapsBRCR Global 33322 Plantation United StatesRekrutierend» Google-MapsFlorida Cancer Specialists PCH 33980 Port Charlotte United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 33705 Saint Petersburg United StatesRekrutierend» Google-MapsFlorida Cancer Specialists SAC 34232 Sarasota United StatesRekrutierend» Google-MapsFlorida Cancer Specialists SAD 34236 Sarasota United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 34994 Stuart United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 32308 Tallahassee United StatesRekrutierend» Google-MapsImpression Imaging 33321 Tamarac United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 33607 Tampa United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 32159 The Villages United StatesRekrutierend» Google-MapsFlorida Cancer Specialist 34655 Trinity United StatesRekrutierend» Google-MapsFlorida Cancer Specialists VIS 34285 Venice United StatesRekrutierend» Google-MapsFlorida Cancer Specialists VHP 34292 Venice United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 32960 Vero Beach United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 33414 Wellington United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 33401 West Palm Beach United StatesRekrutierend» Google-MapsFlorida Cancer Specialists 32789 Winter Park United StatesRekrutierend» Google-MapsNorton Cancer Institute - Downtown 40202 Louisville United StatesRekrutierend» Google-MapsNorton Cancer Institute, Downtown 40202 Louisville United StatesRekrutierend» Google-MapsNorton Hospital 40202 Louisville United StatesRekrutierend» Google-MapsNorton Cancer Institute, St Matthews Campus 40207 Louisville United StatesRekrutierend» Google-MapsNorton Women's & Children's Hospital 40207 Louisville United StatesRekrutierend» Google-MapsNorton Brownsboro Hospital 40241 Louisville United StatesRekrutierend» Google-MapsNorton Cancer Institute, Brownsboro Hospital Campus 40241 Louisville United StatesRekrutierend» Google-MapsUniversity Medical Center New Orleans 70112 New Orleans United StatesRekrutierend» Google-MapsLouisiana State University Health Sciences Shreveport 71103 Shreveport United StatesRekrutierend» Google-MapsHattiesburg Clinic Hematology/Oncology 39401 Hattiesburg United StatesRekrutierend» Google-MapsMercy Clinic Oncology and Hematology 63011 Ballwin United StatesRekrutierend» Google-MapsMercy Research - David C. Pratt Cancer Center 63141 Saint Louis United StatesRekrutierend» Google-MapsComprehensive Cancer Centers of Nevada 89052 Henderson United StatesRekrutierend» Google-MapsComprehensive Cancer Centers of Nevada 89074 Henderson United StatesRekrutierend» Google-MapsComprehensive Cancer Centers of Nevada 89128 Las Vegas United StatesRekrutierend» Google-MapsComprehensive Cancer Centers of Nevada 89144 Las Vegas United StatesRekrutierend» Google-MapsComprehensive Cancer Centers of Nevada 89148 Las Vegas United StatesRekrutierend» Google-MapsComprehensive Cancer Centers of Nevada 89169 Las Vegas United StatesRekrutierend» Google-MapsDartmouth-Hitchcock Medical Center 03756 Lebanon United StatesNoch nicht rekrutierend» Google-MapsMSK Basking Ridge 07920 Basking Ridge United StatesRekrutierend» Google-MapsAstera Cancer Care 08816 East Brunswick United StatesRekrutierend» Google-MapsMSK Monmouth 07748 Middletown United StatesRekrutierend» Google-MapsMemorial Sloan Kettering - Bergen 07645 Montvale United StatesRekrutierend» Google-MapsMSK Commack 11725 Commack United StatesRekrutierend» Google-MapsHematology-Oncology Associates of Central New York, PC 13057 East Syracuse United StatesRekrutierend» Google-MapsMSK Westchester 10604 Harrison United StatesRekrutierend» Google-MapsMSKCC Investigational Drug Service Pharmacy 11101 Long Island City United StatesRekrutierend» Google-MapsMemorial Sloan Kettering Cancer Center 10065 New York United StatesRekrutierend» Google-MapsMSK Evelyn H. Lauder Breast and Imaging Center 10065 New York United StatesRekrutierend» Google-MapsHematology Oncology Associates of Rockland 10960 Nyack United StatesRekrutierend» Google-MapsMSK Nassau 11553 Uniondale United StatesRekrutierend» Google-MapsCancer Centers of Southwest Oklahoma 73505 Lawton United StatesRekrutierend» Google-MapsCancer Centers of Southwest Oklahoma 73506 Lawton United StatesRekrutierend» Google-MapsFrank C Love Cancer Institute 73102 Oklahoma City United StatesRekrutierend» Google-MapsHightower Clinical Trial Services 73102 Oklahoma City United StatesRekrutierend» Google-MapsSSM Health Medical Group - St Anthony 73102 Oklahoma City United StatesRekrutierend» Google-MapsProvidence Cancer Institute Franz Clinic 97213 Portland United StatesNoch nicht rekrutierend» Google-MapsProvidence Portland Medical Center 97213 Portland United StatesNoch nicht rekrutierend» Google-MapsTennessee Oncology, PLLC 37055 Dickson United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37067 Franklin United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37066 Gallatin United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37075 Hendersonville United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37076 Hermitage United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37090 Lebanon United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37129 Murfreesboro United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37203 Nashville United StatesRekrutierend» Google-MapsTennessee Oncology, PLLC 37203 Nashville United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37205 Nashville United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37207 Nashville United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37211 Nashville United StatesRekrutierend» Google-MapsTennessee Oncology, PLLC 37160 Shelbyville United StatesRekrutierend» Google-MapsTennessee Oncology PLLC 37167 Smyrna United StatesRekrutierend» Google-MapsValley Cancer Associates 78550 Harlingen United StatesRekrutierend» Google-MapsThe University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center 75701 Tyler United StatesRekrutierend» Google-MapsHematology Oncology Associates of Fredericksburg 22408 Fredericksburg United StatesRekrutierend» Google-MapsBon Secours Memorial Regional Medical Center 23116 Mechanicsville United StatesRekrutierend» Google-MapsBon Secours Cancer Institute at St. Francis 23114 Midlothian United StatesNoch nicht rekrutierend» Google-MapsBon Secours St. Francis Medical Center 23114 Midlothian United StatesRekrutierend» Google-MapsBon Secours St. Mary's Hospital 23226 Richmond United StatesRekrutierend» Google-MapsWest Virginia University 26506 Morgantown United StatesNoch nicht rekrutierend» Google-MapsFundación Cenit Para La Investigación En Neurociencias 1125 Caba ArgentinaRekrutierend» Google-MapsSanatorio de La Mujer S2000ORE Rosario ArgentinaRekrutierend» Google-MapsCentro Oncologico Korben 1426 Buenos Aires ArgentinaRekrutierend» Google-MapsFundación Respirar C1426ABP Buenos Aires ArgentinaNoch nicht rekrutierend» Google-MapsSunshine Coast University Private Hospital 4575 Birtinya AustraliaNoch nicht rekrutierend» Google-MapsSunshine Coast University Private Hospital 4575 Birtinya AustraliaRekrutierend» Google-MapsIcon Cancer Centre Hobart 7000 Hobart AustraliaRekrutierend» Google-MapsCabrini Hospital -Brighton 3186 Brighton AustraliaRekrutierend» Google-MapsBarwon Health 3220 Geelong AustraliaRekrutierend» Google-MapsCabrini Hospital - Malvern 3144 Malvern AustraliaRekrutierend» Google-MapsAntwerp University Hospital 2650 Edegem BelgiumNoch nicht rekrutierend» Google-MapsCliniques universitaires Saint-Luc 1200 Woluwe-Saint-Lambert BelgiumNoch nicht rekrutierend» Google-MapsGrand Hôpital de Charleroi 6000 Charleroi BelgiumNoch nicht rekrutierend» Google-MapsUZ Leuven 3000 Leuven BelgiumNoch nicht rekrutierend» Google-MapsHospital Santa Rita de Cassia 29041-295 Vitoria BrazilRekrutierend» Google-MapsONCOSITE - Centro de Pesquisa Clinica em Oncologia 98700-000 Ijui BrazilRekrutierend» Google-MapsHospital Moinhos de Vento 90035-001 Porto Alegre BrazilNoch nicht rekrutierend» Google-MapsCentro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa 90110-270 Porto Alegre BrazilRekrutierend» Google-MapsCentro de Pesquisa Clínica - Área Administrativa 90850-170 Porto Alegre BrazilRekrutierend» Google-MapsHospital Mae de Deus 90880-480 Porto Alegre BrazilRekrutierend» Google-MapsFaculdade de Medicina do ABC 09060-650 Santo André BrazilRekrutierend» Google-MapsA. C. Camargo Cancer Center 01509-010 Sao Paulo BrazilRekrutierend» Google-MapsIBCC - Instituto Brasileiro de Controle do Câncer 03102002 São Paulo BrazilRekrutierend» Google-MapsIBCC - Núcleo de Pesquisa e Ensino 04014-002 São Paulo BrazilRekrutierend» Google-MapsComplex Oncology Center - Burgas 8000 Burgas BulgariaRekrutierend» Google-MapsMultiprofile Hospital for Active Treatment Dr. Tota Venkova AD 5300 Gabrovo BulgariaRekrutierend» Google-MapsSpecialized Hospital for Active Treatment of Oncology - Haskovo 6300 Haskovo BulgariaRekrutierend» Google-MapsComplex Oncology Center - Plovdiv EOOD 4004 Plovdiv BulgariaRekrutierend» Google-MapsComplex Oncology Center - Ruse EOOD 7002 Ruse BulgariaRekrutierend» Google-MapsComplex Oncology Center - Vratsa 3000 Vratsa BulgariaRekrutierend» Google-MapsCross Cancer Institute T6G 1Z2 Edmonton CanadaNoch nicht rekrutierend» Google-MapsBC Cancer Surrey V3V 1Z2 Surrey CanadaNoch nicht rekrutierend» Google-MapsThe Moncton Hospital E1C 6Z8 Moncton CanadaRekrutierend» Google-MapsGrand River Hospital N2G 1G3 Kitchener CanadaRekrutierend» Google-MapsSunnybrook Research Institute M4N 3M5 Toronto CanadaNoch nicht rekrutierend» Google-MapsSunnybrook Research Institute M4N 3M5 Toronto CanadaRekrutierend» Google-MapsUnity Health Toronto, St. Michael's Hospital M5B 1W8 Toronto CanadaRekrutierend» Google-MapsUnité de Recherche Clinique du CISSS des Laurentides J7Z 2V4 St-Jerome CanadaRekrutierend» Google-MapsUnité de Recherche Clinique du CISSS des Laurentides J7Z 5T3 St-Jerome CanadaRekrutierend» Google-MapsAnhui Provincial Hospital 230001 Hefei ChinaNoch nicht rekrutierend» Google-MapsAnhui Provincial Cancer Hospital 230031 Hefei ChinaRekrutierend» Google-MapsFujian Medical University Union Hospital-1 Bingfanglou 350001 Fuzhou Fujian ChinaNoch nicht rekrutierend» Google-MapsSun Yat-sen University Cancer Center 510060 Guangzhou ChinaRekrutierend» Google-MapsGuangxi Medical University Affiliated Tumor Hospital 530021 Nanning ChinaRekrutierend» Google-MapsWuhan Union Hospital Cancer Center 430022 Wuhan ChinaRekrutierend» Google-MapsHubei Cancer Hospital 430079 Wuhan ChinaRekrutierend» Google-MapsNanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School 210031 Nanjing ChinaRekrutierend» Google-MapsThe Second Affiliated Hospital of Soochow University 215004 Suzhou ChinaRekrutierend» Google-MapsThe First Affiliated Hospital of Nanchang University 330006 Nanchang ChinaRekrutierend» Google-MapsThe First Hospital of Jilin University 130021 Changchun ChinaNoch nicht rekrutierend» Google-MapsThe First Hospital of China Medical University 110001 Shenyang ChinaRekrutierend» Google-MapsThe Second Affiliated Hospital of Xi'an Jiaotong University 710004 Xi'an ChinaRekrutierend» Google-MapsThe Second Affiliated Hospital of Xi'an Jiaotong University 710004 Xi'an ChinaNoch nicht rekrutierend» Google-MapsThe Second Affiliated Hospital of Xi'an Jiaotong University 710004 Xi'an ChinaRekrutierend» Google-MapsShandong Cancer Hospital 250117 Jinan ChinaNoch nicht rekrutierend» Google-MapsRuijin Hospital Shanghai Jiaotong University School of Medicine 200025 Shanghai ChinaNoch nicht rekrutierend» Google-MapsFudan University Shanghai Cancer Center 200032 Shanghai ChinaRekrutierend» Google-MapsYunnan Province Cancer Hospital 650106 Kunming ChinaNoch nicht rekrutierend» Google-MapsSir Run Run Shaw Hospital of Zhejiang University School of Medicine 310016 Hangzhou ChinaRekrutierend» Google-MapsZhejiang Cancer Hospital 310022 Hangzhou ChinaNoch nicht rekrutierend» Google-MapsThe Second Affiliated hospital of Zhejiang University school of medicine 310052 Hangzhou ChinaRekrutierend» Google-MapsHenan Cancer Hospital 450008 Zhengzhou ChinaRekrutierend» Google-MapsFakultní nemocnice Brno Bohunice 625 00 Brno CzechiaRekrutierend» Google-MapsFakultni Thomayerova nemocnice 14059 Prague CzechiaRekrutierend» Google-MapsFakultni nemocnice Bulovka 180 81 Prague CzechiaRekrutierend» Google-MapsFakultni nemocnice Olomouc 779 00 Olomouc CzechiaRekrutierend» Google-MapsFakultni nemocnice Kralovske Vinohrady 10034 Praha 10 CzechiaRekrutierend» Google-MapsTampereen yliopistollinen sairaala 33520 Tampere FinlandNoch nicht rekrutierend» Google-MapsVaasan Keskussairaala 65130 Vaasa FinlandNoch nicht rekrutierend» Google-MapsOulun yliopistollinen sairaala 90220 Oulu FinlandNoch nicht rekrutierend» Google-MapsSatakunnan Keskussairaala 28500 Pori FinlandNoch nicht rekrutierend» Google-MapsCentre Georges François Leclerc 21079 Dijon FranceRekrutierend» Google-MapsInstitut de Cancérologie de l'Ouest 44805 Saint Herblain FranceRekrutierend» Google-MapsInstitut de Cancérologie de l'Ouest 49055 ANGERS cedex 02 FranceRekrutierend» Google-MapsCentre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne 63011 Clermont-Ferrand FranceRekrutierend» Google-MapsCentre Hospitalier Universitaire de Poitiers 86021 Poitiers FranceRekrutierend» Google-MapsHenri Mondor Hospital 94000 Créteil FranceRekrutierend» Google-MapsUniversity Hospital of Patras 26504 Patras GreeceRekrutierend» Google-MapsAlexandra General Hospital of Athens 115 28 Athens GreeceRekrutierend» Google-MapsAttikon General University Hospital 12462 Chaidari/Athens GreeceNoch nicht rekrutierend» Google-MapsUniversity General Hospital of Heraklion 715 00 Heraklion GreeceNoch nicht rekrutierend» Google-MapsUniversity General Hospital of Larissa 41110 Larissa GreeceRekrutierend» Google-MapsBudapesti Uzsoki Utcai Kórház 1145 Budapest HungaryNoch nicht rekrutierend» Google-MapsCity Cancer Centre - Vijayawada 520002 Vijayawada IndiaRekrutierend» Google-MapsHcg Pet Imaging Centre 520002 Vijayawada IndiaRekrutierend» Google-MapsAll India Institute of Medical Sciences 110029 New Delhi IndiaNoch nicht rekrutierend» Google-MapsRajiv Gandhi Cancer Institute And Research Centre 110085 New Delhi IndiaRekrutierend» Google-MapsArtemis hospital 122001 Gurgaon IndiaRekrutierend» Google-MapsTata Memorial Hospital 400012 Mumbai IndiaNoch nicht rekrutierend» Google-MapsHCG Manavata Cancer Centre 422002 Nashik IndiaRekrutierend» Google-MapsSahyadri Super Speciality Hospital, Hadapsar 411028 Pune IndiaNoch nicht rekrutierend» Google-MapsBhakti Vedanta Hospital and Research Institute 401107 Thane IndiaRekrutierend» Google-MapsInstitute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital 700020 Kolkata IndiaRekrutierend» Google-MapsRabin Medical Center 4941492 Petah Tikva IsraelRekrutierend» Google-MapsKaplan Medical Center 7610001 Rehovot IsraelRekrutierend» Google-MapsYitzhak Shamir Medical Center 70300 Zerifin IsraelRekrutierend» Google-MapsIstituto Nazionale Tumori IRCCS Fondazione Pascale 80131 Napoli ItalyRekrutierend» Google-MapsHumanitas Istituto Clinico Catanese 95045 Misterbianco ItalyRekrutierend» Google-MapsIRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola 40138 Bologna ItalyRekrutierend» Google-MapsFondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuor 00168 Roma ItalyRekrutierend» Google-MapsFondazione IRCCS San Gerardo dei Tintori 20900 Monza ItalyRekrutierend» Google-MapsAzienda Ospedaliero Universitaria delle Marche 60126 Ancona ItalyRekrutierend» Google-MapsAzienda Ospedaliero Universitaria Pisana 56126 Pisa ItalyRekrutierend» Google-MapsOspedale Generale Provinciale Macerata 62100 Macerata ItalyRekrutierend» Google-MapsIstituto Europeo di Oncologia IRCCS 20141 Milano ItalyRekrutierend» Google-MapsIstituto Oncologico Veneto IRCCS 35128 Padova ItalyRekrutierend» Google-MapsAichi Cancer Center Hospital 464-8681 Nagoya JapanRekrutierend» Google-MapsNagoya University Hospital 466-8560 Nagoya JapanRekrutierend» Google-MapsNagoya City University Hospital 467-8602 Nagoya JapanRekrutierend» Google-MapsChiba cancer center 260-8717 Chiba-shi JapanRekrutierend» Google-MapsNational Cancer Center Hospital East 277-8577 Kashiwa JapanRekrutierend» Google-MapsNational Hospital Organization Hokkaido Cancer Center 003-0804 Sapporo JapanRekrutierend» Google-MapsKanagawa cancer center 2418515 Yokohama JapanRekrutierend» Google-MapsOsaka University Hospital 565-0871 Suita JapanRekrutierend» Google-MapsSaitama Prefectural Cancer Center 362-0806 Ina-machi JapanRekrutierend» Google-MapsJuntendo University Hospital 113-8431 Bunkyo-ku JapanRekrutierend» Google-MapsTokyo Metropolitan Komagome Hospital, Department of Breast Surgery 113-8677 Bunkyo-ku JapanRekrutierend» Google-MapsCancer Institute Hospital of JFCR 135-8550 Koto-ku JapanRekrutierend» Google-MapsJapanese Foundation for Cancer Research 135-8550 Koto JapanRekrutierend» Google-MapsNational Center for Global Health and Medicine 162-8655 Shinjuku City JapanRekrutierend» Google-MapsCenter Hospital of the National Center for Global Health and Medicine 162-8655 Shinjuku-ku JapanRekrutierend» Google-MapsCenter Hospital of the National Center for Global Health and Medicine 162-8655 Shinjyuku-ku JapanRekrutierend» Google-MapsNational Hospital Organization Kyushu Cancer Center 811-1395 Fukuoka JapanRekrutierend» Google-MapsSagara Hospital 892-0833 Kagoshima JapanRekrutierend» Google-MapsOkayama University Hospital 700-8558 Okayama JapanRekrutierend» Google-MapsJuntendo University Hospital 113-8431 Tokyo JapanRekrutierend» Google-MapsGachon University Gil Medical Center 21565 Namdong-gu Korea, Republic ofRekrutierend» Google-MapsNational Cancer Center 10408 Goyang-si Korea, Republic ofRekrutierend» Google-MapsSeoul National University Bundang Hospital 13620 Seongnam Korea, Republic ofRekrutierend» Google-MapsAjou University Hospital 16499 Suwon Korea, Republic ofRekrutierend» Google-MapsKorea University Anam Hospital 02841 Seoul Korea, Republic ofRekrutierend» Google-MapsSeoul National University Hospital 03080 Seoul Korea, Republic ofRekrutierend» Google-MapsSeverance Hospital, Yonsei University Health System 03722 Seoul Korea, Republic ofRekrutierend» Google-MapsAsan Medical Center 05505 Seoul Korea, Republic ofRekrutierend» Google-MapsGangnam Severance Hospital, Yonsei University Health System 06273 Seoul Korea, Republic ofRekrutierend» Google-MapsSamsung Medical Center 06351 Seoul Korea, Republic ofRekrutierend» Google-MapsThe Catholic Univ. of Korea Seoul St. Mary's Hospital 06591 Seoul Korea, Republic ofRekrutierend» Google-MapsEwha Womans University Mokdong Hospital Seoul Korea, Republic ofRekrutierend» Google-MapsAkershus Universitetssykehus 1474 Lorenskog NorwayNoch nicht rekrutierend» Google-MapsDrammen Sykehus, Vestre Viken HF 3004 Drammen NorwayNoch nicht rekrutierend» Google-MapsNarodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie 02-781 Warszawa PolandNoch nicht rekrutierend» Google-MapsCentrum Badań Klinicznych Jagiellońskie Centrum Innowacji sp. z o.o. 30-348 Kraków PolandRekrutierend» Google-MapsKLIMED Marek Klimkiewicz 15-704 Białystok PolandRekrutierend» Google-MapsCOPERNICUS PL, Wojewodzkie Centrum Onkologii 80-219 Gdansk PolandRekrutierend» Google-MapsCentrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna 90-338 Lodz PolandRekrutierend» Google-MapsPuerto Rico Medical Research Center 00917 Hato Rey Puerto RicoRekrutierend» Google-MapsPan American Center for Oncology Trials, LLC 00935 Rio Piedras Puerto RicoRekrutierend» Google-MapsPan American Center for Oncology Trials- Hospital Oncologico 00935 Rio Piedras Puerto RicoRekrutierend» Google-MapsAuxilio Mutuo Cancer Center 00917 San Juan Puerto RicoNoch nicht rekrutierend» Google-MapsFDI Clinical Research 00927 San Juan Puerto RicoRekrutierend» Google-MapsOnkologicky ustav sv. Alzbety, s.r.o. 812 50 Bratislava SlovakiaRekrutierend» Google-MapsNarodny onkologicky ustav 833 10 Bratislava SlovakiaRekrutierend» Google-MapsVychodoslovensky onkologicky ustav, a.s. 04191 Kosice SlovakiaRekrutierend» Google-MapsNemocnica s poliklinikou Stefana Kukuru Michalovce, a.s. 07101 Michalovce SlovakiaRekrutierend» Google-MapsNemocnica na okraji mesta n o 95801 Partizanske SlovakiaRekrutierend» Google-MapsFakultna nemocnica s poliklinikou J.A. 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1. Progression Free Survival (PFS) (Time Frame - From randomization date (every 8 weeks for the first 48 weeks and then every 12 weeks thereafter) to date of first documentation of progression OR death (approximately 2 years).): Progression-free survival is defined as the time interval from the date of randomization to the date of first documented tumor progression determined by blinded independent central review (BICR) assessment as per Response Evaluation Criteria in Solid Tumors (RECIST 1.1) or death due to any cause, whichever come first.
Secondary outcome:
1. Overall survival (OS) (Time Frame - From randomization date (every 3 months) to date of death (approximately 3 years)): Overall survival is defined as the time interval from the date of randomization to the date of documented death due to any cause.
2. Objective Response Rate (ORR) (Time Frame - From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) to the date of progression OR death (approximately to 2 years).): Objective response rate is defined as the proportion of participants who have a confirmed CR or PR, as best overall response assessed by BICR as per RECIST 1.1, from the date of randomization to the date of disease progression, death due to any cause, whichever occurs first.
3. Duration of response (DR) (Time Frame - From the date of the first objective response (every 8 weeks during the first 48 weeks and then every 12 week) to the date of disease progression or death (approximately to 2 years).): Duration of response is defined as the time from first documented evidence of CR or PR until progressive disease (PD) as determined by BICR assessment as per RECIST 1.1 or death due to any cause, whichever occurs first.
4. Clinical Benefit Rate (Time Frame - From randomization date (every 8 weeks during the first 48 weeks and then every 12 weeks) to the date of progression or death (approximately to 2 years).): Clinical benefit rate is defined as the proportion of participants who have a confirmed CR, PR at any time, or SD or nonCR/non PD for at least 24 weeks determined by BICR assessment as per RECIST 1.1, from the date of randomization until disease progression, death due to any cause, whichever occurs first.
5. Number of participants with treatment emergent adverse events (TEAEs), serious adverse events (SAEs), electrocardiogram (ECG) and laboratory abnormalities (Time Frame - From screening until 28 days after the last dose (approximately 2 years).): Incidence of participants with TEAEs, SAEs ECGs and laboratory abnormalities. TEAE/SAE and laboratory abnormalities will be graded according to NCI CTCAE V5.
6. QT Interval (QTc) (Time Frame - From baseline to end of treatment (approximately 2 years).): Triplicate 12-lead electrocardiogram (ECG) measurements (each recording separated by approximately 2 minutes) are performed.
7. Plasma Concentration Versus Time of ARV-471 (Time Frame - From randomization date up to cycle 7 (each cycle is 28 days).): Plasma concentrations of ARV-471
8. Health state utility and health status will be assessed using the European Quality of Life Group questionnaire with 5 dimensions and 5 levels per dimension (EQ-5D-5L) (Time Frame - From screening and every cycle until cycle 6 (each cycle is 28 days), and then every other cycle until 28 days after the last dose (approximately 2 years).): Change from baseline and time to deterioration between treatment comparison in Quality of Life using the EQ-5D 5L questionnaire.
9. Disease-related Quality of Life will be assessed using the European Organization for Research and Treatment of Cancer (EORTC) core quality of life questionnaire (QLQ-C30) (Time Frame - From screening and every cycle until cycle 6 (each cycle is 28 days), and then every other cycle until 28 days after the last dose (approximately 2 years).): Change from baseline and time to deterioration between treatment comparison in Quality of Life using the EORTC QLQ-C30 questionnaire.
10. Disease- and treatment-related Quality of Life will be assessed using the European Organization for Research and Treatment of Cancer (EORTC) breast cancer module (QLQ-BR23) questionnaire (Time Frame - From screening and every cycle until cycle 6 (each cycle is 28 days), and then every other cycle until 28 days after the last dose (approximately 2 years).): Change from baseline and time to deterioration between treatment comparison in Quality of Life Using the EORTC QLQ-BR23 (Breast) questionnaire.
11. Clinical Pain and its impact on functioning will be assessed using Brief Pain Inventory Short Form (BPI-SF) questionnaire. (Time Frame - From screening and every cycle until cycle 6 (cycle=28 days) and then every other cycle until 28 days after the last dose (appr. 2 yrs).The modified BPI-SF (worst pain severity and pain interference) daily from baseline until the EOT (appr 2 yrs)): Change from baseline and time to deterioration between treatment comparison in Brief Pain Inventory Short Form questionnaire.
12. circulating deoxyribonucleic acid (DNA) (Time Frame - From baseline to end of treatment (approximately 2 years).): Quantitative changes from baseline
