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JOURNAL ONKOLOGIE – STUDIE

Atezolizumab Plus 8 Gy Single-fraction Radiotherapy for Advanced Oligoprogressive NSCLC

Rekrutierend

NCT-Nummer:
NCT04549428

Studienbeginn:
Oktober 2020

Letztes Update:
27.04.2022

Wirkstoff:
Atezolizumab

Indikation (Clinical Trials):
Carcinoma, Non-Small-Cell Lung

Geschlecht:
Alle

Altersgruppe:
Erwachsene (18+)

Phase:
Phase 2

Sponsor:
Oncology Institute of Southern Switzerland

Collaborator:
Ente Ospedaliero Cantonale, Bellinzona, Istituto Cantonale di Patologia, Clinical Trial Unit Ente Ospedaliero Cantonale,

Studienleiter

Luciano Wannesson, MD
Principal Investigator
Oncology Institute of Southern Switzerland

Kontakt

Studienlocations
(3 von 3)

Oncology Institute of Southern Switzerland
6500 Bellinzona
SwitzerlandRekrutierend» Google-Maps
Ansprechpartner:
Luciano Wannesson, MD
Phone: +41 (0)91 811 87 56
E-Mail: luciano.wannesson@eoc.ch» Ansprechpartner anzeigen

Studien-Informationen

Detailed Description:

Atezolizumab will be administered at a fixed dose of 1,200 mg by intravenous infusion every

21 days on an outpatient basis according to the its approved prescribing information.

Palliative radiation therapy will be delivered concomitant to the 2nd dose of atezolizumab as

a single fraction of 8 Gy to all eligible metastatic and primary sites.

Ein-/Ausschlusskriterien

Inclusion Criteria

1. Signed Informed Consent Form

2. Male or female aged ≥ 18 years

3. Ability to comply with the procedures of the study protocol, in the investigator's

judgment

4. Histologically or cytologically confirmed diagnosis of metastatic (Stage IV) NSCLC as

per the American Joint Committee on Cancer (AJCC) 8th edition

5. No sensitizing EGFR mutation (L858R or exon 19 deletions), ALK fusion oncogene or ROS1

rearrangement detected

6. Progressing to one line of chemotherapy defined as follows:a) A platinum-doublet.

b) In case of patients being ineligible for platinum-containing regimens but otherwise

compliant with the other inclusion-exclusion criteria of the present study, at least

one line of mono-chemotherapy is required.

c) As an exception, patients with oligoprogression to anti PD-1 agents alone for whom

the investigator considers local treatment of metastases and continuation of

immunotherapy appropriate (i.e. would not be eligible for 2nd line treatment) may be

enrolled without a previous line of chemotherapy. In this case, approval by the

Project Leader is necessary.

7. Progressing to an anti-PD-1 agent, either associated to chemotherapy or as monotherapy

(e.g., pembrolizumab or nivolumab)

8. Life expectancy ≥ 8 weeks

9. Patients with treated, asymptomatic central nervous system (CNS) metastases are

eligible, provided they meet all of the following criteria:

1. Measurable disease outside CNS.

2. Only supratentorial and cerebellar metastases allowed (i.e., no metastases to

midbrain, pons, medulla or spinal cord).

3. No ongoing requirement for corticosteroids as therapy for CNS disease;

anticonvulsants at a stable dose allowed.

4. No stereotactic radiation within 7 days or whole-brain radiation within 14 days

prior to initiating study treatment.

5. No evidence of interim progression between the completion of CNS-directed therapy

and the screening radiographic study.

6. Patients with new asymptomatic CNS metastases detected at the screening scan must

receive radiation therapy and/or surgery for CNS metastases. Following treatment,

these patients may then be eligible without the need for an additional brain scan

prior to initiating study treatment, if all other criteria are met, including

clinical confirmation of no evidence of interim disease progression

10. Measurable disease by RECIST v1.1. Previously irradiated lesions can only be

considered as measurable disease if disease progression has been unequivocally

documented at that site since radiation and the previously irradiated lesion is not

the only site of disease.

11. Oligoprogressive disease defined as follows:

1. A minimum of 1 and a maximum of 4 progressing lesions (with up to 3 total organs

and 3 lesions per organ, except skeletal lesions) as assessed by a Positron

Emission Tomography-Computed Tomography (PET-CT) scan (contrast enhanced).

2. Definition of progression is made by RECIST 1.1 criteria (new lesions or

increased pre-existing ones).

12. Adequate hematologic and end organ function, defined by the following laboratory

results obtained within 14 days prior to initiating study treatment:

a) Absolute neutrophil count ≥ 1,500 cells/μL without granulocyte colony-stimulating

factor support b) White blood cell (WBC) counts > 2,500/μL c) Lymphocyte count >

500/μL d) Serum albumin > 2.5 g/dL e) Platelet count ≥ 100,000/μL without transfusion

within 2 weeks of laboratory test used to determine eligibility f) Hemoglobin ≥ 9.0

g/dL, patients may be transfused or receive erythropoietic treatment to meet this

criterion g) Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and

alkaline phosphatase (ALK) ≤ 2.5 × ULN with the following exceptions: patients with

documented liver metastases: AST and/or ALT ≤ 5 × ULN; patients with documented liver

or bone metastases: ALK ≤ 5 × ULN.

h) Serum bilirubin ≤ 1.5 × ULN. Patients with known Gilbert's syndrome who have serum

bilirubin level ≤ 3 × ULN may be enrolled i) Serum creatinine ≤ 1.5 × ULN

13. For female patients of childbearing potential agreement to remain abstinent (refrain

from heterosexual intercourse) or to use highly effective form(s) of contraceptive

methods that result in a failure rate of < 1% per year when used consistently and

correctly during the treatment period and for at least 5 months after the last dose of

atezolizumab.

1. A woman is considered to be of childbearing potential if she is postmenarcheal,

has not reached a postmenopausal state (≥ 12 continuous months of amenorrhea with

no identified cause other than menopause), and has not undergone surgical

sterilization (removal of ovaries and/or uterus)

2. Examples of contraceptive methods with a failure rate of < 1% per year include

bilateral tubal ligation, male sterilization, and established, proper use of

hormonal contraceptives that inhibit ovulation (combined estrogen and progestogen

containing hormonal contraception, or progestogen-only hormonal contraception

associated with inhibition of ovulation together with another additional barrier

method always containing a spermicide), hormone-releasing intrauterine devices,

and copper intrauterine devices

3. The reliability of sexual abstinence should be evaluated in relation to the

duration of the clinical trial and the preferred and usual lifestyle of the

patient. Periodic abstinence (e.g., calendar, ovulation, symptothermal, or

postovulation methods) and withdrawal are not acceptable methods of

contraception.

4. Oral contraception should always be combined with an additional contraceptive

method because of a potential interaction with the study drug.

5. Women who are not postmenopausal (≥ 12 months of non-therapy-induced amenorrhea)

or surgically sterile must have a negative serum pregnancy test result within 14

days prior to initiation of study drug.

Exclusion criteria

Cancer-specific exclusion criteria

1. Patients with an ECOG Performance status >2

2. Active or untreated CNS metastases as determined by Computed Tomography (CT) or

magnetic resonance imaging (MRI) evaluation of the brain during screening and prior

radiographic assessments

3. Spinal cord compression not definitively treated with surgery and/or radiation or

previously diagnosed and treated spinal cord compression without evidence that disease

has been clinically stable for > 2 weeks prior to initiating study treatment

4. Leptomeningeal disease.

5. Uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent

drainage procedures (once monthly or more frequently). Patients with indwelling

catheters (e.g., PleurX®) are allowed.

6. Uncontrolled hypercalcemia (>1.5 mmol/L ionized calcium or >3 mmol/L of corrected

serum calcium) or symptomatic hypercalcemia requiring continued use of bisphosphonate

therapy or denosumab (patients who are receiving bisphosphonate therapy or denosumab

specifically to prevent skeletal events and who do not have a history of clinically

significant hypercalcemia are eligible; patients who are receiving denosumab to

prevent or for mild hypercalcemia prior to enrollment must be willing and eligible to

discontinue its use and replace it with a bisphosphonate instead while on study.)

7. History of other malignancy within 5 years prior to screening, with the exception of

those with a negligible risk of metastasis or death (e.g. expected 5-year OS > 90%)

treated with expected curative outcome (such as adequately treated carcinoma in situ

of the cervix, basal or squamous cell skin cancer, localized prostate cancer treated

with curative intent, breast ductal carcinoma in situ treated surgically with curative

intent).

8. NCI CTCAE Grade 3 or higher toxicities due to any prior therapy (e.g., radiotherapy)

(excluding alopecia), which have not shown improvement and are strictly considered to

interfere with current study medication, with special focus on prior toxicity to

anti-PD1 agents.

General medical exclusion criteria

1. Women who are pregnant or lactating, or intending to become pregnant during the study.

Women of childbearing potential including women who have had a tubal ligation, must

have a negative serum pregnancy test result within 14 days prior to initiation of

study drug.

2. History of autoimmune disease. Exceptions are:

a) Patients with a history of autoimmune-related hypothyroidism on a stable dose of

thyroid-replacement hormone may be eligible for this study.

b) Patients with controlled Type I diabetes mellitus on a stable dose of insulin

regimen are eligible for this study.

c) Patients with eczema, psoriasis, lichen simplex chronicus, or vitiligo with

dermatologic manifestations only (e.g., patients with psoriatic arthritis would be

excluded) are permitted provided that they meet the following conditions:

- Rash must cover less than 10% of body surface area (BSA)

- Disease is well controlled at baseline and only requiring low potency topical

steroids

- No acute exacerbations of underlying condition within the last 12 months

requiring treatment with either psoralen plus ultraviolet radiation (PUVA),

methotrexate, retinoids, biologic agents, oral calcineurin inhibitors or high

potency or oral steroids

3. History of idiopathic pulmonary fibrosis (IPF), organizing pneumonia (e.g.,

bronchiolitis obliterans), drug-induced pneumonitis, idiopathic pneumonitis, or

evidence of active pneumonitis on screening chest CT scan. History of radiation

pneumonitis in the radiation field (fibrosis) is permitted.

4. Known positivity for human immunodeficiency virus (HIV)

a) Testing is not required in the absence of clinical symptoms and signs suggestive of

HIV infection.

b) Patients with a past history of/or symptoms of HIV are eligible only if serological

tests are negative.

5. Known active hepatitis B (chronic or acute; defined as having a positive hepatitis B

surface antigen [HBsAg] test at screening) or known active hepatitis C a) Patients

with past hepatitis B virus (HBV) infection or resolved HBV infection (defined as the

presence of hepatitis B core antibody [HBcAb] and hepatitis B surface antibody [HBsAb]

and absence of HBsAg) are eligible. HBV DNA test must be performed if HBcAb is

positive and HBsAb and HBsAg are negative, and in this case, a positive viremia

excludes the patient from eligibility. Patients positive for hepatitis C virus (HCV)

antibody are eligible only if polymerase chain reaction is negative for HCV RNA.

6. Severe infections within 4 weeks prior to initiating study treatment, including but

not limited to hospitalization for complications of infection, bacteremia, or severe

pneumonia

7. Significant cardiovascular disease, such as New York Heart Association (NYHA) cardiac

disease (Class II or greater), myocardial infarction within 3 months prior to

initiating study treatment, unstable arrhythmias, or unstable angina.

a) Patients with known coronary artery disease, congestive heart failure not meeting

the above criteria, or left ventricular ejection fraction (LVEF) < 50% must be on a

stable medical regimen that is optimized in the opinion of the treating physician, in

consultation with a cardiologist if appropriate.

8. Major surgical procedure other than for diagnosis within 4 weeks prior to initiating

study treatment or anticipation of need for a major surgical procedure during the

course of the study

9. Prior allogeneic bone marrow transplantation or solid organ transplant

10. Any serious medical condition (including metabolic dysfunction, physical examination

finding) or abnormality in clinical laboratory tests that, in the investigator's

judgment, precludes the patient's safe participation in and completion of the study or

that may affect the interpretation of the results or render the patient at high risk

for treatment complications

11. Patients with an illness or condition that may interfere with capacity or compliance

with the study protocol, as per investigator's judgment

12. Treatment with any other investigational agent or participation in another clinical

study with therapeutic intent for the lung cancer within 28 days prior to initiating

study treatment

Exclusion criteria related to atezolizumab

1. History of severe allergic, anaphylactic, or other hypersensitivity reactions to

chimeric or humanized antibodies or fusion proteins

2. Known hypersensitivity to biopharmaceuticals produced in Chinese hamster ovary cells

or any component of the atezolizumab formulation

3. Oral or IV antibiotic treatment. Patients will thus need to have recovered from any

infection requiring antibiotics. Patients receiving prophylactic antibiotics (e.g.,

for prevention of a urinary tract infection or to prevent chronic obstructive

pulmonary disease exacerbation) are eligible.

4. Administration of a live, attenuated vaccine within 4 weeks before initiating study

treatment or anticipation that such a live attenuated vaccine will be required during

the study a) Influenza vaccination is allowed, but should be given during influenza

season. However, patients must not receive live, attenuated influenza vaccine (e.g.,

FluMist®) within 4 weeks prior to initiating study treatment, at any time during the

study or within 5 months after the last atezolizumab dose.

5. Prior treatment with CD137 agonists or anti-PD-L1 therapeutic antibodies. Patients who

have had prior anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) treatment may

be enrolled, provided the following requirements are met:

a) Minimum of 6 weeks from the last dose of anti-CTLA-4 b) No history of severe immune

related adverse effects from anti-CTLA-4 (NCI CTCAE Grade 3 and 4)

6. Treatment with systemic corticosteroids or other immunosuppressive medications

(including but not limited to prednisone, dexamethasone, cyclophosphamide,

azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [anti-TNF]

agents)

7. Patients who have received acute, low-dose, systemic immunosuppressant medications

(e.g., a one-time dose of dexamethasone for nausea) may be enrolled in the study after

discussion with and approval by the Medical Monitor.

a) The use of inhaled corticosteroids for chronic obstructive pulmonary disease,

mineralocorticoids (e.g., fludrocortisone) for patients with orthostatic hypotension,

and low-dose supplemental corticosteroids for adrenocortical insufficiency are

allowed.

8. Patients with history of allergic reaction to IV contrast requiring steroid

pre-treatment should have baseline and subsequent tumor assessments done by MRI.

9. Patients not willing to stop treatment with traditional herbal medicines

Exclusion criteria related to radiotherapy

1. Previously irradiated lesions having received the maximum permissible dose.

Studien-Rationale

Primary outcome:

1. Objective Response Rate (Time Frame - 3 months):
Percentage of patients with a complete response or partial response



Secondary outcome:

1. Overall Survival (Time Frame - 12 months):
Time in months from the first day of study treatment to the date of death

2. Progression Free-Survival (Time Frame - 12 months):
Time in months from the first day of study treatment until the first evidence of tumour progression

Geprüfte Regime

  • Atezolizumab (Tecentriq):
    Intravenous infusion every 21 days, until disease progression, intolerance or loss of clinical benefit.

Quelle: ClinicalTrials.gov


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