JOURNAL ONKOLOGIE – STUDIE
A Study of Belzutifan (MK-6482) Versus Everolimus in Participants With Advanced Renal Cell Carcinoma (MK-6482-005)
Rekrutierend
NCT-Nummer:
NCT04195750
Studienbeginn:
Februar 2020
Letztes Update:
14.01.2021
Wirkstoff:
Everolimus, Belzutifan
Indikation (Clinical Trials):
Carcinoma, Carcinoma, Renal Cell
Geschlecht:
Alle
Altersgruppe:
Erwachsene (18+)
Phase:
Phase 3
Sponsor:
Merck Sharp & Dohme Corp.
Collaborator:
-
Studienleiter
Study Director
Merck Sharp & Dohme Corp.
Kontakt
Kontakt:
Phone: 1-888-577-8839
E-Mail: Trialsites@merck.com» Kontaktdaten anzeigen
Studienlocations (3 von 136)
Universitaetsklinik fuer Urologie ( Site 0405)
72076 Tuebingen
(Baden-Württemberg)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4970712980349» Ansprechpartner anzeigenUniversitaetsklinikum Essen ( Site 0401)
45122 Essen
(Nordrhein-Westfalen)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +492017233213» Ansprechpartner anzeigenUniversitaetsklinikum Carl Gustav Carus Dresden ( Site 0403)
01307 Dresden
(Sachsen)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +493514582447» Ansprechpartner anzeigen
72076 Tuebingen
(Baden-Württemberg)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4970712980349» Ansprechpartner anzeigenUniversitaetsklinikum Essen ( Site 0401)
45122 Essen
(Nordrhein-Westfalen)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +492017233213» Ansprechpartner anzeigenUniversitaetsklinikum Carl Gustav Carus Dresden ( Site 0403)
01307 Dresden
(Sachsen)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +493514582447» Ansprechpartner anzeigen
Universitaetsklinikum Jena ( Site 0402)
07747 Jena
(Thüringen)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4936419329901» Ansprechpartner anzeigenUniversitaetsmedizin Berlin ( Site 0400)
10117 Berlin
(Berlin)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4930450515288» Ansprechpartner anzeigenUniversitatsklinikum Hamburg-Eppendorf ( Site 0408)
20246 Hamburg
(Hamburg)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4915222815585» Ansprechpartner anzeigenUniversity of Alabama - Birmingham ( Site 1538)
35294 Birmingham
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 205-975-0370» Ansprechpartner anzeigenSt Joseph Heritage Healthcare ( Site 1531)
95403 Santa Rosa
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 707-521-3830» Ansprechpartner anzeigenUniversity Of Colorado ( Site 1540)
80045 Aurora
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 720-848-1776» Ansprechpartner anzeigenUCHealth Highlands Ranch Hospital ( Site 1560)
80129 Highlands Ranch
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 720-848-1776» Ansprechpartner anzeigenSibley Memorial Hospital ( Site 1559)
20016 Washington
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 202-660-6500» Ansprechpartner anzeigenNorthwest Georgia Oncology Centers PC ( Site 1520)
30060 Marietta
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 770-333-2161» Ansprechpartner anzeigenThe University of Chicago Medical Center ( Site 1539)
60637 Chicago
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 773-702-3498» Ansprechpartner anzeigenOchsner Medical Center ( Site 1522)
70121 New Orleans
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 504-842-3682» Ansprechpartner anzeigenSidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 1514)
21287 Baltimore
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 443-287-7790» Ansprechpartner anzeigenMassachusetts General Hospital ( Site 1558)
02114 Boston
United StatesRekrutierend» Google-Maps
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Phone: 617-643-0202» Ansprechpartner anzeigenBeth Israel Deaconess Medical Center ( Site 1501)
02215 Boston
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 617-975-7412» Ansprechpartner anzeigenDana Farber Cancer Institute ( Site 1505)
02215 Boston
United StatesRekrutierend» Google-Maps
Ansprechpartner:
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Phone: 877-338-7425» Ansprechpartner anzeigenHenry Ford Cancer Center ( Site 1511)
48202 Detroit
United StatesRekrutierend» Google-Maps
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Phone: 313-916-8862» Ansprechpartner anzeigenHattiesburg Clinic ( Site 1509)
39401 Hattiesburg
United StatesRekrutierend» Google-Maps
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Phone: 601-288-2495» Ansprechpartner anzeigenSt. Vincent Frontier Cancer Center ( Site 1549)
59102 Billings
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Phone: 406-238-6290» Ansprechpartner anzeigenJohn Theurer Cancer Center at Hackensack University Med Ctr ( Site 1513)
07601 Hackensack
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Study Coordinator
Phone: 551-996-1379» Ansprechpartner anzeigenUniversity of Rochester Medical Center ( Site 1543)
14620 Rochester
United StatesRekrutierend» Google-Maps
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Phone: 585-276-4415» Ansprechpartner anzeigenUniversity of North Carolina at Chapel Hill ( Site 1537)
27215 Chapel Hill
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Phone: 919-966-4432» Ansprechpartner anzeigenOncology Hematology Care, Inc. ( Site 1524)
45242 Cincinnati
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Ansprechpartner:
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Phone: 513-751-2273» Ansprechpartner anzeigenCleveland Clinic ( Site 1504)
44195 Cleveland
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Phone: 216-445-6592» Ansprechpartner anzeigenOklahoma Cancer Specialists and Research Institute, LLC ( Site 1523)
74146 Tulsa
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Phone: 918-505-3200» Ansprechpartner anzeigenOregon Health & Science University ( Site 1553)
97239 Portland
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Phone: 503-494-0703» Ansprechpartner anzeigenAbramson Cancer Center ( Site 1525)
19104 Philadelphia
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Phone: 267-581-6080» Ansprechpartner anzeigenFox Chase Cancer Center ( Site 1506)
19111 Philadelphia
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Phone: 215-728-3889» Ansprechpartner anzeigenMedical University of South Carolina ( Site 1518)
29425 Charleston
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Phone: 843-792-9007» Ansprechpartner anzeigenHenry Joyce Cancer Clinic ( Site 1544)
37232 Nashville
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Phone: 800-811-8480» Ansprechpartner anzeigenTexas Oncology-Austin Central ( Site 1533)
78731 Austin
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Phone: 512-427-9467» Ansprechpartner anzeigenTexas Oncology, P.A.-Dallas ( Site 1534)
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30130-090 Belo Horizonte
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01321-030 Sao Paulo
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Phone: +1 905 387-9495» Ansprechpartner anzeigenSunnybrook Research Institute ( Site 0153)
M4N 3M5 Toronto
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Phone: +1 416-480-5000» Ansprechpartner anzeigenCHU de Quebec-Universite Laval-Hotel Dieu de Quebec ( Site 0152)
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Phone: 418525444420414» Ansprechpartner anzeigenSociedad de Investigaciones Medicas Limitadas ( Site 0004)
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Phone: 56452982404» Ansprechpartner anzeigenBradfordhill ( Site 0003)
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Phone: +56954240753» Ansprechpartner anzeigenFundacion Centro de Investigacion Clinica CIC ( Site 1703)
050021 Medellin
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Study Coordinator
Phone: 573137431031» Ansprechpartner anzeigenSociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 1709)
200001 Valledupar
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Phone: +5755602310» Ansprechpartner anzeigenAdministradora Country SA - Clinica del Country ( Site 1701)
110221 Bogota
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Phone: +573153679697» Ansprechpartner anzeigenClinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 1702)
110311 Bogota
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Phone: +573103469453» Ansprechpartner anzeigenOncologos del Occidente S.A. ( Site 1708)
660001 Pereira
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Phone: +573187715522» Ansprechpartner anzeigenMasarykuv onkologicky ustav ( Site 0105)
656 53 Brno
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Phone: +420543136226» Ansprechpartner anzeigenFakultni nemocnice Ostrava ( Site 0103)
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Phone: +420721782888» Ansprechpartner anzeigenFakultni nemocnice Hradec Kralove ( Site 0106)
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Phone: +420495832176» Ansprechpartner anzeigenFakultni nemocnice Olomouc ( Site 0104)
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Phone: +420588444295» Ansprechpartner anzeigenFakultni nemocnice Kralovske Vinohrady ( Site 0102)
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Phone: +420775154635» Ansprechpartner anzeigenThomayerova nemocnice ( Site 0107)
140 59 Praha 4
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Phone: +420261083530» Ansprechpartner anzeigenHerlev Hospital ( Site 0251)
2730 Herlev
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Phone: +4578450000» Ansprechpartner anzeigenTampereen yliopistollinen sairaala ( Site 0300)
33520 Tampere
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Phone: +358331163454» Ansprechpartner anzeigenKuopion Yliopistollinen Sairaala ( Site 0304)
70210 Kuopio
FinlandRekrutierend» Google-Maps
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Phone: +358 44 717 9433» Ansprechpartner anzeigenHYKS. ( Site 0302)
00290 Helsinki
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Phone: +358504279697» Ansprechpartner anzeigenTYKS T-sairaala Syopatautien pkl ( Site 0301)
20520 Turku
FinlandRekrutierend» Google-Maps
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Phone: +35823130729» Ansprechpartner anzeigenInstitut de cancérologie Strasbourg Europe (ICANS) ( Site 0350)
67200 Strasbourg
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Phone: +33388116768» Ansprechpartner anzeigenCentre Francois Baclesse ( Site 0360)
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Phone: +33231455002» Ansprechpartner anzeigenCHU Besancon - Hopital Jean Minjoz ( Site 0351)
25000 Besancon
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Phone: +33381218605» Ansprechpartner anzeigenInstitut de Cancerologie du Gard - CHU Caremeau ( Site 0352)
30029 Nimes
FranceRekrutierend» Google-Maps
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Study Coordinator
Phone: +33466683301» Ansprechpartner anzeigenCHU de Bordeaux- Hopital Saint Andre ( Site 0359)
33075 Bordeaux
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Ansprechpartner:
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Phone: +33556794708» Ansprechpartner anzeigenCentre Alexis Vautrin Institut de Cancerologie de Lorraine ( Site 0356)
54519 Vandoeuvre les Nancy
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Phone: +33383598461» Ansprechpartner anzeigenCentre Hospitalier Lyon Sud ( Site 0354)
69310 Pierre Benite
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94800 Villejuif
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Hong Kong
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Phone: 852 35051040» Ansprechpartner anzeigenQueen Mary Hospital ( Site 1051)
Hong Kong
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Phone: +85222556220» Ansprechpartner anzeigenQueen Elizabeth Hospital. ( Site 1052)
Kowloon
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Study Coordinator
Phone: +85235068888» Ansprechpartner anzeigenBekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 0505)
5700 Gyula
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Study Coordinator
Phone: +36704397973» Ansprechpartner anzeigenBorsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás Ce
3526 Miskolc
HungaryRekrutierend» Google-Maps
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Phone: +36302780644» Ansprechpartner anzeigenOrszagos Onkologiai Intezet ( Site 0503)
1122 Budapest
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Phone: +3612248600» Ansprechpartner anzeigenDebreceni Egyetem Klinikai Kozpont ( Site 0504)
4032 Debrecen
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70124 Bari
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Phone: +390805594167» Ansprechpartner anzeigenMedical Oncology Ospedale San Donato ( Site 0609)
52100 Arezzo
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40138 Bologna
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41125 Modena
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Phone: +390594222648» Ansprechpartner anzeigenFondazione Salvatore Maugeri IRCCS ( Site 0600)
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105077 Moscow
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115478 Moscow
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Phone: +79166590224» Ansprechpartner anzeigenFirst Moscow State Medical University n.a. I.M.Sechenov ( Site 1163)
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Phone: +79031691379» Ansprechpartner anzeigenOmsk Clinical Oncology Dispensary ( Site 1150)
644013 Omsk
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Phone: +73812601741» Ansprechpartner anzeigenSBHI SPb Clinical Research Centre of specialized types of medical care ( Site 1159)
197758 Saint-Petersburg
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198255 Sankt-Petersburg
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Phone: +79219315267» Ansprechpartner anzeigenRussian Scientific Center of Radiology and Surgical Technologies ( Site 1153)
197758 St. Petersburg
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Phone: +79219629807» Ansprechpartner anzeigenInstituto Catalan de Oncologia - ICO ( Site 1251)
08908 L Hospitalet De Llobregat
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Phone: +34932607744» Ansprechpartner anzeigenHospital Universitari Vall d Hebron ( Site 1250)
08035 Barcelona
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Ansprechpartner:
Study Coordinator
Phone: +34934894350» Ansprechpartner anzeigenInstituto Valenciano de Oncologia - IVO ( Site 1254)
46009 Valencia
SpainRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +34961104605» Ansprechpartner anzeigenHospital Ramon y Cajal ( Site 1253)
28034 Madrid
SpainRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +34913368263» Ansprechpartner anzeigenHospital General Universitario 12 de Octubre ( Site 1252)
28041 Madrid
SpainRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +34913908339» Ansprechpartner anzeigenChang Gung Medical Foundation - Kaohsiung ( Site 1104)
83301 Kaohsiung
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +886975056834» Ansprechpartner anzeigenTaichung Veterans General Hospital ( Site 1105)
40705 Taichung
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +886423592525» Ansprechpartner anzeigenNational Cheng Kung University Hospital ( Site 1103)
704 Tainan
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +88662353535» Ansprechpartner anzeigenNational Taiwan University Hospital ( Site 1100)
10002 Taipei
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 88623123456x67680» Ansprechpartner anzeigenTaipei Veterans General Hospital ( Site 1101)
11217 Taipei
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 886228757519x315» Ansprechpartner anzeigenAnkara Universitesi Tip Fakultesi ( Site 1311)
06100 Ankara
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905337483275» Ansprechpartner anzeigenHacettepe Universitesi Tip Fakultesi ( Site 1300)
06230 Ankara
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905322814217» Ansprechpartner anzeigenGazi Universitesi Tip Fakultesi ( Site 1308)
06560 Ankara
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905055873568» Ansprechpartner anzeigenTrakya University Medical Faculty Balkan Oncology Hospital ( Site 1302)
22030 Edirne
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905322480988» Ansprechpartner anzeigenIstanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 1305)
34098 Istanbul
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905324167355» Ansprechpartner anzeigenGöztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 1303)
34722 Istanbul
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905063509061» Ansprechpartner anzeigenEge Universitesi Tip Fakultesi Hastanesi ( Site 1304)
35100 Izmir
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905323758439» Ansprechpartner anzeigenIzmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma Hastanesi ( Site 1306)
35360 Izmir
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905324078648» Ansprechpartner anzeigenMI Dnipr Regional Clinical Hospital named after I.I. Mechnikov ( Site 1453)
49005 Dnipropetrovsk
UkraineRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +380505896241» Ansprechpartner anzeigenMI Precarpathian Clinical Oncology Center ( Site 1452)
76018 Ivano-Frankivsk
UkraineRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +380502094000» Ansprechpartner anzeigenKyiv City Clinical Oncology Center ( Site 1450)
03115 Kyiv
UkraineRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +380667027558» Ansprechpartner anzeigenWestern General Hospital ( Site 1400)
EH4 2XU Edinburgh
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +441315372211» Ansprechpartner anzeigenThe Beatson West of Scotland Cancer Centre ( Site 1402)
G12 0YN Glasgow
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4401413017227» Ansprechpartner anzeigenBarts Health NHS Trust ( Site 1407)
EC1A 7BE London
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +44 7882 8494» Ansprechpartner anzeigenRoyal Marsden NHS Foundation Trust ( Site 1403)
SW3 6JJ London
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +442087523829» Ansprechpartner anzeigenImperial Healthcare NHS Trust Charing Cross Hospital ( Site 1409)
W6 8RF London
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4420 331 10275» Ansprechpartner anzeigenRoyal Marsden Hospital Sutton-Surrey ( Site 1411)
SM2 5PT Sutton
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +442087523829» Ansprechpartner anzeigenThe Christie NHS Foundation Trust ( Site 1401)
M20 4BX Manchester
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +44 161 918 7217» Ansprechpartner anzeigen
Alle anzeigen 07747 Jena
(Thüringen)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4936419329901» Ansprechpartner anzeigenUniversitaetsmedizin Berlin ( Site 0400)
10117 Berlin
(Berlin)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4930450515288» Ansprechpartner anzeigenUniversitatsklinikum Hamburg-Eppendorf ( Site 0408)
20246 Hamburg
(Hamburg)
GermanyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4915222815585» Ansprechpartner anzeigenUniversity of Alabama - Birmingham ( Site 1538)
35294 Birmingham
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 205-975-0370» Ansprechpartner anzeigenSt Joseph Heritage Healthcare ( Site 1531)
95403 Santa Rosa
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 707-521-3830» Ansprechpartner anzeigenUniversity Of Colorado ( Site 1540)
80045 Aurora
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 720-848-1776» Ansprechpartner anzeigenUCHealth Highlands Ranch Hospital ( Site 1560)
80129 Highlands Ranch
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 720-848-1776» Ansprechpartner anzeigenSibley Memorial Hospital ( Site 1559)
20016 Washington
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 202-660-6500» Ansprechpartner anzeigenNorthwest Georgia Oncology Centers PC ( Site 1520)
30060 Marietta
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 770-333-2161» Ansprechpartner anzeigenThe University of Chicago Medical Center ( Site 1539)
60637 Chicago
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 773-702-3498» Ansprechpartner anzeigenOchsner Medical Center ( Site 1522)
70121 New Orleans
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 504-842-3682» Ansprechpartner anzeigenSidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 1514)
21287 Baltimore
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 443-287-7790» Ansprechpartner anzeigenMassachusetts General Hospital ( Site 1558)
02114 Boston
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 617-643-0202» Ansprechpartner anzeigenBeth Israel Deaconess Medical Center ( Site 1501)
02215 Boston
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 617-975-7412» Ansprechpartner anzeigenDana Farber Cancer Institute ( Site 1505)
02215 Boston
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 877-338-7425» Ansprechpartner anzeigenHenry Ford Cancer Center ( Site 1511)
48202 Detroit
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 313-916-8862» Ansprechpartner anzeigenHattiesburg Clinic ( Site 1509)
39401 Hattiesburg
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 601-288-2495» Ansprechpartner anzeigenSt. Vincent Frontier Cancer Center ( Site 1549)
59102 Billings
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 406-238-6290» Ansprechpartner anzeigenJohn Theurer Cancer Center at Hackensack University Med Ctr ( Site 1513)
07601 Hackensack
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 551-996-1379» Ansprechpartner anzeigenUniversity of Rochester Medical Center ( Site 1543)
14620 Rochester
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 585-276-4415» Ansprechpartner anzeigenUniversity of North Carolina at Chapel Hill ( Site 1537)
27215 Chapel Hill
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 919-966-4432» Ansprechpartner anzeigenOncology Hematology Care, Inc. ( Site 1524)
45242 Cincinnati
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 513-751-2273» Ansprechpartner anzeigenCleveland Clinic ( Site 1504)
44195 Cleveland
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 216-445-6592» Ansprechpartner anzeigenOklahoma Cancer Specialists and Research Institute, LLC ( Site 1523)
74146 Tulsa
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 918-505-3200» Ansprechpartner anzeigenOregon Health & Science University ( Site 1553)
97239 Portland
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 503-494-0703» Ansprechpartner anzeigenAbramson Cancer Center ( Site 1525)
19104 Philadelphia
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 267-581-6080» Ansprechpartner anzeigenFox Chase Cancer Center ( Site 1506)
19111 Philadelphia
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 215-728-3889» Ansprechpartner anzeigenMedical University of South Carolina ( Site 1518)
29425 Charleston
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 843-792-9007» Ansprechpartner anzeigenHenry Joyce Cancer Clinic ( Site 1544)
37232 Nashville
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 800-811-8480» Ansprechpartner anzeigenTexas Oncology-Austin Central ( Site 1533)
78731 Austin
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 512-427-9467» Ansprechpartner anzeigenTexas Oncology, P.A.-Dallas ( Site 1534)
75230 Dallas
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 972-566-7790» Ansprechpartner anzeigenPERSONAL - Oncologia de Precisao e Personalizada ( Site 1657)
30130-090 Belo Horizonte
BrazilRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 55 31 36576864» Ansprechpartner anzeigenInstituto de Cancer e Transplante de Curitiba ICTR ( Site 1650)
80510-130 Curitiba
BrazilRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +554133361110» Ansprechpartner anzeigenLiga Norte Riograndense Contra o Cancer ( Site 1651)
59075-740 Natal
BrazilRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 558240095595» Ansprechpartner anzeigenHospital de Clinicas de Porto Alegre ( Site 1655)
90035-903 Porto Alegre
BrazilRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +555133598619» Ansprechpartner anzeigenReal e Benemerita Associacao Portuguesa de Beneficencia ( Site 1653)
01321-030 Sao Paulo
BrazilRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 551135056687» Ansprechpartner anzeigenBC Cancer - Vancouver Center ( Site 0155)
V5Z 4E6 Vancouver
CanadaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 604-877-6000» Ansprechpartner anzeigenJuravinski Cancer Centre ( Site 0154)
L8V 1C3 Hamilton
CanadaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +1 905 387-9495» Ansprechpartner anzeigenSunnybrook Research Institute ( Site 0153)
M4N 3M5 Toronto
CanadaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +1 416-480-5000» Ansprechpartner anzeigenCHU de Quebec-Universite Laval-Hotel Dieu de Quebec ( Site 0152)
G1R 2J6 Quebec
CanadaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 418525444420414» Ansprechpartner anzeigenSociedad de Investigaciones Medicas Limitadas ( Site 0004)
4810469 Temuco
ChileRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 56452982404» Ansprechpartner anzeigenBradfordhill ( Site 0003)
8420383 Santiago
ChileRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +56954240753» Ansprechpartner anzeigenFundacion Centro de Investigacion Clinica CIC ( Site 1703)
050021 Medellin
ColombiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 573137431031» Ansprechpartner anzeigenSociedad de Oncología Y Hematología del Cesar S.A.S. ( Site 1709)
200001 Valledupar
ColombiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +5755602310» Ansprechpartner anzeigenAdministradora Country SA - Clinica del Country ( Site 1701)
110221 Bogota
ColombiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +573153679697» Ansprechpartner anzeigenClinica Colsanitas S.A. Sede Clinica Universitaria Colombia ( Site 1702)
110311 Bogota
ColombiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +573103469453» Ansprechpartner anzeigenOncologos del Occidente S.A. ( Site 1708)
660001 Pereira
ColombiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +573187715522» Ansprechpartner anzeigenMasarykuv onkologicky ustav ( Site 0105)
656 53 Brno
CzechiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +420543136226» Ansprechpartner anzeigenFakultni nemocnice Ostrava ( Site 0103)
708 52 Ostrava
CzechiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +420721782888» Ansprechpartner anzeigenFakultni nemocnice Hradec Kralove ( Site 0106)
500 05 Hradec Kralove
CzechiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +420495832176» Ansprechpartner anzeigenFakultni nemocnice Olomouc ( Site 0104)
779 00 Olomouc
CzechiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +420588444295» Ansprechpartner anzeigenFakultni nemocnice Kralovske Vinohrady ( Site 0102)
100 34 Praha 10
CzechiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +420775154635» Ansprechpartner anzeigenThomayerova nemocnice ( Site 0107)
140 59 Praha 4
CzechiaRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +420261083530» Ansprechpartner anzeigenHerlev Hospital ( Site 0251)
2730 Herlev
DenmarkRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4538683868» Ansprechpartner anzeigenAarhus University Hospital Skejby ( Site 0250)
8200 Aarhus
DenmarkRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4578450000» Ansprechpartner anzeigenTampereen yliopistollinen sairaala ( Site 0300)
33520 Tampere
FinlandRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +358331163454» Ansprechpartner anzeigenKuopion Yliopistollinen Sairaala ( Site 0304)
70210 Kuopio
FinlandRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +358 44 717 9433» Ansprechpartner anzeigenHYKS. ( Site 0302)
00290 Helsinki
FinlandRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +358504279697» Ansprechpartner anzeigenTYKS T-sairaala Syopatautien pkl ( Site 0301)
20520 Turku
FinlandRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +35823130729» Ansprechpartner anzeigenInstitut de cancérologie Strasbourg Europe (ICANS) ( Site 0350)
67200 Strasbourg
FranceRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +33388116768» Ansprechpartner anzeigenCentre Francois Baclesse ( Site 0360)
14076 Caen
FranceRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +33231455002» Ansprechpartner anzeigenCHU Besancon - Hopital Jean Minjoz ( Site 0351)
25000 Besancon
FranceRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +33381218605» Ansprechpartner anzeigenInstitut de Cancerologie du Gard - CHU Caremeau ( Site 0352)
30029 Nimes
FranceRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +33466683301» Ansprechpartner anzeigenCHU de Bordeaux- Hopital Saint Andre ( Site 0359)
33075 Bordeaux
FranceRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +33556794708» Ansprechpartner anzeigenCentre Alexis Vautrin Institut de Cancerologie de Lorraine ( Site 0356)
54519 Vandoeuvre les Nancy
FranceRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +33383598461» Ansprechpartner anzeigenCentre Hospitalier Lyon Sud ( Site 0354)
69310 Pierre Benite
FranceRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +33478864324» Ansprechpartner anzeigenGustave Roussy ( Site 0353)
94800 Villejuif
FranceRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +33142115252» Ansprechpartner anzeigenPrince of Wales Hospital ( Site 1050)
Hong Kong
Hong KongRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 852 35051040» Ansprechpartner anzeigenQueen Mary Hospital ( Site 1051)
Hong Kong
Hong KongRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +85222556220» Ansprechpartner anzeigenQueen Elizabeth Hospital. ( Site 1052)
Kowloon
Hong KongRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +85235068888» Ansprechpartner anzeigenBekes Megyei Kozponti Korhaz - Pandy Kalman Tagkorhaza ( Site 0505)
5700 Gyula
HungaryRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +36704397973» Ansprechpartner anzeigenBorsod-Abaúj-Zemplén Megyei Központi Kórház és Egyetemi Okta-Klinikai Onkológiai és Sugárterápiás Ce
3526 Miskolc
HungaryRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +36302780644» Ansprechpartner anzeigenOrszagos Onkologiai Intezet ( Site 0503)
1122 Budapest
HungaryRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +3612248600» Ansprechpartner anzeigenDebreceni Egyetem Klinikai Kozpont ( Site 0504)
4032 Debrecen
HungaryRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +3652255585» Ansprechpartner anzeigenAzienda Ospedaliera Policlinico di Bari ( Site 0610)
70124 Bari
ItalyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +390805594167» Ansprechpartner anzeigenMedical Oncology Ospedale San Donato ( Site 0609)
52100 Arezzo
ItalyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +390575255436» Ansprechpartner anzeigenPoliclinico S. Orsola-Malpighi ( Site 0606)
40138 Bologna
ItalyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +390512142204» Ansprechpartner anzeigenAzienda Ospedaliero Universitaria di Modena Policlinico ( Site 0604)
41125 Modena
ItalyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +390594222648» Ansprechpartner anzeigenFondazione Salvatore Maugeri IRCCS ( Site 0600)
27100 Pavia
ItalyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +390382592265» Ansprechpartner anzeigenFondazione Policlinico Universitario A. Gemelli ( Site 0607)
00168 Roma
ItalyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +390630154953» Ansprechpartner anzeigenAzienda Ospedaliera Santa Maria ( Site 0602)
05100 Terni
ItalyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +390744205410» Ansprechpartner anzeigenAzienda Ospedaliera Universitaria di Verona ( Site 0605)
37126 Verona
ItalyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +390458122768» Ansprechpartner anzeigenNational Cancer Center Hospital East ( Site 1001)
277-8577 Kashiwa
JapanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +81-4-7133-1111» Ansprechpartner anzeigenNational Cancer Center Hospital ( Site 1003)
104-0045 Tokyo
JapanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +81-3-3542-2511» Ansprechpartner anzeigenToranomon Hospital ( Site 1004)
105-8470 Tokyo
JapanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +81-3-3588-1111» Ansprechpartner anzeigenThe Cancer Institute Hospital of JFCR ( Site 1000)
135-8550 Tokyo
JapanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +81-3-3520-0111» Ansprechpartner anzeigenKeio University Hospital ( Site 1002)
160-8582 Tokyo
JapanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +81-3-3353-1211» Ansprechpartner anzeigenNational Cancer Center ( Site 1204)
10408 Gyeonggi-do
Korea, Republic ofRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +82319201505» Ansprechpartner anzeigenChungnam National University Hospital ( Site 1205)
35015 Daejeon
Korea, Republic ofRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +82422808369» Ansprechpartner anzeigenKorea University Anam Hospital ( Site 1203)
02841 Seoul
Korea, Republic ofRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +8229206267» Ansprechpartner anzeigenSeverance Hospital Yonsei University Health System ( Site 1202)
03722 Seoul
Korea, Republic ofRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +82222288138» Ansprechpartner anzeigenAsan Medical Center ( Site 1200)
05505 Seoul
Korea, Republic ofRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 82230105977» Ansprechpartner anzeigenSamsung Medical Center ( Site 1201)
06351 Seoul
Korea, Republic ofRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +82234101767» Ansprechpartner anzeigenAkershus universitetssykehus ( Site 0851)
1478 Lorenskog
NorwayRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4767963800» Ansprechpartner anzeigenHelse Bergen HF - Haukeland Universitetssykehus ( Site 0854)
5021 Bergen
NorwayRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4755974018» Ansprechpartner anzeigenKrasnoyarsk Regional Clinical Oncological Dispensary ( Site 1151)
660133 Krasnoyarsk
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +79135349316» Ansprechpartner anzeigenSBIH City clinical hospital named after D.D. Pletniov ( Site 1160)
105077 Moscow
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +79164091611» Ansprechpartner anzeigenN.N. Blokhin NMRCO ( Site 1156)
115478 Moscow
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +79037380779» Ansprechpartner anzeigenRussian Scientific Center of Roentgenoradiology ( Site 1155)
117997 Moscow
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +79166590224» Ansprechpartner anzeigenFirst Moscow State Medical University n.a. I.M.Sechenov ( Site 1163)
119146 Moscow
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +79037490597» Ansprechpartner anzeigenCentral Clinical Hospital with Polyclinic ( Site 1157)
121359 Moscow
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +79031691379» Ansprechpartner anzeigenOmsk Clinical Oncology Dispensary ( Site 1150)
644013 Omsk
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +73812601741» Ansprechpartner anzeigenSBHI SPb Clinical Research Centre of specialized types of medical care ( Site 1159)
197758 Saint-Petersburg
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +78125739191» Ansprechpartner anzeigenCity clinical oncological dispensary ( Site 1154)
198255 Sankt-Petersburg
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +79219315267» Ansprechpartner anzeigenRussian Scientific Center of Radiology and Surgical Technologies ( Site 1153)
197758 St. Petersburg
Russian FederationRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +79219629807» Ansprechpartner anzeigenInstituto Catalan de Oncologia - ICO ( Site 1251)
08908 L Hospitalet De Llobregat
SpainRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +34932607744» Ansprechpartner anzeigenHospital Universitari Vall d Hebron ( Site 1250)
08035 Barcelona
SpainRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +34934894350» Ansprechpartner anzeigenInstituto Valenciano de Oncologia - IVO ( Site 1254)
46009 Valencia
SpainRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +34961104605» Ansprechpartner anzeigenHospital Ramon y Cajal ( Site 1253)
28034 Madrid
SpainRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +34913368263» Ansprechpartner anzeigenHospital General Universitario 12 de Octubre ( Site 1252)
28041 Madrid
SpainRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +34913908339» Ansprechpartner anzeigenChang Gung Medical Foundation - Kaohsiung ( Site 1104)
83301 Kaohsiung
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +886975056834» Ansprechpartner anzeigenTaichung Veterans General Hospital ( Site 1105)
40705 Taichung
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +886423592525» Ansprechpartner anzeigenNational Cheng Kung University Hospital ( Site 1103)
704 Tainan
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +88662353535» Ansprechpartner anzeigenNational Taiwan University Hospital ( Site 1100)
10002 Taipei
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 88623123456x67680» Ansprechpartner anzeigenTaipei Veterans General Hospital ( Site 1101)
11217 Taipei
TaiwanRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: 886228757519x315» Ansprechpartner anzeigenAnkara Universitesi Tip Fakultesi ( Site 1311)
06100 Ankara
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905337483275» Ansprechpartner anzeigenHacettepe Universitesi Tip Fakultesi ( Site 1300)
06230 Ankara
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905322814217» Ansprechpartner anzeigenGazi Universitesi Tip Fakultesi ( Site 1308)
06560 Ankara
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905055873568» Ansprechpartner anzeigenTrakya University Medical Faculty Balkan Oncology Hospital ( Site 1302)
22030 Edirne
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905322480988» Ansprechpartner anzeigenIstanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 1305)
34098 Istanbul
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905324167355» Ansprechpartner anzeigenGöztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 1303)
34722 Istanbul
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905063509061» Ansprechpartner anzeigenEge Universitesi Tip Fakultesi Hastanesi ( Site 1304)
35100 Izmir
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905323758439» Ansprechpartner anzeigenIzmir Katip Celebi Universitesi Ataturk Egitim ve Arastirma Hastanesi ( Site 1306)
35360 Izmir
TurkeyRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +905324078648» Ansprechpartner anzeigenMI Dnipr Regional Clinical Hospital named after I.I. Mechnikov ( Site 1453)
49005 Dnipropetrovsk
UkraineRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +380505896241» Ansprechpartner anzeigenMI Precarpathian Clinical Oncology Center ( Site 1452)
76018 Ivano-Frankivsk
UkraineRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +380502094000» Ansprechpartner anzeigenKyiv City Clinical Oncology Center ( Site 1450)
03115 Kyiv
UkraineRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +380667027558» Ansprechpartner anzeigenWestern General Hospital ( Site 1400)
EH4 2XU Edinburgh
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +441315372211» Ansprechpartner anzeigenThe Beatson West of Scotland Cancer Centre ( Site 1402)
G12 0YN Glasgow
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4401413017227» Ansprechpartner anzeigenBarts Health NHS Trust ( Site 1407)
EC1A 7BE London
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +44 7882 8494» Ansprechpartner anzeigenRoyal Marsden NHS Foundation Trust ( Site 1403)
SW3 6JJ London
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +442087523829» Ansprechpartner anzeigenImperial Healthcare NHS Trust Charing Cross Hospital ( Site 1409)
W6 8RF London
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +4420 331 10275» Ansprechpartner anzeigenRoyal Marsden Hospital Sutton-Surrey ( Site 1411)
SM2 5PT Sutton
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +442087523829» Ansprechpartner anzeigenThe Christie NHS Foundation Trust ( Site 1401)
M20 4BX Manchester
United KingdomRekrutierend» Google-Maps
Ansprechpartner:
Study Coordinator
Phone: +44 161 918 7217» Ansprechpartner anzeigen
Studien-Informationen
Brief Summary:The primary objective of this study is to compare belzutifan to everolimus with respect to
progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1
(RECIST 1.1) as assessed by Blinded Independent Central Review (BICR) and to compare
everolimus with respect to overall survival (OS). The hypothesis is that belzutifan is
superior to everolimus with respect to PFS and OS.
Ein-/Ausschlusskriterien
Inclusion Criteria:- Has unresectable, locally advanced or metastatic clear cell renal cell carcinoma (RCC)
- Has had disease progression on or after having received systemic treatment for locally
advanced or metastatic RCC with both Programmed cell death 1 ligand 1 (PD-1/L1)
checkpoint inhibitor and a vascular endothelial growth factor - tyrosine kinase
inhibitor (VEGF-TKI) in sequence or in combination.
- Has received no more than 3 prior systemic regimens for locally advanced or metastatic
RCC.
- A male participant is eligible to participate if he is abstinent from heterosexual
intercourse or agrees to use contraception during the intervention period and for at
least 5 days after the last dose of study intervention
- A female participant is eligible to participate if she is not pregnant, not
breastfeeding, and at least 1 of the following conditions applies: Not a (woman of
childbearing potential) WOCBP OR A WOCBP who agrees to follow the contraceptive
guidance during the intervention period and for at least 30 days after the last dose
of study intervention for those randomized to belzutifan and for at least 8 weeks
after the last dose of study intervention for those randomized to everolimus.
- The participant (or legally acceptable representative if applicable) provides written
informed consent for the study.
- Has adequate organ function
Exclusion Criteria:
- Has a known additional malignancy that is progressing or has required active treatment
within the past 3 years. (Participants with basal cell carcinoma of the skin, squamous
cell carcinoma of the skin, or carcinoma in situ [e.g., breast carcinoma, cervical
cancer in situ] that have undergone potentially curative therapy are not excluded.)
- Has known central nervous system (CNS) metastases and/or carcinomatous meningitis.
(Participants with previously treated brain metastases may participate provided they
are radiologically stable for at least 4 weeks (28 days) by repeat imaging.)
- Has clinically significant cardiac disease, including unstable angina, acute
myocardial infarction within 6 months from Day 1 of study drug administration, or New
York Heart Association Class III or IV congestive heart failure. (Medically controlled
arrhythmia stable on medication is permitted.)
- Has poorly controlled hypertension defined as systolic blood pressure (SBP) ≥150 mm Hg
and/or diastolic blood pressure (DBP) ≥90 mm Hg.
- Has moderate to severe hepatic impairment (Child-Pugh B or C).
- Has a known psychiatric or substance abuse disorder that would interfere with
cooperation with the requirements of the study.
- Is unable to swallow orally administered medication or has a gastrointestinal disorder
affecting absorption (e.g., gastrectomy, partial bowel obstruction, malabsorption).
- Has known hypersensitivity or allergy to the active pharmaceutical ingredient or any
component of the study intervention (belzutifan or everolimus) formulations.
- Has received prior treatment with belzutifan or another hypoxia inducible factor 2α
(HIF-2α inhibitor).
- Has received prior treatment with everolimus or any other specific or selective target
of rapamycin complex 1 (TORC1)/ phosphatidylinositol 3-kinase (PI3K)/ protein kinase B
(AKT) inhibitor (e.g., temsirolimus) in the advanced disease setting.
- Has received any type of systemic anticancer antibody (including investigational
antibody) within 4 weeks before randomization.
- Has received prior radiotherapy within 2 weeks prior to randomization.
- Has had major surgery within 3 weeks prior to randomization.
- Has received a live vaccine within 30 days prior to randomization. Examples of live
vaccines include, but are not limited to, the following: measles, mumps, rubella,
varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guérin (BCG),
and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed
virus vaccines and are allowed; however, intranasal influenza vaccines are live
attenuated vaccines and are not allowed.
- Is currently receiving either strong (e.g., itraconazole, telithromycin,
clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir,
saquinavir, nelfinavir, boceprevir, telaprevir) or moderate (e.g., ciprofloxacin,
erythromycin, diltiazem, fluconazole, verapamil) inhibitors of cytochrome P450 3A4
(CYP3A4) that cannot be discontinued for the duration of the study.
- Is currently receiving either strong (phenobarbital, enzalutamide, phenytoin,
rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John's Wort) or
moderate (e.g., bosentan, efavirenz, modafinil) inducers of CYP3A4 that cannot be
discontinued for the duration of the study.
- Is currently participating in a study of an investigational agent or is currently
using an investigational device.
- Has an active infection requiring systemic therapy.
- Has active bacillus tuberculosis (TB).
- Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
(dosing exceeding 10 mg daily of prednisone equivalent) or any other form of
immunosuppressive therapy within 7 days prior to randomization.
- Has a known history of human immunodeficiency virus (HIV) infection. (Testing for HIV
at screening is only required if mandated by local health authority.
- Has a known history of Hepatitis B virus (HBV) (defined as Hepatitis B surface antigen
[HBsAg] reactive) or known active Hepatitis C virus (HCV) (defined as HCV ribonucleic
acid [RNA] [qualitative] is detected) infection.
Studien-Rationale
Primary outcome:1. Progression-free Survival (PFS) per Response Criteria in Solid Tumors Version 1.1 (RECIST 1.1) (Time Frame - Up to approximately 47 months):
PFS is defined as the time from randomization to the first documented progressive disease (PD) or death due to any cause, whichever occurs first. Per RECIST 1.1, PD is defined as ≥20% increase in the sum of diameters of target lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of ≥5 mm. The appearance of one or more new lesions is also considered PD. PFS as assessed by blinded independent central review will be presented
2. Overall Survival (OS) (Time Frame - Up to approximately 47 months):
Time from randomization to death due to any cause
Secondary outcome:
1. Objective Response Rate (ORR) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) (Time Frame - Up to approximately 47 months):
ORR is defined as the percentage of participants who have a complete response (CR: Disappearance of all target lesions) or a partial response (PR: At least a 30% decrease in the sum of diameters of target lesions) per RECIST 1.1. The percentage of participants who experience a CR or PR as assessed by blinded independent central review based on RECIST 1.1 will be presented.
2. Duration of Response (DOR) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) (Time Frame - Up to approximately 47 months):
For participants who demonstrate a confirmed complete response (CR: Disappearance of all target lesions) or confirmed partial response (PR: At least a 30% decrease in the sum of diameters of target lesions) per RECIST 1.1, DOR is defined as the time from first documented evidence of CR or PR until disease progression or death. The DOR as assessed by blinded independent central review will be presented.
3. Number of Participants Who Experience One or More Adverse Events (AEs) (Time Frame - Up to approximately 47 months):
An adverse event (AE) is defined as any unfavorable and unintended sign including an abnormal laboratory finding, symptom or disease associated with the use of a medical treatment or procedure, regardless of whether it is considered related to the medical treatment or procedure, that occurs during the course of the study.
4. Number of Participants Who Discontinued Study Treatment Due to an Adverse Event (AE) (Time Frame - Up to approximately 47 months):
An AE is defined as any unfavorable and unintended sign including an abnormal laboratory finding, symptom or disease associated with the use of a medical treatment or procedure, regardless of whether it is considered related to the medical treatment or procedure, that occurs during the course of the study. The number of participants who discontinue study treatment due to an AE will be presented.
5. Time to Deterioration in Health-Related Quality-of-Life (HRQoL) Using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) Items 29 and 30 Score (Time Frame - Up to approximately 47 months):
Time to Deterioration (TTD) is defined as the time from baseline to the first onset of a ≥10-point negative change (decrease) from baseline in global health status (Item 29) & quality of life (Item 30) combined score. Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. The TTD, as assessed based on a ≥10-point negative change (decrease) from baseline in global health status and quality of life combined score, will be presented. A longer TTD indicates a better outcome.
6. Time to Deterioration in Physical Functioning Using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) Items 1- 5 Score (Time Frame - Up to approximately 47 months):
TTD is defined as the time from Baseline to the first onset of a ≥10-point negative change (decrease) from Baseline in physical functioning (EORTC QLQ-C30 Items 1-5) score. Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. The TTD, as assessed based on a ≥10-point negative change (decrease) from Baseline in physical functioning score, will be presented.
7. Time to Deterioration in Disease Symptoms Using the Functional Assessment of Cancer Therapy-Kidney Symptom Index-Disease-related Symptoms (FKSI-DRS) Items 1-9 Score (Time Frame - Up to approximately 47 months):
The FKSI-DRS index consists of a 9-item questionnaire that assesses the extent of participant symptoms from kidney cancer over the previous 7 days. Responses are scored on a 5-point scale (0=Not at all to 4=Very much) and summed to generate an index symptom score. These scores can range from 0 to 36, with a higher score indicating more favorable kidney cancer symptom status.
8. Change From Baseline in Health-Related Quality-of-Life (HRQoL) Using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) Items 29 and 30 Score (Time Frame - Baseline (Day 1) and up to approximately 47 months):
The EORTC QLQ-C30 is a questionnaire to assess the overall quality of life of cancer patients. Participant responses for global health status (Item 29) & quality of life (Item 30) are scored on a 7-point scale (1= Very poor to 7=Excellent). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better overall health status. The change from baseline in EORTC QLQ-C30 Items 29 and 30 scores will be presented.
9. Change From Baseline in Physical Functioning Using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) Items 1- 5 Score (Time Frame - Baseline (Day 1) and up to approximately 47 months):
The EORTC QLQ-C30 is a questionnaire to assess the overall quality of life of cancer patients. Participant responses to 5 questions about their physical functioning are scored on a 4-point scale (1=Not at All to 4=Very Much). Using linear transformation, raw scores are standardized, so that scores range from 0 to 100. A higher score indicates a better quality of life. The change from baseline in Physical Functioning (EORTC QLQ-C30 Items 1-5) score will be presented.
10. Change From Baseline in Disease Symptoms Using the Functional Assessment of Cancer Therapy-Kidney Symptom Index-Disease-related Symptoms (FKSI-DRS) Items 1-9 Score (Time Frame - Baseline (Day 1) and up to approximately 47 months):
The FKSI-DRS index consists of a 9-item questionnaire that assesses the extent of participant symptoms from kidney cancer over the previous 7 days. Responses are scored on a 5-point scale (0=Not at all to 4=Very much) and summed to generate an index symptom score. These scores can range from 0 to 36, with a higher score indicating more favorable kidney cancer symptom status.
11. Change from Baseline in European Quality of Life 5 Dimensions, 5-level Questionnaire (EuroQoL EQ-5D-5L) Health Utility Score (Time Frame - Baseline (Day 1) and up to approximately 47 months):
The EQ-5D-5L questionnaire assesses 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/ depression. Each dimension has 5 response options (no problems, slight problems, moderate problems, severe problems and extreme problems) that reflect increasing levels of difficulty, which are coded on a scale from 1 (no problems) to 5 (extreme problems). The participant is also asked to indicate his/her current health state by selecting the most appropriate level on a visual analog scale from 0 to 100, with 0 being the worst imaginable health state.
Studien-Arme
- Experimental: Belzutifan
Participants receive 120 mg of belzutifan orally once daily (QD) - Active Comparator: Everolimus
Participants receive 10 mg of Everolimus orally once daily (QD)
Geprüfte Regime
- Belzutifan (MK-6482):
Oral tablets - Everolimus (Afinitor / Afinitor DISPERZ / Zortress / ):
Oral tablets
Quelle: ClinicalTrials.gov