Sponsor:
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Collaborator:
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Studienleiter
J. J. Bergman, MD, PhD Principal Investigator Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) R. E. Pouw, MD, PhD Principal Investigator Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
1. 5-year disease-specific mortality/survival (descriptive statistics in SPSS, percentages, survival analysis) (Time Frame - 5 years): Disease specific mortality is decribed as mortality directly linked to the esophageal adenocarcinoma (i.e., metastasized EAC, metastasized disease with a simultaneously primary cancer present and it cannot be ruled out (based on histology) that the metastases are related to the other primary cancer, death due to complications of the endoscopic procedure, death due to complications after surgery or CRT, no clear cause of death in patients who have metastases or untreated local recurrence). If patients are diagnosed with distant metastases, and subsequently die of a non-tumor related cause, patients will still be documented as tumor-related death. Will be measured in number of patients and percentages. Survival analysis using Kaplan Meier will be performed.
2. Overall survival (descriptive statistics in SPSS, percentages, survival analysis) (Time Frame - 5 years): Overall survival of study population (tumor-related + non-tumor-related deaths). Measured in numbers and percentages, survival analysis (KM).
Secondary outcome:
1. Lymph node metastasis, confirmed by cytology and/or histology (descriptive statistics in SPSS, number of patients (%)) (Time Frame - 5 years): Confirmed by cytology and/or histology by performing FNA during EUS or biopsies.
2. Local recurrence eligible for endoscopic therapy (descriptive statistics in SPSS, number of patients (%)) (Time Frame - 5 years): In case a local recurrence is found during FU endoscopy, histopathology have to show if it is recurrent cancer.
3. Local recurrence requiring surgical therapy (descriptive statistics in SPSS, number of patients (%)) (Time Frame - 5 years): In case a local cancer recurrence is not amendable for endoscopic re-treatment, for example due to extensive disease or fibrosis, a patient will be referred for surgery if possible.
4. Distant metastasis, histologically proven (descriptive statistics in SPSS, number of patients (%)) (Time Frame - 5 years): Primary tumor of distant metastasis should be histopathologically evalueted by taking biopsies.
5. Quality of life during follow-up endoscopies (questionnaires) (Time Frame - 5 years): Quality of life is assessed by using questionnaires on set time points during the whole study.
