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JOURNAL ONKOLOGIE – STUDIE

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

Rekrutierend

NCT-Nummer:
NCT02912559

Studienbeginn:
September 2017

Letztes Update:
15.04.2021

Wirkstoff:
Atezolizumab, Fluorouracil, Leucovorin Calcium, Oxaliplatin

Indikation (Clinical Trials):
Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis

Geschlecht:
Alle

Altersgruppe:
Erwachsene (18+)

Phase:
Phase 3

Sponsor:
National Cancer Institute (NCI)

Collaborator:
-

Studienleiter

Frank A Sinicrope
Principal Investigator
Alliance for Clinical Trials in Oncology

Studienlocations
(3 von 950)

University Cancer Center-Regensburg
Franz-Josef-Strauß-Allee 11
93053 Regensburg
(Bayern)
DeutschlandSchwebend» Google-Maps
Anchorage Associates in Radiation Medicine
98508 Anchorage
United StatesSchwebend» Google-Maps
Alaska Breast Care and Surgery LLC
99508 Anchorage
United StatesSchwebend» Google-Maps
Alaska Oncology and Hematology LLC
99508 Anchorage
United StatesSchwebend» Google-Maps
Alaska Women's Cancer Care
99508 Anchorage
United StatesSchwebend» Google-Maps
Anchorage Oncology Centre
99508 Anchorage
United StatesSchwebend» Google-Maps
Providence Alaska Medical Center
99508 Anchorage
United StatesSchwebend» Google-Maps
Mayo Clinic Hospital in Arizona
85054 Phoenix
United StatesAktiv, nicht rekrutierend» Google-Maps
Mayo Clinic in Arizona
85259 Scottsdale
United StatesAktiv, nicht rekrutierend» Google-Maps
CHI Saint Vincent Cancer Center Hot Springs
71913 Hot Springs
United StatesSchwebend» Google-Maps
Sutter Cancer Centers Radiation Oncology Services-Auburn
95603 Auburn
United StatesSchwebend» Google-Maps
Alta Bates Summit Medical Center-Herrick Campus
94704 Berkeley
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 415-209-2686
E-Mail: bernicl@sutterhealth.org» Ansprechpartner anzeigen
Providence Saint Joseph Medical Center/Disney Family Cancer Center
91505 Burbank
United StatesSchwebend» Google-Maps
Mills-Peninsula Medical Center
94010 Burlingame
United StatesSchwebend» Google-Maps
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
95682 Cameron Park
United StatesSchwebend» Google-Maps
Eden Hospital Medical Center
94546 Castro Valley
United StatesSchwebend» Google-Maps
Community Cancer Institute
93611 Clovis
United StatesSchwebend» Google-Maps
John Muir Medical Center-Concord Campus
94520 Concord
United StatesAktiv, nicht rekrutierend» Google-Maps
UC Irvine Health Cancer Center-Newport
92627 Costa Mesa
United StatesAktiv, nicht rekrutierend» Google-Maps
Fremont - Rideout Cancer Center
95901 Marysville
United StatesSchwebend» Google-Maps
Palo Alto Medical Foundation-Camino Division
94040 Mountain View
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 415-209-2686
E-Mail: bernicl@sutterhealth.org» Ansprechpartner anzeigen
Palo Alto Medical Foundation-Gynecologic Oncology
94040 Mountain View
United StatesSchwebend» Google-Maps
Sutter Cancer Research Consortium
94945 Novato
United StatesSchwebend» Google-Maps
UC Irvine Health/Chao Family Comprehensive Cancer Center
92868 Orange
United StatesAktiv, nicht rekrutierend» Google-Maps
Sutter Cancer Centers Radiation Oncology Services-Roseville
95661 Roseville
United StatesSchwebend» Google-Maps
California Pacific Medical Center-Pacific Campus
94115 San Francisco
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 415-209-2686
E-Mail: bernicl@sutterhealth.org» Ansprechpartner anzeigen
Sutter Pacific Medical Foundation
95403 Santa Rosa
United StatesSchwebend» Google-Maps
Sutter Cancer Centers Radiation Oncology Services-Vacaville
95687 Vacaville
United StatesSchwebend» Google-Maps
City of Hope West Covina
91790 West Covina
United StatesAktiv, nicht rekrutierend» Google-Maps
Rocky Mountain Cancer Centers-Penrose
80907 Colorado Springs
United StatesSchwebend» Google-Maps
Denver Health Medical Center
80204 Denver
United StatesSchwebend» Google-Maps
National Jewish Health-Main Campus
80206 Denver
United StatesSchwebend» Google-Maps
The Women's Imaging Center
80209 Denver
United StatesSchwebend» Google-Maps
Colorado Blood Cancer Institute
80218 Denver
United StatesSchwebend» Google-Maps
Presbyterian - Saint Lukes Medical Center - Health One
80218 Denver
United StatesSchwebend» Google-Maps
SCL Health Saint Joseph Hospital
80218 Denver
United StatesSchwebend» Google-Maps
Mountain Blue Cancer Care Center
80401 Golden
United StatesSchwebend» Google-Maps
National Jewish Health-Western Hematology Oncology
80401 Golden
United StatesSchwebend» Google-Maps
Saint Mary's Hospital and Regional Medical Center
81501 Grand Junction
United StatesSchwebend» Google-Maps
Grand Valley Oncology
81505 Grand Junction
United StatesAktiv, nicht rekrutierend» Google-Maps
Good Samaritan Medical Center
80026 Lafayette
United StatesSchwebend» Google-Maps
Rocky Mountain Cancer Centers-Lakewood
80228 Lakewood
United StatesSchwebend» Google-Maps
Littleton Adventist Hospital
80122 Littleton
United StatesSchwebend» Google-Maps
Rocky Mountain Cancer Centers-Longmont
80501 Longmont
United StatesSchwebend» Google-Maps
Rocky Mountain Cancer Centers-Parker
80138 Parker
United StatesSchwebend» Google-Maps
Saint Mary Corwin Medical Center
81004 Pueblo
United StatesSchwebend» Google-Maps
Rocky Mountain Cancer Centers - Pueblo
81008 Pueblo
United StatesSchwebend» Google-Maps
National Jewish Health-Northern Hematology Oncology
80260 Thornton
United StatesSchwebend» Google-Maps
Rocky Mountain Cancer Centers-Thornton
80260 Thornton
United StatesSchwebend» Google-Maps
SCL Health Lutheran Medical Center
80033 Wheat Ridge
United StatesSchwebend» Google-Maps
Smilow Cancer Hospital Care Center at Saint Francis
06105 Hartford
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 203-785-5702
E-Mail: canceranswers@yale.edu» Ansprechpartner anzeigen
Yale-New Haven Hospital North Haven Medical Center
06473 North Haven
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 203-785-5702
E-Mail: canceranswers@yale.edu» Ansprechpartner anzeigen
Smilow Cancer Hospital Care Center - Waterford
06385 Waterford
United StatesSchwebend» Google-Maps
Bayhealth Hospital Kent Campus
19901 Dover
United StatesAktiv, nicht rekrutierend» Google-Maps
Bayhealth Hospital Sussex Campus
19963 Milford
United StatesAktiv, nicht rekrutierend» Google-Maps
Delaware Clinical and Laboratory Physicians PA
19713 Newark
United StatesSchwebend» Google-Maps
Christiana Care Health System-Christiana Hospital
19718 Newark
United StatesSchwebend» Google-Maps
TidalHealth Nanticoke / Allen Cancer Center
19973 Seaford
United StatesSchwebend» Google-Maps
Christiana Care Health System-Wilmington Hospital
19801 Wilmington
United StatesSchwebend» Google-Maps
Halifax Health Medical Center-Centers for Oncology
32114 Daytona Beach
United StatesSchwebend» Google-Maps
Regional Cancer Center-Lee Memorial Health System
33905 Fort Myers
United StatesSchwebend» Google-Maps
Mayo Clinic in Florida
32224-9980 Jacksonville
United StatesSchwebend» Google-Maps
University Cancer and Blood Center LLC
30607 Athens
United StatesSchwebend» Google-Maps
Queen's Cancer Center - Pearlridge
96701 'Aiea
United StatesSchwebend» Google-Maps
The Cancer Center of Hawaii-Pali Momi
96701 'Aiea
United StatesSchwebend» Google-Maps
Hawaii Cancer Care Inc - Waterfront Plaza
96813 Honolulu
United StatesSchwebend» Google-Maps
University of Hawaii Cancer Center
96813 Honolulu
United StatesSchwebend» Google-Maps
Hawaii Cancer Care Inc-Liliha
96817 Honolulu
United StatesSchwebend» Google-Maps
The Cancer Center of Hawaii-Liliha
96817 Honolulu
United StatesSchwebend» Google-Maps
Kapiolani Medical Center for Women and Children
96826 Honolulu
United StatesSchwebend» Google-Maps
Wilcox Memorial Hospital and Kauai Medical Clinic
96766 Lihue
United StatesSchwebend» Google-Maps
Saint Alphonsus Cancer Care Center-Caldwell
83605 Caldwell
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Walter Knox Memorial Hospital
83617 Emmett
United StatesSchwebend» Google-Maps
Idaho Urologic Institute-Meridian
83642 Meridian
United StatesSchwebend» Google-Maps
Memorial Hospital of Carbondale
62902 Carbondale
United StatesSchwebend» Google-Maps
University of Chicago Comprehensive Cancer Center
60637 Chicago
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 773-702-8222
E-Mail: cancerclinicaltrials@bsd.uchicago.edu» Ansprechpartner anzeigen
Decatur Memorial Hospital
62526 Decatur
United StatesSchwebend» Google-Maps
Saint Francis Hospital
60202 Evanston
United StatesAktiv, nicht rekrutierend» Google-Maps
Western Illinois Cancer Treatment Center
61401 Galesburg
United StatesSchwebend» Google-Maps
NorthShore University HealthSystem-Highland Park Hospital
60035 Highland Park
United StatesSchwebend» Google-Maps
UC Comprehensive Cancer Center at Silver Cross
60451 New Lenox
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 773-702-8222
E-Mail: cancerclinicaltrials@bsd.uchicago.edu» Ansprechpartner anzeigen
University of Chicago Medicine-Orland Park
60462 Orland Park
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 773-702-8222
E-Mail: cancerclinicaltrials@bsd.uchicago.edu» Ansprechpartner anzeigen
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
61554 Pekin
United StatesSchwebend» Google-Maps
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
61615 Peoria
United StatesSchwebend» Google-Maps
Methodist Medical Center of Illinois
61636 Peoria
United StatesSchwebend» Google-Maps
OSF Saint Francis Medical Center
61637 Peoria
United StatesSchwebend» Google-Maps
Hematology Oncology Associates of Illinois - Skokie
60076 Skokie
United StatesAktiv, nicht rekrutierend» Google-Maps
Memorial Medical Center
62781 Springfield
United StatesSchwebend» Google-Maps
Southwest Illinois Health Services LLP
62226 Swansea
United StatesSchwebend» Google-Maps
Indiana University/Melvin and Bren Simon Cancer Center
46202 Indianapolis
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 317-278-5632
E-Mail: iutrials@iu.edu» Ansprechpartner anzeigen
University of Iowa Healthcare Cancer Services Quad Cities
52722 Bettendorf
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 563-355-7733
E-Mail: kedaprile@rccqc.com» Ansprechpartner anzeigen
Medical Oncology and Hematology Associates-West Des Moines
50325 Clive
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 308-398-6518
E-Mail: clinicaltrials@sfmc-gi.org» Ansprechpartner anzeigen
Alegent Health Mercy Hospital
51503 Council Bluffs
United StatesSchwebend» Google-Maps
Greater Regional Medical Center
50801 Creston
United StatesSchwebend» Google-Maps
Medical Oncology and Hematology Associates-Laurel
50314 Des Moines
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 308-398-6518
E-Mail: clinicaltrials@sfmc-gi.org» Ansprechpartner anzeigen
Iowa Lutheran Hospital
50316 Des Moines
United StatesSchwebend» Google-Maps
Mercy Medical Center - North Iowa
50401 Mason City
United StatesAktiv, nicht rekrutierend» Google-Maps
Methodist West Hospital
50266-7700 West Des Moines
United StatesSchwebend» Google-Maps
Coffeyville Regional Medical Center
67337 Coffeyville
United StatesSchwebend» Google-Maps
Central Care Cancer Center - Garden City
67846 Garden City
United StatesSchwebend» Google-Maps
Saint Catherine Hospital
67846 Garden City
United StatesSchwebend» Google-Maps
Central Care Cancer Center - Great Bend
67530 Great Bend
United StatesSchwebend» Google-Maps
University of Kansas Cancer Center-West
66112 Kansas City
United StatesSchwebend» Google-Maps
Kansas Institute of Medicine Cancer and Blood Center
66219 Lenexa
United StatesSchwebend» Google-Maps
Minimally Invasive Surgery Hospital
66219 Lenexa
United StatesSchwebend» Google-Maps
Menorah Medical Center
66209 Overland Park
United StatesSchwebend» Google-Maps
University of Kansas Cancer Center-Overland Park
66210 Overland Park
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 913-588-3671
E-Mail: KUCC_Navigation@kumc.edu» Ansprechpartner anzeigen
Saint Luke's South Hospital
66213 Overland Park
United StatesAktiv, nicht rekrutierend» Google-Maps
Cotton O'Neil Cancer Center / Stormont Vail Health
66606 Topeka
United StatesSchwebend» Google-Maps
Cancer Center of Kansas - Wellington
67152 Wellington
United StatesSchwebend» Google-Maps
University of Kansas Hospital-Westwood Cancer Center
66205 Westwood
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 913-588-3671
E-Mail: KUCC_Navigation@kumc.edu» Ansprechpartner anzeigen
Cancer Center of Kansas-Wichita Medical Arts Tower
67208 Wichita
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 316-268-5374
E-Mail: Keisha.humphries@ascension.org» Ansprechpartner anzeigen
Flaget Memorial Hospital
40004 Bardstown
United StatesSchwebend» Google-Maps
Commonwealth Cancer Center-Corbin
40701 Corbin
United StatesSchwebend» Google-Maps
Saint Joseph Radiation Oncology Resource Center
40504 Lexington
United StatesSchwebend» Google-Maps
Saints Mary and Elizabeth Hospital
40215 Louisville
United StatesSchwebend» Google-Maps
Jewish Hospital Medical Center Northeast
40245 Louisville
United StatesSchwebend» Google-Maps
Jewish Hospital Medical Center South
40165 Shepherdsville
United StatesSchwebend» Google-Maps
Louisiana Hematology Oncology Associates LLC
70809 Baton Rouge
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 225-215-1353
E-Mail: clinicalresearch@marybird.com» Ansprechpartner anzeigen
Our Lady of the Lake Physicians Group - Medical Oncology
70809 Baton Rouge
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 225-215-1353
E-Mail: clinicalresearch@marybird.com» Ansprechpartner anzeigen
Northshore Oncology Associates-Covington
70433 Covington
United StatesSchwebend» Google-Maps
Oncology Center of The South Incorporated
70360 Houma
United StatesAktiv, nicht rekrutierend» Google-Maps
Eastern Maine Medical Center
04401 Bangor
United StatesSchwebend» Google-Maps
University of Maryland/Greenebaum Cancer Center
21201 Baltimore
United StatesSchwebend» Google-Maps
TidalHealth Richard A Henson Cancer Institute
21811 Ocean Pines
United StatesAktiv, nicht rekrutierend» Google-Maps
TidalHealth Peninsula Regional
21801 Salisbury
United StatesAktiv, nicht rekrutierend» Google-Maps
Lowell General Hospital
01854 Lowell
United StatesAktiv, nicht rekrutierend» Google-Maps
University of Michigan Comprehensive Cancer Center
48109 Ann Arbor
United StatesAktiv, nicht rekrutierend» Google-Maps
IHA Hematology Oncology Consultants-Brighton
48114 Brighton
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
IHA Hematology Oncology Consultants-Canton
48188 Canton
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
IHA Hematology Oncology Consultants-Chelsea
48118 Chelsea
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Hematology Oncology Consultants-Clarkston
48346 Clarkston
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Henry Ford Macomb Hospital-Clinton Township
48038 Clinton Township
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 313-916-3721
E-Mail: CTOResearch@hfhs.org» Ansprechpartner anzeigen
Great Lakes Cancer Management Specialists-Doctors Park
48054 East China Township
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Michigan State University Clinical Center
48824-7016 East Lansing
United StatesAktiv, nicht rekrutierend» Google-Maps
Genesee Cancer and Blood Disease Treatment Center
48503 Flint
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Academic Hematology Oncology Specialists
48236 Grosse Pointe Woods
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
48236 Grosse Pointe Woods
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Michigan Breast Specialists-Grosse Pointe Woods
48236 Grosse Pointe Woods
United StatesSchwebend» Google-Maps
William Beaumont Hospital-Grosse Pointe
48230 Grosse Pointe
United StatesSchwebend» Google-Maps
Great Lakes Cancer Management Specialists-Macomb Medical Campus
48044 Macomb
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Michigan Breast Specialists-Macomb Township
48044 Macomb
United StatesSchwebend» Google-Maps
Saint Mary's Oncology/Hematology Associates of Marlette
48453 Marlette
United StatesSchwebend» Google-Maps
Toledo Clinic Cancer Centers-Monroe
48162 Monroe
United StatesSchwebend» Google-Maps
21st Century Oncology-Pontiac
48341 Pontiac
United StatesSchwebend» Google-Maps
Lake Huron Medical Center
48060 Port Huron
United StatesSchwebend» Google-Maps
Great Lakes Cancer Management Specialists-Rochester Hills
48309 Rochester Hills
United StatesSchwebend» Google-Maps
Michigan Cancer Specialists
48066 Roseville
United StatesSchwebend» Google-Maps
Oakland Colon Rectal Associates
48067 Royal Oak
United StatesSchwebend» Google-Maps
Cancer Care Associates PC
48073 Royal Oak
United StatesSchwebend» Google-Maps
Comprehensive Medical Center PLLC
48073 Royal Oak
United StatesSchwebend» Google-Maps
Hematology Oncology Consultants PC
48073 Royal Oak
United StatesSchwebend» Google-Maps
Oncology Hematology Associates of Saginaw Valley PC
48604 Saginaw
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Bhadresh Nayak MD PC-Sterling Heights
48312 Sterling Heights
United StatesSchwebend» Google-Maps
Premier Hematology Oncology Care
48312 Sterling Heights
United StatesSchwebend» Google-Maps
Mitchell Folbe MD PC
48314 Sterling Heights
United StatesSchwebend» Google-Maps
Michigan Institute of Urology-Town Center
48084 Troy
United StatesSchwebend» Google-Maps
Hematology Oncology Consultants PC-Troy
48098 Troy
United StatesSchwebend» Google-Maps
Advanced Breast Care Center PLLC
48088 Warren
United StatesSchwebend» Google-Maps
Great Lakes Cancer Management Specialists-Macomb Professional Building
48093 Warren
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Macomb Hematology Oncology PC
48093 Warren
United StatesSchwebend» Google-Maps
Michigan Breast Specialists-Warren
48093 Warren
United StatesSchwebend» Google-Maps
Saint Mary's Oncology/Hematology Associates of West Branch
48661 West Branch
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Huron Gastroenterology PC
48106 Ypsilanti
United StatesSchwebend» Google-Maps
IHA Hematology Oncology Consultants-Ann Arbor
48197 Ypsilanti
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 734-712-3671
E-Mail: stephanie.couch@stjoeshealth.org» Ansprechpartner anzeigen
Sanford Joe Lueken Cancer Center
56601 Bemidji
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 218-333-5000
E-Mail: OncologyClinicalTrialsFargo@sanfordhealth.org» Ansprechpartner anzeigen
Essentia Health Saint Joseph's Medical Center
56401 Brainerd
United StatesSchwebend» Google-Maps
Essentia Health Saint Mary's Medical Center
55805 Duluth
United StatesSchwebend» Google-Maps
Lake Region Healthcare Corporation-Cancer Care
56537 Fergus Falls
United StatesSchwebend» Google-Maps
Fairview Clinics and Surgery Center Maple Grove
55369 Maple Grove
United StatesSchwebend» Google-Maps
Minneapolis VA Medical Center
55417 Minneapolis
United StatesAktiv, nicht rekrutierend» Google-Maps
North Memorial Medical Health Center
55422 Robbinsdale
United StatesSchwebend» Google-Maps
Coborn Cancer Center at Saint Cloud Hospital
56303 Saint Cloud
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 877-229-4907
E-Mail: coborncancercenter@centracare.com» Ansprechpartner anzeigen
Park Nicollet Clinic - Saint Louis Park
55416 Saint Louis Park
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 952-993-1517
E-Mail: mmcorc@healthpartners.com» Ansprechpartner anzeigen
Saint Francis Regional Medical Center
55379 Shakopee
United StatesSchwebend» Google-Maps
Fairview Lakes Medical Center
55092 Wyoming
United StatesSchwebend» Google-Maps
Singing River Hospital
39581 Pascagoula
United StatesAktiv, nicht rekrutierend» Google-Maps
Central Care Cancer Center - Bolivar
65613 Bolivar
United StatesSchwebend» Google-Maps
Parkland Health Center-Bonne Terre
63628 Bonne Terre
United StatesSchwebend» Google-Maps
Cox Cancer Center Branson
65616 Branson
United StatesSchwebend» Google-Maps
Centerpoint Medical Center LLC
64057 Independence
United StatesSchwebend» Google-Maps
Capital Region Southwest Campus
65109 Jefferson City
United StatesSchwebend» Google-Maps
Saint Luke's Hospital of Kansas City
64111 Kansas City
United StatesAktiv, nicht rekrutierend» Google-Maps
The University of Kansas Cancer Center-South
64131 Kansas City
United StatesSchwebend» Google-Maps
Research Medical Center
64132 Kansas City
United StatesSchwebend» Google-Maps
University of Kansas Cancer Center - Lee's Summit
64064 Lee's Summit
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 913-588-3671
E-Mail: KUCC_Navigation@kumc.edu» Ansprechpartner anzeigen
Saint Luke's East - Lee's Summit
64086 Lee's Summit
United StatesAktiv, nicht rekrutierend» Google-Maps
Delbert Day Cancer Institute at PCRMC
65401 Rolla
United StatesSchwebend» Google-Maps
Mercy Clinic-Rolla-Cancer and Hematology
65401 Rolla
United StatesSchwebend» Google-Maps
Heartland Regional Medical Center
64506 Saint Joseph
United StatesSchwebend» Google-Maps
Saint Louis Cancer and Breast Institute-South City
63109 Saint Louis
United StatesSchwebend» Google-Maps
Siteman Cancer Center at Saint Peters Hospital
63376 Saint Peters
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 800-600-3606
E-Mail: info@siteman.wustl.edu» Ansprechpartner anzeigen
CoxHealth South Hospital
65807 Springfield
United StatesSchwebend» Google-Maps
Mercy Hospital Washington
63090 Washington
United StatesSchwebend» Google-Maps
Saint Peter's Community Hospital
59601 Helena
United StatesSchwebend» Google-Maps
Kalispell Regional Medical Center
59901 Kalispell
United StatesSchwebend» Google-Maps
Saint Patrick Hospital - Community Hospital
59802 Missoula
United StatesSchwebend» Google-Maps
Heartland Hematology and Oncology
68845 Kearney
United StatesSchwebend» Google-Maps
Saint Elizabeth Regional Medical Center
68510 Lincoln
United StatesSchwebend» Google-Maps
Alegent Health Immanuel Medical Center
68122 Omaha
United StatesSchwebend» Google-Maps
Hematology and Oncology Consultants PC
68122 Omaha
United StatesSchwebend» Google-Maps
Alegent Health Lakeside Hospital
68130 Omaha
United StatesSchwebend» Google-Maps
Creighton University Medical Center
68131 Omaha
United StatesSchwebend» Google-Maps
Midlands Community Hospital
68046 Papillion
United StatesSchwebend» Google-Maps
Carson Tahoe Regional Medical Center
89703 Carson City
United StatesSchwebend» Google-Maps
Cancer and Blood Specialists-Henderson
89052 Henderson
United StatesSchwebend» Google-Maps
Comprehensive Cancer Centers of Nevada - Henderson
89052 Henderson
United StatesSchwebend» Google-Maps
Comprehensive Cancer Centers of Nevada-Horizon Ridge
89052 Henderson
United StatesSchwebend» Google-Maps
Las Vegas Cancer Center-Henderson
89052 Henderson
United StatesSchwebend» Google-Maps
21st Century Oncology-Henderson
89074 Henderson
United StatesSchwebend» Google-Maps
Comprehensive Cancer Centers of Nevada-Southeast Henderson
89074 Henderson
United StatesSchwebend» Google-Maps
University Medical Center of Southern Nevada
89102 Las Vegas
United StatesSchwebend» Google-Maps
Cancer and Blood Specialists-Shadow
89106 Las Vegas
United StatesSchwebend» Google-Maps
Radiation Oncology Centers of Nevada Central
89106 Las Vegas
United StatesSchwebend» Google-Maps
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
89109 Las Vegas
United StatesSchwebend» Google-Maps
HealthCare Partners Medical Group Oncology/Hematology-San Martin
89113 Las Vegas
United StatesSchwebend» Google-Maps
Radiation Oncology Centers of Nevada Southeast
89119 Las Vegas
United StatesSchwebend» Google-Maps
Cancer Therapy and Integrative Medicine
89121 Las Vegas
United StatesSchwebend» Google-Maps
21st Century Oncology-Vegas Tenaya
89128 Las Vegas
United StatesSchwebend» Google-Maps
Cancer and Blood Specialists-Tenaya
89128 Las Vegas
United StatesSchwebend» Google-Maps
Comprehensive Cancer Centers of Nevada - Northwest
89128 Las Vegas
United StatesSchwebend» Google-Maps
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
89128 Las Vegas
United StatesSchwebend» Google-Maps
Comprehensive Cancer Centers of Nevada-Summerlin
89144 Las Vegas
United StatesSchwebend» Google-Maps
Summerlin Hospital Medical Center
89144 Las Vegas
United StatesSchwebend» Google-Maps
Las Vegas Cancer Center-Medical Center
89148-2405 Las Vegas
United StatesSchwebend» Google-Maps
21st Century Oncology-Fort Apache
89148 Las Vegas
United StatesSchwebend» Google-Maps
Comprehensive Cancer Centers of Nevada
89148 Las Vegas
United StatesSchwebend» Google-Maps
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
89149 Las Vegas
United StatesSchwebend» Google-Maps
Comprehensive Cancer Centers of Nevada - Central Valley
89169 Las Vegas
United StatesSchwebend» Google-Maps
Hope Cancer Care of Nevada-Pahrump
89048 Pahrump
United StatesSchwebend» Google-Maps
Saint Mary's Regional Medical Center
89503 Reno
United StatesSchwebend» Google-Maps
Radiation Oncology Associates
89509 Reno
United StatesSchwebend» Google-Maps
Englewood Hospital and Medical Center
07631 Englewood
United StatesAktiv, nicht rekrutierend» Google-Maps
Neurosurgeons of New Jersey-Ridgewood
07450 Ridgewood
United StatesSchwebend» Google-Maps
Robert Wood Johnson University Hospital Somerset
08876 Somerville
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 908-685-2481
E-Mail: Siby.Varughese@rwjbh.org» Ansprechpartner anzeigen
Inspira Medical Center Vineland
08360 Vineland
United StatesSchwebend» Google-Maps
Valley Health System-Hematology/Oncology
07675 Westwood
United StatesSchwebend» Google-Maps
Presbyterian Rust Medical Center/Jorgensen Cancer Center
87124 Rio Rancho
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 505-559-6113
E-Mail: WBurman@phs.org» Ansprechpartner anzeigen
Laura and Isaac Perlmutter Cancer Center at NYU Langone
10016 New York
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 212-263-4434
E-Mail: prmc.coordinator@nyumc.org» Ansprechpartner anzeigen
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
10032 New York
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 212-305-6361
E-Mail: nr2616@cumc.columbia.edu» Ansprechpartner anzeigen
Vassar Brothers Medical Center
12601 Poughkeepsie
United StatesSchwebend» Google-Maps
Rochester General Hospital
14621 Rochester
United StatesSchwebend» Google-Maps
University of Rochester
14642 Rochester
United StatesAktiv, nicht rekrutierend» Google-Maps
Stony Brook University Medical Center
11794 Stony Brook
United StatesAktiv, nicht rekrutierend» Google-Maps
Dickstein Cancer Treatment Center
10601 White Plains
United StatesSchwebend» Google-Maps
Cone Health Cancer Center at Alamance Regional
27215 Burlington
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 336-538-7725
E-Mail: kaye.shoffner@conehealth.com» Ansprechpartner anzeigen
UNC Lineberger Comprehensive Cancer Center
27599 Chapel Hill
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 877-668-0683
E-Mail: cancerclinicaltrials@med.unc.edu» Ansprechpartner anzeigen
Wayne Memorial Hospital
27534 Goldsboro
United StatesAktiv, nicht rekrutierend» Google-Maps
Margaret R Pardee Memorial Hospital
28791 Hendersonville
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 828-696-4716
E-Mail: karen.morris@unchealth.unc.edu» Ansprechpartner anzeigen
Onslow Memorial Hospital
28546 Jacksonville
United StatesAktiv, nicht rekrutierend» Google-Maps
Southeastern Medical Oncology Center-Jacksonville
28546 Jacksonville
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 910-587-9084
E-Mail: jfields@cancersmoc.com» Ansprechpartner anzeigen
Vidant Oncology-Richlands
28574 Richlands
United StatesSchwebend» Google-Maps
Sanford Bismarck Medical Center
58501 Bismarck
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 701-323-5760
E-Mail: OncologyClinicalTrialsFargo@sanfordhealth.org» Ansprechpartner anzeigen
Essentia Health Cancer Center-South University Clinic
58103 Fargo
United StatesSchwebend» Google-Maps
Sanford Broadway Medical Center
58122 Fargo
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 701-323-5760
E-Mail: OncologyClinicalTrialsFargo@sanfordhealth.org» Ansprechpartner anzeigen
Sanford Roger Maris Cancer Center
58122 Fargo
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 701-234-6161
E-Mail: OncologyClinicalTrialsFargo@sanfordhealth.org» Ansprechpartner anzeigen
Altru Cancer Center
58201 Grand Forks
United StatesAktiv, nicht rekrutierend» Google-Maps
Dayton Physicians LLC-Miami Valley South
45459 Centerville
United StatesSchwebend» Google-Maps
Oncology Hematology Care Inc-Kenwood
45236 Cincinnati
United StatesSchwebend» Google-Maps
Bethesda North Hospital
45242 Cincinnati
United StatesSchwebend» Google-Maps
TriHealth Cancer Institute-Westside
45247 Cincinnati
United StatesSchwebend» Google-Maps
TriHealth Cancer Institute-Anderson
45255 Cincinnati
United StatesSchwebend» Google-Maps
Cleveland Clinic Cancer Center/Fairview Hospital
44111 Cleveland
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 866-223-8100
E-Mail: TaussigResearch@ccf.org» Ansprechpartner anzeigen
Mount Carmel East Hospital
43213 Columbus
United StatesSchwebend» Google-Maps
Riverside Methodist Hospital
43214 Columbus
United StatesSchwebend» Google-Maps
Mount Carmel Health Center West
43222 Columbus
United StatesSchwebend» Google-Maps
Good Samaritan Hospital - Dayton
45406 Dayton
United StatesSchwebend» Google-Maps
Dayton Physician LLC-Miami Valley Hospital North
45415 Dayton
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 937-528-2900
E-Mail: clinical.trials@daytonncorp.org» Ansprechpartner anzeigen
Miami Valley Hospital North
45415 Dayton
United StatesSchwebend» Google-Maps
Delaware Radiation Oncology
43015 Delaware
United StatesSchwebend» Google-Maps
Armes Family Cancer Center
45840 Findlay
United StatesSchwebend» Google-Maps
Blanchard Valley Hospital
45840 Findlay
United StatesSchwebend» Google-Maps
Atrium Medical Center-Middletown Regional Hospital
45005-1066 Franklin
United StatesSchwebend» Google-Maps
Dayton Physicians LLC-Atrium
45005 Franklin
United StatesSchwebend» Google-Maps
Dayton Physicians LLC-Wayne
45331 Greenville
United StatesSchwebend» Google-Maps
Greater Dayton Cancer Center
45409 Kettering
United StatesSchwebend» Google-Maps
First Dayton Cancer Care
45420 Kettering
United StatesSchwebend» Google-Maps
Kettering Medical Center
45429 Kettering
United StatesSchwebend» Google-Maps
Fairfield Medical Center
43130 Lancaster
United StatesSchwebend» Google-Maps
Toledo Clinic Cancer Centers-Maumee
43537 Maumee
United StatesAktiv, nicht rekrutierend» Google-Maps
Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
43537 Maumee
United StatesAktiv, nicht rekrutierend» Google-Maps
Knox Community Hospital
43050 Mount Vernon
United StatesSchwebend» Google-Maps
Mercy Health Perrysburg Cancer Center
43551 Perrysburg
United StatesSchwebend» Google-Maps
Springfield Regional Cancer Center
45504 Springfield
United StatesSchwebend» Google-Maps
Springfield Regional Medical Center
45505 Springfield
United StatesSchwebend» Google-Maps
Dayton Physicians LLC-Upper Valley
45373 Troy
United StatesSchwebend» Google-Maps
Cleveland Clinic Wooster Family Health and Surgery Center
44691 Wooster
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 866-223-8100
E-Mail: TaussigResearch@ccf.org» Ansprechpartner anzeigen
University of Oklahoma Health Sciences Center
73104 Oklahoma City
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 405-271-8777
E-Mail: ou-clinical-trials@ouhsc.edu» Ansprechpartner anzeigen
Saint Alphonsus Medical Center-Baker City
97814 Baker City
United StatesSchwebend» Google-Maps
Clackamas Radiation Oncology Center
97015 Clackamas
United StatesSchwebend» Google-Maps
Providence Cancer Institute Clackamas Clinic
97015 Clackamas
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 503-215-2614
E-Mail: CanRsrchStudies@providence.org» Ansprechpartner anzeigen
Good Samaritan Hospital
97330 Corvallis
United StatesAktiv, nicht rekrutierend» Google-Maps
Abington Memorial Hospital
19001 Abington
United StatesSchwebend» Google-Maps
Christiana Care Health System-Concord Health Center
19317 Chadds Ford
United StatesSchwebend» Google-Maps
Ephrata Community Hospital
17522 Ephrata
United StatesSchwebend» Google-Maps
Cherry Tree Cancer Center
17331 Hanover
United StatesSchwebend» Google-Maps
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
17109 Harrisburg
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 717-724-6765
E-Mail: klitchfield@PINNACLEHEALTH.org» Ansprechpartner anzeigen
Geisinger Medical Center-Cancer Center Hazleton
18201 Hazleton
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 570-459-2901
E-Mail: HemonCCTrials@geisinger.edu» Ansprechpartner anzeigen
Allegheny Valley Hospital
15065 Natrona Heights
United StatesSchwebend» Google-Maps
Allegheny General Hospital
15212 Pittsburgh
United StatesSchwebend» Google-Maps
Geisinger Medical Oncology-Selinsgrove
17870 Selinsgrove
United StatesSchwebend» Google-Maps
Geisinger Wyoming Valley/Henry Cancer Center
18711 Wilkes-Barre
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 570-271-5251
E-Mail: HemonCCTrials@geisinger.edu» Ansprechpartner anzeigen
WellSpan Health-York Hospital
17403 York
United StatesSchwebend» Google-Maps
Prisma Health Cancer Institute - Spartanburg
29316 Boiling Springs
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 864-522-2066
E-Mail: kim.williams3@prismahealth.org» Ansprechpartner anzeigen
Medical University of South Carolina
29425 Charleston
United StatesAktiv, nicht rekrutierend» Google-Maps
Prisma Health Cancer Institute - Laurens
29325 Clinton
United StatesSchwebend» Google-Maps
Prisma Health Cancer Institute - Butternut
29605 Greenville
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 864-522-2066
E-Mail: kim.williams3@prismahealth.org» Ansprechpartner anzeigen
Prisma Health Greenville Memorial Hospital
29605 Greenville
United StatesSchwebend» Google-Maps
Prisma Health Cancer Institute - Eastside
29615 Greenville
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 864-522-2066
E-Mail: kim.williams3@prismahealth.org» Ansprechpartner anzeigen
Self Regional Healthcare
29646 Greenwood
United StatesAktiv, nicht rekrutierend» Google-Maps
Sanford Cancer Center Oncology Clinic
57104 Sioux Falls
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 605-312-3320
E-Mail: OncologyClinicTrialsSF@sanfordhealth.org» Ansprechpartner anzeigen
Sanford USD Medical Center - Sioux Falls
57117-5134 Sioux Falls
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 605-312-3320
E-Mail: OncologyClinicalTrialsSF@SanfordHealth.org» Ansprechpartner anzeigen
Wellmont Bristol Regional Medical Center
37620 Bristol
United StatesSchwebend» Google-Maps
Cookeville Regional Medical Center
38501 Cookeville
United StatesSchwebend» Google-Maps
Pulmonary Medicine Center of Chattanooga-Hixson
37343 Hixson
United StatesSchwebend» Google-Maps
Wellmont Medical Associates Oncology and Hematology-Johnson City
37604 Johnson City
United StatesSchwebend» Google-Maps
Regional Cancer Center at Indian Path Community Hospital
37660 Kingsport
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 423-578-8538
E-Mail: Justin.reynolds@balladhealth.org» Ansprechpartner anzeigen
Wellmont Holston Valley Hospital and Medical Center
37660 Kingsport
United StatesSchwebend» Google-Maps
Meharry Medical College
37208 Nashville
United StatesSchwebend» Google-Maps
Saint Joseph Regional Cancer Center
77802 Bryan
United StatesSchwebend» Google-Maps
UT Southwestern/Simmons Cancer Center-Dallas
75390 Dallas
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 214-648-7097
E-Mail: canceranswerline@UTSouthwestern.edu» Ansprechpartner anzeigen
Scott and White Healthcare Round Rock
78665 Round Rock
United StatesAktiv, nicht rekrutierend» Google-Maps
Scott and White Memorial Hospital
76508 Temple
United StatesAktiv, nicht rekrutierend» Google-Maps
American Fork Hospital / Huntsman Intermountain Cancer Center
84003 American Fork
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 801-855-4100
E-Mail: officeofresearch@imail.org» Ansprechpartner anzeigen
Intermountain Medical Center
84107 Murray
United StatesSchwebend» Google-Maps
Dixie Medical Center Regional Cancer Center
84770 Saint George
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 435-688-4167
E-Mail: officeofresearch@imail.org» Ansprechpartner anzeigen
Huntsman Cancer Institute/University of Utah
84112 Salt Lake City
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 888-424-2100
E-Mail: cancerinfo@hci.utah.edu» Ansprechpartner anzeigen
South Jordan Health Center
84009 South Jordan
United StatesSchwebend» Google-Maps
Centra Lynchburg Hematology-Oncology Clinic Inc
24501 Lynchburg
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 434-200-5925
E-Mail: Kevin.Patel@centrahealth.com» Ansprechpartner anzeigen
Bon Secours Memorial Regional Medical Center
23116 Mechanicsville
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 804-893-8663
E-Mail: Jaime_scott@bshsi.org» Ansprechpartner anzeigen
Bon Secours DePaul Medical Center
23505 Norfolk
United StatesSchwebend» Google-Maps
Virginia Commonwealth University/Massey Cancer Center
23298 Richmond
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 804-628-1914
E-Mail: klcampbell@vcu.edu» Ansprechpartner anzeigen
Peninsula Cancer Institute-Cancer Specialists of Tidewater
23454 Virginia Beach
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 773-702-9171
E-Mail: protocols@AllianceNCTN.org» Ansprechpartner anzeigen
Providence Regional Cancer System-Aberdeen
98520 Aberdeen
United StatesSchwebend» Google-Maps
PeaceHealth Saint Joseph Medical Center
98225 Bellingham
United StatesSchwebend» Google-Maps
Harrison HealthPartners Hematology and Oncology-Bremerton
98310 Bremerton
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 308-398-6518
E-Mail: clinicaltrials@sfmc-gi.org» Ansprechpartner anzeigen
Harrison Medical Center
98310 Bremerton
United StatesSchwebend» Google-Maps
Highline Medical Center-Main Campus
98166 Burien
United StatesSchwebend» Google-Maps
Providence Regional Cancer System-Centralia
98531 Centralia
United StatesSchwebend» Google-Maps
Swedish Cancer Institute-Edmonds
98026 Edmonds
United StatesSchwebend» Google-Maps
Saint Elizabeth Hospital
98022 Enumclaw
United StatesSchwebend» Google-Maps
Providence Regional Cancer Partnership
98201 Everett
United StatesSchwebend» Google-Maps
Saint Francis Hospital
98003 Federal Way
United StatesSchwebend» Google-Maps
Swedish Cancer Institute-Issaquah
98029 Issaquah
United StatesSchwebend» Google-Maps
Kadlec Clinic Hematology and Oncology
99336 Kennewick
United StatesSchwebend» Google-Maps
Providence Regional Cancer System-Lacey
98503 Lacey
United StatesSchwebend» Google-Maps
PeaceHealth Saint John Medical Center
98632 Longview
United StatesSchwebend» Google-Maps
Harrison HealthPartners Hematology and Oncology-Poulsbo
98370 Poulsbo
United StatesSchwebend» Google-Maps
Virginia Mason Medical Center
98101 Seattle
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 206-342-6954
E-Mail: vmmc.cancer_clinical_research@VirginiaMason.org» Ansprechpartner anzeigen
Pacific Gynecology Specialists
98104 Seattle
United StatesSchwebend» Google-Maps
Swedish Medical Center-Ballard Campus
98107 Seattle
United StatesSchwebend» Google-Maps
Kaiser Permanente Washington
98112 Seattle
United StatesAktiv, nicht rekrutierend» Google-Maps
Swedish Medical Center-Cherry Hill
98122-5711 Seattle
United StatesSchwebend» Google-Maps
Providence Regional Cancer System-Shelton
98584 Shelton
United StatesSchwebend» Google-Maps
MultiCare Deaconess Cancer and Blood Specialty Center - Valley
99216 Spokane Valley
United StatesSchwebend» Google-Maps
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
99204 Spokane
United StatesSchwebend» Google-Maps
MultiCare Deaconess Cancer and Blood Specialty Center - North
99218 Spokane
United StatesSchwebend» Google-Maps
Franciscan Research Center-Northwest Medical Plaza
98405 Tacoma
United StatesSchwebend» Google-Maps
Northwest Medical Specialties PLLC
98405 Tacoma
United StatesSchwebend» Google-Maps
PeaceHealth Southwest Medical Center
98664 Vancouver
United StatesSchwebend» Google-Maps
Providence Saint Mary Regional Cancer Center
99362 Walla Walla
United StatesSchwebend» Google-Maps
Providence Regional Cancer System-Yelm
98597 Yelm
United StatesSchwebend» Google-Maps
WVUH-Berkely Medical Center
25401 Martinsburg
United StatesSchwebend» Google-Maps
West Virginia University Healthcare
26506 Morgantown
United StatesSchwebend» Google-Maps
Camden Clark Medical Center
26101 Parkersburg
United StatesSchwebend» Google-Maps
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
53045 Brookfield
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 414-635-6420
E-Mail: AWRI.Inquiry@Ascension.org» Ansprechpartner anzeigen
Marshfield Medical Center-EC Cancer Center
54701 Eau Claire
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 800-782-8581
E-Mail: oncology.clinical.trials@marshfieldresearch.org» Ansprechpartner anzeigen
Ascension Saint Francis - Reiman Cancer Center
53132 Franklin
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 414-635-6420
E-Mail: AWRI.Inquiry@Ascension.org» Ansprechpartner anzeigen
Saint Vincent Hospital Cancer Center Green Bay
54301 Green Bay
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 920-433-8889
E-Mail: ewd_research_admin@hshs.org» Ansprechpartner anzeigen
Saint Vincent Hospital Cancer Center at Saint Mary's
54303 Green Bay
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 920-433-8889
E-Mail: ewd_research_admin@hshs.org» Ansprechpartner anzeigen
Marshfield Medical Center-Marshfield
54449 Marshfield
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 800-782-8581
E-Mail: oncology.clinical.trials@marshfieldresearch.org» Ansprechpartner anzeigen
Marshfield Clinic-Minocqua Center
54548 Minocqua
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 800-782-8581
E-Mail: oncology.clinical.trials@marshfieldresearch.org» Ansprechpartner anzeigen
Saint Vincent Hospital Cancer Center at Oconto Falls
54154 Oconto Falls
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 920-433-8889
E-Mail: ewd_research_admin@hshs.org» Ansprechpartner anzeigen
Marshfield Medical Center-Rice Lake
54868 Rice Lake
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 800-782-8581
E-Mail: oncology.clinical.trials@marshfieldresearch.org» Ansprechpartner anzeigen
Marshfield Clinic Stevens Point Center
54482 Stevens Point
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 800-782-8581
E-Mail: oncology.clinical.trials@marshfieldresearch.org» Ansprechpartner anzeigen
Saint Vincent Hospital Cancer Center at Sturgeon Bay
54235-1495 Sturgeon Bay
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 920-433-8889
E-Mail: ewd_research_admin@hshs.org» Ansprechpartner anzeigen
Ascension Medical Group Southeast Wisconsin - Mayfair Road
53226 Wauwatosa
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 414-635-6420
E-Mail: AWRI.Inquiry@Ascension.org» Ansprechpartner anzeigen
Marshfield Medical Center - Weston
54476 Weston
United StatesRekrutierend» Google-Maps
Ansprechpartner:
Site Public Contact
Phone: 800-782-8581
E-Mail: oncology.clinical.trials@marshfieldresearch.org» Ansprechpartner anzeigen
Cheyenne Regional Medical Center-West
82001 Cheyenne
United StatesSchwebend» Google-Maps
Doctor's Cancer Center-Arecibo
00614 Arecibo
Puerto RicoSchwebend» Google-Maps
Hematologia Oncologia San Pablo
00961 Bayamon
Puerto RicoSchwebend» Google-Maps
HIMA San Pablo Oncologic Hospital
00726 Caguas
Puerto RicoSchwebend» Google-Maps
Instituto Oncologia Moderna Ponce
00716 Ponce
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Primary Care Physician Group
00920 San Juan
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Centro de Hematologia y Oncologia del Sur
00757 Santa Isabel
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Studien-Informationen

Detailed Description:

PRIMARY OBJECTIVE:

I. To determine whether atezolizumab combined with oxaliplatin, leucovorin calcium, and

fluorouracil (FOLFOX) and its continuation as monotherapy can significantly improve

disease-free survival (DFS) compared to FOLFOX alone in patients with stage III colon cancers

and deficient DNA mismatch repair (dMMR).

SECONDARY OBJECTIVES:

I. To determine whether atezolizumab combined with FOLFOX and its continuation as monotherapy

can significantly improve overall survival compared to FOLFOX alone in patients with stage

III colon cancers and dMMR.

II. To assess the adverse events (AE) profile and safety of each treatment arm, using the

Common Terminology Criteria for Adverse Events (CTCAE) and patient related outcomes

(PRO)-CTCAE.

QUALITY OF LIFE OBJECTIVE:

I. To determine the impact of the addition of atezolizumab to FOLFOX on patient-reported

neuropathy, health-related quality of life (QOL), and functional domains of health-related

QOL.

POTENTIAL CORRELATIVE SCIENCE OBJECTIVES:

I. To determine if the "immunoscore" can predict the efficacy of atezolizumab for

disease-free survival among patients with stage III colon cancer.

II. To assess whether circulating immune cell populations can predict the efficacy of

atezolizumab as adjuvant therapy for stage III colon cancer.

III. To explore the associations of genomic alterations identified in cell-free (cf)DNA with

DFS in patients treated with FOLFOX with or without atezolizumab.

IV. To assess whether soluble markers of systemic inflammation in blood can predict the

efficacy of atezolizumab as adjuvant therapy for stage III colon cancer.

V. To assess the relationship between baseline plasma 25(OH) D levels, change in 25(OH)D

levels, and DFS and overall survival (OS) in patients with stage III colon cancer receiving

FOLFOX +/- atezolizumab.

VI. To determine the ability of using fecal microbiota and their metabolic products to

predict survival benefit from anti-PD-L1 antibody therapy in dMMR colon cancer patients.

VII. To determine if hypermutation or hyper-indel status is associated with response to

atezolizumab.

VIII. To determine if unique messenger ribonucleic acid (mRNA) expression signatures are

predictive of disease-free survival among patients receiving adjuvant chemotherapy for stage

III colon cancer.

IX. To determine if the efficacy of atezolizumab differs among dMMR cancers due to germline

MMR mutation (MLH1, MSH2, MSH6, PMS2) versus those with MLH1 hypermethylation and CIMP in

patients with stage III colon cancer.

X. To identify overall mutational burden and number of putative tumor neoantigens in colon

carcinoma specimens.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients receive oxaliplatin intravenously (IV) over 2 hours and leucovorin calcium IV

over 2 hours on day 1, and fluorouracil IV as a bolus on day 1, then continuously over 46

hours on days 1-3. Treatment repeats every 14 days for up to 12 cycles in the absence of

disease progression or unacceptable toxicity. Patients also receive atezolizumab IV over

30-60 minutes starting on day 1 of cycle 1 or 2. Treatment repeats every 14 days for up to 25

cycles in the absence of disease progression or unacceptable toxicity.

ARM II: Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours

on day 1, and fluorouracil IV as a bolus on day 1, then continuously over 46 hours on days

1-3. Treatment repeats every 14 days for up to 12 cycles in the absence of disease

progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for recurrence every 6 months

for 2 years, then annually for 3 years. Patients are also followed up for survival every 6

months for up to 8 years.

Ein-/Ausschlusskriterien

Inclusion Criteria:

- Histologically proven stage III colon adenocarcinoma (any T [Tx, T1, T2, T3, or T4],

N1-2M0; includes N1C); tumors must be deemed to originate in the colon including

tumors that extend into/involve the small bowel (e.g. those at the ileocecal valve)

- Presence of deficient (d) DNA mismatch repair (dMMR); MMR status must be assessed by

immunohistochemistry (IHC) for MMR protein expression (MLH1, MSH2, MSH6, PMS2) where

loss of one or more proteins indicates dMMR; dMMR may be determined either locally or

by site-selected reference lab; Note: loss of MLH1 and PMS2 commonly occur together;

formalin-fixed paraffin-embedded (FFPE) tumor tissue is required for subsequent

retrospective central confirmation of dMMR status

- Patients with testing that did not show dMMR (loss of MMR protein) are not eligible to

participate; patients whose tumors show MSI-H by polymerase chain reaction (PCR)-based

assay are not eligible to participate unless they also have MMR testing by IHC and are

found to have dMMR (i.e. loss of one or more MMR proteins)

- Patients who are known to have Lynch syndrome and have been found to carry a specific

germline mutation in an MMR gene (MLH1, MSH2, MSH6, PMS2) are eligible to participate

- Tumors must have been completely resected; in patients with tumor adherent to adjacent

structures, en bloc R0 resection must be documented in the operative report or

otherwise confirmed by the surgeon; near or positive radial margins are acceptable so

long as en bloc resection was performed; proximal or distal margin positivity is not

permitted

- Entire tumor must be in the colon (rectal involvement is an exclusion); surgeon

confirmation that entire tumor was located in the colon is required only in cases

where it is important to establish if the tumor is a colon versus (vs.) rectal

primary; patients with more than one primary colon adenocarcinoma are eligible if the

qualifying stage III tumor is confined to the colon, and not rectum, and the other

cancers of lower stage are removed in the en bloc R0 resection

- Based upon the operative report and other source documentation, the location of the

primary tumor will be categorized as proximal or distal to the splenic flexure

(included with distal), and further categorization will be as follows:

cecum/ascending, transverse, descending, sigmoid colon, or rectosigmoid colon

- No evidence of residual involved lymph node disease or metastatic disease at the time

of registration based on clinician assessment of imaging; the treating physician will

determine if incidental lesions on imaging require workup to exclude metastatic

disease; if based on review of images, the treating physician determines the patient

to be stage III, then the patient is eligible

- No prior medical therapy (chemotherapy, immunotherapy, biologic or targeted therapy)

or radiation therapy for the current colon cancer except for one cycle of mFOLFOX6

- Eastern Cooperative Oncology Group (ECOG) performance status =< 2

- This study involves: 1) an investigational agent whose genotoxic, mutagenic and

teratogenic effects on the developing fetus and newborn are unknown; and 2) an agent

that has known genotoxic, mutagenic, and teratogenic effects; therefore, for women of

childbearing potential only, a negative pregnancy test done =< 7 days prior to

registration is required; a female of childbearing potential is a sexually mature

female who: 1) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has

not been naturally postmenopausal for at least 12 consecutive months (i.e. has had

menses at any time in the preceding 12 consecutive months)

- Absolute neutrophil count (ANC) >= 1500 mm^3

- Platelet count >= 100,000 mm^3; platelets >= 75,000 required for patients who received

cycle 1 of mFOLFOX6 prior to registration

- Creatinine =< 1.5 x upper limit of normal (ULN) or

- Calculated creatinine clearance >= 45 mL/min by Cockcroft-Gault equation

- Total bilirubin =< 1.5 x upper limit of normal (ULN) except in the case of Gilbert

disease

- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit

of normal (ULN)

- Thyroid-stimulating hormone (TSH) within normal limits (WNL); supplementation is

acceptable to achieve a TSH WNL; in patients with abnormal TSH, if free T4 is normal

and patient is clinically euthyroid, patient is eligible

- No active known autoimmune disease, including colitis, inflammatory bowel disease

(i.e. ulcerative colitis or Crohn's disease), rheumatoid arthritis,

panhypopituitarism, adrenal insufficiency

- No known active hepatitis B or C

- Active hepatitis B can be defined as:

- Hepatitis B virus surface antigen (HBsAg) detectable for > 6 months;

- Serum hepatitis B virus (HBV) DNA 20,000 IU/ml (105 copies/ml); lower values

2,000-20,000 IU/ml (104-105 copies/ml) are often seen in hepatitis B virus e

antigen (HBeAg)-negative chronic hepatitis B

- Persistent or intermittent elevation in ALT/AST levels

- Liver biopsy showing chronic hepatitis with moderate or severe

necroinflammation

- Active hepatitis C can be defined as:

- Hepatitis C antibody (AB) positive AND

- Presence of hepatitis C virus (HCV) RNA

- Excluded if known active pulmonary disease with hypoxia defined as:

- Oxygen saturation < 85% on room air, or

- Oxygen saturation < 88% despite supplemental oxygen

- No grade >= 2 peripheral motor or sensory neuropathy

- Patients positive for human immunodeficiency virus (HIV) are eligible only if they

meet all of the following:

- A stable regimen of highly active anti-retroviral therapy (HAART)

- No requirement for concurrent antibiotics or antifungal agents for the prevention

of opportunistic infections

- A CD4 count above 250 cells/mcL, and an undetectable HIV viral load on standard

PCR-based tests

- No other planned concurrent investigational agents or other tumor directed therapy

(chemotherapy, radiation) while on study

- No systemic daily treatment with either corticosteroids (> 10 mg daily prednisone

equivalents) or other immunosuppressive medications within 7 days of registration

- No known history of severe allergic anaphylactic reactions to chimeric, human or

humanized antibodies, or fusion proteins

- No known hypersensitivity to Chinese hamster ovary (CHO) cell products or any

component of the atezolizumab formulation

- No known allergy to 5-fluorouracil, oxaliplatin, or leucovorin

Studien-Rationale

Primary outcome:

1. Disease free survival (DFS) (Time Frame - From the time from randomization to first documentation of disease recurrent or death, assessed up to 5 years):
DFS will be compared between treatment arms using the stratified log rank test at one-sided level 0.025. The hazard ratio (HR) for DFS will be estimated using a stratified Cox proportional hazards model and the 95% confidence interval (CI) for the HR will be provided. Results from an unstratified analysis will also be provided. Kaplan-Meier methodology will be used to estimate the median DFS for each treatment arm, and Kaplan-Meier curves will be produced. Brookmeyer Crowley methodology will be used to construct the 95% CI for the median DFS for each treatment arm.



Secondary outcome:

1. Overall survival (Time Frame - From the time from randomization to death, from any cause, assessed up to 5 years):
The distribution of overall survival will be estimated using the method of Kaplan-Meier. Overall survival will be compared between treatment arms using the log-rank test.

2. Incidence of adverse events (Time Frame - Up to 30 days after last treatment):
Assessed by Common Terminology Criteria for Adverse Events version 4.0. Frequency tables will be reviewed to determine the patterns. The overall adverse event rates will be compared between treatment arms using Chi-square test (or Fisher's exact test if the data in contingency table is sparse).

Studien-Arme

  • Experimental: Arm I (combination chemotherapy, atezolizumab)
    Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV as a bolus on day 1, then continuously over 46 hours on days 1-3. Treatment repeats every 14 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity. Patients also receive atezolizumab IV over 30-60 minutes starting on day 1 of cycle 1 or 2. Treatment repeats every 14 days for up to 25 cycles in the absence of disease progression or unacceptable toxicity.
  • Active Comparator: Arm II (combination chemotherapy)
    Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours on day 1, and fluorouracil IV as a bolus on day 1, then continuously over 46 hours on days 1-3. Treatment repeats every 14 days for up to 12 cycles in the absence of disease progression or unacceptable toxicity.

Geprüfte Regime

  • Atezolizumab (MPDL 3280A / MPDL 328OA / MPDL-3280A / MPDL3280A / MPDL328OA / RG7446 / RO5541267 / Tecentriq / ):
    Given IV
  • Fluorouracil (5 Fluorouracil / 5 Fluorouracilum / 5 FU / 5-Fluoro-2,4(1H, 3H)-pyrimidinedione / 5-Fluorouracil / 5-Fluracil / 5-Fu / 5FU / AccuSite / Carac / Fluoro Uracil / Fluouracil / Flurablastin / Fluracedyl / Fluracil / Fluril / Fluroblastin / Ribofluor / Ro 2-9757 / Ro-2-9757 / ):
    Given IV
  • Laboratory Biomarker Analysis:
    Correlative studies
  • Leucovorin Calcium (Adinepar / Calcifolin / Calcium (6S)-Folinate / Calcium Folinate / Calcium Leucovorin / Calfolex / Calinat / Cehafolin / Citofolin / Citrec / Citrovorum Factor / Cromatonbic Folinico / Dalisol / Disintox / Divical / Ecofol / Emovis / Factor, Citrovorum / Flynoken A / Folaren / Folaxin / FOLI-cell / Foliben / Folidan / Folidar / Folinac / Folinate Calcium / folinic acid / Folinic Acid Calcium Salt Pentahydrate / Folinoral / Folinvit / Foliplus / Folix / Imo / Lederfolat / Lederfolin / Leucosar / leucovorin / Rescufolin / Rescuvolin / Tonofolin / Wellcovorin / ):
    Given IV
  • Oxaliplatin (1-OHP / Ai Heng / Aiheng / Dacotin / Dacplat / Diaminocyclohexane Oxalatoplatinum / Eloxatin / Eloxatine / JM-83 / Oxalatoplatin / Oxalatoplatinum / RP 54780 / RP-54780 / SR-96669 / ):
    Given IV
  • Quality-of-Life Assessment (Quality of Life Assessment):
    Ancillary studies

Quelle: ClinicalTrials.gov


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