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JOURNAL ONKOLOGIE – STUDIE
IMreal

A Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated in Routine Clinical Practice

Rekrutierend

NCT-Nummer:
NCT03782207

Studienbeginn:
Februar 2019

Letztes Update:
08.04.2021

Wirkstoff:
Atezolizumab

Indikation (Clinical Trials):
Lung Neoplasms, Small Cell Lung Carcinoma, Carcinoma, Carcinoma, Hepatocellular

Geschlecht:
Alle

Altersgruppe:
Erwachsene (18+)

Phase:
-

Sponsor:
Hoffmann-La Roche

Collaborator:
-

Studienleiter

Clinical Trials
Study Director
Hoffmann-La Roche

Kontakt

Reference Study ID Number: MO40653 www.roche.com/about_roche/roche_worldwide.htm
Kontakt:
Phone: 888-662-6728 (U.S. and Canada)
E-Mail: global-roche-genentech-trials@gene.com
» Kontaktdaten anzeigen

Studienlocations
(3 von 280)

Inst. Alexander Fleming; Oncology Dept
C1426ANZ Buenos Aires
ArgentinaRekrutierend» Google-Maps
Consultorio Privado Korbenfeld
C1426AGE Caba
ArgentinaRekrutierend» Google-Maps
Lucen S.A.
C1405CUB Ciudad Autónoma de Buenos Aires
ArgentinaRekrutierend» Google-Maps
Klinikum Klagenfurt; Abteilung für Pulmologie
9020 Klagenfurt
AustriaRekrutierend» Google-Maps
Salzkammergut-Klinikum Voecklabruck
4840 Vöcklabruck
AustriaRekrutierend» Google-Maps
Klinikum Wels-Grieskirchen; Lungenabt.
4600 Wels
AustriaRekrutierend» Google-Maps
Wilhelminenspital; Ii. Medizinische Abt.
1160 Wien
AustriaZurückgezogen» Google-Maps
AZ St Maarten Campus Leopoldstr
2800 Mechelen
BelgiumAktiv, nicht rekrutierend» Google-Maps
COT - Centro Oncologico do Triangulo
38408-150 Uberlandia
BrazilZurückgezogen» Google-Maps
ELO Pesquisa Clínica, Ensino e Consultoria Médica
87015-200 Maringa
BrazilNoch nicht rekrutierend» Google-Maps
D'or Instituto de Pesquisa e Educação
Rio de Janeiro
BrazilNoch nicht rekrutierend» Google-Maps
Oncoclinicas Rio de Janeiro S.A.
Rio de Janeiro
BrazilZurückgezogen» Google-Maps
Beneficencia Portuguesa de Sao Paulo
01323-900 Sao Paulo
BrazilRekrutierend» Google-Maps
Multiprofile Hospital for Active Treatment Uni Hospital; Department of medicinal oncology
4500 Panagyurishte
BulgariaRekrutierend» Google-Maps
Umhat Dr Georgi Stranski; Clinic of Chemotherapy
5800 Pleven
BulgariaRekrutierend» Google-Maps
University Hospital Palmed; Medical Oncology Ward
4001 Plovdiv
BulgariaRekrutierend» Google-Maps
Complex Oncological Center - Plovdiv, EOOD; Third Internal Department
4004 Plovdiv
BulgariaRekrutierend» Google-Maps
Complex Oncology Center - Plovdiv First Internal Chemotherapy Department
4004 Plovdiv
BulgariaRekrutierend» Google-Maps
Multi profiled Hospital for active treatment Park Hospital; Department of medicinal oncology
Plovdiv
BulgariaZurückgezogen» Google-Maps
Complex Oncological Center-Ruse EOOD; Department of Medical Oncology
7000 Ruse
BulgariaRekrutierend» Google-Maps
UMHAT "Sv. Ivan Rilski", EAD
1431 Sofia
BulgariaZurückgezogen» Google-Maps
Specialized Hospital for Active Cancer Treatment, Dr. Mark Antonov Markov - Varna Ltd
9010 Varna
BulgariaRekrutierend» Google-Maps
Southern Medical University Nanfang Hospital
510515 Guangdong Province Guangzhou City
ChinaNoch nicht rekrutierend» Google-Maps
The First Affiliated Hospital of Guangzhou Medical University
510120 Guangzhou
ChinaNoch nicht rekrutierend» Google-Maps
Shandong Cancer Hospital
250117 Jinan
ChinaNoch nicht rekrutierend» Google-Maps
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
210008 Nanjing City
ChinaNoch nicht rekrutierend» Google-Maps
Jiangsu Cancer Hospital
211100 Nanjing City
ChinaNoch nicht rekrutierend» Google-Maps
Jiangsu Province Hospital
210036 Nanjing
ChinaNoch nicht rekrutierend» Google-Maps
Guangxi Cancer Hospital of Guangxi Medical University
530021 Nanning
ChinaNoch nicht rekrutierend» Google-Maps
Tianjin Medical University General Hospital
300052 Tianjin
ChinaNoch nicht rekrutierend» Google-Maps
Tianjin Cancer Hospital
300060 Tianjin
ChinaNoch nicht rekrutierend» Google-Maps
The Affiliated Hospital of Xuzhou Medical College
221000 Xuzhou
ChinaNoch nicht rekrutierend» Google-Maps
Henan Provincial People's Hospital
450003 Zhengzhou
ChinaNoch nicht rekrutierend» Google-Maps
Organizacion Sanitas Internacional
Bogota
ColombiaRekrutierend» Google-Maps
Clinical Hospital Centre Osijek
31000 Osijek
CroatiaAktiv, nicht rekrutierend» Google-Maps
Klinicki Bolnicki Centar Split
21000 Split
CroatiaAktiv, nicht rekrutierend» Google-Maps
Clinical Hospital Center Sestre Milosrdnice; Clinic for tumors
10000 Zagreb
CroatiaAktiv, nicht rekrutierend» Google-Maps
Clinical Hospital Center Sestre Milosrdnice
10000 Zagreb
CroatiaAktiv, nicht rekrutierend» Google-Maps
Clinical Hospital Centre Zagreb
10000 Zagreb
CroatiaAktiv, nicht rekrutierend» Google-Maps
Yasser Abdel Kader Private Clinic
11391 Cairo
EgyptRekrutierend» Google-Maps
International Medical Center; Oncology Department
Cairo
EgyptRekrutierend» Google-Maps
Clinique Du Docteur Calabet; Cromg
47000 Agen
FranceAktiv, nicht rekrutierend» Google-Maps
Ch Du Pays D Aix; Pneumologie
13616 Aix En Provence
FranceAktiv, nicht rekrutierend» Google-Maps
Clinique de l'Europe
80090 Amiens
FranceAktiv, nicht rekrutierend» Google-Maps
Centre Hospitalier Uni Ire; Pneumology
49933 Angers
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Prive D Antony; Oncologie
92166 Antony
FranceAktiv, nicht rekrutierend» Google-Maps
CHG Henri Dufaut médecine interne-onco-hematologie
84902 Avignon
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Jean Minjoz; Pneumologie
25030 Besancon
FranceAktiv, nicht rekrutierend» Google-Maps
Ch De Beziers; Pneumologie
34525 Beziers
FranceAktiv, nicht rekrutierend» Google-Maps
Clinique Tivoli; Chimiotherapie Radiotherapie
33030 Bordeaux
FranceAktiv, nicht rekrutierend» Google-Maps
Polyclinique Bordeaux Nord Aquitaine; Chimiotherapie Radiotherapie
33077 Bordeaux
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Cote De Nacre; Pneumologie
14000 Caen
FranceAktiv, nicht rekrutierend» Google-Maps
Ch De Chambery; Pneumologie
73011 Chambery
FranceAktiv, nicht rekrutierend» Google-Maps
Oncologie 37; Bureau
37170 Chambray Les Tours
FranceAktiv, nicht rekrutierend» Google-Maps
Centre Jean Perrin Centre Regional de Lutte Contre Le Cancer D auvergne
63003 Clermont-ferrand
FranceZurückgezogen» Google-Maps
Hopital Gabriel Montpied; Service de Pneumologie
63003 Clermont-ferrand
FranceAktiv, nicht rekrutierend» Google-Maps
Ch De Compiegne; Pneumologie
60321 Compiegne
FranceAktiv, nicht rekrutierend» Google-Maps
Ch Laennec; Pneumologie
60109 Creil
FranceAktiv, nicht rekrutierend» Google-Maps
Centre Georges Francois Leclerc; Oncologie 3
21079 Dijon
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Simone Veil Eaubonne; Hopital De Jour
95602 Eaubonne
FranceAktiv, nicht rekrutierend» Google-Maps
Chi Alpes Du Sud Site De Gap; Pneumologie
05007 GAP
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Nord Ouest;Unite 2c
69400 Gleize
FranceAktiv, nicht rekrutierend» Google-Maps
Ch Saint Louis; Pneumologie
17019 La Rochelle
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital La Source; Pneumologie
45100 La Source
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Louis Pasteur; Oncologie Hematologie
28630 Le Coudray
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Louis Pasteur; Pneumologie
28630 Le Coudray
FranceAktiv, nicht rekrutierend» Google-Maps
Centre Hospitalier Du Mans; Maladies Respiratoires
72000 Le Mans
FranceAktiv, nicht rekrutierend» Google-Maps
Hôpital Privé La Louviere; Pneumologie
59042 Lille
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Dupuytren; Pneumologie
87042 Limoges
FranceAktiv, nicht rekrutierend» Google-Maps
Ch Bretagne Sud Site Scorff; Oncologie Medicale
56100 Lorient
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Privé Jean Mermoz; Pneumologie
69008 Lyon
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Europeen
13003 Marseille
FranceAktiv, nicht rekrutierend» Google-Maps
Clinique Clementville; Hopital De Jour
34070 Montpellier
FranceAktiv, nicht rekrutierend» Google-Maps
Centre Regional de Lutte contre le Cancer Val d Aurelle - Paul Lamarque; Service d oncologie
34298 Montpellier
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Emile Muller;Pneumologie
68070 Mulhouse
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Caremeau; Pneumologie
30029 Nimes
FranceAktiv, nicht rekrutierend» Google-Maps
Polyclinique Kenval ; Radiotherapie Oncologie
30900 Nimes
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Cochin; Unite Fonctionnelle D Oncologie
75014 Paris
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Europeen Georges Pompidou; Service D'Oncologie Medicale
75908 Paris
FranceAktiv, nicht rekrutierend» Google-Maps
Centre Hospitalier; Pneumologie
64046 PAU
FranceAktiv, nicht rekrutierend» Google-Maps
Centre Catalan D' Oncologie
66000 Perpignan
FranceAktiv, nicht rekrutierend» Google-Maps
Chu La Miletrie; Pneumologie
86021 Poitiers
FranceZurückgezogen» Google-Maps
CH ANNECY - GENEVOIS; Pneumologie
74374 Pringy
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital De La Maison Blanche;Maladies Respiratoires
51092 Reims
FranceAktiv, nicht rekrutierend» Google-Maps
Clinique Mutualiste L Estuaire; Oncologie
44606 Saint Nazaire
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Nord; Service de Pneumologie
42770 Saint Priest En Jarez
FranceAktiv, nicht rekrutierend» Google-Maps
HOPITAL ROBERT PAX; Pneumologie
Sarreguemines
FranceAktiv, nicht rekrutierend» Google-Maps
Ch De Saint Quentin; Medecine B14
02321 St Quentin
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Sainte Musse; Pneumologie
83056 Toulon
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Larrey; Pneumologie
31059 Toulouse
FranceAktiv, nicht rekrutierend» Google-Maps
Clinique Pasteur; Oncologie Medicale
31076 Toulouse
FranceZurückgezogen» Google-Maps
Centre Hospitalier de Valence; Pneumologie
26000 Valence
FranceAktiv, nicht rekrutierend» Google-Maps
Service de pneumologie Clinique médico-chirurgicale Tessier
59326 Valenciennes Cedex
FranceAktiv, nicht rekrutierend» Google-Maps
Ch Bretagne Atlantique; Pneumologie-Oncologie
56017 Vannes
FranceAktiv, nicht rekrutierend» Google-Maps
Hopital Robert Schuman; Pneumologie
57070 Vantoux
FranceAktiv, nicht rekrutierend» Google-Maps
Semmelweis Egyetem, AOK, Pulmonologiai Klinika
1083 Budapest
HungaryRekrutierend» Google-Maps
Orszagos Koranyi TBC es Pulmonologiai Intezet
1121 Budapest
HungaryAktiv, nicht rekrutierend» Google-Maps
Debreceni Egyetem, Klinikai Kozpont, Tudogyogyaszati Klinika
4032 Debrecen
HungaryRekrutierend» Google-Maps
University of Pecs; 1St Department of Medicine
7623 Pecs
HungaryAktiv, nicht rekrutierend» Google-Maps
Tudogyogyintezet Torokbalint; Onkologiai és Jarobeteg Centrum
2045 Törökbálint
HungaryRekrutierend» Google-Maps
Soroka Medical Center; Oncology Dept
8410100 Beer Sheva
IsraelNoch nicht rekrutierend» Google-Maps
Rambam Medical Center; Oncology
3109601 Haifa
IsraelNoch nicht rekrutierend» Google-Maps
Chaim Sheba Medical Center; Oncology Dept
5262100 Ramat Gan
IsraelNoch nicht rekrutierend» Google-Maps
Ospedale San Salvatore, UOC Oncologia
67100 L'Aquila
ItalyRekrutierend» Google-Maps
Ist. Ricovero e Cura a Carattere Scientifico-Centro Rif. Oncologico della Basilica
85028 Rionero In Vulture (PZ)
ItalyRekrutierend» Google-Maps
Grande Ospedale Metropolitano; Oncologia Medica
89133 Reggio Calabria
ItalyRekrutierend» Google-Maps
Az. Osp. Monaldi; 1 Pneumologia Oncologica
80131 Napoli
ItalyRekrutierend» Google-Maps
Istituto Nazionale Tumori Fondazione G. Pascale; U.O.C. Oncologia Medica Toraco Polmonare
80131 Napoli
ItalyRekrutierend» Google-Maps
IRST Istituto Scientifico Romagnolo Per Lo Studio E Cura Dei Tumori, Sede Meldola; Oncologia Medica
47014 Meldola
ItalyRekrutierend» Google-Maps
A.O. Universitaria Policlinico Di Modena; Oncologia
41100 Modena
ItalyRekrutierend» Google-Maps
Azienda Ospedaliera San Camillo Forlanini; U.O.C. Pneumologia Ad Indirizzo Oncologico 1
00152 Roma
ItalyRekrutierend» Google-Maps
Ospedale S.S. Trinità Nuovo; Divisione Oncologia
03039 Sora
ItalyRekrutierend» Google-Maps
IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A
16132 Genova
ItalyRekrutierend» Google-Maps
Ospedale Mater Salutis; Dept of Oncology
37045 Legnago
ItalyRekrutierend» Google-Maps
Ospedale Maggiore Policlinico; U.O.C. di Oncologia Medica
20122 Milano
ItalyRekrutierend» Google-Maps
Asst Santi Paolo E Carlo; Unita Operativa Di Oncologia Medica
20142 Milano
ItalyRekrutierend» Google-Maps
Ospedale Di Circolo E Fondazione Macchi; Oncologia Medica
21100 Varese
ItalyRekrutierend» Google-Maps
Ospedale Civile SS. Antonio E Biagio DI Alessandria; Oncologia
15100 Alessandria
ItalyRekrutierend» Google-Maps
Presidio Ospedaliero Vito Fazzi; Unita Operativa Di Oncologia Medica
73044 Lecce
ItalyRekrutierend» Google-Maps
Ospedale Oncologico A.Businco; Div. Oncologia Medica II
09121 Cagliari
ItalyRekrutierend» Google-Maps
Az Ospedaliera Nuovo Garibaldi Quartiere Nesima; Oncologia Medica
95122 Catania
ItalyRekrutierend» Google-Maps
Casa di Cura La Maddalena; Oncologia Medica
90146 Palermo
ItalyRekrutierend» Google-Maps
Azienda Ospedaliero-Universitaria Careggi; SOD Radioterapia
50134 Firenze
ItalyRekrutierend» Google-Maps
Ospedale Nuovo Della Versilia; Divisione Di Oncologia Medica
55043 Lido Di Camaiore
ItalyRekrutierend» Google-Maps
Ospedale Di Bolzano; Dept. Di Oncologia
39100 Bolzano
ItalyZurückgezogen» Google-Maps
Azienda ULSS 8 Berica; Oncologia Medica - Ospedlae di Vicenza
36100 Vicenza
ItalyRekrutierend» Google-Maps
Middle East Institute of Health Hospital
2624 0000 Bsalim, Mount Lebanon-Metn
LebanonAktiv, nicht rekrutierend» Google-Maps
Hospital of Lithuanian University of Health Sciences Kaunas Clinics, Public Institution
50009 Kaunas
LithuaniaRekrutierend» Google-Maps
National Cancer Institute; Department of Thoracic Surgery and Oncology
LT-08660 Vilnius
LithuaniaRekrutierend» Google-Maps
Onze Lieve Vrouwe Gasthuis, locatie Oost
1091 AC Amsterdam
NetherlandsAktiv, nicht rekrutierend» Google-Maps
Wilhelmina Ziekenhuis Assen
9401 RK Assen
NetherlandsZurückgezogen» Google-Maps
Deventer ziekenhuis
7416 SE Deventer
NetherlandsZurückgezogen» Google-Maps
Catharina ziekenhuis
5623 EJ Eindhoven
NetherlandsAktiv, nicht rekrutierend» Google-Maps
Medisch Centrum Leeuwarden
8934 AD Leeuwarden
NetherlandsAktiv, nicht rekrutierend» Google-Maps
Maasstadziekenhuis
3079 DZ Rotterdam
NetherlandsZurückgezogen» Google-Maps
Zaans Medisch Centrum
1502 DV Zaandam
NetherlandsAktiv, nicht rekrutierend» Google-Maps
Chinese General Hospital and Medical Center
1014 Manila
PhilippinesRekrutierend» Google-Maps
San Juan de Dios Hospital;Oncology Unit
1300 Pasay
PhilippinesRekrutierend» Google-Maps
Lung Center of the Philippines
1104 Quezon City
PhilippinesRekrutierend» Google-Maps
Centrum Pulmonologii i Torakochirurgii; Oddzial Pulmonologiczny z Pododdzialem Chemioterapii
43-360 Bystra
PolandZurückgezogen» Google-Maps
Copernicus Podmiot Medyczny Sp. z o.o. Wojewodzkie Centrum Onkologii
80-219 Gdansk
PolandZurückgezogen» Google-Maps
Centrum Onkologii w Gliwicach; II Klinika Radioterapii i Chemioterapii
44-101 Gliwice
PolandAktiv, nicht rekrutierend» Google-Maps
Regionalny Szpital Specjalistyczny im. W. Bieganskiego; Oddzial Onkologii Klinicznej
86-300 Grudziądz
PolandAktiv, nicht rekrutierend» Google-Maps
Uniwersyteckie Centrum Kliniczne im. K. Gibinskiego SUM; Oddzial Onkologii Klinicznej
40-514 Katowice
PolandZurückgezogen» Google-Maps
Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie
20-954 Lublin
PolandAktiv, nicht rekrutierend» Google-Maps
Samodzielny Publiczny Zespol Gruzlicy i Chorob Pluc w Olsztynie
10-357 Olsztyn
PolandAktiv, nicht rekrutierend» Google-Maps
Mazowieckie Centrum Leczenia Chorob Pluc I Gruzlicy; Oddzial Iii
05-400 Otwock
PolandAktiv, nicht rekrutierend» Google-Maps
SK Przemienienia Panskiego UM im.K.Marcinkowskiego
60-569 Poznan
PolandAktiv, nicht rekrutierend» Google-Maps
Instytut Gruzlicy i Chorob Płuc
01-138 Warszawa
PolandAktiv, nicht rekrutierend» Google-Maps
Wojskowy Instytut Medyczny
04-141 Warszawa
PolandZurückgezogen» Google-Maps
Dolnoslaskie Centrum Onkologii; VII Onkologia Kliniczna
53-439 Wroclaw
PolandZurückgezogen» Google-Maps
WZZOZ Centrum Leczenia Chorob Pluc i Rehabilitacji; O. Pulmonologii i Chemioterapii Nowotworow Pluc
91-520 Łódź
PolandAktiv, nicht rekrutierend» Google-Maps
Wojewódzki Szpital Specjalistyczny im. M. Kopernika w Łodzi
93-513 Łódź
PolandAktiv, nicht rekrutierend» Google-Maps
Hospital Geral; Servico de Pneumologia
3041-801 Coimbra
PortugalAktiv, nicht rekrutierend» Google-Maps
Centro Clinico Champalimaud; Unidade de Pulmao
1400-038 Lisboa
PortugalAktiv, nicht rekrutierend» Google-Maps
Hospital Pulido Valente; Servico de Pneumologia
1796-001 Lisboa
PortugalAktiv, nicht rekrutierend» Google-Maps
Hospital Pedro Hispano; Servico de Oncologia
4454-509 Matosinhos
PortugalAktiv, nicht rekrutierend» Google-Maps
Centro Hospitalar do Porto - Hospital de Santo António; Oncologia
4099-001 Porto
PortugalAktiv, nicht rekrutierend» Google-Maps
Hospital CUF Porto; Servico Pneumologia
4100-180 Porto
PortugalAktiv, nicht rekrutierend» Google-Maps
CHVNG/E_Unidade 1; Servico de Pneumologia
4434-502 Vila Nova De Gaia
PortugalAktiv, nicht rekrutierend» Google-Maps
County Hospital Alba; Oncology
510073 Alba Iulia
RomaniaNoch nicht rekrutierend» Google-Maps
Centrul Medical Focus; Oncologie medicala
021389 Bucharest
RomaniaNoch nicht rekrutierend» Google-Maps
University Clinical Emergency Hospital Bucharest
Bucharest
RomaniaNoch nicht rekrutierend» Google-Maps
Institutul Oncologic Prof. Dr. Al. Trestioreanu Bucuresti
022328 Bucuresti
RomaniaNoch nicht rekrutierend» Google-Maps
Sanador Medical Center; Medical Oncology
Bucuresti
RomaniaZurückgezogen» Google-Maps
Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei Constanta
900591 Constanta
RomaniaNoch nicht rekrutierend» Google-Maps
Institutul Regional de Oncologie Iasi
700483 Iasi
RomaniaNoch nicht rekrutierend» Google-Maps
Spitalul Municipal Ploiesti
100337 Ploiesti
RomaniaNoch nicht rekrutierend» Google-Maps
Oncomed SRL; Oncologie
300239 Timisoara
RomaniaNoch nicht rekrutierend» Google-Maps
Oncocenter Timisoara
300166 Timişoara
RomaniaNoch nicht rekrutierend» Google-Maps
Medical Clinic "AB Medical group"
Saint Petersburg
Russian FederationRekrutierend» Google-Maps
SBIH Kaluga Region Clinical Oncology Dispensary
248007 Kaluga
Russian FederationRekrutierend» Google-Maps
Republican Clinical Oncology Dispensary of Ministry of Healthcare of Tatarstan Republic
420029 Kazan
Russian FederationRekrutierend» Google-Maps
Krasnoyarsk Regional Oncology Dispensary n.a. Krizhanovsky; Chemotherapy
660133 Krasnoyarsk
Russian FederationRekrutierend» Google-Maps
S-Pb clinical scientific practical center of specialized kinds of medical care (oncological)
197758 Saint-Petersburg
Russian FederationRekrutierend» Google-Maps
Bashkirian Republican Clinical Oncology Dispensary
450054 UFA
Russian FederationRekrutierend» Google-Maps
Clinical Center of Serbia
11000 Belgrade
SerbiaAktiv, nicht rekrutierend» Google-Maps
INSTITUTE OF ONCOLOGY LJUBLJANA; Lung Cancer Unit
1000 Ljubljana
SloveniaRekrutierend» Google-Maps
Univerzitetni klinični center Maribor; Oddelek za onkologijo
2000 Maribor
SloveniaRekrutierend» Google-Maps
Complejo Hospitalario Torrecardenas; Servicio de Oncologia
04009 Almería
SpainZurückgezogen» Google-Maps
Complejo Hospitalario Torrecardenas; Servicio de Oncologia
04009 Almería
SpainRekrutierend» Google-Maps
Hospital General de Mataro; Servicio de Oncologia
08304 Mataro
SpainAktiv, nicht rekrutierend» Google-Maps
Corporacio Sanitaria Parc Tauli; Servicio de Oncologia
8208 Sabadell
SpainRekrutierend» Google-Maps
Hospital Universitario Son Espases; Servicio de Oncologia
07014 Palma De Mallorca
SpainAktiv, nicht rekrutierend» Google-Maps
Complejo Hospitalario Universitario de Santiago (CHUS) ; Servicio de Oncologia
15706 Santiago de Compostela
SpainRekrutierend» Google-Maps
Hospital de Gran Canaria Dr. Negrin; Servicio de Oncologia
35020 Las Palmas de Gran Canaria
SpainNoch nicht rekrutierend» Google-Maps
Hospital Universitario Puerta de Hierro; Servicio de Oncologia
28222 Majadahonda
SpainRekrutierend» Google-Maps
Hospital Quiron de Madrid; Servicio de Oncologia
28223 Pozuelo de Alarcon
SpainRekrutierend» Google-Maps
Hospital Infanta Sofia; Servico de Oncologia
28702 San Sebastian de Los Reyes
SpainRekrutierend» Google-Maps
Clinica Universitaria de Navarra; Servicio de Oncologia
31008 Pamplona
SpainZurückgezogen» Google-Maps
Clinica Universitaria de Navarra; Servicio de Oncologia
31008 Pamplona
SpainRekrutierend» Google-Maps
Complejo Hospitalario de Navarra; Servicio de Oncologia
31008 Pamplona
SpainRekrutierend» Google-Maps
Hospital Universitario de Canarias;servicio de Oncologia
38320 La Laguna
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38320 La Laguna
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Complejo Hospitalario Nuestra Señora de la Candelaria; Servicio de Oncologia
38010 Santa Cruz de Tenerife
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Hospital Universitario Infanta Cristina; Servicio de Oncologia
06080 Badajoz
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Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
08041 Barcelona
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Hospital de la Santa Creu i Sant Pau; Servicio de Oncologia
08041 Barcelona
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Complejo Asistencial Universitario De Burgos; Servicio de Oncologia
09006 Burgos
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Hospital San Pedro De Alcantara; Servicio de Oncologia
10003 Caceres
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Hospital Generla de Ciudad Real; Servicio de Oncologia
13005 Ciudad Real
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Hospital Clinico de Granada; Servicio de Oncologia
18016 Granada
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Hospital General Universitario de Guadalajara; Servicio de Oncologia
19002 Guadalajara
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Complejo Hospitalario de Jaen-Hospital Universitario Medico Quirurgico; Servicio de Oncologia
23007 Jaen
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Complejo Asistencial Universitario de Leon; Servicio de Oncologia
24071 Leon
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Hospital Lucus Augusti; Servicio de Oncologia
27003 Lugo
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Fundacion Jimenez Diaz; Servicio de Oncologia
28040 Madrid
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Hospital Universitario La Paz; Servicio de Oncologia
28046 Madrid
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HOSPITAL DE MADRID NORTE SANCHINARRO- CENTRO INTEGRAL ONCOLOGICO CLARA CAMPAL; Servicio de Oncologia
28050 Madrid
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Complejo Hospitalario de Orense; Servicio de Oncologia
32005 Orense
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Hospital General de Segovia; Servicio de Oncologia
40002 Segovia
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Hospital Univ. Nuestra Señora de Valme; Servicio de Oncologia
41014 Sevilla
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Complejo Hospitalario de Toledo- H. Virgen de la Salud; Servicio de Oncologia
45004 Toledo
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Hospital Clinico Universitario de Valladolid; Servicio de Oncologia
47005 Valladolid
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Hospital Universitario Miguel Servet; Servicio Oncologia
50009 Zaragoza
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Hospital Universitario Miguel Servet; Servicio Oncologia
50009 Zaragoza
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NMC Speciality Hospital
Abu Dhabi
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Barnet Hospital; ROYAL FREE LONDON NHS FOUNDATION TRUST
EN5 3DJ Barnet
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Royal United Hospital; Oncology Department
BA1 3NG Bath
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Clatterbridge Cancer Centre
CH63 4JY Bebington
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Heartlands Hospital; Department Of Medicine
B9 5SS Birmingham
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East Lancashire Hospitals NHS Trust
BB10 2PQ Burnley
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Addenbrookes Hospital
CB2 0QQ Cambridge
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Velindre Cancer Centre
CF14 2TL Cardiff
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Diana Princess of Wales Hosp.
DN33 2BA Grimsby
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Royal Surrey County Hospital
GU2 7XX Guildford
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Northwick Park Hospital
HA1 3UJ Harrow
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Huddersfield Royal Infirmary; The Learning Centre
HD3 3EA Huddersfield
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Airedale General Hospital; Research Office Ward 12
BD20 6TD Keighley
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Royal Marsden Hospital
KT2 7QB Kingston upon Thames
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St Bartholomew's Hospital
EC1A 7BE London
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Royal Free Hospital; Dept of Oncology
NW3 2QG London
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Guys and St Thomas Hospital
SE1 9RT London
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Queen Elizabeth Hospital
SE18 4QH London
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St George's Hospital; Oncology
SW17 0QT London
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Royal Marsden Hospital - Fulham
SW3 6JJ London
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Hammersmith Hospital; Dept of Oncology
W12 OHS London
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Charing Cross Hospital
W6 8RF London
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Maidstone Hospital; Kent Oncology Centre
ME16 9QQ Maidstone
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Freeman Hospital
NE7 7DN Newcastle upon Tyne
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Nottingham City Hospital; Oncology
NG5 1PB Nottingham
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Royal Preston Hospital
PR2 9HT Preston
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Weston Park Hospital
S10 2SJ Sheffield
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Royal Stoke University Hospital
ST4 6QG Stoke-on-Trent
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Royal Marsden Hospital (Sutton)
SM2 5PT Sutton
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Torbay Hospital; Oncology Department
TQ27AA Torquay
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Royal Cornwall Hospital
TR1 3LQ Truro
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Pinderfields General Hospital
WF1 4DG Wakefield
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Great Western Hospitals NHS Foundation Trust.
SN3 6BB Wiltshire
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New Cross Hospital
WV10 0QP Wolverhampton
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Alle anzeigen

Studien-Informationen

Detailed Description:

The study will be split into separate cohorts based on the approved indications for

atezolizumab treatment, excluding cisplatin ineligible participants receiving atezolizumab as

first line of therapy (LOT1) for locally advanced/metastatic urothelial cancer (locally

advanced/metastatic UC). The study may be amended for inclusion of new cohorts as these are

approved in the participating countries. Participants will be included into each cohort based

on their indication for receiving atezolizumab.

Ein-/Ausschlusskriterien

Inclusion Criteria:

- Patient must have one of the following confirmed diagnoses for which atezolizumab is

locally approved in the SmPC: (1) As monotherapy for the treatment of adult patients

with locally advanced/metastatic UC after prior platinum-containing chemotherapy

(Cohort 1 LOT2+mUC) or (2) As monotherapy for the treatment of adult patients with

locally advanced/metastatic NSCLC after prior chemotherapy. Patients with EGFR

activating mutations or ALK-positive tumour mutations should also have received

targeted therapy before receiving atezolizumab (Cohort 2 LOT2+NSCLC) or (3) In

combination with bevacizumab, paclitaxel and carboplatin for the first line treatment

of adult patients with metastatic non-squamous NSCLC. Patients with EGFR activating

mutations or ALK- positive tumour mutations should also have received targeted therapy

(Cohort 3 LOT1 NSCLC) or (4) In combination with carboplatin and etoposide, is

indicated for the first-line treatment of adult patients with extensive-stage small

cell lung cancer (ES-SCLC) (Cohort 4 LOT1 ES-SCLC) or (5) As a monotherapy, for the

treatment of metastatic NSCLC with high PD-L1 expression, previously untreated (Cohort

5 LOT1 NSCLC) or (6) In combination with bevacizumab for unresectable locally advanced

or metastatic hepatocellular carcinoma previously untreated with systemic therapy

(Cohort 6 LOT1 HCC) .

- Patient is administered atezolizumab therapy for the first time.

- Decision to administer atezolizumab must be made and documented prior to inclusion

into the study and must follow local clinical practice.

Exclusion Criteria:

- Patients not receiving treatment for a disease with atezolizumab according to standard

of care and in line with the current summary of product characteristics (SPC) or local

labelling. Cisplatin ineligible patients receiving atezolizumab LOT1 for the treatment

of locally advanced/metastatic UC patients will be excluded

- Concomitant anti-cancer therapy at the time of starting atezolizumab on the index date

not part of locally approved combination therapy with atezolizumab.

- Treatment with atezolizumab as part of a clinical trial or for compassionate use as

part of a pre-approval or compassionate use program.

- Patients not receiving atezolizumab, but a biosimilar or non-original biologic.

Studien-Rationale

Primary outcome:

1. Overall Survival (OS) (Time Frame - Index date up to approximately 6 years):
Time from index date until date of death from any cause. Index date is the date of administration of the first ever dose of atezolizumab for each patient.

2. OS at 2 Years (Time Frame - After index date up to 2 years):
Percentage of participants alive 2 years after initiation of atezolizumab treatment.

Secondary outcome:

1. Time to Loss of Clinical Benefit (TTLCB) (Time Frame - Index date up to approximately 6 years):
Time from the index date to loss of clinical benefit as assessed by the treating physician.

2. Progression Free Survival (PFS) (Time Frame - Index date up to approximately 6 years):
Time from index date to death or disease progression (PD).

3. Objective Response Rate (ORR) (Time Frame - After index date up to approximately 6 years):
Percentage of participants who have a best overall response (BOR) of Complete Response (CR) or Partial Response (PR). BOR for each participant is the best response achieved after the index date prior to initiation of any subsequent treatment.

4. Time to Response (Time Frame - Index date up to approximately 6 years):
Time from index date to first objective tumor response, CR or PR.

5. Duration of Response (DoR) (Time Frame - Index date up to approximately 6 years):
Time from first documentation of CR or PR (whichever occurs first) after index until death or PD.

6. Disease Control Rate (DCR) (Time Frame - From 12 weeks after index date up to approximately 6 years):
Percentage of participants who have achieved CR, PR and stable disease at least 12 weeks after the index date.

7. Duration of DCR (Time Frame - After index date up to approximately 6 years):
Time from first documentation of CR, PR or stable disease (whichever occurs first) after index until death or PD.

8. EuroQol 5-Dimension 5-Level (EQ-5D-5L) Questionnaire Score (Time Frame - Index date or after ICF signature, & approx. at 6, 12, and 24 weeks of treatment; then at approx. 3 months, 6 months, 12 months, & every 12 months thereafter until end of study (study planned duration up to approximately 6 years)):
EQ-5D-5L during and after atezolizumab treatment will be used to assess HRQoL. Scale is from 1-5 (no problems, slight problems, moderate problems, severe problems and extreme problems).

9. WPAI-GH Score (Time Frame - Index date or after ICF signature, & approx. at 6, 12, & 24 weeks of treatment; then at approx. 3 months, 6 months, 12 months, & every 12 months thereafter until end of study (study planned duration up to approximately 6 years)):
Work Productivity and Activity Impairment Questionnaire General Health V2.0 (WPAI-GH) during and after atezolizumab treatment will be used to assess the ability to work. The WPAI-GH is a standardized questionnaire used to measure the impact of health on work performance. From the WPAI-GH, absenteeism (the percentage of work time missed), presenteeism (the percentage of time when working that productivity is impaired), overall work impairment (a combination of absenteeism and presenteeism), and total activity impairment (the percentage of impairment in daily activities) can be measured.

10. Number of Paricipants with Disease Stage TNM and IUCC (Time Frame - At index date (Index date is the date of administration of the first ever dose of atezolizumab for each patient.))

11. Number of Participants at Each Level of Karnofsky or ECOG Performance Status (Time Frame - At index date (Index date is the date of administration of the first ever dose of atezolizumab for each patient.)

12. Total Number of Infusions of Atezolizuamb (Time Frame - Treatment period until discontinuation (up to approximately 6 years))

13. Duration of Treatment With Atezolizumab (Time Frame - Index date until date of treatment discontinuation (up to approximately 6 years))

14. Time to initiation of subsequent cancer-related therapies (Time Frame - Up to approximately 6 years)

15. Percentage of Participants with Adverse Events (Time Frame - Up to approximately 6 years)

Studien-Arme

  • Cohort 1 (UC LOT2+later lines[LOT2+] & platinum eligible LOT1)
    Participants diagnosed with locally advanced or metastatic Urothelial Cancer previously treated with platinum-containing chemotherapy. Enrollment is closed.
  • Cohort 2 (NSCLC LOT2 plus later lines [LOT2+])
    Participants diagnosed with Locally advanced or metastatic Non-Small Cell Lung Cancer (NSCLC) after prior chemotherapy. Participants with epidermal growth factor receptor (EGFR) activating mutations or anaplastic lymphoma kinase (ALK)-positive tumor mutations should also have received targeted therapy. Enrollment closed.
  • Cohort 3 (NSCLC LOT1 plus EGFR+/ALK+ LOT2+)
    EMA: Participants diagnosed with locally advanced/metastatic non-squamous NSCLC not previously treated. Participants with EGFR-activating mutations or ALK-positive tumor mutations should have received at least one line of targeted therapy. FDA: for the treatment of adult participants with metastatic NSCLC who have disease progression during or following platinum-containing chemotherapy. Participants with EGFR or ALK genomic tumor aberrations should have disease progression on FDA-approved therapy for NSCLC harboring these aberrations prior to receiving TECENTRIQ.
  • Cohort 4 (ES-SCLC LOT1)
    Participants diagnosed with extensive stage (ES) small cell lung cancer (SCLC) not previously treated.
  • Cohort 5 (NSCLC LOT1)
    Participants diagnosed with metastatic Non-Small Cell Lung cancer with high PD-L1 expression, previously untreated.
  • Cohort 6 (HCC LOT1)
    Participants diagnosed with unresectable locally advanced or metastatic hepatocellular carcinoma previously untreated with systemic therapy.

Geprüfte Regime

  • Atezolizumab (Tecentriq):
    Atezolizumab will be administered at the discretion of the treating physician per local guidelines and independently of participation in this study.

Quelle: ClinicalTrials.gov


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