25. Mai 2018 Engagement und Fortschritt im Forschungsbereich Onkologie

Im Bereich der hämatologischen malignen Erkrankungen werden die Forscher Daten zum BCL‑2-Inhibitor Venetoclax, der gemeinsam von AbbVie und Genentech entwickelt wurde, für verschiedene Indikationen vorstellen. Darüber hinaus wird das Unternehmen aktuelle Daten zu Prüfpräparaten von AbbVie in späten Entwicklungsphasen vorstellen, u.a. zu:

· Depatuxizumab-Mafodotin (Depatux‑M; ABT‑414), ein Antikörper-Wirkstoff-Konjugat (antibody drug conjugate, ADC), das bei rezidivierendem Glioblastom (rGBM) mit Amplifikation des epidermalen Wachstumsfaktorrezeptors (epidermal growth factor receptor, EGFR) untersucht wird

· Rovalpituzumab-Tesirin (Rova‑T), ein ADC, das auf Tumore mit Expression eines Proteins namens DLL3 abzielt und bei kleinzelligem Lungenkarzinom (small-cell lung cancer, SCLC) untersucht wird

· Veliparib, ein oraler PARP (Poly-Adenosin-Diphosphat [ADP]-Ribose-Polymerase)-Inhibitor, der im Zusammenhang mit verschiedenen soliden Tumoren untersucht wird

Die im Rahmen des ASCO präsentierten Abstracts sind z.B.

Venetoclax

•Phase 2 Study of Venetoclax Plus Carfilzomib and Dexamethasone in Patients with Relapsed/Refractory Multiple Myeloma; Costa et al.; Abstract 8004; Oral Abstract Session; Friday, June 1, 2018; 3:57 p.m.-4:09 p.m. CT

•Open-Label, Dose-Escalation, Phase 1 Study of Venetoclax in Combination with Navitoclax and Chemotherapy in Patients with Relapsed Acute Lymphoblastic Leukemia; Alexander et al.; Abstract TPS10575; Poster Session; Saturday, June 2, 2018; 8:00 a.m.-11:30 a.m. CT

•High, Durable Minimal Residual Disease Negativity (MRD–) with Venetoclax + Rituximab (VenR) in Relapsed/Refractory (R/R) CLL: MRD Kinetics from Phase 3 MURANO Study; Hillmen et al.; Abstract 7508; Oral Abstract Session; Sunday, June 3, 2018; 11:57 a.m.-12:09 p.m. CT

•Phase 1b Study of Venetoclax in Combination with Azacitidine in Patients with Treatment-Naïve Higher-Risk Myelodysplastic Syndromes; Fong et al.; Abstract TPS7082; Poster Session; Monday, June 4, 2018; 8:00 a.m.-11:30 a.m. CT

•Management and Outcomes of 222 CLL Patients (pts) Treated with Venetoclax (VEN) in the Real World; Nabhan et al.; Abstract 7529; Poster Session; Monday, June 4, 2018; 8:00 a.m.-11:30 a.m. CT

•Mitigation of Tumor Lysis Syndrome (TLS) Complications with Venetoclax (VEN) in CLL; Davids et al.; Abstract 7526; Poster Session; Monday, June 4, 2018; 8:00 a.m.-11:30 a.m. CT

•A Phase 1/2, Multicenter, Dose-Escalation and Expansion Study of Combination Therapy with Venetoclax, Daratumumab, and Dexamethasone (with and without Bortezomib) in Subjects with Relapsed or Refractory Multiple Myeloma; Bueno et al.; Abstract TPS8061; Poster Session; Monday, June 4, 2018; 8:00 a.m.-11:30 a.m. CT

•Durability of Response to Venetoclax (VEN) in Patients with CLL Who are Refractory to or Relapsed After Ibrutinib and/or Idealisib; Byrd et al.; Abstract 7512; Poster Discussion Session; Monday, June 4, 2018; Poster 8:00 a.m.-11:30 a.m. CT; Discussion 1:15 p.m.-2:30 p.m. CT

•Durable Response with Venetoclax in Combination with Decitabine or Azacitadine in Elderly Patients with Acute Myeloid Leukemia (AML); Dinardo et al.; Abstract 7010; Clinical Science Symposium; Monday, June 4, 2018; 4:30 p.m.-6:00 p.m. CT

•Feasibility and Implementation of Geriatric Assessment Measures and Patient-Reported Outcomes in Acute Myeloid Leukemia; Klepin et al.; Publication only

Depatux-M

•Updated Results of the INTELLANCE 2/EORTC Trial 1410 Randomized Phase II Study on Depatux–M Alone, Depatux-M in Combination with Temozolomide (TMZ) and Either TMZ or Lomustine (LOM) in Recurrent EGFR Amplified Glioblastoma (NCT02343406); Van Den Bent et al.; Abstract 2023; Poster Session; Saturday, June 2, 2018; 1:15 p.m.-4:45 p.m. CT

•Effect of Therapeutic Pressure on Stability of EGFR Amplification in Glioblastoma; Ahluwalia et al.; Abstract 2033; Poster Session; Saturday, June 2, 2018; 1:15 p.m.-4:45 p.m. CT

Rova-T

•Efficacy and Safety of Rovalpituzumab Tesirine in Patients with DLL3-Expressing, ≥ 3rd Line Small Cell Lung Cancer: Results from the Phase 2 TRINITY Study; Carbone et al.; Abstract 8507; Oral Abstract Session; Monday, June 4, 2018; 10:12 a.m.-10:24 a.m. CT

•Incidence of Pre-Treatment and Off-Treatment Pericardial and Pleural Effusions by Line of Therapy in Patients with Small Cell Lung Cancer: An Analysis of Electronic Health Records Data; Jiang et al.; Publication only

Veliparib

•Phase 2 Study of Veliparib Plus FOLFIRI ± Bevacizumab versus Placebo Plus FOLFIRI ± Bevacizumab in Metastatic Colorectal Cancer; Gorbunova et al.; Abstract 3543; Poster Session; Sunday, June 3, 2018; 8:00 a.m.-11:30 a.m. CT

•Veliparib in Combination with Nivolumab and Platinum Doublet Chemotherapy (CT) in Metastatic/Advanced NSCLC; Clarke et al.; Abstract 3061; Poster Session; Monday, June 4, 2018; 8:00 a.m.-11:30 a.m. CT